ライフサイエンスコーパス: isozyme

1 ypeptide 1 subunit zeta, and pyruvate kinase isozyme.

2 ide Ca(2)(+) feedback to the remaining RetGC isozyme.

3 sheveled, and ZO1) ligand unique to this PKC isozyme.

4 and siRNA-induced knockdown of specific PKC isozyme.

5 and spatial control of DGK activity to each isozyme.

6 ed single-compartment targeting of each FPGS isozyme.

7 ue spatial and regulatory properties of this isozyme.

8 the assembly and physiology of the DGKdelta isozyme.

9 from the mammalian cofactor-dependent (dPGM) isozyme.

10 a highly reactive cysteine unique to the bGP isozyme.

11 r the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

12 b-wave amplitude and the expression of GSK3 isozymes.

13 embrane-mediated allosterism within PLC-beta isozymes.

14 ed only in cells lacking their corresponding isozymes.

15 bitor of a broad range of Gram-negative TrmD isozymes.

16 redicts the regioselectivity of the last six isozymes.

17 poxic tumors overexpressing extracellular CA isozymes.

18 phosphorylated during the maturation of PKC isozymes.

19 es for Ca(2+) and specificities toward RetGC isozymes.

20 use of U73122 as a general inhibitor of PLC isozymes.

21 y if selective against individual ppGalNAc-T isozymes.

22 e 10-member family of protein kinase C (PKC) isozymes.

23 e lack of potency against gram-positive GlmU isozymes.

24 rities between the TYK2, JAK1, JAK2 and JAK3 isozymes.

25 here should further the understanding of CYP isozymes.

26 scaffolding of conventional and/or novel PKC isozymes.

27 uctures that differentiated between the five isozymes.

28 Arabidopsis contains two ProRS isozymes.

29 istinguish between the two highly homologous isozymes.

30 retina, RD3 inhibited both RetGC1 and RetGC2 isozymes.

31 otent and show selectivity toward particular isozymes.

32 ized sites and covering nine Cytochrome P450 isozymes.

33 ction against the 12 catalytically active CA isozymes.

34 n amino acid residues among the different CA isozymes.

35 discriminate among structurally similar GST isozymes.

36 umor-linked NAD(P)H: quinone oxido-reductase isozyme 1 (hNQO1) results in fast trigger group removal

37 ociated human NAD(P)H:quinone oxidoreductase isozyme 1 (hNQO1).

38 of this process, human lactate dehydrogenase isozyme 1 (LDH-1) microcrystals were separately dissolve

39 kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mammalian target of rapamycin (mTO

40 ursor (GPC) by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) is crucial for p

41 The proprotein convertase subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) plays crucial ro

42 lycoprotein by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

43 SD11B1 (hydroxysteroid 11-beta-dehydrogenase isozyme 1), a key glucocorticoid-activating enzyme, inde

44 shRNA-mediated silencing of the class I HDAC isozymes 1, 2, 3, and 8, but not that of the class II is

45 gs inhibit poly-ADP ribose polymerase (PARP) isozymes 1, 3, and 16.

46 e stability of ACS2 and ACS6, two type I ACS isozymes (1-amino-cyclopropane-1-carboxylic acid synthas

47 The proprotein convertase subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) is implicated in

48 s solfataricus ADH-10 (Alcohol Dehydrogenase isozyme 10) and its use in the dynamic reductive kinetic

49 Pyruvate kinase muscle isozyme 2 (PKM2) is a key regulator of aerobic glycolysi

50 factor-1A and reduced pyruvate kinase muscle isozyme 2 activity, both key regulators of aerobic glyco

51 ed biochemical potency against gram-negative isozymes 300-fold and afforded antimicrobial activity ag

52 Cerebrospinal fluid lactate dehydrogenase isozyme 5, beta2-microglobulin, and immunoglobulin heavy

53 is >7500-fold selective against the related isozymes, 5-hLO, platelet 12-hLO, epithelial 15-hLO-2, o

54 mits GCAP1 access to RetGC2 and makes RetGC1 isozyme a preferential target for the disease-causing GC

55 Similar effects were observed with human GST isozymes A1-1 and M1-1.

56 haped by the sequential recruitment of RetGC isozyme activation by GCAPs according to the different G

57 is revealed few peculiar residues in the 1A3 isozyme active site.

