ライフサイエンスコーパス: it is difficult to

1 Although it is difficult to accomplish in the human host, longitu

2 because memory cannot be measured directly, it is difficult to account for.

3 rapy is underexplored, in large part because it is difficult to accurately and reproducibly measure t

4 major limitation of short-read data is that it is difficult to accurately predict full-length splice

5 However, it is difficult to achieve ballistic transport in a soli

6 It is difficult to achieve controlled cutting of elastic

7 ritical to maintaining glycemic control, yet it is difficult to achieve due to the high individual di

8 However, even when injected locally, it is difficult to achieve efficient distribution of che

9 with designed transition-metal catalysts but it is difficult to achieve exceptionally high levels of

10 It is difficult to achieve minimally invasive injectable

11 However, it is difficult to achieve selectivity when multiple ine

12 However, it is difficult to achieve the therapeutic concentration

13 However, it is difficult to achieve the two goals simultaneously

14 Too often, however, it is difficult to acquire antibodies that specifically

15 k of analyzing population-based data is that it is difficult to adequately control for population sub

16 Also, it is difficult to alleviate the effect of noisy sequenc

17 was excluded as a potential marker, because it is difficult to amplify in fungi, often includes larg

18 ication bias in directed acyclic graphs, but it is difficult to anticipate the magnitude of bias.

19 But it is difficult to anticipate their effect on the migrat

20 the secretory machinery in eukaryotic cells, it is difficult to apply rational engineering for constr

21 within a small, single population means that it is difficult to argue that circadian rhythmicity form

22 -linked to enhance their physical integrity, it is difficult to ascertain and compare the local stiff

23 lifestyles promote horizontal gene transfer, it is difficult to ascertain given the nonrandom samplin

24 However, it is difficult to ascertain if these areas constitute a

25 Consequently, it is difficult to ascertain the mechanism underlying th

26 However, it is difficult to assess damage inflicted exclusively b

27 Due to the lack of external data, it is difficult to assess how this compares with patient

28 However, it is difficult to assess the accuracy of the folding me

29 However, it is difficult to assess the additional cost in terms o

30 It is difficult to assess the entire contained self-reac

31 However, it is difficult to assess the fraction of all genomic re

32 As a result, it is difficult to assess the performance of orthology i

33 atures that may increase expression, however it is difficult to assess the relative influence of thes

34 In a novel situation where it is difficult to assess the risks associated with high

35 ons has received considerable attention, but it is difficult to assess the significance of this issue

36 However, it is difficult to assess the tertiary packing of transi

37 re also more likely to be promoter-proximal, it is difficult to assess whether motifs identified in t

38 ding studies involve many TFs, consequently, it is difficult to assign nucleosome reorganization to t

39 Although it is difficult to associate a precise date to its found

40 For many zoonotic diseases it is difficult to attribute human cases to sources of i

41 the ensuing mechanisms for their production, it is difficult to attribute specific functions as drive

42 e PE/PPEs are very challenging to study, and it is difficult to be certain what role(s) they have in

43 s >8 degree heating weeks); a point at which it is difficult to believe reefs can persist as we know

44 However, it is difficult to calculate the impairment of metabolic

45 However, it is difficult to capture rare dynamic processes, such

46 However, it is difficult to characterize samples pulled from the

47 However, it is difficult to check for any bias in the peer-review

48 terdependence of these contributing factors, it is difficult to circumvent problems and achieve ratio

49 However, it is difficult to combine these approaches due to facto

50 ack of commonly accepted validation methods, it is difficult to compare clustering results between st

51 d skills needed to process and analyze data, it is difficult to compare datasets in an intuitive and

52 As it is difficult to conclude the null, it is also difficu

53 utcome (de novo CKD versus CKD progression), it is difficult to conclude with certainty that AKI is t

54 In these less severely injured patients, it is difficult to connect disorders of arousal with mot

55 any diversification shifts occur after WGDs, it is difficult to consider diversification and duplicat

56 omposition and dynamics of this compartment, it is difficult to construct mechanistic hypotheses or e

57 mining particle properties and behavior, but it is difficult to control and characterize.

58 on are not well understood, however, because it is difficult to control for confounding factors such

59 n, especially in environmental samples where it is difficult to culture phage-host systems.

