ライフサイエンスコーパス: isoprenylation

1 erentiation/function via inhibition of Rap1A isoprenylation.

2 protein function and is normally mediated by isoprenylation.

3 may be related to its inhibition of protein isoprenylation.

4 isoprenoid diphosphate pool used for protein isoprenylation.

5 lgeranyl-pyrophosphate to circumvent loss of isoprenylation.

6 ansduction pathways, are the key targets for isoprenylation.

7 an interaction that is dependent on protein isoprenylation.

8 , two lipid phosphate phosphohydrolases, and isoprenylation.

9 GGPP, independent of restoration of protein isoprenylation.

10 s of diabetic nephropathy, by preventing Rho isoprenylation.

11 inhibit cardiac hypertrophy by blocking Rho isoprenylation.

12 (ii) This increase was independent of isoprenylation.

13 iosynthesis of isoprenoid lipids and protein isoprenylation.

14 9a to furnish identical products of carbonyl isoprenylation 1c-3c.

15 ucts of carbonyl crotylation 1b-6b, carbonyl isoprenylation 1c-6c, and carbonyl reverse 2-methyl pren

16 ue to a lovastatin-induced blockade in their isoprenylation, affects lens cell structure and prolifer

17 s) undergo post-translational modifications (isoprenylation and carboxyl methylation) in pancreatic b

18 After isoprenylation and endoproteolytic processing, the Ras p

19 results expand on the complexity of protein isoprenylation and highlight the impact of post-isopreny

20 metal (gm/gm) mice, which show deficient Rab isoprenylation and macrothrombocytopenia with few granul

21 calmodulin and recoverin, posttranslational isoprenylation and palmitoylation, autophosphorylation,

22 The ability of statins to prevent isoprenylation and perhaps inhibit of Rho restores/prote

23 malian cells substantially decreases protein isoprenylation and results in defects in cell growth and

24 otein expression and signaling by inhibiting isoprenylation and subsequent membrane targeting.

25 Rab18 guanosine triphosphatase activity and isoprenylation are required for stellate cell LD loss an

26 anylgeraniol is independent of acute protein isoprenylation as judged in experiments employing cell-p

27 cts are related to statin blockade of GTPase isoprenylation, as has been shown in older literature, a

28 show that statins selectively inhibit GTPase isoprenylation at clinically relevant doses, leading to

29 dergo posttranslational modifications (e.g., isoprenylation) at their C-terminal cysteine residues.

30 xy-3-methylglutaryl-Coenzyme A reductase and isoprenylation attenuated, whereas exogenously provided

31 soprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biolo

32 otif to two random peptides results in their isoprenylation by PagF, demonstrating utility as a gener

33 We show that inhibition of protein isoprenylation by statins causes the accumulation of APP

34 Prevention of protein isoprenylation by the GGpp transferase inhibitor (GGTI-2

35 lational CAAX-processing events that include isoprenylation, C-terminal proteolytic cleavage, and car

36 CaaX motif undergo three processing events: isoprenylation, C-terminal proteolytic cleavage, and car

37 Members of this family contain consensus isoprenylation (CaaX) sites, which we demonstrate are ef

38 Rac1 isoprenylation contributes to membrane avidity but is no

39 as PDE6delta was unable to associate with an isoprenylation-deficient mutant IP (IPSSLC).

40 erfere with PKCdelta autophosphorylation was isoprenylation-dependent as determined using the farnesy

41 PKCdelta at the cellular membrane through an isoprenylation-dependent mechanism to negatively regulat

42 is is provided by both de novo synthesis and isoprenylation-dependent mechanisms.

43 nstrate that selective inhibition of protein isoprenylation does not mimic lovastatin's ability to in

44 posttranslational modifications that include isoprenylation, endoproteolytic release of the C-termina

45 normal phenotypes revert to normal when post-isoprenylation events are genetically interrupted.

46 prenylation and highlight the impact of post-isoprenylation events in regulating the function of Ydj1

47 latable CaaX motif that is resistant to post-isoprenylation events.

48 tent of the two proteins that do not require isoprenylation for membrane association&sbd;PDGF-recepto

49 The importance of isoprenylation for targeting of Ras proteins to the plas

50 , Chp depends on palmitoylation, rather than isoprenylation, for membrane association and function.

51 ional modifications, autophosphorylation and isoprenylation, found in the native bovine RK.

52 A reductase in these cells decreases protein isoprenylation from endogenously synthesized isoprenoids

53 Consistent with N-BP inhibition of isoprenylation, geranylgeraniol or farnesol prevented ac

54 Atorvastatin reduced Rheb isoprenylation, GTP loading, and membrane localization.

55 phate (GGPP), an isoprenoid used for protein isoprenylation in animal cells, and is a branch point en

56 -positive bacteria and emphasize the role of isoprenylation in bacterial signal transduction.

