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2 and psychosocial impact of chronic pruritus, it is important to accurately assess and measure itch se
5 membrane-associated periodic skeleton (MPS), it is important to address how prevalent this structure
9 (CVDs) for treating cardiovascular diseases, it is important to analyze CVD-associated adverse events
10 DNA and achieve their biological functions, it is important to analyze structures of DNA-protein com
13 w and when to embark on this ambitious goal, it is important to assess current progress along the pat
14 is a relatively new genetic screening tool, it is important to assess its functionality in a number
15 receptor autoantibody (NMDAR-Ab) tests, and it is important to assess the clinical relevance of all
16 en, after having liver transplantation (LT), it is important to assess the quality of life (QOL).
18 reasingly used in agriculture as pesticides, it is important to assess their potential implications f
19 major target of beta-lactams, and therefore it is important to attain a detailed understanding of it
22 ing climate change and species invasions and it is important to be able to predict variability in POP
25 h and acquired disability among adolescents, it is important to better define differences in outcomes
28 te to the early-stage aggregation mechanism, it is important to characterize the effects of the A2T a
29 c pain, and autism spectrum disorders; thus, it is important to characterize the mechanisms regulatin
31 rosolized nontuberculous mycobacteria (NTM), it is important to characterize their persistence in was
32 d modulate the limb-moving lumbar circuitry, it is important to clarify the functional organization o
33 tein and micronutrients and are inexpensive, it is important to clarify their role in the risk of dev
34 When identifying potential trophic cascades, it is important to clearly establish the trophic linkage
35 are being used in physiological studies, so it is important to compare neuronal responses between aw
36 Because PRRT2 plays a role at the synapse, it is important to confirm the exact orientation of its
37 g stress on these traditional water sources, it is important to consider alternative irrigation sourc
39 therapeutic regulation of HIF target genes, it is important to consider both PHD and FIH activity, a
41 ficial to some patients with mood disorders, it is important to consider the limitations of the avail
42 neration of single-cell transcriptomic data, it is important to consider the specific computational a
44 fluence the conformation and affect function it is important to consider this when characterizing the
49 e KPD programs were not designed to help CP, it is important to define allocation metrics that enable
51 r and organismal consequences of aneuploidy, it is important to determine how altered gene doses impa
53 vaccine protects sheep and goats from PPRV, it is important to determine if the reverse is true as t
54 stand the cause of Parkinson's disease (PD), it is important to determine the functional interactions
56 single-molecule TIRF microscopy experiments, it is important to determine the local background intens
57 nt of many analyses, and, in many instances, it is important to determine the set of variants which a
58 roles of microorganisms in the environment, it is important to determine when and under which condit
60 vance of this discrepancy to P450 chemistry, it is important to determine whether Pdx favors the open
61 nts a promising therapeutic strategy in DMD, it is important to determine whether SSPN can be introdu
62 l microbiome members to community functions, it is important to determine which bacteria are actively
63 o harness their full biosynthetic potential, it is important to develop a detailed understanding of t
70 le demonstrations to practical applications, it is important to develop single-copy synthetic modules
72 he function and interaction of biomolecules, it is important to develop structure sensitive technique
74 iple different diseases at the same time and it is important to develop tools that help to identify p
81 are a number of similar characteristics, but it is important to distinguish between these two types o
82 s are often misdiagnosed pre-operatively and it is important to distinguish leiomyomas from other tum
84 and define the most appropriate retreatment, it is important to distinguish virologic relapse from re
91 ase treatment of ribosome-mRNA complexes, as it is important to ensure both stability of ribosomal pa
92 all landscape of their functional diversity, it is important to establish a computational method that
96 As ecosystems progress through recovery, it is important to estimate any resulting deficit in bio
97 diac implantable electronic devices (CIEDs), it is important to estimate the incidence and annual hea
98 genes generate diverse functional products, it is important to evaluate expression at the isoform le
101 iological Diversity's targets are to be met, it is important to evaluate the reasons why they appear
102 f social psychological functioning, and thus it is important to evaluate the variables influencing it
103 disorders such as Parkinson's disease (PD), it is important to examine how AgNPs affect microglial i
106 opy number variation encompasses many genes, it is important to explore individual genotype-phenotype
107 tify candidate genes with similar functions, it is important to explore rather exhaustively multiple
108 isting triboelectric nanogenerators (TENGs), it is important to explore unique methods to further enh
113 order to successfully treat these patients, it is important to first identify these patients, treat
114 ret the outputs of dimensionality reduction, it is important to first understand its outputs for brai
117 similarity between GO annotations of genes, it is important to have a convenient pipeline that quant
118 inetic insight regarding sirtuin inhibitors, it is important to have access to efficient assays.
