ライフサイエンスコーパス: isotopomer

1 sotopomer that shifts to 580.2794 in the 18O-isotopomer.

2 es C, indicating no isomerization to another isotopomer.

3 , which shifts to 672 cm(-1) in the Mn-(18)O isotopomer.

4 as determined for the Tc((16)O)(3)((17)O)(-) isotopomer.

5 is-3-3,4-d(2)) in 64% yield as the exclusive isotopomer.

6 of amino acids containing a pure (13)CHD(2) isotopomer.

7 topomer, and a zero-(2)H-exchanged/two-(13)C isotopomer.

8 ative amount of labelling in a predetermined isotopomer.

9 ere obtained from the results with the three isotopomers.

10 lcohol and its benzylic mono- and dideuterio isotopomers.

11 n is that between the d3-methyl enantiomeric isotopomers.

12 tivity of enzymes for the heavier or lighter isotopomers.

13 aterial and to determine abundances of these isotopomers.

14 the position specific labeling of subsets of isotopomers.

15 e (5'S)-[5'-(2)H(1)]- and (5'R)-[5'-(2)H(1)]-isotopomers.

16 arrageenan gels and the prochiral and chiral isotopomers.

17 ponding spectra of the mu-O(2)(13)C(13)CO(2) isotopomers.

18 ulations of (13)CHD(2) and (13)CH(2)D methyl isotopomers.

19 artate, citrulline and, thereby, [(15)N]urea isotopomers.

20 o the urea cycle, and the production of urea isotopomers.

21 tains experimental MS/MS data on hundreds of isotopomers.

22 l peak magnitudes of the deuterium-exchanged isotopomers.

23 to the distinct spectroscopic signatures of isotopomers.

24 bly selective, affording only the axial-d(1) isotopomers.

25 g mixtures of iCB[6] and its (13)C=O labeled isotopomer (13)C(12)-iCB[6].

26 , (190)Os, and (188)Os) and three unique 13C isotopomers (13C in ethylene, axial, and equatorial posi

27 The isotopomers [15N3]-2'-deoxycytidine and (methyl-d3,ring-

28 red rotational constants for the main osmium isotopomer ((192)Os) are A = 929.3256(6), B = 755.1707(3

29 (both isotopomers, ca. 100%) and C12 (minor isotopomer, 30-35%), that is, an approximately 2:1 mixtu

30 owed observation of transitions for the four isotopomers (63)Cu(12)C(14)N, (65)Cu(12)C(14)N, (63)Cu(1

31 entadiyne (6a), along with both monodeuterio isotopomers 6b and 6c, has been synthesized via a route

32 , an A + 2 peak is comprised of (among other isotopomers) a two-(2)H-exchanged/zero-(13)C isotopomer,

33 isotopomers) a two-(2)H-exchanged/zero-(13)C isotopomer, a one-(2)H-exchanged/one-(13)C isotopomer, a

34 acy and precision in the measurement of mass isotopomer abundances and kinetic parameters were compar

35 lent agreement between measured and expected isotopomer abundances for the different NMR experiments,

36 asuring protein kinetics by quantifying mass isotopomer abundances of mid-sized peptides from protein

37 pectrometric methods to those extracts, mass isotopomer abundances of seven major organic acids were

38 sotope ratios (i.e., less dependence of mass isotopomer abundances on the amount of material injected

39 Mass isotopomer abundances were determined by electrospray io

40 a labeling data set consisting of 155 (13)C isotopomer abundances.

41 ine residues with specific (13)CHD(2) methyl isotopomers against a deuterated background.

42 nbridge-(18)O(2), alphabeta-bridge-(18)O]GTP isotopomer allowed us to probe for positional isotope ex

43 to multiply labeled glutamate and succinate isotopomers, also consistent with the flux through the m

44 The data suggest that combining (13)C isotopomer analyses and dynamic hyperpolarized (13)C spe

45 using a combination of metabolomics and mass isotopomer analyses.