58 he maximal level of activation by GCAP, this isozyme alone could provide a significantly high rate of

59 netics and site of translocation for the PKC isozymes alpha and delta upon treatment with the compoun

60 Importantly, PKC isozymes alpha/beta control alternative splicing of thes

61 Both GSK-3 isozymes (alpha/beta) were hyperactive in this model.

62 B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (

63 rst demonstrated link between a specific PKC isozyme and inhibitor of DNA binding factors, and it poi

64 for elucidating the biological roles of this isozyme and may ultimately be useful for treating specif

65 a mt-2, is the most extensively studied 4-OT isozyme and the founding member of the tautomerase super

66 An isozyme and tumor-selective role of PDE10 were evident b

67 und was devoid of inhibitory activity on COX isozymes and blocked AKR1C3 mediated production of T and

68 hing novel transcriptional effectors for PKC isozymes and may have significant functional and therape

69 and KFB50 physically interact with four PAL isozymes and mediate their proteolytic turnover via the

70 /-) retinas expressed normal levels of RetGC isozymes and other phototransduction proteins, with the

71 ive stimulator of steroidogenesis, both PDE8 isozymes and PDE4 need to be simultaneously targeted.

72 domains, motifs originally identified in PKC isozymes and responsible for binding of phorbol esters a

73 of effectors, the phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (Rh

74 analyzed the functional coupling between COX isozymes and terminal enzymes by developing a PGH2-divid

75 : pathological reduction of synaptogenic PKC isozymes and their downstream synaptogenic substrates, s

76 e of the signaling pathways regulated by PKC isozymes and their effectors, there is essentially no in

77 tance of diacylglycerol and protein kinase C isozymes and then on the molecular motor proteins that f

78 remaining paralogs, encoding six plastidial isozymes and two cytosolic isozymes, were expressed in s

79 methanol-specific methyltransferase 1 (MT1) isozymes and two genes (mtaA1 and mtaA2) with the potent

80 e first rapid and specific inhibition of MEK isozymes, and introducing photoisomerizable linkers in t

81 ented here is applicable to most of the HDAC isozymes, and it can be easily adopted in a high-through

82 are indistinguishable from other hexokinase isozymes, and which displays a 100-fold increase in cata

83 Cytochrome P450 isozymes are also increased in immune cells in irreversi

84 PLC-beta isozymes are autoinhibited, and several proteins, includ

85 The M1 and M2 pyruvate-kinase isozymes are expressed from a single gene through altern

86 Phospholipase C (PLC) isozymes are important signaling molecules, but few smal

87 Protein kinase C (PKC) isozymes are key signal transducers involved in normal p

88 We conclude that PKC isozymes are not the calcium sensors that mediate PTP at

89 the biological effects of selective PLC-beta isozymes are poorly understood.

90 heparosan, the catalytic phenotypes of these isozymes are quite different.

91 Oxidative enzymes such as cytochrome P450 isozymes are rapidly upregulated in TG neurons after oro

92 Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signali

93 y mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor

94 stem cells highlights the potential of this isozyme as a prognosis marker and drug target.

95 nst ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as HPGD an

96 ade for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19 and 2

97 horylase muscle form, pyruvate kinase muscle isozyme, beta-enolase and triosephosphate isomerase and

98 e catalytic constants of both GCAP-activated isozymes between 12- and 19-fold higher than previously

99 Although these isozymes both generate heparosan, the catalytic phenotyp

100 mplex are defined not by a particular target isozyme but the intrinsic properties of GCAPs themselves

101 are integral for the activation of PLC-beta isozymes by diverse modulators, and we propose a model d

102 anism for the unique regulation of PLC-gamma isozymes by their X/Y linker.

103 displaying selectivity for cancer-associated isozymes CA IX and CA XII compared to off-target CA I an

104 o interact with the extracellular domains of isozymes CAIX and CAXII.

105 eraction of the CPOs with the cancer related isozymes CAIX and XII and thereby promoting cellular dam

106 PHLPP isozymes catalyze the dephosphorylation of a conserved r

107 lthiobutyrate, whereas the Ni(2+)-containing isozyme catalyzes an off-pathway shunt with the same sub

108 The Fe(2+)-containing isozyme catalyzes the on-pathway reaction using substrat

109 The main pyruvate kinase isozyme (Cdc19) is phosphorylated in response to environ

110 ree Arabidopsis thaliana secondary cell wall isozymes: CESA4, CESA7, and CESA8.

