ライフサイエンスコーパス: isoxazoline

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1 nucleophilic fragmentation of the resulting isoxazoline.

2 e preparation of chiral 3,4,4-trisubstituted isoxazolines.

3 sfer reaction that leads to the formation of isoxazolines.

4 ed [3+2] dipolar cycloaddition gave bicyclic isoxazoline 17 in a regio- and stereoselective fashion.

5 sulfonamide groups, in conjunction with (5R)-isoxazoline (2S)-diaminopropionate stereochemistry, were

6 f antibacterial agents incorporating a novel isoxazoline A-ring surrogate.

7 The synthetic versatility of the isoxazoline allowed for a broad study of metal binding g

8 In a gratifying result, the initial isoxazoline analogue prepared was found to exhibit in vi

9 activity profile of a preliminary series of isoxazoline analogues incorporating either a C-C or N-C

10 Recently, we reported on a series of isoxazoline and isoxazole monobasic noncovalent inhibito

11 Using the isoxazoline as a common structural feature, three series

12 re a straightforward method employing chiral isoxazolines as key intermediates to access five differe

13 observed between this series and a series of isoxazoline-based selective GPIIbIIIa antagonists.

14 more stable and more synthetically versatile isoxazoline core.

15 An isoxazoline derivative of [6]-gingerol was prepared and

16 report a series of novel biaryl-substituted isoxazoline derivatives in which the biaryl moiety was d

17 ria, by screening a small library of 3-bromo-isoxazoline derivatives that inactivate the enzyme throu

18 Herein we report a series of isoxazoline derivatives which are potent FXa inhibitors.

19 Nine of 17 isoxazolines, each incorporating a different potential m

20 nitrile oxide and an olefin (22) to yield an isoxazoline followed by subsequent conversion into the g

21 cation of the alpha-carbamate substituent of isoxazoline GPIIb/IIIa (alphaIIb beta3) antagonist DMP 7

22 e cycloaddition, providing novel 5-hydroxy-2-isoxazolines in high chemical yield with high levels of

23 itrones to give highly substituted 4-nitro-4-isoxazolines in high yields.

24 m alkenes leading to the direct synthesis of isoxazolines in the presence of tert-butyl nitrite, quin

25 The previously described isoxazoline inhibitor binds at the same site as DAP but

26 DAP) and a ternary complex with NADP+ and an isoxazoline inhibitor have been solved and refined again

27 Grignard addition to this isoxazoline intermediate followed by DCC coupling of the

28 Protonation of the nitrogen of the metalated isoxazoline intermediate results in ring opening and the

29 which underwent N-O coupling to produce new isoxazoline N-oxide derivative.

30 oximes via one-pot halogenation/oxidation of isoxazoline N-oxide derivatives is described here.

31 In all cases, the respective isoxazoline products are produced with exquisite regio-

32 side chain at the quaternary position of the isoxazoline ring led to SK549 which showed subnanomolar

33 nter, and reversal of the orientation of the isoxazoline ring resulted in lowered potency and/or dura

34 1-propene-1,3-sultone affords the respective isoxazoline-ring-fused heterobicyclic products in modera

35 alternative basic groups, elimination of the isoxazoline stereocenter, and reversal of the orientatio

36 zations of two styrenes are involved in this isoxazoline synthesis.

37 We utilized 2 structurally related isoxazolines, which show in vitro inhibition of MIF taut

38 Using isoxazoline XR299 (1a) as a starting point for the desig

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