46 with 13C-labeled substrates using 13C/1H-NMR isotopomer analysis after 30 minutes of low-flow ischemi

47 Both isotopomer analysis and activity assays suggest that cit

48 es of the 3 pathways were identified by mass isotopomer analysis and metabolomics.

49 (13)C-Isotopomer analysis and tandem mass spectrometry measure

50 of the combination of metabolomics and mass isotopomer analysis for pathway discovery.

51 Mass spectrometric (MS) isotopomer analysis has become a standard tool for inves

52 sitive mass spectrometry techniques for mass isotopomer analysis has extended the reach of metabolic

53 QCLAS enables high-precision N(2)O isotopomer analysis in real time.

54 used to convert relative rates derived from isotopomer analysis into quantitative fluxes.

55 13C NMR isotopomer analysis is a powerful method for measuring m

56 This mass isotopomer analysis is referred to as time and relative

57 Mass isotopomer analysis of C(4) and C(5) ketone bodies and o

58 A 13C isotopomer analysis of glutamate isolated from these cel

59 enome annotation and the transcript profile, isotopomer analysis of key metabolites clarifies ambigui

60 ucted a study coupling metabolomics and mass isotopomer analysis of liver gluconeogenesis and citric

61 Isotopomer analysis of liver glutamate confirmed that an

62 the use of J-resolved HSQC (J-HSQC) for 13C isotopomer analysis of tissue samples.

63 bolites were then extracted and subjected to isotopomer analysis to determine relative rates of pathw

64 To examine this question, we applied 13C-isotopomer analysis to quantify flux through three anapl

65 ere, we combined (13)C hyperpolarization and isotopomer analysis to quantify multiple fates of pyruva

66 of 13C NMR spectroscopy makes application of isotopomer analysis to small tissue samples (mouse tissu

67 Here we used stable isotope labeling and isotopomer analysis to trace sterol flux through the two

68 Using mass isotopomer analysis we determined the enrichments of ace

69 ability, and accuracy of this method for the isotopomer analysis were validated.

70 inated from deacetylated APAP), through mass isotopomer analysis, accurate mass measurement, tandem m

71 of genetically modified animal models, mass isotopomer analysis, and metabolomics provides a powerfu

72 strate that FT-ICR MS is a powerful tool for isotopomer analysis, overcoming the problems with both G

73 od of numerical bias estimation regarding MS isotopomer analysis.

74 using a combination of metabolomics and mass isotopomer analysis.

75 1)H and (13)C relaxation rates of (13)CHD(2) isotopomers and (2)H (D) relaxation rates of (13)CH(2)D

76 eport separation of isotopic ions, including isotopomers and isobars, using ion mobility spectrometry

77 leucine and glucose for both highly enriched isotopomers and labeled isotopomers present in low abund

78 The isotopomers and their 50:50 mixtures formed helical dime

79 e isotopes but is blind to isotopic isomers (isotopomers) and, except at very high resolution, specie

80 C isotopomer, a one-(2)H-exchanged/one-(13)C isotopomer, and a zero-(2)H-exchanged/two-(13)C isotopom

81 verse datasets including genomic, proteomic, isotopomer, and DNA sequence variation are becoming avai

82 to detect 5-methyl-2'-deoxycytidine and its isotopomer, and ions of m/z 112 and 115 were used to det

83 Model reactions gave (16)O and (18)O isotopomers, and base-promoted hydrolysis of an O(2),2'-

84 The pABA isotopomers are ethyl esterified, isolated on C18 resin,

85 uterated media, invariably all possible (2)H isotopomers are obtained.

86 Following normal-phase HPLC separation, the isotopomers are silylated to their tBDMS derivatives.

87 g cytidylyl-(3',5')-cytidine phosphoramidite isotopomers as the common synthetic intermediates, with

88 rate) was measured competitively for various isotopomers at 103 degrees C.

