ライフサイエンスコーパス: isotype switching

1 years increased antibody titers and elicited isotype switching.

2 haride/interleukin-4-mediated immunoglobulin isotype switching.

3 cts of immune responses including Ig H chain isotype switching.

4 terleukin-4 (IL-4)-induced immunoglobulin G1 isotype switching.

5 optimal proliferation, differentiation, and isotype switching.

6 C found 4-7 days after KLH facilitates IgG2a isotype switching.

7 s in antibody production, amplification, and isotype switching.

8 of memory B cells, affinity maturation, and isotype switching.

9 t acute infections, and T-bet promotes IgG2a isotype switching.

10 typical T-cell-dependent response involving isotype switching.

11 o cells that undergo affinity maturation and isotype switching.

12 and retained until mature B cells undergo Ig isotype switching.

13 ly impaired, possibly at the stage of B cell isotype switching.

14 ates DNA DSB repair, V(D)J recombination and isotype switching.

15 an respond to T-dependent Ags and support Ig isotype switching.

16 CL3 plays a part in B cell proliferation and isotype switching.

17 l mechanism of regulating the specificity of isotype switching.

18 ed by trans-chromosomal recombination during isotype switching.

19 on plays a critical role in T cell-dependent isotype switching.

20 rmal specific Ab responses with Ag-driven Ig isotype switching.

21 d resisted apoptosis, but was independent of isotype switching.

22 ctivated mature B cell, secretion of Ig, and isotype switching.

23 -cell survival, growth, differentiation, and isotype switching.

24 ndent intracellular signals that lead to IgE isotype switching.

25 R) that includes an enhancer which regulates isotype switching.

26 lper cell differentiation and immunoglobulin isotype switching.

27 eration, differentiation, and immunoglobulin isotype switching.

28 cell proliferation, survival, memory, and Ig isotype switching.

29 te of immunoglobulin affinity maturation and isotype switching.

30 jectory distinct from classical mediators of isotype switching.

31 6 directly provide help to B cells to induce isotype switching.

32 ognate T- and B-cell interactions and normal isotype switching.

33 I ligand APRIL, probably reflecting impaired isotype switching.

34 synthesis at a stage distal to Tfh-mediated isotype switching.

35 2) responses, germinal center formation, and isotype switching.

36 y reports of changes in Ab Id structure with isotype switching.

37 are able to transduce signals that result in isotype switching.

38 losely related to aberrant hypermutation and isotype switching activity in these B cells.

39 icited an antibody response featuring normal isotype switching, affinity maturation, and germinal cen

40 cell dependent immune responses that lead to isotype switching, affinity maturation, and the inductio

41 In addition to their role in isotype switching, AID-induced lesions promote Igh-cMyc

42 Ab class (isotype) switching allows the humoral immune system to a

43 n extension, in targeting Cgamma regions for isotype switching, an IgM+ Burkitt lymphoma cell line (R

44 or TRAF3 but not TRAF6 is essential for CD40 isotype switching and activation in B cells.

45 -) mice provide a novel model for separating isotype switching and affinity maturation during acute (

46 ase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody ge

47 er and memory B cell formation, and antibody isotype switching and affinity maturation.

48 rmed the known role of AID in immunoglobulin isotype switching and also demonstrated few other effect

49 CD28-deficient mice exhibit defects in isotype switching and are more susceptible to pathogens

50 g heavy chain loci precede the occurrence of isotype switching and are thought to play an important t

51 o, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allerg

52 -derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function duri

53 oliferate and induced splenomegaly; however, isotype switching and autoantibody production were dimin

54 These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivity, suggesting

55 As BAFF mediates T-cell-independent isotype switching and B-cell survival, our data implicat

56 ignificant fraction of naive B cells undergo isotype switching and differentiate into plasmacytes.

57 ts interactions with IL-21R are required for isotype switching and differentiation of B cells into Ab

58 B cell Ig isotype switching and differentiation toward IgA product

59 nous Ig genes, Ab H chain transgenes undergo isotype switching and gene conversion-like sequence tran

60 , in the transgenic mice both immunoglobulin isotype switching and germinal center formation were als

61 such primed T cells fail to provide help for isotype switching and IgG production in B cells.

