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1 f cardiovascular disease at the adult stage, it is not known whether a difference in doxorubicin-rela
3 pendent transcription is well characterized, it is not known whether a distinct mechanism governs the
7 e left ventricular ejection fraction (LVEF), it is not known whether a specific level of improvement
11 ite a long tradition of perception research, it is not known whether access to consciousness is requi
14 h insulin resistance in children and adults, it is not known whether altered insulin homeostasis is d
24 r NLRP3-dependent inflammasome function, but it is not known whether ASC is a sufficient partner and
29 in aged rodents has been poorly studied, and it is not known whether beneficial mechanisms evidenced
31 ficient to decrease cell viability; however, it is not known whether blocking lipogenesis in vivo can
33 vity following noxious skin stimulation, but it is not known whether brain processing of nociceptive
35 isms of p300 acetyltransferase activity, but it is not known whether CBP activity is controlled simil
44 ve diversity and specificity within species, it is not known whether coevolutionary dynamics differ a
46 ects reported for camel milk (CMk); however, it is not known whether compounds with GABAergic activit
48 alters metabolism in the adult and fetus but it is not known whether cortisol in the pregnant mother
49 2 are generated at the site of inflammation, it is not known whether crosstalk exists between these 2
50 d is essential for virus infection; however, it is not known whether D2 is also important for infecti
51 ds as the main sources of carbon and energy, it is not known whether de novo synthesis of amino acids
54 y terminals have not been characterized, and it is not known whether developmental plasticity compens
57 ocused on endogenously synthesized proteins, it is not known whether differences exist in the process
61 ately documented across a number of species, it is not known whether each response occurs together wi
67 ed skin diseases such as psoriasis; however, it is not known whether epidermal factors play a primary
71 vents are crucibles for rapid evolution, but it is not known whether evolutionary changes arise mainl
72 factor for cardiovascular diseases; however, it is not known whether excess homocysteine alters retin
77 the actin-binding protein filamin A (FLNA); it is not known whether FLNA binds to WHIM CXCR4 mutants
78 hanges in fluid shear stress (FSS); however, it is not known whether GFR modulates PT endocytosis to
80 is well established for some drugs of abuse, it is not known whether glutamate receptors within the m
81 cytomegalovirus (hCMV) in such patients, but it is not known whether hCMV effects erythropoietin prod
84 ing is highly specialized rhythmic behavior, it is not known whether high-conductance states and irre
85 sible functional overlap of satiety signals, it is not known whether histamine participates in OEA-in
88 miRNA are known to inhibit specific viruses, it is not known whether host-directed microRNAs, downstr
89 nical contexts are hampered by the fact that it is not known whether humans manifest analogous approa
94 nerable to antibody neutralization; however, it is not known whether infection established by the maj
99 hough associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contribut
100 ammatory processes are a cause of early AMD, it is not known whether interventions that reduce system
102 an animal model of human visual processing, it is not known whether invariant visual object recognit
103 e gamma-tubulin complex remains elusive, and it is not known whether it also regulates assembly of th
104 It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway
105 nophen causes oxidative injury in the liver, it is not known whether it causes oxidative stress in th
107 aling regulates multiple steps in oogenesis, it is not known whether it regulates Drosophila ovulatio
108 uitment remains mechanistically unclear, and it is not known whether kinetochore proteins other than
109 compared to corresponding normal tissue, but it is not known whether lack of 5hmC is a cause or a con
113 sity-induced inflammation of adipose tissue, it is not known whether lipolysis-induced inflammation r
117 mor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigene
118 plicated in increased susceptibility to NTS, it is not known whether malaria affects resistance to in
120 sary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cel
124 bilities is currently lacking; specifically, it is not known whether metabolic redundancy will foster
125 metabolic syndrome (MetS) appear heritable, it is not known whether MetS severity as assessed by a c
128 volumes are often elevated in athletes, but it is not known whether moderate physical activity is al
129 corresponding neural correlates in monkeys, it is not known whether monkeys distort probability in a
133 y" to describe short-term memory in animals, it is not known whether multiple, independent memory sys
135 nvironmental fate of these new products, and it is not known whether nanoformulations can be evaluate
137 esidents of disadvantaged neighborhoods, but it is not known whether neighborhood inequalities are sp
142 Breastfeeding provides health benefits, but it is not known whether or how breastfeeding decreases t
143 with physiological cardiac growth; however, it is not known whether or how physical activity-induced
144 Although inflammation promotes fibrogenesis, it is not known whether other events, such as hepatocyte
145 similar beta-sheet secondary structures, but it is not known whether pancreatic amylin affects amyloi
147 luenced by metabolite levels in culture, but it is not known whether physiological variations in meta
150 ERCA2) contributes to septic cardiomyopathy, it is not known whether prevention of the down-regulatio