111 t display superior selectivity for the HDAC6 isozyme compared to other inhibitors.

112 e more widely applicable, we investigated if isozyme competition influenced production of ESA.

113 Our results indicate that isozyme competition is a limiting factor in the engineer

114 erely than in the retinas lacking both RetGC isozymes, consistent with a hypothesis that the inhibito

115 ue signaling properties of each of the eight isozymes constituting these two subgroups.

116 Cardiac isozymes contain one catalytic alpha-subunit isoform (al

117 t structural and regulatory properties of GP isozymes contribute to the different functions of muscle

118 D1, -2, -3, -4, and -6), it is unclear which isozyme contributes to disease pathogenesis.

119 We conclude that Gln-1;2 is the main isozyme contributing to shoot GS1 activity in vegetative

120 a timer for the lifetime of conventional PKC isozymes, converting the enzymes into a species that can

121 heir distinct regulatory features, these two isozymes could confer distinct metabolic functions of gl

122 -/-) and WT mice, suggesting that these PARP isozymes could have distinct roles in different CNS path

123 We propose that individual 3-OST isozymes create distinct modified domains or 'glycocodes

124 Despite a 97% sequence identity, both isozymes differ largely in their ability to hydrolyze AT

125 . truncatula revealed the presence of unique isozymes displaying novel regulatory properties.

126 Two members, the dual oxidase isozymes DUOX1 and DUOX2, share a structurally unique fe

127 A new mitochondrial CH(2)-THF dehydrogenase isozyme, encoded by the MTHFD2L gene, has now been ident

128 In contrast, the PKC isozymes epsilon and theta were relatively abundant at P

129 CR identified SULT1A1, -1A3, and -1E1 as the isozymes expressed in four human lung cell lines.

130 the voltage dependence of human cardiac NKA isozymes expressed in Xenopus oocytes, and of native NKA

131 ompetition between endogenous and transgenic isozymes for substrates limits accumulation of unique FA

132 Plants have an isozyme form of eIF4F (eIFiso4F) with comparable subunit

133 e revealed minor kinetic differences between isozymes formed by different alpha-beta isoform combinat

134 he coexpression of triacylglycerol synthesis isozymes from castor along with the fatty acid hydroxyla

135 one dynamic combinatorial libraries with two isozymes from the glutathione S-transferase class of enz

136 oli--aspC, argD, and gltA--are examined, and isozyme functions are uncovered for each to a different

137 Seven isozyme functions based on genetic and transcriptional e

138 These data establish that PKC isozymes generally function as tumor suppressors, indica

139 Somatic PLC isozymes generate inositol 1,4,5-trisphophate-mediated C

140 r BD can activate glycogen synthase kinase-3 isozymes (GSK3alpha and beta).

141 GSK3 has two mammalian isozymes, GSK3alpha and GSK3beta, whose functions remain

142 The native RetGC isozymes had different basal activity and were accelerat

143 tive small molecule modulators of individual isozymes has been a longstanding goal.

144 us complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis

145 Ten DGK family isozymes have been identified to date, which possess dif

146 CaMKII isozymes have complex structural and autoregulatory prop

147 hemic brain injury, but its human and rodent isozymes have different inhibitor specificities.

148 Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the i

149 Protein kinase C (PKC) isozymes have remained elusive cancer targets despite th

150 inhibition of an important cancer-associated isozyme, hCA XII, with a Ki of 0.79 nM.

151 etic properties of the individual human CTPS isozymes (hCTPS1 and hCTPS2) and regulation through subs

152 1, 2, 3, and 8, but not that of the class II isozyme HDAC6, mimicked the drug effects on H3K4 methyla

153 positions of the structurally characterized isozyme histone deacetylase 8 (HDAC8).

154 The yeast HMGR isozyme Hmg2 also undergoes feedback-regulated ERAD in r

155 The yeast HMG-CoA reductase isozyme Hmg2, like its mammalian counterpart, undergoes

156 Phospholipase C-beta (PLC-beta) isozymes hydrolyze the membrane lipid phosphatidylinosit

157 or-overexpressed CA IX and XII and cytosolic isozymes, identified nanomolar-potent inhibitors against

158 en for inhibitors against carbonic anhydrase isozyme II is performed, in which known inhibitors are c

159 obvious drug targets that have no homologous isozyme in the human host have now been investigated.