89 C labeling of proteinogenic amino acids, and isotopomer balancing all indicated a large increase in t

90 paration is difficult and a major hurdle for isotopomer-based flux analysis of mixed cultures.

91 This study provides the foundation to extend isotopomer-based flux analysis to study metabolism of in

92 Isotopomer-based flux analysis typically relies on hydro

93 ild-type (WT) and PGC-1alpha(-/-) mice using isotopomer-based NMR with complementary gene expression

94 on accurate and precise measurements of mass isotopomers by gas chromatography/mass spectrometry.

95 frared absorption spectra of five deuterated isotopomers, C(6)D(5), p-C(6)H(4)D, p-C(6)HD(4), o-C(6)H

96 tions (patchoulol numbering system) C5 (both isotopomers, ca. 100%) and C12 (minor isotopomer, 30-35%

97 Besides, we show that (2)H-(13)C enantio-isotopomers can be distinguished using 2D NMR in chiral

98 While such isotopomers can be obtained in proteins overexpressed in

99 s of [PO(3)](-)/or [H(2)PO(4)](-) ions, mass isotopomers can be quantified directly from the intensit

100 The MS/MS spectra of additional isotopomers can then be computationally generated and in

101 Given that isobaric isotopomers cannot be separated chromatographically or b

102 Spectra of [2-(13)C] and [3-(13)C] isotopomers contained signals arising from labeled carbo

103 ISA uses all mass isotopomers, correctly identified imposed gradients of p

104 zene, where H-/D-isotopic labelling finds no isotopomer cross-over and the non-reactivity of a nitren

105 Powerful modeling frameworks balancing 'isotopomers', 'cumomers', or 'elementary modeling units'

106 ay upon use of a perdeuteromethyl TMG(3)tren isotopomer, d(36)-1 (KIE = 24 at 25 degrees C).

107 evaluate the accuracy and precision of mass isotopomer data for each fragment.

108 umor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with pe

109 a novel LC-MS/MS workflow, acquisition, and isotopomer deconvolution method for MFA that takes advan

110 Previous experiments with GTP isotopomers demonstrated that the ribose C3' hydrogen at

111 In vivo metabolism of (13)C-labeled glucose isotopomers demonstrates that C-3-C-6 of glucose become

112 ll result in a combinatorial distribution of isotopomers depending on the enrichment and number of "l

113 Notably, such isotopomers differ slightly in mass as a result of the a

114 mass isotopomer distribution analysis (MIDA) and isotopomer s

115 agreed closely with models obtained by mass isotopomer distribution analysis (MIDA) and were consist

116 Mass isotopomer distribution analysis (MIDA) is a stable isot

117 The use of mass isotopomer distribution analysis (MIDA) to quantify plas

118 = 8) or [2-(13)C] glycerol (n = 6) and mass isotopomer distribution analysis (MIDA), or 2H2O (n = 6)

119 Mass isotopomer distribution analysis allows measurement of t

120 Gluconeogenesis measured by mass isotopomer distribution analysis provided 31 +/- 4, 41 +

121 Mass isotopomer distribution analysis was used to measure the

122 althy subjects were studied and DNL (by mass-isotopomer distribution analysis), lipolysis (by dilutio

123 nfusion of [1-(13)C] sodium acetate and mass isotopomer distribution analysis.

124 c tools were used to analyze changes in mass isotopomer distribution and changes in glucose and gluta

125 each metabolite pool by determining the mass isotopomer distribution for all labeled compounds.

126 ionization to rapidly measure the amino acid isotopomer distribution in a biomass hydrolysate of the

127 rate to an organism and then determining the isotopomer distribution in amino acids in proteins.

128 sotopoic enrichment due to their low natural isotopomer distribution in negative chemical ionization

129 es not affect E. coli growth kinetics or the isotopomer distribution in nine key metabolites.

