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1 e decarboxylase (MDD) catalyzes formation of isopentenyl 5-diphosphate in an ATP-dependent irreversib
4 ve found that discadenine and its precursor, isopentenyl adenine, not only maintain spore dormancy bu
6 Other cytokinins, including N(6)-(delta(2)-isopentenyl)adenine, trans-zeatin, benzyladenine, kineti
7 , is a tRNA modifying enzyme that adds an N6-isopentenyl adenosine modification at position 37 on a s
8 Also, increased levels (10- to 20-fold) of isopentenyl adenosine, the product of the reaction catal
10 B attaches a methylthio group at C2 of N(6)-(isopentenyl)adenosine, found at nucleotide 37 in several
11 ins to produce adenine and the corresponding isopentenyl aldehyde, play a major role in regulating cy
14 ate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphat
15 e (MEP) pathway leads to the biosynthesis of isopentenyl diphosphate (IDP) and dimethylallyl diphosph
16 They are derived from the 5C building blocks isopentenyl diphosphate (IDP) and its isomer dimethylall
17 oducts dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) was postulated, but the ex
18 s an isopentenyl phosphate kinase that forms isopentenyl diphosphate (in a reaction analogous to that
19 creased protein levels by 9-fold and reduced isopentenyl diphosphate (IPP) accumulation by 4-fold.
21 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
22 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
23 ve-carbon building blocks of all terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosph
24 e synthesized from the isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosph
25 l 2-phosphate (MEP) pathway for synthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
26 point at which the pathway branches to form isopentenyl diphosphate (IPP) and dimethylallyl diphosph
27 e isomerase catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
28 equential chain elongation reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosph
29 s D-glyceraldehyde phosphate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosph
30 (HMBPP) into the two isoprenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosph
31 C(15) and C(20) isoprenoid diphosphates from isopentenyl diphosphate (IPP) and dimethylallyl diphosph
32 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
34 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
37 ginate from the five-carbon building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylall
38 ntenyl diphosphate isomerase (IDI) activates isopentenyl diphosphate (IPP) for polymerization by conv
39 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate (IPP) in a reaction catalyzed by
40 sphate isomerase (IDI) catalyzed reaction of isopentenyl diphosphate (IPP) in D(2)O gives a 66% yield
41 actions of allylic diphosphate acceptor with isopentenyl diphosphate (IPP) in the cis (Z) configurati
42 osphates to the carbon-carbon double bond in isopentenyl diphosphate (IPP) in the primary building re
47 rase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules to an allylic di
49 (IDI) catalyzes the essential conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphospha
50 enoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphospha
53 lta2 T cells: pyrophosphomonoesters, such as isopentenyl diphosphate (IPP), nitrogen-containing bisph
54 ynthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate
61 he consecutive head-to-tail condensations of isopentenyl diphosphate (IPP, C5) with dimethylallyl dip
62 on of the two isoprenoid universal C5 units, isopentenyl diphosphate and dimethylally diphosphate, to
63 iene synthesis, we amplified the flux toward isopentenyl diphosphate and dimethylallyl diphosphate pr
64 thetic origin in the initial condensation of isopentenyl diphosphate and dimethylallyl diphosphate to
65 synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to
66 hly dependent on the ratio of the substrates isopentenyl diphosphate and dimethylallyl diphosphate us
67 I-2), which catalyzes the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, c
69 hways operate in plants for the synthesis of isopentenyl diphosphate and dimethylallyl diphosphate, t
70 alloenzyme that catalyzes interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, w
71 esis of their two universal building blocks, isopentenyl diphosphate and dimethylallyl diphosphate, w
72 yzes the formation of neryl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.
73 he biosynthesis of the isoprenoid precursors isopentenyl diphosphate and dimethylallyl diphosphate.
74 ene geranyl diphosphate, when incubated with isopentenyl diphosphate and dimethylallyl diphosphate.
75 ate on the mevalonate-independent pathway to isopentenyl diphosphate and dimethylallyl diphosphate.
76 sis of the universal terpene building blocks isopentenyl diphosphate and dimethylallyl diphosphate.
77 oducing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
78 l diphosphate (HMBPP) into the two products, isopentenyl diphosphate and dimethylallyl diphosphate.
79 ducing the universal precursors of terpenes: isopentenyl diphosphate and dimethylallyl diphosphate.
80 s the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.
