ライフサイエンスコーパス: isotype

1 status and only marginally involves the IgG4 isotype.

2 erythrocytes, were predominantly of the IgM isotype.

3 of up to 60 different antibodies of the IgG1 isotype.

4 R7 also drives antibody response towards Th1 isotypes.

5 and provides limited information on antibody isotypes.

6 t residues 274-281 in different beta-tubulin isotypes.

7 ed by the functional redundancy of conserved isotypes.

8 gh variations in primary sequence of tubulin isotypes.

9 s with native tail sequences swapped between isotypes.

10 usters compared with the other three L chain isotypes.

11 lative to that achieved by antibodies of IgG isotypes.

12 ith IgG2a and IgG2b being the most effective isotypes.

13 ntributes to the special properties of those isotypes.

14 with high homogeneity on different antibody isotypes.

15 produce high-affinity antibodies of various isotypes.

16 mpassing complete or nearly complete sets of isotypes.

17 can discriminate between human gamma-tubulin isotypes.

18 M expression to the expression of downstream isotypes.

19 onproductive rearrangements of other L chain isotypes.

20 TH2-based immune responses based on antibody isotyping.

21 Human immunoglobulin G isotype 4 (IgG4) antibodies (Abs) are potential candidat

22 strate very distinct outcomes of IgM and IgD isotype activation in CLL cells, providing novel insight

23 s IL-10 and TGF-beta, the production of IgG4 isotype allergen-specific blocking antibodies, and decre

24 Isotype analysis revealed a predominant IgM response eve

25 Isotype and blocking studies experiments showed tracer-s

26 that sensitively and accurately measures the isotype and clonal composition of the circulating B cell

27 skewed immune response as judged by antibody isotype and cytokine profiles.

28 determinants of mAb immunotherapy, with mAb isotype and FcgammaR interaction governing therapeutic e

29 y to assess the apparent affinities for each isotype and IgG subclass of FVIII-specific antibodies wi

30 We compared these isotype and N-glycoform variants with commercially avail

31 nflammasome dependent; IgG1 was the dominant isotype and partially TLR5 and inflammasome dependent.

32 r of palivizumab (antibody 1129) matched for isotype and pre-F protein binding affinities.

33 existing memory helper cells determines both isotype and specificity of donor-reactive alloantibodies

34 ways: by the expression of different tubulin isotypes and by posttranslational modifications (PTMs).

35 e reported that distinct immunoglobulin (Ig) isotypes and IgG subclasses of factor VIII (FVIII)-speci

36 paired production of switched immunoglobulin isotypes and normal or elevated IgM levels.

37 ns from precursors expressing other switched isotypes and rarely IgM or IgD, suggesting that IgE is d

38 ering antibodies of different specificities, isotypes and species are still needed for many research

39 The "tubulin code"-a combination of tubulin isotypes and tubulin post-translational modifications-ca

40 ched B cell cannot revert back to the parent isotype, and a terminally differentiated plasma cell can

41 n, 10 g/L), less frequent lambda light chain isotype, and evaluable difference between involved and u

42 favor isotype switching to the secretory IgA isotype, and how their GC responses may uniquely contrib

43 elonging to clones expressing other switched isotypes, and possibly larger clone size than the rest o

44 Eukaryotic genomes contain multiple tubulin isotypes, and their missense mutations cause a range of

45 up of 3 MAbs potently neutralized VACV in an isotype- and complement-independent manner.

46 uced T-helper type 1 responses such as IgG2a isotype antibodies and IFN-gamma producing cells at high

47 in ADPKD are already available, they are IgG isotype antibodies that are not expected to gain access

48 Specific IgM, IgG, and IgA isotype antibodies to nonself ABH subtypes were detected

49 of a monoclonal antibody against IL17 or an isotype antibody (control).

50 othelial dysfunction (P<0.05), compared with isotype antibody-treated Ang II-infused mice.

51 on and selection of a strain-matched H chain isotype are critical to generate ideal surrogate Abs for

52 Abs of the IgG isotype are glycosylated in their Fc domain at a conserv

53 ing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the path

54 All Slitrk isotypes are highly expressed in the CNS, where they med

55 ation models by antigen-specific IgG1; other isotypes are less potent at preventing disease.

