ライフサイエンスコーパス: isoquinoline

1 ermediates to transform them ultimately into isoquinoline.

2 solution-phase Pomeranz-Fritsch synthesis of isoquinoline.

3 ine formation and reduction of the resulting isoquinoline.

4 -substituted derivatives of 1H-pyrrolo[3,2-c]isoquinoline.

5 s including indole, thiophene, pyridine, and isoquinoline.

6 rrolo[3,2-c][1,2,4]triazolo[5,1-a] or [3,4-a]isoquinolines.

7 aroyl-substituted imidazo-/benzimidazo-fused isoquinolines.

8 tandem synthesis of indolo and pyrrolo[2,1-a]isoquinolines.

9 nd ultimately to imidazo[4,5-c]pyridines and isoquinolines.

10 hyl-2, 1-ethanediyl)]-bis(5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione] dimethanesulfonate) is a nov

11 ent is introduced at the C-6 position of the isoquinoline-1,3(2H,4H)-dione core.

12 The series of 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione derivatives reported here

13 the headpiece of the 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione, a basic amine substituent

14 ethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3- diones with substituents at the 4, 8,

15 The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)ami

16 )-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here

17 We report herein the discovery of isoquinoline-1,3-dione as a viable chemotype for selecti

18 ent is introduced at the C-6 position of the isoquinoline-1,3-dione core.

19 It is also shown that 2-hydroxy-4H-isoquinoline-1,3-dione--an inhibitor of ribonucleases th

20 w 2-[2'-(dimethylamino)ethyl]-3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at the 6- and

21 The copper isoquinoline-1-carboxylate salt was precipitated from th

22 Glycosyl isoquinoline-1-carboxylate was developed as a novel benc

23 ,2,3,5,6alpha,10beta-hexahydropyrrol o[2,1-a]isoquinoline ((11)C-McN 5652) was the first PET radiotra

24 thesis of diversely substituted indolo[2,1-a]isoquinolines 11a-r, pyrrolo[2,1-a]isoquinolines 12a-d,

25 dro-6-[4-(methylthio)phenyl]pyrrolo-[2,1-a]- isoquinoline ([11C]McN 5652) is the first PET radioligan

26 olo[2,1-a]isoquinolines 11a-r, pyrrolo[2,1-a]isoquinolines 12a-d, and indolo-, pyrrolo[2,1-f][1,6]nap

27 d by benzo[a]quinolizine 8 and pyrrolo[2,1-a]isoquinoline 13, with an interest in stereochemistry and

28 lo[1,2-a]pyridines 7a-k and imidazolo[2, 1-a]isoquinolines 13a,b in good yields.

29 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (13c) and 5,6-dihydro-6-(4-hydroxybut-1-yl)

30 irect synthesis of bisindolo-, pyrrolo[2,1-a]isoquinolines 15a-g, a regioisomer of the bisindolo[1,2-

31 m pyrolysis (FVP) of 1-(5-(13)C-5-tetrazolyl)isoquinoline 18 generates 1-((13)C-diazomethyl)isoquinol

32 oxy-2,3,4,6,7,11b-hex ahydro-1H-pyrido[2,1-a]isoquinoline ((18)F-AV-266), and (2S,3R,11bR)-9-(3-fluor

33 oquinoline 18 generates 1-((13)C-diazomethyl)isoquinoline 19 and 1-isoquinolyl-((13)C-carbene) 22, wh

34 9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (19a), did not unwind DNA and did not affec

35 cyclic 1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinolines 1a-c and 2,3,10,10a-tetrahydroimidazo[1,5-

36 Quinoline (1) and isoquinoline (2), upon activation by strong acids, lead

37 the complex of hCA II with 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)benzenesulfonamide (3) (PDB code

38 les (5, 7, 10, 13), 5,6-dihydroindolo[2, 1-a]isoquinolines (20, 21), and 6,7-dihydro-5H-benzo[c]azepi

39 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (21) and cis-6-allyl-5,6,12,13-tetrahydro-2

40 The 10-methoxy-5,6-dihydroindolo[2, 1-a]isoquinolines (21a-c) had higher binding affinities than

41 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (22), both of which displayed submicromolar

42 yl)-5,6-dihydro-5, 11-dioxo-11H-indeno[1,2-c]isoquinoline (26) and 6-ethyl-2, 3-dimethoxy-8,9-(methyl

43 FVP of 3-(5-tetrazolyl)isoquinoline 28 similarly generates 3-diazomethylisoquin

44 d compounds 25 and 26, the 5,6-dihydrobenz[f]isoquinoline 28, and the benzofuro[3,2-c]pyridine 30.

