ライフサイエンスコーパス: isopropylidene

1 Synthesis of Fmoc-3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-D-glucitol-gamma-glutamat

2 For poly(7-isopropylidene-2,3-dicarbomenthoxynorbornadiene) the str

3 report here the polymerization of several 7-isopropylidene-2,3-disubstituted norbornadienes, 7-oxa-2

4 trated by the synthesis of a series of 5,6-O-isopropylidene-2-allyl-3-keto-l-galactono-gamma-lactone

5 hodology for the syntheses of D- and l-4,5-O-isopropylidene-2-cyclopentenone (9 and 22), versatile in

6 The utility of D- and l-4,5-O-isopropylidene-2-cyclopentenone is demonstrated by their

7 ocyclopenta[1,3]dioxol-4-one ((4R, 5R)-4,5-O-isopropylidene-2-cyclopentenone) (8), which was achieved

8 ommon bicyclic intermediate (5R,8R,9R)-8,9-O-isopropylidene-2-keto-1,7-dioxaspiro[4.4]nonane (10) tha

9 pyrophosphate (13, 3%) and P1,P2-bis(2',3'-O-isopropylidene-3-(carbamoylphenyl)-5'-ribosyl)py rophosp

10 l-3-keto-l-galactono-gamma-lactone and 5,6-O-isopropylidene-3-allyl-2-keto-l-galactono-gamma-lactone

11 Treatment of a 1,2-O-isopropylidene-3-ketopentofuranose derivative (obtained

12 Treatment of 2',3'-O-isopropylidene-4',5'-unsaturated compounds derived from

13 f the aryl phosphoramidate prodrugs of 2,3-O-isopropylidene-4-erythrono hydroxamate by synthesizing a

14 2,3-O-Isopropylidene-4-erythrono hydroxamate is a potent inhib

15 lacement of the 5'-mesyl function of 2',3'-O-isopropylidene-5'-O-mesyltiazofurin (24) with the difluo

16 Removal of the isopropylidene acetal and subsequent acetylation gave th

17 diols bearing a 1,2-diol moiety masked as an isopropylidene acetal group and long alkyl chains compri

18 clic dimethyl ether backbone in lieu of the (isopropylidene) acetal moiety characteristic for traditi

19 ith benzylidene acetals on one periphery and isopropylidene acetals on the other had an association c

20 port methods for quantitation of hexose di-O-isopropylidene acetate (IPAc) or pentafluorobenzoyl (PFB

21 n 10 steps from commercially available 2',3'-isopropylidene adenosine.

22 pyridyldimethylglyoximatocobalt-1,2:5,6-di-O-isopropylidene- alpha-D-glucofuranose 4 for the 4:5 epim

23 were synthesized stereoselectively from di-O-isopropylidene-alpha-D-apiose.

24 ochiral selection of 4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-pentofuranose (diastereomeric exc

25 logenation of 3-O-benzoyl-5,6-dideoxy-1, 2-O-isopropylidene-alpha-D-ribo-hex-5-enofuranose gave 6-hal

26 ed by Moffatt oxidation of 3-O-benzoyl-1,2-O-isopropylidene-alpha-D-ribo-hexofuranose (2c) with the d

27 5-O-acyl-4-C-acyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-alpha-D-ribofuranose has been achieved in

28 ctions in 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-d-ribofuranose has been achieved.

29 5-O-Benzyl-1, 2-O-isopropylidene-alpha-D-ribofuranose was prepared by an i

30 i-O-benzyl-3-O-alpha-D-glucopyranosyl-1, 2-O-isopropylidene-alpha-D-ribofuranose.

31 truct 4-[5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-alpha-d-ribofuranosy l]-6,7-dichloroquino

32 zed from commercially available 1,2:3,5-di-O-isopropylidene-alpha-D-threo-apiofuranose (7) by a very

33 was prepared by an improved route from 1,2-O-isopropylidene-alpha-D-xylofuranose and was coupled with

34 a variety of protected glycals into 1,2-cis-isopropylidene-alpha-glycosides in good yield.

35 sion of glycals to the corresponding 1,2-cis-isopropylidene-alpha-glycosides.

36 f 2-trimethylsilyl thiazole to 5-deoxy-1,2-O-isopropylidene-alpha-L-erythro-pentofuran-3-ulose (2), w

37 n efficient route to methyl 3-O-benzyl-1,2-O-isopropylidene-alpha-l-idopyranosiduronate 6 from diacet

38 2,3-O-Carbonyl- and 2,3-O-isopropylidene-alpha-L-rhamnopyranosyl thioglycosides ar

39 (PCET) reactions and thermochemistry of 5,6-isopropylidene ascorbate (iAscH-) have been examined in

40 define the thermochemical landscape for 5,6-isopropylidene ascorbic acid and its derivatives in MeCN

41 onor 14 and 5-azido-3-O-benzyl-5-deoxy-1,2-O-isopropylidene-beta-d-fructopyranose (23) to form disacc

42 diate 18 which upon reaction with 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)benzamide (19) gave,

43 Treatment of 3-(2,3-O-isopropylidene-beta-D-ribofuranosyl)benzamide (6) with P

44 matically monodeacetylated compound to 1,2-O-isopropylidene-C-4-spiro-oxetanoribofuranose.