56 o within their heterodimers, the RXR and RAR isotypes are not functionally redundant, and it also unv

57 one L chain isotype at the surface and other isotypes as nonproductive VJ, sterile transcripts, or in

58 detect four different antibodies of the same isotype at nanomolar concentration levels.

59 lusion, a shark B cell expresses one L chain isotype at the surface and other isotypes as nonproducti

60 The ratios of Th2 to Th1 antibody isotypes at each time p.i indicated that both forms of M

61 Data from 613,641 multi-isotype B-cell clonal lineages, of which 592 include an

62 IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR (IgD-BCR).

63 s, where it constrained transport of the IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR (Ig

64 pproximately threefold lower than those with isotype betaIII, a suppression similar to that achieved

65 found that compared with other beta-tubulin isotypes, betaIII-tubulin bound the least amount of 2-(m

66 of drug that binds to different beta-tubulin isotypes, bovine brain tubulin was photolabeled and the

67 Most CLL cells express BCRs of IgM and IgD isotypes, but the contribution of these isotypes to func

68 ching to the pro-inflammatory IgG2c antibody isotype by limiting the expression of activation-induced

69 ch recombination is directed toward specific isotypes by a cell-autonomous imprinted state.

70 evoid of effector function, whereas the IgG4 isotype can undergo in vivo Fab arm exchange leading to

71 the differential activation of the multiple isotypes can be advantageously used in receptor editing.

72 Furthermore, different antibody isotypes can be quantitatively differentiated by adoptin

73 IgG isotypes can differentially bind to Fcgamma receptors an

74 Yet IgG1, the predominant murine serum Ig isotype, cannot activate complement by the classical pat

75 It has become clear over recent years that isotype choice is vital to therapeutic success with agen

76 ctivation induces terminal maturation and Ig isotype class switch (class switch recombination [CSR]).

77 collagen IgG responses, suggesting defective isotype class switching in CD73-deficient mice.

78 lk specific when secreting antibodies of IgA isotypes compared to those secreting IgG.

79 NAbs of the IgG, IgA, or IgM isotype contain germline or close to germline sequences

80 ifferent sources, with distinct beta-tubulin isotype content, were specifically photolabeled with a t

81 fects of fremanezumab (30 mg/kg, IV) and its isotype control Ab on spontaneous and evoked activity in

82 ubular necrosis compared with mice receiving isotype control Abs.

83 ed with anti-GM-CSF neutralizing antibody or isotype control and assessed for histopathological indic

84 by intraperitoneal injection of anti-CD8 or isotype control antibodies.

85 (MBCD4), endothelial P-selectin (MBPSel), or isotype control antibody (MBIso) and MB with a negative

86 mucosal healing and Rag1(-/-) mice given an isotype control antibody developed severe colitis.

87 ed colitis scores compared to mice receiving isotype control antibody, as well as decreased eosinophi

88 versus that in the bladders of mice given an isotype control antibody.

89 C3 expression in the liver compared with the isotype control group.

90 pretreated intraperitoneally with anti-S1P, isotype control mAb, JTE-013, or vehicle before antigen

91 BMDCs were pretreated with SAM11 or isotype control or stattic and stimulated with Per a 10.

92 esulted in greater tumor burdens compared to isotype control treated mice.

93 dministration of anti-CD47 antibodies or IgG isotype control were not found to be statistically diffe

94 nstillation of anti-MHC class I Abs, but not isotype control, followed by murine Sendai virus infecti

95 erall tissue damage in the CNS compared with isotype control-treated mice.

96 re given different antibodies against TNF or isotype (control) antibodies and disease activity index

97 Isotype controls with antilysozyme and anti-DM4 B-Fabs a

98 All O:4-specific antibody isotypes could mediate cell-free killing and phagocytosi

99 m ( approximately 20%), suggesting that CD45 isotypes could regulate signaling thresholds in differen

100 riations in C4 copy number (CN), length, and isotype create a highly diverse gene cluster in which in

101 lta mice have minimal serum titers of all Ab isotypes, decreased numbers of GC and plasma B cells, an

102 ells express J chain regardless of expressed isotype, despite the documented presence of J chain(-) p

103 y and relative quantity of each beta-tubulin isotype determined.