119 he advent of biosimilars to the U.S. market, it is important to have better analytical tools to ensur
121 As profiling campaigns expand in scope, it is important to homogenize, summarize, and analyze th
122 onal data and capitalize on this clinically, it is important to identify (1) critical AML-defining mo
126 ecular, cellular, and immunologic therapies, it is important to identify differences in care that may
127 the analysis of disease and design of drugs, it is important to identify essential proteins from a se
130 tter diagnosis and treatment for both sexes, it is important to identify factors that underlie the ob
131 nalysis of large-scale gene expression data, it is important to identify groups of genes with common
132 ation, and is a target for cancer therapies, it is important to identify how cFLIPL regulates type I
146 rials, and to develop preventative measures, it is important to identify the properties of particles
147 or both basic research and drug development, it is important to identify the sumoylation sites in pro
148 o understand the neuronal bases of behavior, it is important to identify the underlying neural circui
149 ssile polyps or laterally spreading lesions, it is important to identify those at risk for submucosal
152 , following the initial fluid resuscitation, it is important to identify which patients will benefit
153 three-dimensional genome structural models, it is important to integrate all available sources of ex
156 teran population is a special population and it is important to investigate how PTSD in the veteran p
157 t-term monitoring and large spatial extents, it is important to investigate the effects of sampling p
158 both environmentally and via close contact, it is important to investigate the relative influence of
159 high concentration of alpha-syn in neurons, it is important to investigate whether natural control m
161 In crafting countermeasures to offset this, it is important to know as precisely as possible the cap
162 the likely impacts of serotype replacement, it is important to know how patterns in the transmission
163 ld, insects are unlikely to be consumed raw, it is important to know how processing and in vitro dige
165 e of Nrf2 as a marker of drug-induced stress it is important to know if this adaptive response is tru
168 plicing depends on protein-RNA interactions, it is important to know the tertiary structures surround
170 an efficient management of these resources, it is important to know where the devices are located, h
172 and also a host of Ras family small GTPases, it is important to know which specific GEF-small GTPase
175 ny physiological processes in all organisms, it is important to learn their role and characteristics
176 Majorana type Kramers Doublet (MTKD) state, it is important to lift both the spin and the Dirac Cone
177 iesel engines with low environmental impact, it is important to link health and climate-relevant soot
191 s traditionally considered pro-inflammatory, it is important to note that some of these genes also se
197 Auger effect, which is very localized; thus, it is important to place the gold nanoparticles on or in
198 nduct integrated control of OFM effectively, it is important to predict the optimum control period.
200 volume of publically available information, it is important to provide a concise summary of the most
204 c understanding, and progress in TB control, it is important to re-assess the global burden of LTBI.
206 treatment of chronic pain in this population.It is important to realize that guidelines cannot always
208 ophages and DCs overlap to some extent, thus it is important to reassess the contributions of each of
210 apeutic approaches and patient survival, and it is important to recognize the key interplay between R
215 ociated with forest resiliency, finding that it is important to reduce the uncertainty in both of the
218 mes more widely used in biomedical research, it is important to revisit existing data analysis paradi
220 ted contacts in folding proteins accurately, it is important to study the challenges of reconstructin
221 ing mechanisms of various biological events, it is important to study the structure-function correlat
223 s on various ingredients of processed items, it is important to study their thermodynamic, transport
224 kite solar cells and photocatalytic devices, it is important to tailor its band edges via doping.
226 and the loss of IL-5R on airway eosinophils, it is important to take IL-3 and GM-CSF into account to
229 istinction and grouping are helpful and that it is important to take into account the strong overlap
233 erstand stress-associated human pathologies, it is important to uncover the molecular events underlyi
236 re used for drinking water purification, and it is important to understand how contaminants interact
237 e vaccine that does not enhance RSV illness, it is important to understand how formalin and heat inac
238 order to better understand complex diseases, it is important to understand how genetic variation in t
241 wever, because every model has shortcomings, it is important to understand how predictive the differe
246 nked to fatal malignancies such as leukemia, it is important to understand how these decisions are co
247 ly and often extended antibiotic therapy(2), it is important to understand how these interventions al
248 are known to result in distinct pathologies, it is important to understand how these truncations affe
249 a major cause of viral gastroenteritis, and it is important to understand how they interact with the
250 high levels of morbidity and can be lethal, it is important to understand how Toxoplasma traffics to
254 its durable responses to targeted therapies, it is important to understand mechanisms by which tumor
255 increasing share of the world's population, it is important to understand relationships between the
256 unity and to inform rational vaccine design, it is important to understand the adaptive immune correl
257 on under environmentally extreme conditions, it is important to understand the adventitious root deve
259 e to polycyclic aromatic hydrocarbons (PAHs) it is important to understand the binding mechanisms bet
260 equent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms th
261 in mechanistic insight into these processes, it is important to understand the cellular origin of cyt
266 o understand how inhibition controls timing, it is important to understand the dynamics of activity i
268 wer density in lithium batteries; therefore, it is important to understand the electrochemical behavi
269 es recently exceeding 45% of the population, it is important to understand the impact that vaccinatio
271 cessing for their texturizing functionality, it is important to understand the influence of SNP on gu
275 tion morphology and cardiovascular outcomes, it is important to understand the mechanisms leading to
277 ACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC reg
278 e length equilibrium leads to disease; thus, it is important to understand the mechanisms that regula
281 essential for E. coli colonization, and thus it is important to understand the molecular mechanisms t
283 uate exactly how dry today's environment is, it is important to understand the ongoing current weathe
285 er these conditions, our study suggests that it is important to understand the process of normal brai
288 ajor global sources of methane (CH4); hence, it is important to understand the seasonal and climatic
290 ancial conflicts of interest in health care, it is important to understand the types and distribution
291 To develop drug carriers to macrophages, it is important to understand their biological roles and
292 ore the recycling potential of these metals, it is important to understand their distribution in the
294 on innate signals rather than TCR ligation, it is important to understand what mechanisms exist to c
295 etiology of metabolic syndrome development, it is important to understand whether its 5 component di
297 es between these two classes of lymphocytes, it is important to understand which functions of ILCs ar
300 rom electronic medical records for research, it is important to validate International Classification
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