130 n of (15)N amino acids results in a new mass isotopomer distribution in protein, which is approximate

131 ound by MS, for which high accuracy mass and isotopomer distribution measurements are critical.

132 he uptake of the acetate tracer and the mass isotopomer distribution of acetyl-CoA.

133 ngle highly expressed protein to analyze the isotopomer distribution of amino acids from one organism

134 beling measurements to quantify the complete isotopomer distribution of aspartate by least-squares re

135 thod for determining the complete positional isotopomer distribution of aspartate carbon atoms by gas

136 The mass isotopomer distribution of intermediates reveals the rev

137 or [5-(13)C]glutamine and analyzed the mass isotopomer distribution of key metabolites using models

138 lyl derivatization, and analysis of the mass isotopomer distribution of malonate.

139 ometry assays for the concentration and mass isotopomer distribution of malonyl-CoA in tissues.

140 The mass isotopomer distribution of malonyl-CoA was compared with

141 two companion articles, we compare the mass isotopomer distribution of metabolites of liver gluconeo

142 The isotopomer distribution of peptides after labeling can b

143 ometry assays for the concentration and mass isotopomer distribution of propionyl-CoA, methylmalonyl-

144 d EryI), a pathway fully consistent with the isotopomer distribution of the erythrose-4-phosphate-der

145 of key metabolites using models that fit the isotopomer distribution to fluxes.

146 The accurate determination of mass isotopomer distributions (MID) is of great significance

147 pe labeling experiments and analysis of mass isotopomer distributions (MID) of cellular metabolites i

148 based on the combinatorial analyses of mass isotopomer distributions (MIDs) of fatty acids and stero

149 scan types that maximizes the number of mass isotopomer distributions (MIDs) that can be acquired in

150 intracellular intermediate and cofactor mass isotopomer distributions (MIDs),1 it was found that a to

151 imulations, it was observed that carbon mass isotopomer distributions and measurement noise can be de

152 Metabolite profiles and their isotopomer distributions can be studied noninvasively in

153 cids but higher signal for nucleotides, mass isotopomer distributions from sorted cells were generall

154 without any fitting parameters, of the mass isotopomer distributions of fatty acids from cells grown

155 The mass isotopomer distributions of propionyl-CoA, methylmalonyl

156 o demonstrate this method, we determined the isotopomer distributions of samples of 13C-labeled leuci

157 At each step, the mass isotopomer distributions of the samples were analyzed by

158 ver, commonly used techniques to measure the isotopomer distributions require derivatization prior to

159 Mass isotopomer distributions were quantified precisely by LC

160 or inorganic phosphate and altered phosphate isotopomer distributions, consistent with increased phos

161 ctional lipogenesis calculated from the mass isotopomer distributions.

162 bined information is then utilized to derive isotopomer distributions.

163 termined by least-squares regression of mass isotopomer distributions.

164 cribed to differential H-bonding for the two isotopomers due to zero point energy differences.

165 ed an accurate GC/MS measurement for the low isotopomer enrichment assay of formic acid, acetic acid,

166 cidence measurements carried out on methanol isotopomers, ethylene glycol, and acetone.

167 2) shows rapid formation of all of the other isotopomers except 1.

168 stribution and available experimental (e.g., isotopomer) flux data.

169 imulated the expected abundance at each mass isotopomer for the GSNEM ion at various values for N, wa

170 of ATP hydrolyzed and the sum of new acetone isotopomers formed.

171 asured and allowed the identification of all isotopomers formed.

172 h precision for isotopologue and tandem mass isotopomer fractions representing >10% of total abundanc

173 e identification of isotopologues as well as isotopomers from biological samples and provides a platf

174 Spectroscopic data for triplet isotopomers H-C-C-C-H, H-(13)C-C-C-H, and H-C-(13)C-C-H

175 oron quadrupole coupling strengths for three isotopomers, H(6)C(4)(11)B(14)N, H(6)C(4)(10)B(14)N, and

176 thods; data for the deuterium and barium 137 isotopomers have been measured as well.