45 simple straightforward syntheses of triazolo isoquinolines (3) and isochromenes (7) from 2-alkynylben

46 -(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide).

47 -methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide)] or DPA-714 in excess.

48 methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)-isoquinoline-3-carboxamide].

49 henyl)methyl-1,2,3,4,4a,5,6,7,8,8a-decahydro isoquinoline-3-carboxylic acid), which antagonizes kaina

50 Ketone-containing isoquinolines 36 and 49-51 have also been prepared by th

51 droxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de] isoquinoline (4, dinapsoline).

52 oped for the synthesis of hexahydro-1H-spiro[isoquinoline-4,4'-pyran] derivatives through the condens

53 For example, the isoquinoline 49D1E2 has NFkappaB agonism with pIC50 of 8

54 ey intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positi

55 l)thieno[2',3':5,6]pyrido[3,4-g]thieno[3,2-c]isoquinoline-5,11(4H, 10H)-dione) (PNTPD); poly(5-(4,10-

56 thieno[2',3':5',6']pyrido[3,4-g]thieno[3,2-c]isoquinoline-5,11(4H,10H)-dione and fluorenedicyclopenta

57 d 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36) (3) is among the fe

58 fore, NBS furnished direct conversion to the isoquinoline-5,8-dione; alternatively, N-haloimides of c

59 lyzed synthesis of oxazine/benzoxazine-fused isoquinolines 5a-q and naphthyridines 6a-v by the reacti

60 3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propyla mino}-propane bis(trifluoroaceta

61 9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinoline-7-one), both of which bind in the ATP-bindi

62 (23) and 8-hydroxy-1,2,3,4-tetrahydrobenz[h]isoquinoline (9)].

63 Berberine, an isoquinoline alkaloid derived from a plant used traditio

64 ans excrete a small but steady amount of the isoquinoline alkaloid morphine in their urine.

65 Berberine is an isoquinoline alkaloid used for its pharmacological funct

66 As proof of concept, a fluorinated isoquinoline alkaloid, (18) F-aspergillitine is prepared

67 lecule pharmaceutical, a naturally occurring isoquinoline alkaloid, and endogenous compounds includin

68 Berberine, an isoquinoline alkaloid, is a traditional oriental medicin

69 There is no doubt that a simple isoquinoline alkaloid, tetrahydropapaveroline (THP), is

70 hrome P450 genes (CYP28) from two species of isoquinoline alkaloid-resistant Drosophila and the cosmo

71 Hence, only that portion of the isoquinoline alkaloids excreted in urine unmetabolized c

72 ipecac alkaloids, a series of monoterpenoid-isoquinoline alkaloids such as emetine and cephaeline, w

73 he asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a family of natural products sho

74 aromatic substitution reactions to make the isoquinoline allows direct access to analogues possessin

75 Here we report the discovery of several isoquinoline analogues, exemplified by 1 and 2, which bi

76 sentatives of 7H-imidazo[2,1-a]pyrrolo[3,2-c]isoquinoline and 1H-imidazo[2,1-a]pyrrolo[3,4-c]isoquino

77 Chiral acid chlorides were reacted with isoquinoline and 6,7-dimethoxy-3,4-dihydroisoquinoline t

78 A Pomeranz-Fritsch synthesis of isoquinoline and Friedlander and Combes syntheses of sub

79 hod affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high

80 Multisubstituted isoquinoline and pyridine N-oxides have been prepared by

81 found to be optimum for activity in both the isoquinoline and quinazoline series.

82 Porphyrins with fused isoquinoline and quinoline units have been prepared by t

83 plex I inhibitors, including rotenone, MPP+, isoquinoline and tetrahydroisoquinoline, induce apoptosi

84 enantioselective synthesis of pyrrolo[2,1-a]isoquinolines and an attempted synthesis of the alkaloid

85 amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines.