60 ore toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissimil

61 Although it is difficult to define quantitatively, the activity o

62 ns a challenge in cancer precision medicine; it is difficult to deliver a targeted therapy to cancer

63 ver, because PEL is highly multi-dimensional it is difficult to describe how the system moves around

64 In complex condensed-phase systems, however, it is difficult to design Monte Carlo moves with high ac

65 Given their size it is difficult to detect and visualize the presence of

66 It is difficult to detect engraftment of donor cells in

67 c compounds in individual aerosol particles, it is difficult to detect PAHs at relevant concentration

68 orescence background of many tissue samples, it is difficult to detect single-molecule fluorescence i

69 Importance: It is difficult to determine disease activity in vitilig

70 Y-STR haplotypes have a few mismatched loci, it is difficult to determine if they are from the same m

71 However, it is difficult to determine the exact position of d-ami

72 Experimentally it is difficult to determine the ionic mechanisms of dep

73 on observations of forming systems, however, it is difficult to determine the true initial multiplici

74 ue locations of nucleosomes are unknown, and it is difficult to determine their exact locations using

75 As with many large predators, however, it is difficult to determine to what extent predators li

76 gion Imaging Spectrograph (IRIS) reveal that it is difficult to determine what is up and down, even i

77 It is difficult to determine whether a specific constell

78 It is difficult to determine whether early tuberculosis

79 It is difficult to determine whether research and develo

80 ndia and China compared to the USA, although it is difficult to determine whether this effect is the

81 However, it is difficult to determine whether this review is exha

82 r relative frequencies have been identified, it is difficult to determine which mechanisms of resista

83 However, it is difficult to develop a selective ligand if the poi

84 It is difficult to develop appropriate treatment guideli

85 When it is difficult to develop selective ligands within a fa

86 It is difficult to diagnose metastases in local lymph no

87 Because it is a disease of unknown etiology, it is difficult to diagnose, to predict disease course a

88 the variety of clinical symptoms and signs, it is difficult to diagnose.

89 Without longitudinal clinical data, it is difficult to differentiate some cases of chronic p

90 sed on traditional morphological characters, it is difficult to differentiate these two genera.

91 a general property of globular proteins, but it is difficult to directly characterize because the tra

92 However, it is difficult to directly detect those states because

93 ry systems of infants, children, and adults, it is difficult to directly extrapolate clinical practic

94 However, it is difficult to directly measure a fitness landscape

95 Yet, because it is difficult to directly measure mechanical stress in

96 ture models of alpha-syn-seeded aggregation, it is difficult to discern intracellular from extracellu

97 It is difficult to discern the proportion of blood lead

98 Using these methods it is difficult to discriminate the contribution of each

99 efly bioluminescence remains elusive because it is difficult to disentangle different enzyme-lumophor

100 Because it is difficult to disentangle period effects from cohor

101 ion of Ca(2+) homeostasis contributes to AD, it is difficult to disentangle the effects of familial A

102 However, in such studies, it is difficult to disentangle the effects of nutrient s

103 ts may be associated with weight status, but it is difficult to disentangle the effects of strongly c

104 d substantially over the last 3 decades, but it is difficult to disentangle what effects individual i

105 ver, due to the small size of the mouse eye, it is difficult to dissect mouse trabecular meshwork (MT

106 ion and function of these synapses; however, it is difficult to dissect the contribution of intrinsic

107 s between various cells in AD inflamed skin, it is difficult to dissect the precise and multiple role

108 ause DNA shape is a consequence of sequence, it is difficult to dissociate these modes of recognition

109 It is difficult to distinguish at preschool age whether

110 fluences offspring metabolism is unclear, as it is difficult to distinguish between the effects of th

111 It is difficult to distinguish clinically invasive Salmo

112 Therefore, it is difficult to distinguish different incoming waves

113 ver, with limited long-term direct measures, it is difficult to distinguish direct drying effects fro

114 with anecdotal historical reports, although it is difficult to distinguish smallpox from other pustu

115 It is difficult to distinguish the contribution of cardi

116 ogates for many thousands of other SNPs, and it is difficult to distinguish those that may play a fun

117 ology induces astrocytes to become reactive, it is difficult to distinguish whether astrogliosis is a

118 Therefore, it is difficult to draw a conclusion about the performan

119 xpression of GPR56 in the developing cortex, it is difficult to draw a specific conclusion as to whic

120 e studies included in this review means that it is difficult to draw strong conclusions as to the tru

121 Currently, it is difficult to efficiently diagnose and monitor earl

122 However, it is difficult to ensure that the atomic models retain

123 rmoury of virulence factors it produces, and it is difficult to eradicate because of its intrinsic re

124 rgery has been extended to neonatal surgery, it is difficult to establish its role for neonatal disor

125 contain a small quantity of unbound iodine, it is difficult to establish the degree to which thyroid

126 tients with cardiovascular disease, although it is difficult to establish the detailed release kineti

127 It is difficult to establish when people started to use

128 rare, and even rarer following vaccination, it is difficult to estimate precise risk.