160 s not inhibit the catalytic activity of aPKC isozymes in cells.

161 Expression analysis of different PARP isozymes in EAE spinal cords showed that PARP-1 was down

162 identified important roles for specific PKC isozymes in erlotinib resistance and EMT in lung cancer

163 bind in the ATP-binding cavities of both JAK isozymes in orientations similar to that observed in cry

164 ressed in Xenopus oocytes, and of native NKA isozymes in rat ventricular myocytes, using normal mamma

165 nd explained substrate preferences among PAL isozymes in sorghum and other monocots, which can serve

166 ular models, the relevance of individual PKC isozymes in the progression of human cancer is still a m

167 his study, we have profiled transglutaminase isozymes in the rat subtotal nephrectomy (SNx) model of

168 s a potential role of protein kinase C (PKC) isozymes in the resistance to TKIs, we used the isogenic

169 two separate assay formats with purified PLC isozymes in vitro.

170 , indicating that GCAP2 activates both RetGC isozymes in vivo.

171 e demonstrate that inhibition of various PDE isozymes, including PDE4, lead to significant increases

172 Transition states of closely related isozymes indicate that the protein's dynamic architectur

173 ere found to be selective against certain CA isozymes, indicating that it should be possible to devel

174 We observed cross-library isozyme inhibition (30-78%) with important differences b

175 at the turn motif, thus converting these PKC isozymes into species that can be efficiently down-regul

176 To identify the PKC isozyme involved, we used a sod2 gene response reporter

177 anhydrases (CAs, EC 4.2.1.1) are ubiquitous isozymes involved in crucial physiological and pathologi

178 The Na,K-ATPase alpha2 isozyme is the major Na,K-ATPase of mammalian skeletal m

179 Although the expression of PKC isozymes is altered in multiple cancer types, the causal

180 ation of conventional protein kinase C (PKC) isozymes is initiated by the binding of their C2 domains

181 of GPAT4 and other LD-localized TG synthesis isozymes is required for LD growth.

182 ycogen phosphorylase, pyruvate kinase muscle isozyme, isoforms of creatine kinase.

183 n organelles isolated from the corresponding isozyme knockout lines, e.g. in plastids and mitochondri

184 in the pathway, and it is provided by three isozymes known to rely upon a divalent metal.

185 on of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatoce

186 cs on the L-asparaginase structural homology isozymes L-asparaginases I (AnsA) and II (AnsB), which a

187 different hepatic zonation patterns of P450 isozyme levels and hepatotoxicity emerge following dosin

188 Consequently, PLC-gamma isozymes link phosphorylation to phospholipase activatio

189 ding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed

190 Atypical protein kinase C (aPKC) isozymes modulate insulin signaling and cell polarity, b

191 he conclusion that PDE3A is the primary PDE3 isozyme modulating basal contractility and SR Ca(2+) con

192 MtDHDPS sequences indicated the presence of isozymes (MtDHDPS2 and MtDHDPS3) with multiple amino aci

193 r, the allosteric regulation of the three GP isozymes (muscle, liver, and brain) by metabolites and p

194 me of pyruvate kinase, in contrast to the M1 isozyme normally expressed in differentiated cells, and

195 tions in the gene for the tissue-nonspecific isozyme of alkaline phosphatase (TNSALP).

196 thetic pathway: ferrochelatase (HemH) and an isozyme of coproporphyrinogen III oxidase (HemF).

197 uated by ectopic expression of hGSTA4-4, the isozyme of glutathione S-transferase with high activity

198 g the 8-transmembrane span ER-resident Hmg2p isozyme of HMG-CoA reductase fused to GFP, which undergo

199 lism involves expression of the embryonic M2 isozyme of pyruvate kinase, in contrast to the M1 isozym

200 level, independently of systemic levels, by isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-

201 ous genes (Bn-FAE1.1 and Bn-FAE1.2) encoding isozymes of 3-keto-acylCoA synthase, a subunit of the cy

202 tro enzyme inhibition studies with the three isozymes of NOS and in vivo experiments to monitor cardi

203 Two isozymes of plant POR, POR A and POR B from barley, whic

204 Additional PAL isozymes of sorghum were characterized and categorized i

205 e roles of the cytoplasmic and mitochondrial isozymes of these enzymes.