86 Monosubstituted isoquinolines and naphthyridines have been synthesized b

87 lenium-, and sulfur-containing disubstituted isoquinolines and naphthyridines, respectively.

88 Monosubstituted isoquinolines and pyridines have been prepared in good t

89 synthesis of 2'-substituted 2-aryl pyridines/isoquinolines and related heterobiaryls.

90 s provides a general approach to an array of isoquinolines and their corresponding N-oxides.

91 Various pyridine, quinoline, isoquinoline, and pyrimidine N-oxides were converted to

92 substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine (1-9 and 28) has been studie

93 es, deazapurines, benzimidazole, quinolines, isoquinolines, and pyridines were efficiently deuterated

94 Various pyridine-, quinoline-, isoquinoline-, and pyrimidine-N-oxides were converted to

95 The indeno[1,2-c]isoquinolines are an important class of topoisomerase I

96 loped electron-deficient directing group and isoquinoline as a ligand.

97 h as quinoxalines, pyridines, quinoline, and isoquinoline as well as quinones.

98 rolo[3,2-c][1,2,4]triazolo[5,1-a] and [3,4-a]isoquinolines, as well two more new heterocyclic systems

99 Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were co

100 es an efficient access to 1,3-functionalized isoquinoline-based antitumor agent.

101 Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridine

102 including the beta-carboline harmine and the isoquinoline berberine, that ameliorated certain aspects

103 ave investigated the gas-phase production of isoquinoline by performing collisional activation on ben

104 l substituents are better than alkyls at the isoquinoline C-1 position.

105 -chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide) ([(11)C](R)-PK11195).

106 -chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide)--a positron-emitting ligand th

107 -chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide).

108 2-chlorphenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline-carboxamide (PK11195) is a ligand specific

109 identified 1-(2-chlorophenylmethylpropyl)-3-isoquinoline-carboxamide (PK11195), a typical peripheral

110 c acid-6'-carboxylic acid, L = 4-picoline or isoquinoline) catalysts proceed through a single-site wa

111 A potent and highly selective isoquinoline CHK1 inhibitor (SAR-020106) was identified,

112 ction of the dearomatized, alkyl-substituted isoquinoline complexes is also reported.

113 gy provides a simple and convenient route to isoquinolines containing an aryl, alkyl, or vinylic grou

114 The 5-isoquinoline-containing compound 14a (hTRPV1 IC50 = 4 nM

115 developed in our laboratories to build a key isoquinoline-containing intermediate comprising the enti

116 oduction of substituents at the C1 carbon of isoquinoline core along with syntheses applying various

117 ing of the nitrogen-containing ring B of the isoquinoline core by the formation of bonds between C1-N

118 alyzed enolate arylation is used to form the isoquinoline core.

119 nes to a series of potent and CHK1-selective isoquinolines demonstrates how fragment-growing and scaf

120 aporphine cores through reactions between an isoquinoline derivative and silylaryl triflates promoted

121 To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblast

122 hat high quantum yields of the quinoline and isoquinoline derivatives are a result of the relative re

123 The photophysical properties of isoquinoline derivatives differ from those of quinolines

124 ization gave general access to pyrrolo[2,1-a]isoquinoline derivatives under very mild conditions.

125 sine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives was investigated by examining t

126 C(4) of the 2-azabuta-1,3-dienes, providing isoquinoline derivatives, can occur at elevated temperat

127 Several 3-(2-pyridinyl)isoquinoline derivatives, including VUF5455, VUF8502, VU

128 tained for previously reported quinoline and isoquinoline derivatives.

129 ynes has been developed for the synthesis of isoquinoline derivatives.

130 hlorides, including pyridine, quinoline, and isoquinoline derivatives.

131 trategy has been illustrated in synthesizing isoquinoline-derived natural products.

132 ual dual BDAC sequence leading to N-N-linked isoquinoline dimer.

