ライフサイエンスコーパス: it is not clear how

1 d bilayer modulates channel gating, although it is not clear how.

2 during morphogenesis is tightly linked, but it is not clear how.

3 ation complex often alter cell width, though it is not clear how.

4 It is not clear how 13 (3R,4S) can selectively inhibit t

5 However, it is not clear how 53BP1 is specifically targeted to th

6 However, it is not clear how a change in pulling direction change

7 ow in many chemosensitive human cancers, and it is not clear how a drug that only kills dividing cell

8 ellular Ca2+ signaling instability; however, it is not clear how a high atrial rate and Ca2+ instabil

9 n, have been performed on 2D substrates, and it is not clear how a more realistic 3D environment infl

10 ssential for Metnase function in DNA repair, it is not clear how a protein with sequence-specific DNA

11 It is not clear how a RING E3 ligase differentiates a na

12 However, it is not clear how a subset cause tissue-specific pheno

13 S1P distribution is controlled in vivo, and it is not clear how a ubiquitously made lipid functions

14 nd are implicated in postsynaptic functions, it is not clear how Abl kinases regulate dendritic morph

15 It is not clear how actin affects EIF2A signaling.

16 en shown to contribute to actin disassembly, it is not clear how activity of these locally acting pro

17 It is not clear how, after a large perturbation, the bra

18 sing of AgrD to produce mature AIP; however, it is not clear how AgrD interacts with AgrB and how thi

19 However, it is not clear how Agrobacterium-delivered factors are

20 However, it is not clear how AL2/C2 proteins are regulated.

21 It is not clear how alginate induction occurs in the wil

22 polycystic liver disease in humans; however, it is not clear how altered SEC63 influences disease man

23 eplete their own tryptophan supply; however, it is not clear how amino acid depletion influences macr

24 -regulatory elements affect gene expression, it is not clear how amino-acid substitutions in transcri

25 It is not clear how anacetrapib exerts these effects; th

26 hortcoming of Kurzban et al.'s model is that it is not clear how animals persist through subjectively

27 is orchestrated with diverse pheromones, but it is not clear how ants perceive these social signals.

28 However, it is not clear how AP-evoked Ca2+ signals and the resul

29 It is not clear how ARL-8 is activated in this process.

30 tening conditions is not known, and, indeed, it is not clear how attended speech is internally repres

31 It is not clear how autophagy is linked to loss of immun

32 cterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with ant

33 In some situations, it is not clear how behavioural inhibition minimises har

34 ll established in high-income countries, but it is not clear how behavioural risk factors are distrib

35 However, it is not clear how best to screen for frailty in preope

36 osa cells in maintaining meiotic arrest, but it is not clear how binding of LH to receptors that are

37 It is not clear how binding of peptidoglycan to the extr

38 However, it is not clear how BMECs balance these dual roles, and

39 It is not clear how brief, low-affinity interactions can

40 is known to affect transcriptional activity, it is not clear how broadly patterns of changes in histo

41 However, it is not clear how Bves confers its role in intercellul

42 However, it is not clear how caspase-2 exerts its apoptotic funct

43 However, it is not clear how CD103(+) DCs are specialized for thi

44 However, it is not clear how CD28 costimulation regulates the gen

45 It is not clear how CD4 T cells interact with infected e

46 It is not clear how cell diversity is created within the

47 In addition, it is not clear how cell movement is coordinated with ce

48 isms of CPPs are still under discussion, and it is not clear how cells compensate the disturbances in

49 phenomenon is known for more than a century, it is not clear how cells perceive the external EF.

50 and aneuploidy are hallmarks of cancer, but it is not clear how changes in the chromosomal content o

51 as circulating indicators of adiposity, but it is not clear how changes in their levels are perceive

52 ical information on the system's components, it is not clear how chemoreceptor clusters are reliably

53 its functional significance remains unknown: it is not clear how connection strength relates to neuro

54 However, it is not clear how cortical reorganization leads to cha

55 and biofilm formation of this bacterium, but it is not clear how covR expression is regulated in S. m

56 However, it is not clear how critical this priming is for immune

57 with cardiovascular complications; however, it is not clear how diabetes promotes cardiac dysfunctio