206 nzyme of fatty acid metabolism with multiple isozymes often expressed in different eukaryotic cellula

207 The sequences of the two isozymes only differ at six amino acid residues.

208 y grown plants, the plastidial phosphorylase isozyme participates in transitory starch degradation an

209 The role of different PDE isozymes, particularly PDE3A vs PDE3B, in the regulation

210 al groups of the endogenous substrate of PLC isozymes, phosphatidylinositol 4,5-bisphosphate (PIP(2))

211 the activity of the plastidial phosphorylase isozyme (PHS1) is increased.

212 eal distinct functional roles of the two PKA isozymes, PKA type I (PKA-I) and PKA-type II (PKA-II), o

213 measures the activation signature of one PKC isozyme, PKC delta, in cells, revealing unique spatial a

214 Of the two human novel PKC isozymes, PKCdelta and PKC, only activation of PKC was o

215 teracts directly with pyruvate kinase muscle isozyme (PKM)2 to modulate metabolic flux in cancer cell

216 Ten protein kinase C (PKC) isozymes play divergent roles in signal transduction.

217 cancer cells, a cellular model in which PKC isozymes play important roles in the control of growth a

218 4-Oxalocrotonate tautomerase (4-OT) isozymes play prominent roles in the bacterial utilizati

219 In contrast, PLC-gamma isozymes (PLC-gamma1 and -gamma2) are structurally disti

220 orted mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable ro

221 JNK isozymes regulate cell death and survival, differentiati

222 both muscle and brain glycogen phosphorylase isozymes regulate glycogen mobilization.

223 he specificity and substrate profile of each isozyme remains largely unknown.

224 ry in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied s

225 arotenoid enzyme, is represented by multiple isozymes residing at unknown plastid sites.

226 Yet, the phospholipase C (PLC) isozymes responsible for coupling the CXCR4-TCR heterodi

227 GGPPS11 and GGPPS1 are the major isozymes responsible for their biosynthesis.

228 either the cytosolic or mitochondrial MTHFD isozyme resulted in decreased cellular NADPH/NADP(+) and

229 Here we have determined the main RetGC isozyme (RetGC1):GCAP1 binding stoichiometry at saturati

230 nthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photorecept

231 eceptor by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) to expedite recovery, but c

232 e guanylyl cyclase (RetGC), comprised of two isozymes, RetGC1 and RetGC2.

233 ermore, elimination of RetGC1 but not RetGC2 isozyme reverses abnormal calcium sensitivity of cGMP sy

234 The sulfatase isozyme S gene constitutes a functional and positional c

235 t provide the initial clues to obtaining JAK-isozyme selective inhibitors.

236 derivative (TM-2-51) serves as a potent and isozyme-selective activator for human histone deacetylas

237 , as well as the challenges in obtaining JAK isozyme-selective inhibitors due to the overall structur

238 ed approach coupled with treatment using PDE isozyme-selective inhibitors to characterize the phospho

239 es, it is particularly difficult to generate isozyme-selective small molecule inhibitors.

240 lso been suggested that HDACi with increased isozyme selectivity and potency may broaden their clinic

241 active site features that contribute to the isozyme selectivity observed in biochemical assays.

242 ed excellent activity against SIRT2 and high isozyme selectivity over SIRT1 and SIRT3.

243 OS, offers compelling insight to explain its isozyme selectivity, which should guide future drug desi

244 lacking Ppp3cb (encoding calcineurin A, beta isozyme) showed no enhancement in cardiac hypertrophy as

245 Previous work has shown that isozyme specific residues (ISRs) distant from the active

246 e structure offers a template for developing isozyme-specific allosteric inhibitors that can be used

247 Here, we report the first PKC isozyme-specific analysis of global gene expression by m

248 ic may provide a useful model to design more isozyme-specific CA IX inhibitors, which may lead to dev

249 By the use of isozyme-specific cAMP analog pairs, we show that both PK

250 Using a PKC isozyme-specific coimmunoprecipitation approach coupled

251 (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of

252 The approach enabled us to profile isozyme-specific engagement and binding kinetics for a p

253 ur study opens new avenues for defining GSK3 isozyme-specific functions in various cellular processes

254 important factor in GBM and suggest that an isozyme-specific inhibitor of SphK1 deserves considerati

255 alpha and TPA, to monitor the effects of PKC isozyme-specific inhibitors and siRNA-induced knockdown

256 fashion by a mechanism that may involve PKC isozyme-specific interacting proteins.