82 early pathway genes known to be involved in isopentenyl diphosphate and farnesyl diphosphate biosynt
83 se enzymes represented upstream pathways for isopentenyl diphosphate and geranylgeranyl diphosphate s
84 cript levels of paralogs encoding isoprenoid isopentenyl diphosphate and geranylgeranyl diphosphate-p
85 ylerythritol phosphate pathway to synthesize isopentenyl diphosphate and its allyl isomer dimethylall
86 renoids are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl dip
87 phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate and its isomer, dimethylallyl di
88 the conversion of radiolabeled mevalonate to isopentenyl diphosphate and other downstream products, i
90 hiolo-dimethylallyl diphosphate and S-thiolo-isopentenyl diphosphate bind intact to S2, but are cleav
91 coding enzymes of the mevalonate pathway for isopentenyl diphosphate biosynthesis in the gram-positiv
92 committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway and is a po
93 e mevalonate-independent pathway is the sole isopentenyl diphosphate biosynthetic pathway in this org
94 structures of Rv2361c in the apo form, with isopentenyl diphosphate bound and with a substrate analo
96 hydrogens of a vinyl thiomethyl analogue of isopentenyl diphosphate exchanged with solvent when the
97 wever, based on in vivo feeding experiments, isopentenyl diphosphate formation in several eubacteria,
98 l three enzymes responsible for synthesis of isopentenyl diphosphate from mevalonate (mevalonate kina
100 for metabolism of mevalonate 5-phosphate to isopentenyl diphosphate in Haloferax volcanii, two open
101 and co-locate with the homoallylic substrate isopentenyl diphosphate in other prenyltransferases.
103 hosphate showed a 10-fold increase of [(14)C]isopentenyl diphosphate incorporation into decaprenyl di
104 phosphate showed a 5-fold increase of [(14)C]isopentenyl diphosphate incorporation into farnesyl diph
105 recombinant strains were assayed for [(14)C]isopentenyl diphosphate incorporation into isoprenyl dip
115 psis thaliana cDNAs (IPP1 and IPP2) encoding isopentenyl diphosphate isomerase (IPP isomerase) were i
119 ntly described the identification of a novel isopentenyl diphosphate isomerase, IDI2 in humans and mi
122 ne, orf177, is a member of a large family of isopentenyl diphosphate isomerases, while sequence homol
123 respectively, the addition of two and three isopentenyl diphosphate molecules to dimethylallyl dipho
125 ting carbon flow from cytosolic or plastidic isopentenyl diphosphate through overexpression in either
126 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate to form geranyl diphosphate.
128 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key
129 phosphate synthase catalyzed the addition of isopentenyl diphosphate to omega,E-geranyl diphosphate o
130 es, responsible for converting mevalonate to isopentenyl diphosphate under the control of an arabinos
133 product of mevalonate metabolism proximal to isopentenyl diphosphate was responsible for the suppress
134 ases catalyze the sequential condensation of isopentenyl diphosphate with allylic diphosphates to syn
135 ead-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate.
136 f 7-8, and K(m) values of 124 micrometer for isopentenyl diphosphate, 38 micrometer for geranyl dipho
137 cteria, green algae, and plant chloroplasts, isopentenyl diphosphate, a key intermediate in the biosy
138 d arenarone bound solely to the homoallylic (isopentenyl diphosphate, IPP) site, not to the allosteri
139 Biosynthesis of the isoprenoid precursor, isopentenyl diphosphate, is a critical function in all i
143 y the nonmevalonate pathway for synthesis of isopentenyl diphosphate, the monomer unit for isoprenoid
150 nzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphosphate/dimethylallyl diphosphate isomer
151 DP-galactopyranose mutase (UGM), and type II isopentenyl diphosphate:dimethylallyl diphosphate isomer
155 ive pathway for carbon flux amplification to isopentenyl-diphosphate (IPP) and dimethylallyl-diphosph
156 hosphate (FPP) synthase (geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase, EC 2.5.