104 Here we summarize how isotype dictates mAb activity and discuss ways in which

105 IgH isotype dictates soluble antibody function, but how mIg

106 nclude that this cell-specific alpha-tubulin isotype dictates the hallmarks of CEM cilia specializati

107 share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions

108 Isotype diversification (toward IgG2) was greatest in HI

109 of HIV and that this would be enhanced by Ab isotype diversification.

110 PTMs and tubulin isotype diversity act as a "tubulin code" that regulates

111 uced higher levels of antigen-specific IgG2c isotype dominant antibodies in CD47-deficient (CD47KO) m

112 fferential expression of human gamma-tubulin isotypes during neuronal development and oxidative stres

113 Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secr

114 Antibodies of IgA isotype effectively engage myeloid effector cells for ca

115 -insulin antibody in the presence of its IgG isotype.Efficient detection of single molecules is vital

116 utations affecting Arg391 in beta-tubulin 4B isotype-encoding (TUBB4B).

117 1F5mIgG1, the only isotype engaging inhibitory FcgammaRIIB expressed in B c

118 n viral pathogens coated with these antibody isotypes enter the cytosol, TRIM21 is rapidly recruited

119 rast to the overwhelming predominance of IgG isotype Env-specific B cells in breast milk of chronical

120 iabetic (NOD) mice, which normally lack this isotype, from spontaneous development of type 1 diabetes

121 Recently, isotype functional diversity has been linked to a "tubul

122 exhibit no functional defects with regard to isotype, functional avidity, expansion after boosting im

123 , namely metal-g-C3N4, semiconductor-g-C3N4, isotype g-C3N4/g-C3N4, graphitic carbon-g-C3N4, conducti

124 iments of direct binding to the three 14-3-3 isotypes gamma, theta, and zeta with phosphopeptides enc

125 ffects for these 3 factors and the M-protein isotype had higher discriminatory power than other model

126 icity by human VH4-34-encoded Abs of the IgM isotype has been well documented.

127 Altered expression of beta-tubulin isotypes has been reported in cancer cell lines resistan

128 ion/expression and receptor editing of these isotypes have not been studied.

129 IgG2 and IgG4 isotypes have significantly lower binding affinity to Fc

130 first time a functional HLA-DQA1/DRB1 mixed isotype heterodimer and its potential association with d

131 The contribution of HLA-DQA1/DRB1 mixed isotype heterodimer to OSP pathogenesis was revealed in

132 as a functional DQA1*01:02;DRB1*15:01 mixed isotype heterodimer.

133 OSP(142-161) to DQA1*01:02;DRB1*15:01 mixed isotype heterodimer.

134 e, we show that, unlike other immunoglobulin isotypes, human IgG2 (h2) imparts FcgammaR-independent a

135 We show that NRG1 isotypes I and II, which like NRG2 are single-pass trans

136 dominates, bft-2 was the most frequent toxin isotype identified in both cases and controls, whereas m

137 pression of CD80 and PD-L2, independently of isotype, identified MBC subsets with distinct functions

138 Antibodies anti-beta-2 glycoprotein-I of IgA isotype (IgA-aB2GP1) have been linked to thrombotic even

139 owever, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple add

140 , or wild-type mice injected IP with control isotype IgG or gammadelta T cell-depleting antibodies, w

141 level, non-specific uptake of (89)Zr-labeled isotype IgG was observed in OVCAR3 tumors; similarly, lo

142 Thus, the Th2-associated isotype IgG1 can play a role in protection against Th1-a

143 e of Fc receptors on basophils, the antibody isotypes IgG1 and IgE, and basophil-derived IL-4/IL-13 d

144 Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half

145 examine recombinant tubulin with human beta isotype IIB and characterize polymerization dynamics.

146 in heterodimers that have human beta-tubulin isotype III (TUBB3), as well as heterodimers with one of

147 Here, we studied isotypes, immunoglobulin G subclasses, and apparent affi

148 showed that gamma-tubulin-1 is the dominant isotype in fetal neurons.

149 ult brain, gamma-tubulin-1 remains the major isotype in various brain regions.