45 -deoxy-1-(4,5-d ichloro-2-nitrophenyl)-3,4-O-isopropylidene-d-allitol (8) as the major product.

46 5-dichloro-2-nitrophenyl)-1,2-dideo xy-3,4-O-isopropylidene-d-allo-1-enitol (5) as the basic skeleton

47 anhydro-6-O-(tert-butyldimethylsil yl)-3,4-O-isopropylidene-d-allose (11), which was subjected to the

48 The synthesis of d-noviose from 2,3-O-isopropylidene-d-erythronolactol is described.

49 ion of PhLi and lithiated dithianes to 2,3-O-isopropylidene-D-erythronolactone affords lactols, which

50 ergent approach from easily accessible 2,3-O-isopropylidene-d-erythrose (2b), and the combination of

51 anoside 8, which was prepared from the 2,3-O-isopropylidene-D-glyceraldehyde 1 in 13 steps.

52 ifluoropentan-2-ol 6 was prepared from 2,3-O-isopropylidene-d-glyceraldehyde 1, which was converted t

53 ate 4, which was readily prepared from 2,3-O-isopropylidene-D-glyceraldehyde in five steps.

54 yl nucleosides (1 and 2) starting from 2,3-O-isopropylidene-d-glyceraldehyde.

55 were synthesized starting with methyl 2,3-O-isopropylidene-d-glycerate (4) and D-ribo-phytosphingosi

56 Single carbon homologation of 1,2-O-isopropylidene-D-glycero-tetrafuranos-3-ulose (15) and o

57 and 32 which were prepared from 1,2:5,6-di-O-isopropylidene-D-mannitol and L-gulonic gamma-lactone, r

58 both been synthesized in 13 steps from di-O-isopropylidene-d-mannitol.

59 via an ester derived from (4R,5R)-(-)-2,3-O-isopropylidene-D-threitol at the 3-position, which was r

60 ucocorticoid agonists than the corresponding isopropylidene derivatives.

61 In contrast, photolysis of the cyclic isopropylidene diazomalonate (3), which also has a Z,Z-c

62 -ring was derived from readily available (R)-isopropylidene glyceraldehyde through a route featuring

63 ith HCl in MeOH achieves deprotection of the isopropylidene group and the N-benzyl group and conversi

64 ilon-CL) chains; (4) hydrolysis of the 1,2-O-isopropylidene group at the sugar core without any subst

65 oselectivity resulting from hindrance by the isopropylidene group favored addition at the beta face.

66 the alcohol 2, selective deprotection of the isopropylidene group of 3, followed by thermal eliminati

67 addition at the beta face (anti to the 1,2-O-isopropylidene group on the alpha face).

68 plus the acid-catalyzed isomerization of an isopropylidene group, provided a suitable pseudosugar pr

69 Moffatt oxidation of 2',3'-O-isopropylidene-L-adenosine and treatment of the resultin

70 ding 3-O- and 2-O-allyl derivatives of 5,6-O-isopropylidene-l-ascorbic acid, respectively, followed b

71 ntermediate 8, which was prepared from 2,3-O-isopropylidene-l-glyceraldehyde 1 in 13 steps, was conde

72 ur target compounds, was prepared from 1,2-O-isopropylidene-L-glyceraldehyde via (R)-2-fluorobutenoli

73 s, namely mono- and diesters of 1,2:5,6-di-O-isopropylidene-myo-inositol and 1,2:5,6-di-O-cyclohexyli

74 s of the resolved 3-O-allyl-6-O-benzyl-1,2-O-isopropylidene-myo-inositol in a convergent synthesis.

75 bserved for 3,6-di-O-triisopropylsilyl-1,2-O-isopropylidene-myo-inositol.

76 he 5R configured enantiomer of racemic 1,2-O-isopropylidene-myo-inositols possessing chemically and s

77 The reagent N-isopropylidene-N'-2-nitrobenzenesulfonyl hydrazine (IPNB

78 A bis-trifluoromethyl-7-isopropylidene norbornadiene was not polymerized stereor

79 lactones possessing either a 16alpha,17alpha-isopropylidene or -butylidene group are described.

80 highly efficient and practical route to 3,4-isopropylidene proline I, starting from (+)-3-carene, wa

81 from C5-C6 cleavage); (2) glucose 1,2,5,6-di-isopropylidene propionate (m/z 301, no cleavage of gluco

82 tization using cesium carbonate gave rise to isopropylidene-protected hexasubstituted resorcylates.

83 onor, which was followed by coupling with an isopropylidene-protected Kdo-fluoride donor to afford a

84 straightforward, as ester, silyl ether, and isopropylidene protection failed to afford desired C-lin

85 stereospecific esterification of 1,2- or 2,3-isopropylidene-sn-glycerols by selected fatty acids is u

86 reagents or Ruppert's reagent (TMS-CF(3)) to isopropylidene tartaric dichloride, is reported.

87 -O-isopropylidene-tartrate, d-dimethyl-2,3-O-isopropylidene-tartrate, and meso-erythritol, respective

88 xides were synthesized from l-dimethyl-2,3-O-isopropylidene-tartrate, d-dimethyl-2,3-O-isopropylidene

89 The oligoenes contain an isopropylidene unit at each end.