157 abolites via the condensation of geranyl- or isopentenyl-diphosphate moieties by geranyltranstransfer
159 l, as well as the diphosphate derivatives of isopentenyl, geranyl, farnesyl, geranylgeranyl, and pres
160 , and Caenorhabditis elegans GRO-1 that adds isopentenyl groups to adenosine 37 (i6A37) of substrate
161 predicted ORF4 product is closely related to isopentenyl isomerase (IDI) enzymes, whereas the predict
164 kinase that catalyzes the phosphorylation of isopentenyl monophosphate as the last step of this biosy
165 terpenes and sesquiterpenes, confirming that isopentenyl monophosphate is the physiologically relevan
166 ted from peppermint glandular trichomes with isopentenyl monophosphate resulted in the rapid producti
168 A pathway where PM is decarboxylated to give isopentenyl phosphate (IP), which is phosphorylated to p
170 discovery of an alternative MVA pathway with isopentenyl phosphate kinase (IPK) catalyzing the final
171 ese missing elements led to the discovery of isopentenyl phosphate kinase (IPK), one of two activitie
172 biosynthesis, Methanocaldococcus jannaschii isopentenyl phosphate kinase is predicted to be a member
173 both the phosphomevalonate decarboxylase and isopentenyl phosphate kinase reactions that are required
174 ese proteins indicated that one enzyme is an isopentenyl phosphate kinase that forms isopentenyl diph
175 0044 gene product was found to phosphorylate isopentenyl phosphate, generating isopentenyl diphosphat
177 rbamoyl phosphate, UDP-glucose, and Delta(2)-isopentenyl-PP play similar roles in using group transfe
179 zation of the two ubiquitous isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyroph
182 amma-dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) to all of the known terp
183 the recombinant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyroph
184 at catalyzes the reversible isomerization of isopentenyl pyrophosphate (IPP) to dimethylallyl pyropho
186 nsecutive condensation of eight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosph
189 ol-4-phosphate pathway used by microbes, and isopentenyl pyrophosphate (IPP), an intermediate in the
190 encoding early steps in the biosynthesis of isopentenyl pyrophosphate (IPP), the precursor of all is
192 present only a subset of the phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-meth
194 ylerythritol-phosphate (MEP) pathway forming isopentenyl pyrophosphate and a heterologous downstream
195 , pulsing of BZ-(C)-C(5)-OPP is inhibited by isopentenyl pyrophosphate and an inactive analog, sugges
197 mulation with prenyl pyrophosphate antigens (isopentenyl pyrophosphate and monomethyl phosphate).
198 madelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and hum
199 ed reactivity to the prenyl pyrophosphate Ag isopentenyl pyrophosphate and to its synthetic analogue
200 ood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic analogue
201 s Ag-nonreactive TCR destroyed reactivity to isopentenyl pyrophosphate and to the mycobacterial super
202 inity of 1.1 muM, whereas the endogenous pAg isopentenyl pyrophosphate binds with an affinity of 627
204 onophosphate kinase superfamily, and between isopentenyl pyrophosphate isomerases and MutT pyrophosph
205 by nonpeptidic monoalkyl phosphates such as isopentenyl pyrophosphate leads to the up-regulation of
206 ay, catalyzes the successive condensation of isopentenyl pyrophosphate with dimethylallyl pyrophospha
207 ethylerythritol phosphate pathway to produce isopentenyl pyrophosphate with more favorable thermodyna
208 the biosynthesis of the isoprenoid precursor isopentenyl pyrophosphate, 1-deoxy-D-xylulose-5-phosphat
209 on of mevalonate 5-diphosphate (MDP) to form isopentenyl pyrophosphate, a ubiquitous precursor for is
210 P), a microbial isoprenoid intermediate, and isopentenyl pyrophosphate, an endogenous isoprenoid inte
211 nic lines showed a three-fold enhancement of isopentenyl pyrophosphate, and targeting AACPR, DBR2, an
212 mportant accessory cells that provide the Ag isopentenyl pyrophosphate, CD56(bright)CD11c(+) NK cells
213 of TRPA1, being inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 k
215 levels > or =30 microM profoundly inhibited isopentenyl pyrophosphate-induced release of the chemoki
225 thesis pathway responsible for production of isopentenyl-pyrophosphate, a short-chain phospholipid th
227 Five compounds, dimethylallyl phosphate, isopentenyl thiolophosphate, 1-butyl phosphate, 3-buten-
228 butylammonium) salt was then used to convert isopentenyl tosylate to (S)-isopentenyl thiodiphosphate
229 Expression from the cytokinin-synthesizing isopentenyl transferase (IPT) enzyme under the control o
232 directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell di
233 plished by employing Omega-mutated virD2 and isopentenyl transferase cytokinin genes to impair T-DNA
234 Expression of the cytokinin-synthesizing isopentenyl transferase enzyme under the control of the
235 ipt, the bacterial gene encoding the enzyme isopentenyl transferase from Agrobacterium tumefaciens,
236 ved in the crown region of nonconnated SAG12-isopentenyl transferase kernels, suggesting that cytokin
240 ne, the product of the reaction catalyzed by isopentenyl transferase, were detected in ros mutant str
244 ho, which encodes a protein with homology to isopentenyl transferases (IPTs), also causes CK-specific
245 be complemented by the plant and human tRNA isopentenyl transferases, but not the bacterial enzymes,
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