62 activation-induced deaminase (AID) that lack isotype switching and immunoglobulin hypermutation.

63 4(+) T cells are required to induce antibody isotype switching and long-term memory responses.

64 B-1b cell expansion and the frequency of IgG isotype switching and plasmablast/plasma cell differenti

65 ay haploinsufficiency both in the context of isotype switching and plasmacytomagenesis.

66 s characterized by failure of immunoglobulin isotype switching and severe defects of cell-mediated im

67 Since isotype switching and somatic hypermutation occur in ger

68 Interestingly, although isotype switching and somatic hypermutation show many pa

69 help shapes the Ab response by facilitating isotype switching and somatic hypermutation, and promoti

70 ptor and communication with T cells, inhibit isotype switching and somatic hypermutation, downregulat

71 d cytidine deaminase, an enzyme required for isotype switching and somatic hypermutation, was also in

72 ndergone comparable levels of immunoglobulin isotype switching and somatic hypermutation, while neith

73 e remodeling, including V(D)J recombination, isotype switching and somatic hypermutation.

74 y B cells, suggesting a reduced frequency of isotype switching and somatic mutation in RV VP6-specifi

75 ination defect in A-T cells affected both Ig isotype switching and TCR rearrangeme

76 T-cell-dependent B-cell isotype switching and the consequent production of IgG a

77 Isotype switching and the initial LCMV-specific IgG resp

78 response in plasma cells that have undergone isotype switching and those resulting from secondary imm

79 response, which was demonstrated by Th2-type isotype-switching and the induction of cellular immune r

80 clonal B-cell activation/expansion, antibody isotype switching, and affinity maturation remain normal

81 TACI-driven proliferation, isotype switching, and antibody responses were measured

82 54, induce dendritic cell maturation, B cell isotype switching, and augment CD8(+) T cell responses b

83 critical signals for B cell differentiation, isotype switching, and B cell memory.

84 were present: significant somatic mutation, isotype switching, and codon insertion/deletion.

85 lls in XLA patients can proliferate, undergo isotype switching, and differentiate into specific Ab-pr

86 In addition, germinal center (GC) formation, isotype switching, and generation of memory B cells, inc

87 B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are

88 iciently induce antibody avidity maturation, isotype switching, and immunological memory in immunized

89 Ag-specific B-1b cell activation, expansion, isotype switching, and plasmablast/plasma cell different

90 g spontaneous formation of germinal centers, isotype switching, and production of autoreactive antibo

91 es, subsequent differentiation of Th1 cells, isotype switching, and stimulation of cross-priming.

92 ired for the generation of germinal centers, isotype switching, and sustained Ab production, even whe

93 events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface mol

94 B cell proliferation, Ig and IL-6 secretion, isotype switching, and up-regulation of surface molecule

95 tial for CD40-mediated B-cell proliferation, isotype switching, and upregulation of CD23, ICAM-1, CD8

96 D40 stimulation on B-cell proliferation, IgE isotype switching, and upregulation of surface expressio

97 ms and significance of the effect of BSAP on isotype switching are discussed.

98 autoantibody responses with some changes in isotype switching as compared with untreated animals.

99 ll activation, germinal center formation, Ig isotype switching as well as plasma cell differentiation

100 ion of ICOS to germinal center formation and isotype switching, as well as its relevance to the fate

101 aged animals was not due to a deficiency in isotype switching because the number of total IgG1 splen

102 IL-4 pathway did not suffice to trigger IgE isotype switching, but promoted IgG1 production and inhi

103 The reduction in isotype switching by Atm-/- B cells occurs at the level

104 y be involved in the mechanism that leads to isotype switching by B cells.

105 ide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and so

106 D86 expression, Ig secretion and heavy chain isotype switching by neonatal B cells.

107 some instances terminal differentiation and isotype switching can occur.

108 can influence fine specificity suggests that isotype switching contributes to the generation of Ab di

109 l activation, we investigated whether B-cell isotype switching could predict acute cellular rejection

110 This would predict isotype-switching deficiency but normal affinity maturat

111 MR-deficient mice show a 35-75% reduction in isotype switching, depending on the isotype and on the p

112 gglutinin+ germinal centers and a failure in isotype switching despite normal B cell signaling in vit

113 antidonor CD8(+) T effector cells and for Ab isotype switching, despite DST/anti-CD40L.