177 is- and trans-ethylene-d2 generates 1-hexene isotopomers having terminal CDH groups, with an isotope

178 e method accurately and precisely determined isotopomer identity and abundance in the labeled materia

179 ction of the pentose cycle on the M2 glucose isotopomer in the liver.

180 Measurement of the distribution of isotopomers in a labeled compound or mixture of labeled

181 ed and (13)C=(18)O-Leu/(15)N-Gly bis-labeled isotopomers in CDCl(3).

182 users to combine MS/MS spectra from various isotopomers in different ratios to obtain a theoretical

183 mulation of the steady state distribution of isotopomers in intermediates of the glycolysis/OPPP netw

184 provides a new means of quantifying glucose isotopomers in metabolic studies.

185 The distribution of sterol isotopomers in plasma mirrored that of liver.

186 Enrichments of M(+1) and M(+2) mass isotopomers in the CK-peptide were measurable but low (c

187 me as the integrated intensity of all of the isotopomers in the isotope distribution.

188 atorial analysis of the distribution of mass isotopomers in triacylglyceride glycerol.

189 This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced

190 etection of (2)H-(13)C isotopomeric isomers (isotopomers) in natural abundance (1.7 x 10(-4)%) both i

191 via indirect detection of 13C providing that isotopomer information can be preserved.

192 tabolite coverage, while also providing rich isotopomer information for a significant number of key m

193 biotechnological samples, while tandem mass isotopomer information is also accessible for a large nu

194 HOD in the jet reveal the formation of only isotopomers involving deuterium in the secondary hydroge

195 ng that the molecular orientation of glycine isotopomers is the same.

196 In addition, the distribution of mass isotopomers is used to study the biosynthesis of diacylg

197 D exchange using D2, and that five different isotopomers/isotopologues of the sigma-alkane complex re

198 IV)(CH(3))(2)D (1-d(1)()) with its scrambled isotopomer, kappa(3)-Tp(Me)2Pt(IV)(CH(3))(CH(2)D)H (1-d(

199 Methyldiazene (HN=N-CH3) isotopomers labeled with 15N at the terminal or internal

200 Further, the isotopomer labeling patterns of amino acids derived from

201 A novel MS/MS-based analysis strategy using isotopomer labels, referred to as "tandem mass tags" (TM

202 of maps to be automatically translated into isotopomer mass-balance equations.

203 fluxes that are typically computed from mass isotopomer measurements is increased.

204 Approximately 1,400 independent mass isotopomer measurements obtained from analysis of 37 met

205 methodology for flux determination from mass isotopomer measurements of biomass hydrolysates, while t

206 The two-isotopomer method did not identify gradients of precurso

207 the samples were analyzed by ISA and the two-isotopomer method to determine whether each method could

208 , did not agree with a simpler algebraic two-isotopomer method.

209 sulin secretion, we have adapted 13C NMR and isotopomer methods to measure influx of metabolic fuels

210 We show that J-HSQC reports isotopomer multiplet patterns identical to those reporte

211 Isotopomer network compartmental analysis (INCA) is the

212 d myc(-/-) and myc(+/+) fibroblasts by (13)C isotopomer NMR analysis.

213 Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be use

214 A doublet peak pattern for the (16)O(18)O isotopomer of 2 in mixed-isotope Raman experiments stron

215 s monitored by the appearance of a plasma M1 isotopomer of glucose, which is produced by the action o

216 Using an isotopomer of tyrosine to evaluate artifactual productio

217 IE) for the interconversion of the two chair isotopomers of 1-trideutero-1,3,3-trimethylcyclohexane w

218 titative evaluation of 13C distribution into isotopomers of 13C-labeled aldoses and ketoses, and the

219 Trapable yields for three isotopomers of 2 range from 72% to 86%.

220 h the use of singly and doubly (13)C-labeled isotopomers of 2.