58 However, it is not clear how different mutations of the same gene

59 ha is present on several neural populations, it is not clear how different regions of the brain media

60 However, it is not clear how dimerization, autophosphorylation, a

61 target proteins identified to date, however, it is not clear how distinct signaling outputs can be ge

62 isease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this pathway influenc

63 However, it is not clear how each mAChR subtype contributes to th

64 However, it is not clear how Ect2 causes transformation and wheth

65 It is not clear how efficient selection of B cells is ma

66 However, it is not clear how either of these complexes is targete

67 nd a more ubiquitous long form (L-WNK1), but it is not clear how either of these isoforms influence r

68 tic embryo divisions are highly regular, but it is not clear how embryo patterning is established in

69 perimental studies on treatment effects, but it is not clear how estimates based on these 2 approache

70 Presently, it is not clear how excitatory transmission via the two

71 cs are commonly prescribed for children, but it is not clear how exposure to antibiotics early in lif

72 However, it is not clear how far the contamination occurs downstr

73 ical signal and activated TGF-beta; however, it is not clear how fibroblasts sense and transmit the m

74 yotrophic lateral sclerosis (FALS); however, it is not clear how FUS mutations cause neurodegeneratio

75 It is not clear how gamma-AApeptides interact with bacte

76 However, it is not clear how genetic networks were incorporated i

77 eptibility to autoimmune disorders; however, it is not clear how genetic variations in these loci con

78 It is not clear how GluRS2 achieves specific recognition

79 However, it is not clear how gNa influences temporal precision.

80 In addition, it is not clear how HDAC6 enzymatic activity is modulate

81 However, it is not clear how Hh regulates Smo accumulation on the

82 Thus, it is not clear how IDPs, lacking such well-defined stru

83 However, it is not clear how IL-2 affects T follicular regulatory

84 However, it is not clear how immune factors affect ER stress and

85 However, it is not clear how important this CO(2)-enhanced water

86 As it is not clear how increased sequencing capacity has af

87 athogenesis of Alzheimer's disease; however, it is not clear how individual amyloid-beta species accu

88 s) are thought to express autoreactive TCRs, it is not clear how individual TCRs influence Treg devel

89 However, it is not clear how information is processed along this

90 wn determinant of overall life satisfaction, it is not clear how it affects moment-to-moment variatio

91 ined to short separations between sites, and it is not clear how it contributes to long-range DNA loo

92 in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy huma

93 It is not clear how its function changes from that of a

94 However, it is not clear how its presence in the gut affects the

95 coronary artery disease in humans; however, it is not clear how its protein product tribbles-1 regul

96 However, it is not clear how Keap1 gains access to the nucleus.

97 It is not clear how kidneys size themselves or if the pr

98 It is not clear how KIR, whose function lies downstream

99 It is not clear how lean body mass (LBM) and fat mass (F

100 es, the mechanisms that control it vary, and it is not clear how licensing is regulated in plants.

101 s SH2B3) are found in Ph-like ALLs; however, it is not clear how LNK regulates normal B cell developm

102 postnatal development and in adulthood, but it is not clear how long these plastic changes persist n

103 Thus, it is not clear how M. hyopneumoniae evades the immune r

104 ts, two beta subunits and one gamma subunit, it is not clear how many alpha and beta subunits must ca

105 known to be important to maintain cohesion, it is not clear how many neighbors each individual can s

106 s are injected into the host blastocyst, but it is not clear how many of the injected cells contribut

107 ousand sites during early embryogenesis, but it is not clear how many of these binding events are fun

108 pulvinar and LGN on their way to cortex, but it is not clear how many synapses are required to comple

109 Yet, it is not clear how MBP influences the organization and

110 It is not clear how membrane events interact with the in

111 d in regulating cell proliferation in vitro, it is not clear how menin regulates cell cycle and wheth

112 l for mutagenesis by retrotransposition, but it is not clear how methylation of these elements is mai

113 However, it is not clear how mitochondrial dysfunction alone can

114 It is not clear how modern enzymes, such as pol II, sele

115 However, it is not clear how MRS-assessed measures of GABA relate

116 Thus, it is not clear how Mst7 transmits the upstream signals

117 an independent risk factor for diabetes, but it is not clear how much adding family history to other