114 lls (Tfh) as the key T cell subset in B cell isotype switching, due to their physical location at the

115 in class switch recombination (CSR) mediates isotype switching during B cell development.

116 n IgG1 and IgE occurs independently from the isotype switching event.

117 onoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-

118 We also find that these inferred isotype switching frequencies are similar in healthy and

119 or modified recipient class II antigens; (c) isotype switching from IgM to IgG alloantibody requires

120 recent years several groups have shown that isotype switching from IgM to IgG to IgA can affect the

121 aracterized by (i) more rapid kinetics, (ii) isotype switching from immunoglobulin M (IgM) to IgG, an

122 ch circular DNA representing in vitro driven isotype switching from mu to alpha.

123 tes, including V(D)J gene rearrangements and isotype switching, generally occur in cis, i.e., intrach

124 -germ line-encoded residues, and intraclonal isotype switching generated a surprising degree of parat

125 MAb can be converted to a protective MAb by isotype switching, (ii) indicate that the efficacy of pr

126 The phospho-mimetic variants fail to mediate isotype switching in activated mouse splenic B lymphocyt

127 nduces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac c

128 helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-med

129 h2 differentiation of CD4(+) T cells and IgE isotype switching in B cells, we hypothesized that basop

130 the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (W

131 ses to protein Ags and is responsible for Ig isotype switching in B cells.

132 of Id3 in cytokine production in T cells and isotype switching in B cells.

133 and cyclophilin ligand interactor) mediates isotype switching in B cells.

134 Ig heavy chain isotype switching in B lymphocytes is known to be preced

135 s receptor CD40 induces proliferation of and isotype switching in B lymphocytes.

136 APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted

137 ducing Cepsilon germline transcripts and IgE isotype switching in human B cells.

138 ctor family members BAFF and APRIL induce Ig isotype switching in human B cells.

139 Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoi

140 restricted almost entirely to IgA, although isotype switching in mediastinal continued to be skewed

141 tandem repeat (SmuTR) sequences each reduce isotype switching in mice by about 2- to 3-fold.

142 yzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and Ig

143 4 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells f

144 exhibit decreased Ab production and impaired isotype switching in response to immunization with a thy

145 - mice, suggesting that IRF9 plays a role in isotype switching in response to self antigens.

146 cells and mice) as well as a restoration of isotype switching in SMUG-transgenic msh2-/- ung-/- mice

147 pable of proliferating, differentiating, and isotype switching in the absence of CD40-CD40L interacti

148 causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4.

149 his can be explained by impaired RA-mediated isotype switching in TLR9/RP105-stimulated CVID-derived

150 Ig, express germ-line CHRNA, and undergo Ig isotype switching in vitro in response to a number of di

151 e, accumulate V genes mutations, and undergo isotype switching in vivo.

152 d clonal amplification, somatic mutation and isotype switching, indicating a local antigen-driven B-c

153 Isotype switching involves a region-specific, nonhomolog

154 Immunoglobulin (Ig) isotype switching is a recombination event that changes

155 This study implies that isotype switching is another mechanism for generating di

156 How the magnitude of immunoglobulin isotype switching is controlled is still poorly understo

157 Isotype switching is the DNA recombination mechanism by

158 , characterized by failure of immunoglobulin isotype switching, is caused by mutations of the CD40 li

159 rom RIP(-/-) mice proliferated and underwent isotype switching normally in response to anti-CD40-IL-4

160 Isotype switching occurs by intrachromosomal DNA recombi

161 These results indicate that isotype switching occurs in lpr/lpr mice deficient in CD

162 The isotype switching of anti-MUC1 Ab was CD4 dependent.

163 r the survival, growth, differentiation, and isotype switching of B lymphocytes.

164 tch recombination (CSR)--a process mediating isotype switching of immunoglobulin--and somatic hypermu

165 We found evidence that secondary isotype switching of mutated IgG1-expressing B cells is

166 al center reactions after Ag stimulation and isotype switching of naive B cells to IgA production hav

167 ted to a subset of B cell lines that support isotype switching on their endogenous loci and to mitoge

168 t local environments and thus affects either isotype switching or homing of IgA-expressing cells.