129 Without these data it is difficult to evaluate perturbations of CPC signali

130 t assay (ELISA)-based ligand-binding assays, it is difficult to evaluate the residual drug, which is

131 area with multiple sources of air pollution, it is difficult to evaluate the spatial impact of a mino

132 It is difficult to evaluate these methods because there

133 abortion have a lower risk of preeclampsia, it is difficult to evaluate whether the observed associa

134 It is difficult to evaluate, however, because most avail

135 It is difficult to explain the differential rates of pro

136 However, it is difficult to explore the structural features under

137 jor challenge to studying LRP1 has been that it is difficult to express such a large, highly glycosyl

138 S. health care system is complex and because it is difficult to find accurate data elsewhere, most co

139 has been harder to decipher, in part because it is difficult to find appropriate metrics to character

140 onduction electrons at room temperature, but it is difficult to find other spin-polarized oxides with

141 act of these effects remains unclear because it is difficult to follow free-living individuals throug

142 m remains poorly understood, in part because it is difficult to gain information about the dimer-scal

143 cause, unlike in other technosocial systems, it is difficult to gather large-scale data about user be

144 to use one class of model or the other, and it is difficult to generalize statements about their rel

145 ould be used to study cancer cells for which it is difficult to generate tumour spheroids.

146 It is difficult to genetically manipulate many gene clus

147 However, it is difficult to hold one pi-conjugated molecular ring

148 geographic arrangement of continental crust, it is difficult to identify a specific causal mechanism.

149 ycans can substitute one mucin molecule, and it is difficult to identify biologically accessible glyc

150 In addition, it is difficult to identify critical cellular and molecu

151 Nevertheless, it is difficult to identify or distinguish various carbo

152 ad through face-to-face social networks, but it is difficult to identify social influence effects in

153 y powerful, but complicates learning because it is difficult to identify the responsible neurons when

154 Treatment is futile in some patients, but it is difficult to identify these patients a priori.

155 nation and respiratory mechanics are linked, it is difficult to identify which variables, pressure or

156 It is difficult to imagine how mammalian hosts have kept

157 s extremely difficult to map and ablate when it is difficult to induce and nonsustained.

158 As a result, it is difficult to infer cause or predict future traject

159 ospeciated with their gut-resident microbes, it is difficult to infer features of our ancestral micro

160 in the primate occipitotemporal cortex, but it is difficult to infer the stimulus selectivities of t

161 The TFs mostly function via repression and it is difficult to integrate multiple inputs in promoter

162 However, it is difficult to integrate these diverse data to recon

163 Despite the apparent simplicity of the test, it is difficult to interpret or rely on.

164 particular, during flow chamber experiments, it is difficult to interpret the interplay of the above-

165 However, it is difficult to interpret the results at the early st

166 It is difficult to isolate cognitive outcomes from motor

167 se two isoforms has not been defined because it is difficult to isolate or purify the alpha.beta dime

168 As a result, it is difficult to isolate the effects of language on th

169 ng what such a model can and cannot explain, it is difficult to justify more complex mechanisms, or u

170 It is difficult to justify preferentially waiting for an

171 binding sites, methylation peaks, etc.), and it is difficult to know a priori which features would be

172 It is difficult to know how the children with Japanese c

173 een limited to experimental systems, because it is difficult to know what happened in the deep past a

174 ubiquitously expressed throughout the brain, it is difficult to know which cell types might mediate t

175 However, it is difficult to link individual networks to specific

176 e to coal-fired utility boilers (CFUBs), but it is difficult to link specific point sources with loca

177 opposite construct of a 'unified whole', but it is difficult to locate proponents of the idea of a DM

178 ntly contribute to background scattering and it is difficult to locate the crystals, making them inco

179 Whereas previous studies suggest it is difficult to maintain attention and vigilance over

180 wing: 1) if the number of RyRs is too small, it is difficult to maintain consecutive openings and sto

181 nonlinear effects of the compliant elements, it is difficult to make generalizations about speed and

182 However, it is difficult to make inferences from these data becau

183 Without these data, it is difficult to make informed regional or national po

184 nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid co

185 ace gravity is a basic stellar property, but it is difficult to measure accurately, with typical unce

186 It is difficult to measure electron transfer in these en

187 edox signaling is poorly understood, because it is difficult to measure H(2)O(2) in vivo.