57 Analysis of isoprenylation in cultured human cells shows that AIPL1

58 er, despite numerous studies linking protein isoprenylation in plants to cell cycle control, meristem

59 This study demonstrates the importance of isoprenylation in the regulation of Ag presentation and

60 In contrast, isoprenylation inhibition had no effect on the distribut

61 Isoprenylation is followed by cleavage of the AAX amino

62 hese results provide the first evidence that isoprenylation is involved in determining levels of intr

63 RhoA isoprenylation is necessary for the RhoA-Trio interactio

64 localization and function are dependent upon isoprenylation, may play an important role in mediating

65 The small C-terminal domain bears an isoprenylation motif and is necessary for the interactio

66 However, replacement of the isoprenylation motif with a bona fide transmembrane anch

67 Ggamma subunits, lacking a carboxyl-terminal isoprenylation motif, are found only in flowering plants

68 stern side of the molecule, three additional isoprenylations occur to form the western and southern r

69 ment of Ras is achieved through an invariant isoprenylation of a C-terminal Cys, supplemented by furt

70 Moreover, S-carvone hindered isoprenylation of a prenylable GFP indicator protein exp

71 nt, doses statins preferentially inhibit the isoprenylation of a subset of GTPases.

72 emonstrate that inhibition of geranylgeranyl isoprenylation of CaaX proteins in the aqueous outflow p

73 ation requires an intact effector domain and isoprenylation of Cdc42 and Rac1.

74 Isoprenylation of gamma(2) and localization of beta(1)ga

75 However, in these p21 null cells, isoprenylation of key substrates of farnesyl transferase

76 Finally, to test the expectation that the isoprenylation of L would increase its hydrophobicity, w

77 actions through their ability to prevent the isoprenylation of members of the Rho family of small G-p

78 Isoprenylation of Rac is also required for efficient int

79 e A (HMG-CoA) reductase and subsequently the isoprenylation of Rac1.

80 ed their intended targets, inhibition of the isoprenylation of Ras and RAP-1A are not sufficient to m

81 ects which may involve interference with the isoprenylation of Ras and Rho GTPases.

82 ion of p21, independent of the inhibition of isoprenylation of Ras or RAP-1.

83 -induced CyPA secretion likely via decreased isoprenylation of small GTPases.

84 altering the ability of FT-alpha to catalyze isoprenylation of targets such as G proteins, lamins, or

85 sequential post-translational modifications: isoprenylation of the cysteine residue, endoproteolysis

86 ergo three coordinated COOH-terminal events: isoprenylation of the cysteine, proteolytic removal of a

87 Furthermore, C-terminal isoprenylation of the gamma subunit is necessary but not

88 anism by which this occurs is due to reduced isoprenylation of the Ggamma-subunit.

89 atins appear to be mediated by inhibition of isoprenylation of the small GTP-binding proteins such as

90 M cells, in part, by limiting geranylgeranyl isoprenylation of these G-proteins.

91 Although the effects of inhibition of isoprenylation on protein function have been examined, t

92 ulation may result from global inhibition of isoprenylation or depletion of key regulatory isoprenoid

93 ominant negative Rab3D mutants did not alter isoprenylation or membrane association of endogenous Rab

94 AML cells (AMLs) does not correlate with Ras isoprenylation or with activating Ras mutations.

95 he addition of specific intermediates in the isoprenylation pathway reversed this effect, whereas spe

96 ation is the only reversible reaction in the isoprenylation pathway, it could be a site of regulation

97 In studies addressing which isoprenylation pathway--geranylgeranylation or farnesyla

98 uilding to identify the probable location of isoprenylation, PDE6gamma subunits, and catalytic sites.

99 nfirming that membrane localization, but not isoprenylation per se, is required for function.

100 This was consistent with a blockade in isoprenylation preventing normal association with membra

101 However, the role of post-isoprenylation protein processing in ABA signal transduc

102 -carboxyl methyltransferase involved in post-isoprenylation protein processing.

103 l modifications, including carboxyl terminal isoprenylation, proteolysis, and methylation.

104 After isoprenylation, Ras and other CAAX proteins undergo endo

105 r cellular function as well as substrates in isoprenylation reactions.

106 Statin inhibition of protein isoprenylation results in decreased Abeta secretion.

107 eldin A or mevastatin and when the conserved isoprenylation sequence (CTIL) at the carboxyl terminus

108 ucts to the plasma membrane via a C-terminal isoprenylation sequence induced PC12 cells to extend neu

109 se into host cells, inactivation of the Rac1 isoprenylation signal that is required for membrane loca

110 ds that are alternate substrates for protein isoprenylation that are not inhibitors of squalene synth

111 In each case with identical isoprenylation, the beta(1)gamma(2) dimer displayed sign

112 After isoprenylation, the Ras proteins and other CAAX proteins

113 ma8 is identical with Tbeta1gamma1 in Tgamma isoprenylation, the spatial organization, and the mode o

114 ication by mGBP2 requires GTP hydrolysis and isoprenylation thus, enabling reversible oligomerization

115 ion of RhoA was accompanied by inhibition of isoprenylation via reductions in geranylgeranyl transfer

116 Isoprenylation was also demonstrated by (14)C incorporat

117 IP isoprenylation was critical for this interaction, as PDE

118 tory production of RK, but posttranslational isoprenylation was deficient.

119 been attributed to the inhibition of Ras/Rho isoprenylation, we have previously shown that statin tox

120 of statins are mediated by the inhibition of isoprenylation, which ensures proper membrane insertion