150 , we studied autoantibody repertoires and Ig isotypes in 71 mothers and their 104 healthy newborns (i

151 omparing type I and II antibodies of various isotypes in ADCC and antibody-dependent cellular-phagocy

152 The role of other immunoglobulin isotypes in the birch pollen-plant food syndrome has not

153 tion and class switch recombination to major isotypes) in activated B cells and antibody production i

154 c B cells isolated from breast milk were IgA isotype, in stark contrast to the overwhelming predomina

155 er on the charge transport properties of the isotype In2 O3 /Li-ZnO heterojunctions as well as on the

156 fic antibody responses representing multiple isotypes, including IgA.

157 e different levels of protection and the IgG isotype induced may need to be a consideration when desi

158 Analysis of the antibody isotypes induced by immunization with Pyfabb/f(-) showed

159 tates soluble antibody function, but how mIg isotype influences B cell behavior is not well defined.

160 ced by natural infection, it is assumed this isotype is important.

161 Recent evidence suggests that the IgG2 isotype is not completely devoid of effector function, w

162 yclonal contexts, comparing both IgG and IgA isotypes isolated from human donors.

163 ain isotypes, mu and omega, and four L chain isotypes, kappa, lambda, sigma, and sigma-2).

164 Nurse sharks express four L chain isotypes, kappa, lambda, sigma, and sigma-2, encoded by

165 duction of 1 or 2 noninvolved immunoglobulin isotype levels (immunoparesis).

166 on of VEGF-neutralizing antibody but not the isotype-matched control antibody decreased endothelial-c

167 ng 3-fold higher than that of the irrelevant isotype-matched control antibody DP47GS, clearly indicat

168 idneys were flushed with CD47mAb OX101 or an isotype-matched control immunoglobulin and stored at 4 d

169 ic use, were collected and used to construct isotype-matched IgG1 antibodies, which were then express

170 body (CD47mAb) in the treatment group, or an isotype-matched immunoglobulin in the control group.

171 d until after IgLlambda becomes the dominant isotype may help explain the extreme deviations in the I

172 bunits from the wide range of haplotypes and isotypes may form, but most of these combinations, in pa

173 imers and the evolutionary origin of matched isotype mixed dimer formation.

174 bohydrate maturation of various HLA-class II isotype-mixed alpha and beta subunits was dependent on t

175 In this study we investigated assembly of isotype-mixed HLA class II alpha and beta heterodimers.

176 ombinations, in particular those produced by isotype mixing, yielded mismatched dimers.

177 f its classical Ig gene content (two H chain isotypes, mu and omega, and four L chain isotypes, kappa

178 everity can be predicted neither by antibody isotype nor by titer, indicating that other factors play

179 IgG is the predominant autoantibody isotype of EBA, the pathogenicity of which has been demo

180 true prevalence, quantitative levels, and Ab isotype of pre-existing anti-PEG Ab remain poorly unders

181 suggesting a specific influence of antibody isotype of the epitopes for these two MET mAbs.

182 d, cloned, and sequenced belonged to the IgM isotype of the innate immune system.

183 ong-term effect of therapy was to change the isotype of the pathogenic Ab response from IgG2b, which

184 expression of P-glycoprotein and the betaIII isotype of tubulin.

185 sm of antitumor efficacy using different IgG isotypes of 1F5 in human CD27-transgenic mice.

186 tions for quantification of both IgA and IgG isotypes of anti-tTG in order to assess suitability of t

187 were detected at 15 days postinfection, and isotyping of the Ig subclass showed that the total IgG r

188 ing the expression of the two major antibody isotypes on the surface of most mature B cells.

189 SCID gammaC-deficient mice, which were given isotype or anti-inducible T-cell costimulator ligand (IC

190 uantitative analytical method for other hIgG isotypes or next generation biotherapeutics.

191 onsible for acquisition of maternal antibody isotypes other than IgG are not fully understood.

192 ombinant alpha1A/betaIII tubulin, a neuronal isotype overexpressed in many tumors, proportionally tun

193 There are seven beta-tubulin isotypes present in distinct quantities in mammalian cel

194 We show that Tuba8, another alpha-tubulin isotype previously associated with cortical malformation

195 KIF17, whereas a cell-specific alpha-tubulin isotype regulates ciliary ultrastructure, intraflagellar

196 ovine brain tubulin was photolabeled and the isotypes resolved by high-resolution isoelectrofocusing.