133 nervous system regeneration to show that the isoquinoline drug praziquantel (PZQ) acts as a small mol

134 tic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sig

135 a binding motif led to the identification of isoquinoline ethyl urea 13 as a promising starting point

136 2,2'-bipyridine-6,6'-dicarboxylate; isoq is isoquinoline) exists as the open-arm chelate, [Ru(II)(CO

137 (sp(2))-H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridin

138 e triflate and a boronate ester, followed by isoquinoline formation and reduction of the resulting is

139 monium acetate, and a variety of substituted isoquinolines, furopyridines, and thienopyridines is pre

140 potency, they were ranked in the order of 5-isoquinoline > 8-quinoline = 8-quinazoline > 8-isoquinol

141 oquinoline > 8-quinoline = 8-quinazoline > 8-isoquinoline > or = cinnoline approximately phthalazine

142 ncluding N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H-89), adenosine 3'-5'cyclic monophosphoth

143 nhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89) or the p38 mitogen-activated protein

144 nhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89).

145 ocked by N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89)] and extracellular signal-regulated k

146 N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89; a protein kinase A inhibitor) stimula

147 In addition, isoquinoline heterocycles have been prepared in excellen

148 quinoline and 1H-imidazo[2,1-a]pyrrolo[3,4-c]isoquinoline heterocyclic skeletons, which were further

149 ctive synthesis of the hexahydroimidazo[1,5b]isoquinoline (HHII) scaffold as a surrogate for the ster

150 imethoxy-8,9-methylenedioxy-11H-indeno[1,2-c]isoquinoline hydrochloride (14) is a strong topoisomeras

151 9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline hydrochloride (19a), which proved to be a v

152 roxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline hydrochloride 6 and the resolution of its e

153 dimethoxy-(m ethylenedioxy)-11H-indeno[1,2-c]isoquinoline hydrochloride), the cytotoxicity of bisinde

154 or the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields.

155 rolo[3,4-c][1,2,4]triazolo[5,1-a] and [3,4-a]isoquinolines, in good yields without triazole ring clea

156 fluorenones and fluorenones containing fused isoquinoline, indole, pyrrole, thiophene, benzothiophene

157 We have tested whether these isoquinolines inhibit P2X receptor function in human emb

158 gression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta

159 itivity to the rat P2X7R; this suggests that isoquinolines interact with residues in the amino-termin

160 isomeric pyrrolo[3,2-c][1,2,4]triazolo[3,4-a]isoquinolines involves, besides the triazole ring openin

161 e a novel "one-pot" process to assemble aryl(isoquinoline)iodonium salts in 40-94 % yields from mesoi

162 leophiles to N-acyl activated quinolines and isoquinolines is described.

163 sisted one-pot reaction for the synthesis of isoquinolines is developed.

164 -2,3,3a,4,5,6,9b-hexahydro-1H-pyrrolo-[3,2h]-isoquinoline) is a conformationally restricted analog of

165 effect was inhibited by oxidized ATP and the isoquinoline KN-62, two known P2X7 receptor antagonists.

166 m, cyclization of each olefin afforded fused isoquinoline lactams as single diastereomers epimeric at

167 -TsOH, cyclization occurred to produce fused isoquinoline lactams by a mechanism that involves an ini

168 The unique impact of the isoquinoline ligand underscores the importance of subtle

169 nd involving the ring nitrogen-2 atom of the isoquinoline must be preserved, but that the ring can fl

170 Atropisomeric biaryl pyridine and isoquinoline N-oxides were synthesized enantioselectivel

171 The total synthesis of the isoquinoline natural product decumbenine B has been acco

172 s the key step in a concise synthesis of the isoquinoline natural product illudinine.

173 ontacts between the extended enolate and the isoquinoline of the catalyst.

174 nzyl group on compounds containing either an isoquinoline or indazole heterocyclic core.

175 onverted into aminoallenylidene isochromans, isoquinolines, or tetrahydronaphtalenes with silver(I) s

176 however, a new, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee's a

177 I) intermediate, improving the yields of the isoquinoline products.

178 e, tetrahydroisoquinoline, 5,6-dihydrobenz[f]isoquinoline, pyrindine, and pyridine heterocycles have

179 boronate functionalized heterocycles such as isoquinoline, pyrrole, and indole.

180 Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has

181 successfully used for this reaction, such as isoquinolines, quinoline, phenanthridine, quinazoline, p

182 g between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbe

183 are novel but poorly characterized cytotoxic isoquinoline quinones and iminoquinones identified in ex

184 hy l-5,6,7,8-tetrahydro-[1,3]-di-oxolo[4,5-g]isoquinoline (Red-Br-nos), exerts a novel autophagic res

185 isubstituted indenones and 1,3-disubstituted isoquinolines, respectively.