118 populations against epidemics in nature, but it is not clear how much diversity is required to preven

119 It is not clear how much MI adds beyond standard (robust

120 Furthermore, it is not clear how much of an SNR improvement is necess

121 lain a small proportion of the genetic risk, it is not clear how much of the heritability these SNPs

122 However, it is not clear how much the additivity assumption affec

123 indle in female meiosis in many species, but it is not clear how multiple chromosomes form one shared

124 brogate WNK kinase degradation in cells, but it is not clear how mutant forms of CUL3 promote WNK sta

125 However, it is not clear how NAc neurons encode this information

126 However, it is not clear how narrative contexts are represented i

127 It is not clear how NC specifically destabilizes TAR RNA

128 ain is essential for cognitive function, but it is not clear how neural circuits support reliable and

129 development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is

130 It is not clear how nitric oxide (NO) released from ente

131 of fumarate hydratase (FH) inactivation, but it is not clear how NRF2 may be activated in sporadic fo

132 pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity contributes to pancreatic ca

133 Nonetheless, it is not clear how OCs might contribute to the progress

134 However, it is not clear how one pathway is chosen over the other

135 Thus, it is not clear how or even if pol II can initiate in th

136 f angiogenesis in IBD is well characterized, it is not clear how or if increased lymphangiogenesis pr

137 isease progression in treated HIV infection, it is not clear how or whether inflammatory mediators co

138 iates RAS-driven tumor development: however, it is not clear how p110alpha/RAS-dependant signaling me

139 However, it is not clear how Parkin functions in mitochondrial tu

140 th behavioral and cognitive dysfunction, but it is not clear how Pb produces these behavioral changes

141 ns are involved in direction perception, but it is not clear how perceptual decisions are related to

142 However, it is not clear how previously learned stimuli influence

143 However, it is not clear how prior exposure to cytotoxic therapy

144 It is not clear how properties of transcriptional pulses

145 It is not clear how protein prenylation of small GTPases

146 However, it is not clear how PRP affects the inflammatory respons

147 Consequently, it is not clear how quantitatively defined resilience di

148 Furthermore, it is not clear how recovery and fork restart occur in h

149 ey intracellular mediators of Fas signaling, it is not clear how recruitment of these proteins to the

150 However, it is not clear how reduction of apoE levels after birth

151 pagate into axons, given their unusual shape it is not clear how reliably these bursts reach nerve te

152 However, it is not clear how repeated stress promotes learning of

153 However, it is not clear how restriction of ligand movement to th

154 In addition, it is not clear how risk factors influence the developme

155 an pass through the channel to engage Rrp44, it is not clear how RNA is directed to Rrp6 or whether R

156 sites for the same transcription factor, and it is not clear how robust enhancers can evolve loss of

157 d musculoskeletal injuries in nursing staff, it is not clear how safe these new programs are for pati

158 and lower urinary tract symptoms (LUTS), and it is not clear how sex steroid hormones contribute to t

159 However, it is not clear how SIRT1 activity is regulated by intra

160 s of cancer, including lung cancer; however, it is not clear how SLIT functions in lung cancer.

161 It is not clear how Southern Ocean phytoplankton communi

162 ing TGF-beta functions in hepatic cells, but it is not clear how STATs are activated under these circ

163 It is not clear how stem and proliferating cells cope wi

164 It is not clear how stereocilia can stick together later

165 However, it is not clear how subthreshold stimuli are processed i

166 Yet, it is not clear how such effective attenuation is obtain

167 However, it is not clear how such interactions emerge and evolve

168 lection and execution of motor commands, but it is not clear how such interactions occur.

169 It is not clear how such lesions (which, unlike bulky ad

170 However, it is not clear how sufficient number of the bacteria su

171 However, in most cases it is not clear how sumoylation regulates various cellul

172 commercial biorefining plants in operation, it is not clear how sustainable they really are.

173 However, it is not clear how synaptic plasticity influences spiki

174 However, it is not clear how T-cell responses in the blood correl

175 h TGF-beta activation in podocytes; however, it is not clear how TGF-beta signaling promotes disease.

