ライフサイエンスコーパス: isoprenyl

1 pheromones as well as in the masses of their isoprenyl adducts.

2 cted with prenyl-type selenosulfides to give isoprenyl alkyl sulfides.

3 e pathway and precursors for the addition of isoprenyl anchors to many membrane proteins.

4 rom the outer leaflet of the membrane to the isoprenyl binding site observed in the previously report

5 renyl-binding protein delta (PrBP/delta), an isoprenyl-binding protein that is highly expressed in ph

6 on; type II semiquinones like PQ-9- have the isoprenyl C beta C gamma bond coplanar with the aromatic

7 inates from nonbonded repulsions between the isoprenyl chain and the C6 methyl group present in type

8 The data show that the conformation of the isoprenyl chain at C beta relative to the aromatic ring

9 lated analogues Z- and E-crotyl chloride and isoprenyl chloride.

10 ferase, RCE-1 (Ras-converting enzyme-1), and isoprenyl cysteine carboxyl methyltransferase host farne

11 s also did not inhibit the activities of the isoprenyl-cysteine carboxyl methyltransferase ICMT or th

12 We show that the choice of isoprenyl derivative is determined by the C-terminal (ma

13 hosphates in the presence of various allylic isoprenyl diphosphate acceptors.

14 natural products are generally derived from isoprenyl diphosphate precursors with trans double-bond

15 we identified nine divergent putative trans-isoprenyl diphosphate synthase (trans-IDS) transcripts.

16 The recombinant enzyme P. cochleariae isoprenyl diphosphate synthase 1 (PcIDS1) yields 96% C10

17 and partial characterization of two unique Z-isoprenyl diphosphate synthase homologs from Mycobacteri

18 is is the first description of a short chain isoprenyl diphosphate synthase that generates products w

19 conserved operon which includes an adjacent isoprenyl diphosphate synthase, shown here to produce th

20 losis H37Rv genome sequence encodes a unique isoprenyl diphosphate synthase.

21 The short-chain isoprenyl diphosphate synthases (IDS) are situated at cr

22 Isoprenyl diphosphate synthases (IDSs) produce the ubiqu

23 Previously, all known short chain isoprenyl diphosphate synthases catalyze the synthesis o

24 transcript levels by RNA interference of the isoprenyl diphosphate synthases identified GGPP synthase

25 To investigate the role of isoprenyl diphosphate synthases in pheromone biosynthesi

26 ids obtained from a sequence alignment of 35 isoprenyl diphosphate synthases that synthesize farnesyl

27 s the sequence structural motifs common to E-isoprenyl diphosphate synthases.

28 , shares little sequence identity with other isoprenyl diphosphate synthases; yet it is absolutely re

29 be involved in the specialized production of isoprenyl diphosphates for the posttranslational modific

30 C]isopentenyl diphosphate incorporation into isoprenyl diphosphates in the presence of various allyli

31 ain IDSs (scIDSs) make the C10, C15, and C20 isoprenyl diphosphates separately.

32 ded form and bound to Mg2+ and two different isoprenyl diphosphates.

33 P), an allyl ether type PCE (PCEA-P), and an isoprenyl ether type PCE (PCEI-P) with ethylene oxide (E

34 These variants included modifications of the isoprenyl group (gamma), residues involved in the confor

35 Since the isoprenyl group is required for G protein function, it i

36 It has been proposed that the isoprenyl group of Gbetagamma inserts into this pocket,

37 her, while both peaks are isoprenylated, the isoprenyl groups consist of mixtures of C5, C10, C15, an

38 largely unknown, but involves the binding of isoprenyl groups on PDE6 to the FKBP domain of AIPL1.

39 Post-translational attachment of isoprenyl groups to conserved cysteine residues at the C

40 e differentially conjugated to palmitoyl and isoprenyl groups.

41 ble to their ability to reduce the levels of isoprenyl intermediates in the cholesterol biosynthetic

42 ition of either a farnesyl or geranylgeranyl isoprenyl lipid moiety to the cysteine residue of the CA

43 ications of proteins, such as addition of an isoprenyl lipid to a carboxyl-terminal cysteine in prote

44 odification of a C-terminal cysteine with an isoprenyl lipid via a process called protein prenylation

45 -carbon farnesyl or 20-carbon geranylgeranyl isoprenyl lipid, proteolysis of the C-terminal -AAX trip

46 e cell membrane and also identify a role for isoprenyl lipids.

47 PDE6 is membrane associated through isoprenyl membrane anchors attached to the C-termini of

48 REP-1 enables posttranslational isoprenyl modification of Rab GTPases, proteins that con

49 enzymes that catalyze the post-translational isoprenyl modifications of proteins, exhibit potent anti

50 y small G-proteins require addition of these isoprenyl moieties at their C termini for normal GTPase

51 ) of Rabs is posttranslationally modified by isoprenyl moieties that enable membrane association.

52 1F, both in the apo form and in complex with isoprenyl moieties.

53 consist of mixtures of C5, C10, C15, and C20 isoprenyl moieties.

54 d evidence indicates that Rce1p requires the isoprenyl moiety as an important substrate determinant.

55 ted substrates in vitro, indicating that the isoprenyl moiety is not required for substrate recogniti

56 Competition experiments with water-soluble isoprenyl monophosphates showed that MPD flippase recogn

57 , an undecaprenol kinase that provides C(55)-isoprenyl phosphate by de novo synthesis.

58 rtate-rich region that is common among trans-isoprenyl phosphate synthases.

59 The addition of the isoprenyl precursors, mevalonic acid, and geranylgeranyl

60 hly conserved domains common among all known isoprenyl pyrophosphate synthases.

61 The action of Dpp1p on isoprenyl pyrophosphates was confirmed by characterizati

62 were gamma 9+ delta 2+ T cells reactive with isoprenyl pyrophosphates.

63 on center protein structures surrounding the isoprenyl/quinone head junction of QA to accommodate the

64 r protein and ultimately generate a Delta(2)-isoprenyl-S-carrier protein.

65 K-2 has a folded conformation defined by the isoprenyl side-chain folding back over the napthoquinone

66 A variety of aryl and isoprenyl substituents are shown to afford effective inh

67 ree enzymes, and a scenario for evolution of isoprenyl synthases in plants is presented.

68 at both imparts lipophilicity in lieu of the isoprenyl tail of ubiquinone, and reports on redox chang

69 ta action does not alter the overall protein isoprenyl transferase activity in Mv1Lu mink lung epithe

70 Studies involving the specific isoprenyl transferase inhibitors FTI-277 and GGTI-286 de

71 enol phosphate (PP) containing nine repeated isoprenyl units (C(45)-PP).