169 p-1 expression in Irf4(-/-) B cells promoted isotype switching or secretion, respectively.

170 creted Abs, but no deficiencies in survival, isotype switching, or expression of germinal center (GC)

171 ired for the generation of germinal centers, isotype switching, or sustained Ab production.

172 This defect is not due to a failure of the isotype switching process, but rather to reduced levels

173 CD40-mediated isotype switching, proliferation, and activation of p38,

174 ration in that significant somatic mutation, isotype switching, receptor revision, codon insertion/de

175 rocesses, we have analyzed H chain transgene isotype switching, sequence transfer, and somatic hyperm

176 specific B cells that have not yet undergone isotype switching showed a relatively higher expression

177 T cell-dependent B cell responses, including isotype switching, somatic hypermutation, and limited af

178 In order to probe the isotype switching status of HCL, RNA transcripts of V(H)

179 ontribute to the activation of Ab secretion, isotype switching, T cell costimulation, and immunologic

180 rotection of an IgG1 MAb can be increased by isotype switching to another subclass, (iii) show that p

181 ith a SphK1 inhibitor or in SphK1(-/-) mice, isotype switching to antigen-specific IgE was decreased

182 cytokine environment was adequate to support isotype switching to cytophilic IgGs, the isotypes that

183 The ability of GE2 to block human isotype switching to epsilon, in addition to its already

184 surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.

185 We evaluate models for isotype switching to IgE in human subjects using immunog

186 t deficiencies in eosinophil recruitment and isotype switching to IgE production may be at least part

187 lon germline transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.

188 transcripts, an essential step preceding Ig isotype switching to IgE, requires activation of transcr

189 believed to be a necessary prerequisite for isotype switching to IgG1 and IgE, respectively.

190 on and are normally required for T-dependent isotype switching to IgG1 and IgE.

191 g both p50 and p65 secreted Ig and underwent isotype switching to IgG1 as efficiently as B cells lack

192 Frequencies of isotype switching to IgG1, IgG2b, IgG2c, and IgG3 were t

193 uble NTB-A-Fc fusion protein inhibits B cell isotype switching to IgG2a and IgG3, commonly induced by

194 er increase their IgM production nor undergo isotype switching to IgG2a in response to the infection.

195 HC region regulate autoantigen selection and isotype switching to IgG3 but have minimal effect on end

196 Isotype switching to immunoglobulin G (IgG) was abrogate

197 lar to that in the controls, including rapid isotype switching to immunoglobulin G antibody.

198 e previously showed that IgW VDJ can perform isotype switching to mu C regions; in this study, we fou

199 gens, causes stronger antibody responses and isotype switching to the IgG isotypes.

200 cell encounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how

201 y reported, we observed a defect in antibody isotype switching toward the IgG1 isotype in ICOS-/- mic

202 CD40 signaling is crucial for Ab production, isotype switching, up-regulation of surface molecules, d

203 s induces immunoglobulin (Ig)M-to-IgG B-cell isotype switching via costimulatory regulatory pathways.

204 c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and

205 The reduction in isotype switching was demonstrated to be at the level of

206 lpha to stimulate the Ab response and induce isotype switching was markedly reduced in mice in which

207 B cell Ig isotype switching was measured by enzyme-linked immunosp

208 To determine the role of these receptors in isotype switching, we examined B cells from mice deficie

209 irect effect on any of the steps involved in isotype switching, we generated a transgenic mouse that

210 To directly examine the effects of BSAP on isotype switching, we use a tetracycline-regulated expre

211 I antigens for >30 days and the lack of IgG isotype switching were associated with protection agains

212 were present, but NK cell number and B cell isotype switching were reduced.

213 immune responses, including induction of IgG isotype switching, were characterized in calves immunize

214 udy demonstrates that peptides can induce TI isotype switching when antigen and TLR ligand are assemb

215 ar mechanisms underlying the coordination of isotype switching with plasma cell differentiation are p

216 ression of IRF-4 developmentally coordinates isotype switching with plasma cell differentiation.

217 y reactive T cells from SLE patients induced isotype switching, with a striking increase in IgG produ