176 However, it is not clear how the 26S proteasome, the ubiquitin-de

177 Although it is not clear how the 5' intron finds the 3' introns,

178 However, it is not clear how the abundance and function of PHF8 a

179 However, it is not clear how the activation of Gi-coupled GPCRs a

180 nelles themselves are inherently active, and it is not clear how the active, energy-consuming process

181 However, it is not clear how the activity of these neurons is reg

182 e is required for stomatal closure; however, it is not clear how the anion is released.

183 improve future housing interventions, though it is not clear how the built environment and occupant b

184 However, it is not clear how the c-IAPs specifically recognize an

185 ernal Ca(2+) store depletion in these cells, it is not clear how the cells decode individual Ca(2+) s

186 Yet, from a computational standpoint, it is not clear how the challenge of object recognition

187 s critical for drug seeking and relapse, but it is not clear how the circuitry centred on hypocretin-

188 However, it is not clear how the competing actions of these recep

189 BACKGROUND & AIMS: It is not clear how the complex interactions between die

190 ates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem ce

191 However, it is not clear how the conversion of Orb2 to the amyloi

192 However, it is not clear how the different processes, expansion a

193 However, it is not clear how the diversity of available refugia i

194 However, it is not clear how the exocyst is targeted to and physi

195 repression of transposable elements (TE) but it is not clear how the extensive loss of DNA methylatio

196 However, it is not clear how the functions of these GTPases are c

197 of language processing in natural contexts: it is not clear how the human brain processes linguistic

198 It is not clear how the hypertrophic and fibrotic respon

199 Although it is not clear how the IL28B haplotype affects HCV clea

200 However, it is not clear how the immune responses in the lamina p

201 Here it is not clear how the immune system reconciles recepto

202 It is not clear how the innate immune system effectively

203 to splicing is often explored and utilized, it is not clear how the intein navigates through the rea

204 dorsolateral prefrontal cortex (dlPFC), but it is not clear how the interactions among these regions

205 It is not clear how the interferon target promoters, whi

206 However, it is not clear how the K-level designation objectively

207 However, it is not clear how the local surface properties of the

208 this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is

209 al for modulating p53 tumor suppression, but it is not clear how the loop is regulated.

210 It is not clear how the major airway mucins MUC5AC and M

211 nked to changes in gene expression; however, it is not clear how the multiple remodeling enzymes foun

212 However, it is not clear how the NF-kappaB response is tailored t

213 Specifically, it is not clear how the primordial mutational processes

214 However, it is not clear how the production of abundant quantitie

215 these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet p

216 However it is not clear how the protein environment controls thi

217 Currently it is not clear how the SMN protein levels are regulated

218 ies of a TCR to the peptide and the MHC, but it is not clear how the specificity to both components d

219 However, it is not clear how the strength of DNA binding for indi

220 Further, it is not clear how the sympathetic nervous system affec

221 It is not clear how the transcriptional profile of a pro

222 However, it is not clear how the two differentiated cells are gen

223 However, at an environmental response level, it is not clear how the two organelles intersect in prog

224 creased ER-mediated protein degradation, but it is not clear how the UPR is involved in the postprand

225 factors and function as obligate dimers, but it is not clear how the various dimer combinations contr

226 However, it is not clear how the various regulatory and nonregula

227 igen within the respiratory endothelium, but it is not clear how the virus can traverse the respirato

228 compete for the same site on the APC/C, but it is not clear how their affinities are balanced.

229 (TAM) may have tumor-promoting activity, but it is not clear how their phenotype is achieved.

230 It is not clear how these algorithms perform in terms of

231 e involved in the perception of objects, but it is not clear how these areas interact with first tier

232 AG1), which encodes a Notch ligand, although it is not clear how these contribute to disease developm

233 mechanisms differ among animal species, but it is not clear how these differences evolve.