197 However, the receptors and Ab isotypes responsible for MPhi adherence and Arg1 inducti

198 rinized DTA-1 Abs on a C57BL/6-matched IgG2c isotype resulted in reduced development and severity of

199 y been discovered by us as highly potent and isotype-selective hSirt2 inhibitors.

200 HeLa cells, our SirReal-based PROTAC induced isotype-selective Sirt2 degradation that results in the

201 ging ligands (SirReals) as highly potent and isotype-selective Sirt2 inhibitors with thalidomide, a b

202 However, isotype-selectivity with regard to its closest relative,

203 tinib effectively inhibited both IgM and IgD isotype signaling.

204 The human isotype Sirt2 has been implicated in the pathogenesis of

205 he relative efficiency of different antibody isotypes specific for the O:4 antigen of S. Typhimurium

206 erize innate immune components that regulate isotype-specific Ab responses.

207 and indicate the interspersed arrangement of isotype-specific and shared genomic donor cassettes; the

208 We examined IgH isotype-specific BCR function by analyzing naturally swi

209 ore are largely responsible for the observed isotype-specific changes in dynamic instability paramete

210 nts whose assembly into complex networks and isotype-specific functions are still largely unknown.

211 in the alpha constant gene, display a marked isotype-specific increase of GL transcription in develop

212 Using immunoassays with isotype-specific mAbs, in this study we show that green

213 Our results indicate that IgH isotype-specific mIg/BCR dosage may play a larger role i

214 Fc receptors, TRIM21 shows remarkably broad isotype specificity as it does not only bind IgG but als

215 n of substantial sequence divergence between isotypes, specifies interactions with microtubule-associ

216 tivity: theirreversible genomic selection of isotype/subclass and alterations in glycosylation.

217 n and enough of the IgH C region to identify isotype subtypes.

218 Minor subclones with alternative post-switch isotypes suggested ongoing switch events and clonal evol

219 with enhanced production of IgG2a and IgG2b isotypes, suggesting that SERCA2a 971-990 can potentiall

220 ce expression level of CD23 after undergoing isotype switch and memory B-cell differentiation.

221 lper-1 skewing manifests in an IgG1-to-IgG2c isotype switch in the immunoglobulin response against ox

222 as not caused by the isotype switch, but the isotype switch may contribute to resistance to reinducti

223 versal of chronic EAMG was not caused by the isotype switch, but the isotype switch may contribute to

224 that germinal center (GC) B cell reactions, isotype-switched Ab responses, parasite control, and hos

225 Ultimately, the quality and quantity of isotype-switched Abs produced in Icos(-/-) mice declined

226 Class switch recombination (CSR) generates isotype-switched Abs with distinct effector functions.

227 chabaudi AS infection or production of isotype-switched Abs, but it is necessary for maintenanc

228 ty, but not production, of parasite-specific isotype-switched Abs.

229 tion by DCs was dependent on virus-specific, isotype-switched antibodies (Abs) that facilitated the c

230 en-specific flow sorting express mutated and isotype-switched antibodies.

231 nal center (GC) reactions and high affinity, isotype-switched antibody responses.

232 hile delayed accumulation of virus-specific, isotype-switched ASC requires CD19-dependent GC formatio

233 promotes the differentiation of B cells into isotype-switched B cells and plasma cells.

234 vels, is a driving force for accumulation of isotype-switched B(mem) and ASC.

235 n of B cells ranging from early-activated to isotype-switched differentiation stages is both temporal

236 ntrol and is preceded by accumulation of non-isotype-switched IgD(+) and IgM(+) B cells.

237 d that MF59 was highly effective in inducing isotype-switched IgG antibodies and long-term protective

238 was found to be highly effective in raising isotype-switched IgG antibodies to a T-dependent influen

239 type 2 CPS is able to induce potent IgM and isotype-switched IgGs in mice and pigs, yielding functio

240 ells (MBCs) are long-lived sources of rapid, isotype-switched secondary antibody-forming cell (AFC) r

241 Tfh cells, GC reactions, and development of isotype-switched, flu-specific antibody responses.

242 with phenotypes characteristic of naive, non-isotype-switched, memory (Bmem) cells and antibody-secre

243 n, a large increase in ASC numbers and rapid isotype switches to IgG1 were observed, particularly in

244 oliferate and induced splenomegaly; however, isotype switching and autoantibody production were dimin

245 ignificant fraction of naive B cells undergo isotype switching and differentiate into plasmacytes.