156 t neuronal subtypes can differ [13, 14], but it is not known whether regulation of myelination by act
161 need Rho-kinase for planar cell polarity but it is not known whether Rho-kinase is involved in this w
166 igatory role as an activator of replication, it is not known whether Rta is directly required for rep
167 ed with C(4) photosynthesis in monocots, but it is not known whether selection has acted on Rubisco i
170 n pulmonary arterial hypertension (PAH), but it is not known whether sex hormones are risk factors fo
173 rectly on axons to regulate their outgrowth, it is not known whether signals transduced in dendrites
175 ls of the myoblast lineage secrete exosomes, it is not known whether skeletal muscle fibers (myofiber
183 pically results in strong episodic memories, it is not known whether such long-term memories are nece
184 segregation at high-symmetry boundaries, but it is not known whether superstructures exist at general
186 s polymerase-associated factor 1 (Paf1), but it is not known whether TEFs have gene-specific function
192 le and prevents apoptosis of host cells, but it is not known whether the cell cycle phases influence
194 perceptual interpretation of sensory inputs, it is not known whether the combination of sensory and m
197 eural activity in oculomotor brain circuits, it is not known whether the decision-related activity in
200 factor signaling and striatal vulnerability, it is not known whether the effects are mediated via the
201 channels, and while it is highly conserved, it is not known whether the functional role of this spli
206 en regeneration by CNS axons is facilitated, it is not known whether the intra-axonal content of tran
209 is going to get much bigger, very soon, but it is not known whether the needs of genomics will excee
212 mation relies on the same neural system, but it is not known whether the organisational principles go
214 ereotyped song that is stable for years, but it is not known whether the precise neural patterns unde
216 re targeted by murine monoclonal antibodies, it is not known whether the same epitopes are targeted b
220 mponents, however, is poorly understood, and it is not known whether the static component requires th
223 ium during branching morphogenesis; however, it is not known whether the vasculature has instructive
226 ar organization of spinal limb circuits, but it is not known whether their predecessors, fish axial c
229 rks have primarily been studied in mice, and it is not known whether there are species- or clade-spec
231 an fornix also results in memory impairment, it is not known whether there is a preferential involvem
235 adjacent to the face-selective patches, but it is not known whether these body-selective patches for
236 ortant regulator of learning rules; however, it is not known whether these cellular mechanisms for ho
240 ges or recruited inflammatory monocytes, but it is not known whether these different sources generate
241 eriences represent separable cell types, and it is not known whether these differentially active cell
242 some treatment-resistant patients; however, it is not known whether these effects are independent, o
243 ed by vagal afferent endings in the NTS, but it is not known whether these endings participate in MTI
247 alls with unemployment in the short run, but it is not known whether these negative effects persist,
248 eurons in the inferior temporal (IT) cortex, it is not known whether these neurons respond differenti
252 ions at early stages of cortical processing, it is not known whether these representations include mi
253 and cleavage capability of mesotrypsin, but it is not known whether these residues fully account for
258 eplication by inducing G-to-A hypermutation, it is not known whether they are copackaged and whether
259 from LC neurons can exert analgesic actions, it is not known whether they can act independently of as
260 ll migration and cell-cell adhesion; however it is not known whether they control formation of vessel
261 ins regulate the same developmental process, it is not known whether they function in the same molecu
263 cy decisions; however, many models exist and it is not known whether they produce consistent predicti
268 ciated with higher type 2 diabetes risk, but it is not known whether this association is causal.
270 functions in human cell differentiation, but it is not known whether this class of introns has a simi
271 i are correlated with many muscle disorders, it is not known whether this common phenotype is the res
273 tion and motility of the kinesin-5, Eg5, but it is not known whether this domain regulates kinesin-12
274 otection against myocardial infarction (MI), it is not known whether this effect is generalizable to
275 binoids inhibit GABA release in the RVM, but it is not known whether this effect persists in chronic
276 ng goal-directed actions and their outcomes, it is not known whether this function is localized withi
281 al proportion of patients with melanoma, but it is not known whether this is associated with extended
286 is indispensable for cell survival; however, it is not known whether this pathway functions in the pr
287 hibit considerable functional diversity, but it is not known whether this reflects the existence of a
288 ough coordination with the cytoskeleton, but it is not known whether this response impacts adhesion f
290 died in the context of other drugs of abuse, it is not known whether toluene exposure differentially
293 Exercise reduces insulin resistance, but it is not known whether TRPC1 is involved in exercise-in
295 with global two-dimensional simulations, but it is not known whether turbulence driven by this instab
299 rus particles have been observed in M cells, it is not known whether viruses use M cells to initiate
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