234 It is not clear how these differences in the natural his

235 It is not clear how these diverse morphogenetic processe

236 It is not clear how these elements coordinate telomerase

237 ownstream target genes including MMACHC, but it is not clear how these HCFC1 targets play a role in t

238 However, it is not clear how these impacted clinical practice or

239 on feedback from antennal mechanosensors but it is not clear how these inputs combine to elicit fligh

240 to be important in olfactory processing, but it is not clear how these interactions shape the odour r

241 Nevertheless, it is not clear how these ion channels activate G-protei

242 PKD1 mutations are missense variants, though it is not clear how these mutations promote disease.

243 However, it is not clear how these peptide assemblages disrupt th

244 It is not clear how these PGCs are lost or what factors

245 It is not clear how these pre-patterned AChR clusters ar

246 It is not clear how these proteins cross the outer membr

247 o and iron-regulatory proteins in fungi, but it is not clear how these proteins function in mammalian

248 ssociated with an increase in these repeats, it is not clear how these proteins might have directed a

249 ndrial connexin 43 (Cx43) in cytoprotection, it is not clear how these signaling modules are linked m

250 It is not clear how these signaling pathways interact in

251 Nonetheless, it is not clear how these structural changes alter the f

252 tive of regulation by a bi-modal switch, but it is not clear how these switches are controlled.

253 However, it is not clear how these two types of Ca2+ signals are

254 Its expression levels vary in humans, and it is not clear how these variations affect lipid metabo

255 mportant target for neutralizing antibodies, it is not clear how these viruses avoid cross-neutraliza

256 into the initiating events of HTRs; however, it is not clear how they are modulated and how they comb

257 t a query about the logic of forward models: It is not clear how they are supposed to work, nor why t

258 address the question from different angles, it is not clear how they compare with each other.

259 ine ignores such technological developments, it is not clear how they would fit within her framework.

260 Besides this therapeutic feature it is not clear how this abundant fat supply may affect

261 However, it is not clear how this action affects neural circuits

262 However, it is not clear how this activity of Otub1 is regulated

263 BIR domain interactions are well understood, it is not clear how this binding event influences the ac

264 precedes the stable flipped-out complex, but it is not clear how this complex differs from nonspecifi

265 high in glioblastoma-type brain tumors, but it is not clear how this contributes to tumor growth.

266 pear to activate pDCs through their TLRs and it is not clear how this difference affects IFN-alpha/be

267 It is not clear how this effect is mediated, nor whether

268 However, it is not clear how this enzyme can impact the bioavaila

269 It is not clear how this interaction affects the lithiat

270 rvate the striatum die in Parkinson disease, it is not clear how this loss leads to symptoms.

271 However, it is not clear how this modification is regulated durin

272 s in calcium (Ca(2+) responses) in glia, but it is not clear how this process affects intestinal func

273 ny positive regulators have been identified, it is not clear how this process is inhibited at transcr

274 orming a complex with the SECIS element, but it is not clear how this regulates eEFSec during Sec inc

275 It is not clear how this relates to the stage of retinop

276 erved in postpartum breast cancers; however, it is not clear how this remodeling process promotes met

277 tical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell

278 and sometimes coexisting conformations, and it is not clear how this three-dimensional structure aff

279 ost common alterations in human cancers, yet it is not clear how this transcription factor acts to pr

280 d ability to obtain a feeding territory, but it is not clear how this translates into performance in

281 It is not clear how tissue stress and adaptive immunity

282 It is not clear how to best diagnose AMS.

283 ains crucial information about this process, it is not clear how to extract this information.

284 However, to date it is not clear how to perform a PCA of censored data.

285 In particular, it is not clear how to rationalize the small apparent in

286 However, it is not clear how to reconcile this idea with the fact

287 However, it is not clear how transcription-factor binding and chr

288 Yet it is not clear how tumor cells make their way into the

289 At present, it is not clear how twitching motility emerges from thes

290 However, it is not clear how type 2 diabetes affects the resoluti

291 It is not clear how type I IFN regulates NK cell activat

292 It is not clear how using partial-mouth periodontal exam

293 However, it is not clear how values for saccade goal selection ar

294 However, it is not clear how VEGF signaling and mechanobiological

295 Currently, it is not clear how VH replacement is regulated during e

296 ulted in highly diverse viral sequences, and it is not clear how viral proteins such as Tat, which pl

297 oss-species pathogen transmissions; however, it is not clear how viruses adapt to productively infect

298 It is not clear how weight loss affects histologic featu

299 ty, and rad51 mutations cause lethality, but it is not clear how widely these functions are conserved

300 It is not clear how WNT augments the capacity of osteobl