221 The microwave spectra of 10 isotopomers of 8 and 5 isotopomers of 9 were obtained us

222 crowave spectra of 10 isotopomers of 8 and 5 isotopomers of 9 were obtained using a pulsed nozzle Fou

223 atom fragmentations to fully resolve all 16 isotopomers of aspartate.

224 ly labeled with nondeuterated and deuterated isotopomers of CPM, respectively.

225 insic spectra and relative abundances of all isotopomers of ergosterol whose carbon atoms in the 5,7-

226 articular, metabolic flux analysis uses mass isotopomers of metabolic products typically formed from

227 In order to elucidate positional isotopomers of nucleosides from RNA and DNA, we screened

228 technical limitations, we failed to separate isotopomers of phosphorylated sugars.

229 Our results establish that isotopomers of plant archives contain metabolic informat

230 laser spectra have been compiled for several isotopomers of small (dimer through hexamer) water clust

231 Rotational spectra of seven isotopomers of tetracarbonylethyleneosmium, Os(CO)4(eta2

232 R data are reported for the (15)N and (64)Ni isotopomers of the cofactor, both in the intact enzyme a

233 Several isotopomers of the complex were generated, and the IR sp

234 Isotopomers of the ribosomal P-site substrate, the trinu

235 developed protocol is suited to measure mass isotopomers of these alpha-keto acids in tracer studies

236 nitio procedure is demonstrated for the main isotopomers of water.

237 Mass isotopomers of whole glucose from medium or glycogen and

238 amolecular deuterium distribution (deuterium isotopomers) of photosynthetic C3 glucose contains a sig

239 actions were quantified for each cycloalkane isotopomer on each surface.

240 H- and (13)C-substituted 2-deoxyribofuranose isotopomer on which to investigate this potential effect

241 ion of perhydrido and perdeutero cycloalkane isotopomers on the hexagonally close-packed Ru(001) and

242 ion framework for designing a set of protein isotopomers, or labeling schedules, to reduce the conges

243 the activation barriers for each cycloalkane isotopomer pair, and also by comparison with other relev

244 the single carbon source, in order that the isotopomer pattern of all metabolites would mirror the l

245 calculated by combinatorial analysis of mass isotopomer patterns in peptides correlate very closely w

246 e- and two-carbon elongation mechanisms: (a) isotopomer patterns in terminal carbon atom pairs of bra

247 The isotopomer patterns of proteinogenic amino acids reveale

248 The mass isotopomer patterns of the synthetic peptides were analy

249 ass spectrometry (LC-MS/MS) analysis of mass isotopomer patterns to measure protein turnover.

250 matic errors unique for each individual mass isotopomer peak.

251 brated back to the imide A-py slowly, as the isotopomer (PNP)Sc(ND[DIPP])(eta(2)-NC(5)H(4)) (2-d(1))

252 both highly enriched isotopomers and labeled isotopomers present in low abundance against a natural i

253 fore, the hormonal regulation of [(15)N]urea isotopomer production depends upon the coordinate action

254 , Rb(+), NH(4)(+)), and produced mixtures of isotopomers, ranging from singly exchanged H(1)D(5)- to

255 predicted, the less thermodynamically stable isotopomer rearranges at cryogenic temperatures in the d

256 revious HDX MS methods did not resolve these isotopomers, requiring a natural-abundance-only (before

257 ed to detect 2'-deoxycytidine and its stable isotopomer, respectively.

258 nt evidence from enzyme activity assays, the isotopomer results from both gas chromatography-mass spe

259 vatives, thus diminishing the possibility of isotopomer scrambling during GC analysis.