188 However, it is difficult to measure on the within-trial time scal

189 However, it is difficult to measure strain hardening via nanoinde

190 However, it is difficult to measure the activities of all possibl

191 fying organisms is poorly understood because it is difficult to measure the chemistry of in vivo biom

192 ging because, even in isolated mitochondria, it is difficult to measure the proton motive force while

193 However, it is difficult to measure the volume of the hard or sof

194 As the spheroids are comparably sizable, it is difficult to monitor larger numbers of them by opt

195 Because it is difficult to objectively measure population-level

196 However, it is difficult to observe these dynamics directly over

197 s of action of all BCL2 family proteins, but it is difficult to obtain a precise view of how BCL2 fam

198 n imaging on a conventional SPECT camera, as it is difficult to obtain diagnostic image quality on a

199 Because it is difficult to obtain enough field observations on d

200 ed by RhP2 complexes, the typical catalysts, it is difficult to obtain high conversions using the alt

201 a high heart rate and arrhythmia which makes it is difficult to obtain images.

202 It is difficult to obtain insight into the mechanisms oc

203 hanism of transport of P-gp, in part because it is difficult to obtain purified protein in well defin

204 However, it is difficult to obtain quantitative data from microsc

205 Because of cell to cell variation, it is difficult to obtain statistically significant data

206 It is difficult to overstate the cultural and biological

207 oxyanion holes for substrate activation, but it is difficult to parse out the independent contributio

208 rn in fraud verification, especially because it is difficult to percept adulterations with the naked

209 However, it is difficult to perform this technique on frozen samp

210 ssenger mutations in the human tumor genome, it is difficult to pinpoint causative driver genes.

211 the gold standard for anastomosing vessels, it is difficult to place sutures correctly through colla

212 wever, because graphene is chemically inert, it is difficult to precisely assemble inorganic nanomate

213 This smoothness is also the reason that it is difficult to precisely determine the transition po

214 botanical record or phylogeographic pattern, it is difficult to precisely identify the time and place

215 nanoparticle delivery is controversial, and it is difficult to predict how a targeted nanoparticle d

216 It is difficult to predict hydro-volcanic eruptions beca

217 Consequently, it is difficult to predict on an individual basis the ri

218 icity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-depe

219 equence motifs, such as G-boxes (CACGTG), so it is difficult to predict regulatory relationships.

220 It is difficult to predict risk for behavioral inhibitio

221 xylic acid metabolism and storage means that it is difficult to predict the best way to engineer alte

222 It is difficult to predict the rate of the transition be

223 However, it is difficult to predict their properties based on mac

224 les behind proteasomal splicing are unknown, it is difficult to predict these spliced Ags.

225 Given this apparent complexity, it is difficult to predict where, when, or even whether

226 Since it is difficult to predict which influenza virus subtype

227 It is difficult to predict, diagnose and manage.

228 ntigen but as there is antigenic drift in HA it is difficult to prepare a vaccine in advance against

229 f current membrane materials and techniques, it is difficult to prepare microporous membranes thinner

230 icant cognitive deficits in humans; however, it is difficult to probe the function of TH in early bra

231 Although it is difficult to prospectively identify those patients

232 It is suggestive that it is difficult to protect against aerosol challenge.

233 However it is difficult to prove deep biosphere activity in the

234 educes photosynthetic productivity; however, it is difficult to quantify accurately in complex canopi

235 explain this "paradox of the plankton," but it is difficult to quantify and track variation in phyto

236 However, it is difficult to quantify both the FRET efficiency (E)

237 It is difficult to quantify the probability of common so

238 detrimental to health than others; however, it is difficult to quantify the uncertainty associated w

239 te to the signal in a single pixel, however, it is difficult to quantify their individual contributio

