ライフサイエンスコーパス: isthmic

1 onsistent with it being at least part of the isthmic activity which can repolarise the former tissue

2 We show that an FGF-dependent isthmic Atoh1 domain is the origin of distinct populatio

3 the activity of two different organisers: an isthmic Atoh1 domain, which gives rise to isthmic nuclei

4 In this study, we use Fgf8 as a marker for isthmic cells to examine how interactions between midbra

5 na to be preserved following insertion of an isthmic cerclage suture.

6 m results of percutaneous treatment of adult isthmic coarctation of the aorta by means of a self-expa

7 The isthmic complex is part of a visual midbrain circuit tho

8 ea interposed among the IC, the TeO, and the isthmic complex that receives strong synaptic input from

9 to programmed cell death and the loss of the isthmic constriction and cerebellum.

10 rhombomeres (r) 1-3 fail to develop and the isthmic expression of Fgf8 is reduced and disorganized.

11 the cerebellar anlage, the downregulation of isthmic FGF signals is required for induction of rhombic

12 CTI length was assessed along three parallel isthmic levels (paraseptal, central, and inferolateral).

13 rostral rhombencephalon at the level of the isthmic Muller cell I1 close to sulcus limitans of His.

14 data suggest that aortic arch hypoplasia and isthmic narrowing are associated with angioplasty failur

15 we revise the neurochemical identity of the isthmic nuclei by using in situ hybridization assays for

16 an isthmic Atoh1 domain, which gives rise to isthmic nuclei, and the rhombic lip, which generates dee

17 In the absence of Gbx2 function, isthmic nuclei, the cerebellum, motor nerve V, and other

18 hx9-positive neurons in the extra-cerebellar isthmic nuclei.

19 licit synchronized feedback signals from two isthmic nuclei: the isthmi parvocelullaris (Ipc) and ist

20 he superficial tectum, and the parvocellular isthmic nucleus.

21 The anterior neural ridge (ANR), and the isthmic organiser (IsO) represent two signalling centres

22 trochlear motor neurons are born within the isthmic organiser and also immediately posterior to it i

23 ecreted molecule Fgf8 is a key player of the isthmic organiser function, the mechanisms by which it a

24 gf8-expressing tissue with properties of the isthmic organiser is generated when midbrain and rhombom

25 at ectopic FGF8 protein, a candidate for the isthmic organising activity, is able to induce and repre

26 s produced by a signaling center, termed the isthmic organizer (IsO), which is localized at the bound

27 elops in response to signals produced by the isthmic organizer (IsO).

28 n after embryonic day 14, at which time Fgf8 isthmic organizer activity is complete and the major out

29 The isthmic organizer and its key effector molecule, fibrobl

30 nction as repressors in establishment of the isthmic organizer and neural crest, and Iro genes may ha

31 Although signals from the isthmic organizer are known to specify cerebellar territ

32 es and r1 are neuromeres that along with the isthmic organizer are partitioned along the anterior-pos

33 l crest development and establishment of the isthmic organizer at the MHB.

34 the requirement of Lmx1b function for normal isthmic organizer at the mid-hindbrain boundary complica

35 of FGF signals originated from the so-called isthmic organizer at the mid/hindbrain junction; however

36 factor Gbx2; all of which are essential for isthmic organizer function.

37 to the regulatory interactions that maintain isthmic organizer gene expression and the consequences o

38 During embryogenesis, the isthmic organizer, a well-described signaling center at

39 stablishing dorsal polarity, maintaining the isthmic organizer, and cardiac ventricle formation.

40 or colliculus in the absence of Fgf8 and the isthmic organizer, indicating that FGF and Mek1(DD) init

41 Wnt1 and Fgf8, two crucial components of the isthmic organizer, is no longer segregated to adjacent d

42 at GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain devel

43 The isthmic organizer, which is located at the midbrain-hind

44 ural ridge, zona limitans intrathalamica and isthmic organizer-are present in the hemichordate Saccog

45 ZLI, reminiscent of the Fgf8/Wnt1-expressing isthmic organizer.

46 terning defects as well as disruption of the isthmic organizer.

47 in-hindbrain boundary and maintenance of the isthmic organizer.

48 e coordinated by FGF ligands produced by the isthmic organizer.

49 splantation of a local signaling center, the isthmic organizer.

50 t to be key components of the mid/hindbrain (isthmic) organizer.

51 bute tectofugal projections to the thalamus, isthmic region, and hindbrain.

52 eral visceral nucleus (SGN/V) located in the isthmic region.

53 elial and ciliary bindings formed within the isthmic regions of the female oviducts, leading to a con

54 nd the first rhombomere was not seen and the isthmic rhombomere could not be identified.

55 posterior patterning result from an abnormal isthmic signaling center.

56 ression and knockdown to explore the role of isthmic signalling in patterning these domains.

57 of efferent cell bodies were centered in the isthmic tegmentum; other efferent cells extended more ro

58 1 is able to express Hox genes but that both isthmic tissue and FGF8 inhibit their expression.

59 We demonstrate that both isthmic tissue and Fgf8 protein are attractants for troc

60 etween midbrain and hindbrain can regenerate isthmic tissue and, thereby, gain insight into the norma

61 Isthmic tissue grafts transform chick caudal forebrain i

62 e use of chick/quail chimeras shows that the isthmic tissue is largely derived from rhombomere 1.

63 e midbrain-inducing and polarizing effect as isthmic tissue.

64 ing with the resident cranial motor axons at isthmic (trochlear) or r2 (trigeminal) levels of the axi