257 tty acid metabolism in various tissues in an isozyme-specific manner.

258 a interacts with mitochondria by a novel and isozyme-specific mechanism distinct from its canonical r

259 y, recent proteomics studies have identified isozyme-specific reactive cysteine residues in brain gly

260 cture offers a molecular explanation for the isozyme specificity of EGCG, which is corroborated exper

261 mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer.

262 DPH oxidase subunit, beta-myosin heavy chain isozyme switch, accumulation of AGE, fibrosis, and decre

263 aturation-resistant NB4-LR1 cells have a PKA isozyme switch: compared with the NB4 cells, they have d

264 While none of the GST isozymes tested (GSTA1-1, A4-4, M1a-1a, and P1a-1a) enha

265 eveal molecular features unique to the brain isozyme that provide a deeper understanding of the diffe

266 fatty acid synthase systems, the individual isozymes that catalyze these steps are quite diverse in

267 There are three isozymes that effectively catalyze the first committed s

268 etween human bGP and the two other mammalian isozymes, the bGP structures reveal molecular features u

269 ied to develop functional substrates for PLC isozymes, thereby serving as the foundation for further

270 nity to discover selective inhibitors of Nox isozymes, through enhanced conceptual understanding of t

271 This CH(2)-THF dehydrogenase isozyme thus fills the remaining gap in the pathway from

272 ds the hydrophobic motif of conventional PKC isozymes to catalyze the isomerization of the phospho-Th

273 ine kinases directly phosphorylate PLC-gamma isozymes to enhance their lipase activity, the underlyin

274 sine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosph

275 onsistent with targeting of one or more FPGS isozymes to multiple organelles.

276 of the C2 domain in driving conventional PKC isozymes to the plasma membrane and reveal that not only

277 which recruits multiple protein kinase (PK)C isozymes to the synaptic membrane.

278 onventional and novel protein kinase C (PKC) isozymes transduce the abundance of signals mediated by

279 tial PSY locations, linked with activity and isozyme type, advances the engineering potential for mod

280 Protein kinase C (PKC) isozymes undergo down-regulation upon sustained stimulat

281 , and regulation of native RetGC1 and RetGC2 isozymes using mice lacking guanylyl cyclase activating

282 Only one major trypsin isozyme was isolated with high purity, as assessed by SD

283 ty levels of the three mammalian glutaminase isozymes was established, with GAC being the most active

284 ous alkaline phosphatase (tissue-nonspecific isozyme) was inhibitory.

285 inhibitor of human cytochrome P450 (CYP) 2C9 isozyme, was identified as a novel and leading cytoprote

286 than 250-fold selectivity versus related LOX isozymes, was a mixed inhibitor, and did not reduce the

287 used to elucidate the specific roles of each isozyme, we describe tetrazole analogs as suitable backb

288 dentify a compound targeting the ppGalNAc-T3 isozyme, we screened libraries to find compounds that ac

289 d the 11-beta hydroxysteroid dehydrogenase 2 isozyme were significantly higher in patients compared t

290 hat the characteristics of both native RetGC isozymes were considerably different from other reported

291 as unaffected when all calcium-dependent PKC isozymes were eliminated.

292 In the present study, Lox isozymes were purified to near homogeneity (107-fold).

293 Starch-related isozymes were then evolutionary conserved by constraints

294 In maize (Zea mays), the three isozymes were transiently expressed and found either in

295 ng six plastidial isozymes and two cytosolic isozymes, were expressed in specific tissues and/or at s

296 ve site distinguishes it from the liver-type isozyme, which is known to be less dependent on this ion

297 ctivity of glycogen synthase kinase 3 (GSK3) isozymes, which are proposed to contribute to both neuro

298 iotemporal activity of phospholipase C (PLC) isozymes with a PLC-selective sensor would dramatically

299 eral, CIIIPRX genes encode a large number of isozymes with ranges of in vitro substrate specificities

300 ore, selective inhibition of individual GSK3 isozymes yields distinct phenotypes from gene deletion,