240 However, it is difficult to quantitatively compare the efficacy o

241 Despite harmful consequences, it is difficult to quit smoking because of its positive

242 It is difficult to reach this threshold with patient-tol

243 and sequence homology among family members, it is difficult to realize sensitive and selective detec

244 However, it is difficult to recapitulate high levels of diversity

245 mutations in four or more driver genes, but it is difficult to recapitulate this degree of genetic c

246 of normal growth is not well characterized, it is difficult to recognize lesions growing at an abnor

247 he population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence

248 However, it is difficult to reconcile network complexities with a

249 This result suggests that it is difficult to reconcile the looping probability wit

250 However, it is difficult to reconcile the reproductive tract's ma

251 It is difficult to reconcile this FliM remodelling with

252 n input" problem presents a major roadblock: it is difficult to reliably distinguish causal connectio

253 It is difficult to reproduce TAI in animal models of clo

254 e human memory is intertwined with language, it is difficult to resist the conclusion that language i

255 ion structure between geographic localities, it is difficult to resolve markers that segregate entire

256 In addition, we show here that it is difficult to resolve subcortical sources because d

257 the analysis of receptor function, such that it is difficult to resolve the molecular basis for compo

258 nsory feedback entrains the stepping rhythm, it is difficult to reveal central pattern generator (CPG

259 lity aptamers have been previously reported, it is difficult to routinely generate aptamers that poss

260 for chimpanzees (Pan troglodytes), for which it is difficult to rule out environmental influences as

261 However, it is difficult to scale down the size of these instrume

262 conventional targeted analytical assays, as it is difficult to screen for "unknown" compounds.

263 mber of possible incorrect folds and because it is difficult to search the fold space for an optimal

264 ing their DNA only during a brief period and it is difficult to select injection doses that would exh

265 ily be cleaved by enzymes such as proteases, it is difficult to selectively break the carbon-nitrogen

266 Some facets are more active than others, but it is difficult to selectively isolate particular facets

267 However, due to the subtlety of DNA damage, it is difficult to sense the presence of damage repair w

268 Such studies are challenging because it is difficult to separate electronic effects from supr

269 cumstances, largely because of the fact that it is difficult to separate out myopia-related structura

270 This finding shows that in some scenarios, it is difficult to simulate the intended contact of mate

271 It is difficult to simultaneously examine division and f

272 n mice and higher mammalian species in which it is difficult to specifically target and manipulate ge

273 This is especially useful in species where it is difficult to study social traits in natural popula

274 It is difficult to study the beginnings of intermodal vi

275 Additionally, in the absence of orthologs it is difficult to study the processes and mechanisms un

276 For the practicing clinician, it is difficult to summarize the prognostic information

277 ture probe stably co-exist in a solution, as it is difficult to sustain an interaction between both t

278 Indeed, it is difficult to synthesize amorphous calcium carbonat

279 Unfortunately, it is difficult to synthesize such colloids because surf

280 While it is difficult to synthesize them, they are also prone

281 However, as FOXC2 is a transcription factor, it is difficult to target by conventional means such as

282 ulated in the majority of colorectal tumors, it is difficult to target directly.

283 of function and lead therapeutics; however, it is difficult to target with small molecules.

284 However, it is difficult to tease apart whether changes in neural

285 of htt N-terminal fragments is so rapid that it is difficult to tease out mechanistic details.

286 Because at present it is difficult to tell where sign stops and gesture beg

287 However, it is difficult to test the validity of this assumption

288 However, it is difficult to test these ideas in natural ecosystem

289 It is difficult to test this idea in human populations,

290 However, it is difficult to uncouple the functions of retrograde

291 nitial segments (AISs) and nodes of Ranvier, it is difficult to uncouple their roles in maintaining a

292 es are differentially temperature dependent, it is difficult to understand how physiological processe

293 characteristics affect cooperation; however, it is difficult to understand how this occurs based on g

294 It is difficult to understand such behavior in terms of

295 to rain, I will take an umbrella-therefore, it is difficult to understand their interplay.

296 However, it is difficult to use any of the packages to analyze ge

297 ory, be used to reproduce results in papers, it is difficult to use in practice.

298 However, it is difficult to vary only the biochemical cues withou

299 stic phenomena, such as Klein tunneling, but it is difficult to visualize directly.

300 Because it is difficult to visualize sacral crest cells independ