246 4(+) T cells are required to induce antibody isotype switching and long-term memory responses.

247 ide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and so

248 We also find that these inferred isotype switching frequencies are similar in healthy and

249 recent years several groups have shown that isotype switching from IgM to IgG to IgA can affect the

250 causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4.

251 We found evidence that secondary isotype switching of mutated IgG1-expressing B cells is

252 ith a SphK1 inhibitor or in SphK1(-/-) mice, isotype switching to antigen-specific IgE was decreased

253 surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.

254 We evaluate models for isotype switching to IgE in human subjects using immunog

255 lon germline transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.

256 Frequencies of isotype switching to IgG1, IgG2b, IgG2c, and IgG3 were t

257 cell encounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how

258 TACI-driven proliferation, isotype switching, and antibody responses were measured

259 B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are

260 iciently induce antibody avidity maturation, isotype switching, and immunological memory in immunized

261 lls (Tfh) as the key T cell subset in B cell isotype switching, due to their physical location at the

262 creted Abs, but no deficiencies in survival, isotype switching, or expression of germinal center (GC)

263 c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and

264 irect effect on any of the steps involved in isotype switching, we generated a transgenic mouse that

265 jectory distinct from classical mediators of isotype switching.

266 6 directly provide help to B cells to induce isotype switching.

267 synthesis at a stage distal to Tfh-mediated isotype switching.

268 t acute infections, and T-bet promotes IgG2a isotype switching.

269 ly impaired, possibly at the stage of B cell isotype switching.

270 d resisted apoptosis, but was independent of isotype switching.

271 Using C. elegans, we show that alpha-tubulin isotype TBA-6 sculpts 18 A- and B-tubule singlets from n

272 e plus ends, and TUBB encodes a beta-tubulin isotype that is expressed abundantly in the developing b

273 esidue, alanine, at 218, compared with other isotypes that contain threonine.

274 e O-antigen-specific antibodies of different isotypes that exert in vitro and in vivo killing of S. T

275 dent nephrotoxic mechanism, and suggest that isotypes that poorly activate effector mechanisms may be

276 demonstrate the adaptive significance of Ig isotypes that poorly activate effector mechanisms, revea

277 PPARalpha was the only isotype to colocalize with all cell types in both adult

278 ass-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions.

279 tibody specificities and the contribution of isotype to pathogenicity.

280 nd complement, making the selection of which isotype to pursue for development of a particular therap

281 IgD isotypes, but the contribution of these isotypes to functional responses remains incompletely de

282 The contribution of different IgG isotypes to protection against bacteria such as S.

283 y and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molec

284 following bacterial challenge compared with isotype-treated mice.

285 Mutation of the alpha-tubulin isotype TUBA1A is associated with cortical malformations

286 motor protein KIF21A or in the beta-tubulin isotypes TUBB3 or TUBB2B.

287 intensity (MFI) values, and immunoglobulin G isotype was determined.

288 G1 and IgG3, whereas the Th2-associated IgG4 isotype was only detected at very low amounts.

289 Accordingly, this isotype was the most effective in eradicating BCL1 lymph

290 Class switch recombination to several isotypes was also reduced in Atad5(+/m) cells, although

291 ne receptors, and immunoglobulin heavy-chain isotypes, was measured.

292 ed surrogate Abs with a murine IgG2c H chain isotype were created.

293 icity-mediating CH38 IgG and its natural IgA isotype were the most potent blocking antibodies.

294 Prevalent antibody isotypes were defined, levels were determined, and glome

295 oth cases and controls, whereas multiple bft isotypes were detected more frequently in cases (P </= .

296 RF isotypes were measured with ELISA, and immune complexes

297 that gamma-tubulin-1 represents a ubiquitous isotype, whereas gamma-tubulin-2 is found predominantly

298 sible for inhibition of drug binding to this isotype, which could influence downstream cellular event

299 y is associated with a unique immunoglobulin isotype, which is now called IgE.

300 IgE is the least abundant Ig isotype, yet it plays a critical role in allergic reacti