260 o those of the para-aminobenzoic acid (pABA) isotopomers; second, substituting an NH2 solid phase ext

261 plished by Raman analysis of 11 different fd isotopomers selectively incorporating deuterium at speci

262 of the 1((15)N) (50% Fe identical with(15)N) isotopomer shows a resonance at 1016 ppm (vs externally

263 By tracing this isotopomer signal in herbarium samples of natural C3 vas

264 N2O isotope and isotopomer signatures, as well as molecular genetic resu

265 + 2 profile example above, deconvolving the isotopomer species resulting from deuterium incorporatio

266 On the basis of batch experiments, an isotopomer-specific kinetic model, and density functiona

267 From these experimental MS/MS isotopomer spectra, precursor atoms can be mapped to fra

268 isotopomer distribution analysis (MIDA) and isotopomer spectral analysis (ISA) represent such method

269 imates of fractional synthesis calculated by isotopomer spectral analysis (ISA), a nonlinear regressi

270 l was decreased by progestins as measured by isotopomer spectral analysis, whereas newly synthesized

271 ts with D2 to afford [D1D](0), but not mixed isotopomers such as [H1D](0).

272 The synthesis and characterization of isotopomer tandem nucleic acid mass tag-peptide nucleic

273 over the range 10-45 degrees C for the three isotopomers Tc((16)O)(4)(-), Tc((16)O)(3)((18)O)(-), and

274 strong ion at an m/z of 576.2703 for the 16O-isotopomer that shifts to 580.2794 in the 18O-isotopomer

275 olyzed biomass and increases the coverage of isotopomers that can be quantified, making it a promisin

276 cm(-)(1); a monotonic sensitivity to cyanide isotopomers that indicates the Fe-CN adduct has a linear

277 ntly consisting of highly and fully labelled isotopomers; the total plant material contained more tha

278 was made along with its doubly (15)N-labeled isotopomer to explore bonding interactions at each imida

279 o-2'-deoxyuridine 5'-diphosphate provides an isotopomer to perturb EPR spectra in a predictable manne

280 e rotational/vibrational states of the ozone isotopomer, together with an analysis of the competition

281 the R132H-isobolome by using targeted (13)C isotopomer tracer fate analysis to trace the metabolic f

282 No difference was detected in the isotopomer trends between beet sugar samples covering th

283 In examples shown here, isotopomer uncertainties were calculated with relative s

284 and (2)H (D) relaxation rates of (13)CH(2)D isotopomers using a single sample.

285 ial to represent any and all combinations of isotopomer variations of that material and to determine

286 of the labeled siderophore, analysis of the isotopomers was conducted via one-dimensional (1)H and (

287 es were identified, and the isotope ratio of isotopomers was quantified.

288 e tracer, [1, 2-13C(2)]glucose (a M2 glucose isotopomer), was administered at 1mg/g body weight to 4-

289 , the calculated EIEs for the monodeuterated isotopomers were analyzed.

290 sis as well as the production of [(15)N]urea isotopomers were determined using gas chromatography-mas

291 ESI-cleavable peptide TNT isotopomers were introduced into PNA oligonucleotide seq

292 s, monodeuterated 1,5-dimethylsemibullvalene isotopomers were prepared and investigated by IR spectro

293 Aqueous solutions of the three (13)C isotopomers were studied by (1)H and (13)C NMR spectrosc

294 These isotopomers were synthesized by coupling cytidylyl-(3',5

295 e with 93% (13)C isotopic purity, and 55% of isotopomers were uniformly labelled.

296 typically involve measurements on (13)CHD(2) isotopomers, where the (13)C relaxation mechanism is par

297 population of the desired (13)CHD(2) methyl isotopomer, which is ideal for (1)H and (13)C spin relax

298 ange of trans beta-carotene (tbeta-carotene) isotopomers with a peak enrichment at molecular mass plu

299 oacetyl derivatives of ethyl-esterified pABA isotopomers with heptafluorobutyl derivatives, which are

300 ow here that fragmentation of glutamate mass isotopomers yields additional mass spectral data that si