186 lacement of the nucleophilic co-catalyst for isoquinoline resulted in a divergent reaction pathway an

187 reparation of a wide range of (18) F-labeled isoquinolines resulting in up to 92 % radiochemical conv

188 e-activity relationship between the nitrated isoquinoline ring and a methylenedioxy-substituted inden

189 the protonated and unprotonated forms of the isoquinoline ring of papaverine were identified.

190 bromo, nitro, acetyl, and aminomethyl on the isoquinoline ring resulted in a significant loss of acti

191 ubsite of the inhibitor which identified the isoquinoline ring system as a key template for improving

192 A methoxy moiety at the C6 position of this isoquinoline ring system proved to be optimal with respe

193 ses pointed to a proton at position-9 of the isoquinoline ring that can be modified without compromis

194 austive series was prepared using a nitrated isoquinoline ring that has been previously demonstrated

195 epared utilizing a 2,3-dimethoxy-substituted isoquinoline ring.

196 s significantly enhanced by nitration of the isoquinoline ring.

197 roup at C-3 and an aroyl group at C-4 of the isoquinoline ring.

198 rophobic contacts and the hydrogen bond with isoquinoline ring.

199 rwent oxidative coupling to form the desired isoquinoline salts and regenerate [Cp*MCl2]2.

200 Moreover, it was possible to synthesize the isoquinoline salts from readily available starting mater

201 Bi-, tri-, and tetracyclic isoquinoline salts were readily synthesized in excellent

202 The 7-hydroxy group of the isoquinoline skeleton of the aglycon is methylated by Ip

203 g H89 (N-[2-(p-bromo-cinnamylamino)-ethyl]-5-isoquinoline-sulfon-amide 2HCl) and Ht31, disruptors of

204 d H89 (N-[2-(p-bromo-cinnamylamino)-ethyl]-5-isoquinoline-sulfon-amide 2HCl), as well as by the AKAP

205 A large family of isoquinoline sulfonamide compounds inhibits protein kina

206 n signals was inferred from experiments with isoquinoline sulfonamide protein kinase inhibitors.

207 G (PKG) inhibitor N-[2-(methylamino)ethy]-5-isoquinoline-sulfonamide (H8) blocks NECA, hydroxylamine

208 fully blocked by N-[2-(methylamino)ethyl]-5'-isoquinoline-sulfonamide and 2-[1-(3-dimethylaminopropyl

209 Rhodobacter sphaeroides (10 microg/ml); the isoquinoline-sulfonamide H-8 (10 and 100 microM), which

210 n kinase, N-[2(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfonamide hydrochloride (H-89) and myrist

211 inase A inhibitor N-(2-(methylamino)ethyl)-5-isoquinoline-sulfonamide.

212 The ability of isoquinoline sulfonamides to potently inhibit human and

213 The PKC inhibitor 1-(5-isoquinoline sulfonyl)-2-methylpiperazine-HCl eliminated

214 ,5,12,12a alpha-octahydroquinolino-[2,3,3-g]-isoquinoline; TAN67) were coadministered in GH(3)MORDOR

215 A wide variety of substituted isoquinoline, tetrahydroisoquinoline, 5,6-dihydrobenz[f]

216 Within the 6,6-series, isoquinoline, tetralin, tetralone, and benzopyran nuclei

217 se complexes reacted with 2,2'-bipyridine or isoquinoline, they facilitated the alkyl migration of th

218 The formation of a substituted isoquinoline using benzyl cyanide as the second nitrile

219 n of the trans diastereomers to indeno[1,2-c]isoquinolines using selenoxide elimination and Friedel-C

220 he trans products do not afford indeno[1,2-c]isoquinolines using this method.

221 h to regioselectively synthesize substituted isoquinolines via coupling with aryloxime esters.

222 A second small isoquinoline was subsequently shown to bind in a single

223 Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under sim

224 d pyridines and single isomer formation with isoquinolines were observed.

225 This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moi

226 es a valuable new route to 3,4-disubstituted isoquinolines with aryl, allylic, benzylic, 1-alkynyl, a

227 cts can be readily converted to indeno[1,2-c]isoquinolines with thionyl chloride, the trans products

228 zo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic condi

229 -methyle nedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline) with both similarities and differences fro