ライフサイエンスコーパス: it is unclear how

1 It is unclear how a conserved histidine can mediate acti

2 ptic encephalopathy (Ohtahara syndrome), but it is unclear how a partial loss of Munc18-1 produces th

3 However, it is unclear how a quiescent or inflammatory environmen

4 However, it is unclear how aberrant ITS formation is suppressed i

5 However, it is unclear how absorbed molecules are transported thr

6 hermodynamically unfavorable, and therefore, it is unclear how AIP-producing bacteria produce suffici

7 Yet, it is unclear how Akt controls alternate T cell fate dec

8 It is unclear how alcohol-evoked plasticity in the DMS c

9 and BECN1:ATG14 subcomplex do not touch, and it is unclear how allosteric signals are transmitted to

10 the membrane properties of SCN neurons, but it is unclear how alterations in CRY1/2 stability affect

11 yology.Early in human embryonic development, it is unclear how amniotic sac formation is regulated.

12 he basilar membrane traveling wave; however, it is unclear how amplification is achieved with sharp f

13 ts are produced in supernova explosions, but it is unclear how and where dust grains condense and gro

14 However, it is unclear how and where these function in developmen

15 de-offs between contraction speed and force, it is unclear how animals evolve the ability to produce

16 ssed and localized within the bacterium, and it is unclear how antigen localization modulates the imm

17 Furthermore, it is unclear how antitoxins are selected for proteolysi

18 protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membran

19 However, it is unclear how AR functions in HER2 positive (+) BC.

20 However, it is unclear how ATP binding and hydrolysis spatially a

21 But it is unclear how attentional focus on the primary dimen

22 It is unclear how autophagy of synaptic vesicles and com

23 nity is a core objective of health care, yet it is unclear how best to measure this in the ICU settin

24 However, it is unclear how blood-borne factors dynamically access

25 It is unclear how both fast and slow traveling waves wit

26 However, it is unclear how bound proteins influence U4/U6 unwindi

27 ral representations of similar contexts, but it is unclear how broadly responsive neurons help distin

28 Still, it is unclear how broadly these pathways apply, given th

29 tor (RyRs) Ca(2+) release channel is low and it is unclear how Ca(2+) release can be activated in the

30 ial for consolidating episodic memories, but it is unclear how CA1 activity patterns drive memory for

31 It is unclear how CAS performance may be influenced by t

32 tress signals can induce either process, and it is unclear how cells 'assess' cellular damage and mak

33 A and protein constituents of chromatin, and it is unclear how cells respond to this compound injury.

34 tant for generating distinct cell types, but it is unclear how cells use the same set of regulatory m

35 omb repressive complexes modify histones but it is unclear how changes in chromatin states alter kine

36 However, it is unclear how changes in sarcomere length and lattic

37 Yet, it is unclear how changing precipitation regimes may aff

38 However, it is unclear how chemically diverse kairomones can elic

39 However, it is unclear how chemotactic and haptotactic pathways i

40 zed by depleted nucleosome contact; however, it is unclear how chromatin accessibility is governed.

41 a different identity on its neighbours, and it is unclear how chromatin in equipotent progenitors un

42 However, it is unclear how coenzyme F430 is synthesized from the

43 It is unclear how communication between brain networks r

44 Presently, it is unclear how complexin binding to the postfusion co

45 MELD) score has improved wait list survival, it is unclear how contemporary wait list mortality can b

46 While it is unclear how controlling chemotaxis via multiple pa

47 rowing pressure to reduce COPD readmissions, it is unclear how COPD readmission rates are related to

48 However, it is unclear how cortical circuits generate and maintai

49 s), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness in the suboptim

50 It is unclear how CVD risk and events are distributed am

51 However, it is unclear how DA mediates opposing patterns of behav

52 ellular decisions in noisy environments, but it is unclear how digital systems transmit temporal info

53 It is unclear how distal resistance is modulated.

54 It is unclear how DivL overcomes inhibition by DivK~P in

55 It is unclear how DNA tumor viruses regulate these enzym

56 en, Batrachochytrium dendrobatidis (Bd), but it is unclear how dominant these anti-Bd bacteria are in

57 To date, it is unclear how Drp1 assembles on the mitochondrial ou

58 Yet, it is unclear how durable these neuronal representations

59 It is unclear how earthworms interact with soil manageme

60 increasingly popular in pediatrics; however, it is unclear how effective these interventions are in c

61 However, it is unclear how efficiently this occurs for tissue-res

62 It is unclear how elevated CO2 (eCO2 ) and the correspon

63 ating epigenetics and psychiatric disorders, it is unclear how epigenetics, particularly DNA methylat

64 However, it is unclear how epithelial cell division is controlled

65 parts of the Y complex has been elucidated, it is unclear how exactly it oligomerizes in situ.

66 trations below their carcinogenic potencies; it is unclear how exposure leads to adverse health outco

67 However, it is unclear how expression is established at the top o

68 ty is oncogenic in several malignancies, but it is unclear how expression or function of downstream e

69 soil predominantly represents intact cells, it is unclear how extracellular DNA affects molecular an

70 It is unclear how frequently patients with atrial fibril

71 s PG insertion at the division plane, though it is unclear how FtsZ structure and dynamics are mechan

72 ought to present large ATP demands; however, it is unclear how fuel availability and electrical activ

73 Mechanistically, it is unclear how functional modulation of H-NS by such

74 It is unclear how genes, such as RPGR (retinitis pigment

75 izobium species can nodulate bean roots, but it is unclear how genetically isolated these species rem

76 plications in biomedicine and nanotechnology.It is unclear how Gram-positive bacteria, with a thick c

77 In mammalian hair, it is unclear how hair follicle stem cells can enter an

78 In part, this is because it is unclear how heterogeneity in soils affects plant r

79 enerate complex organ-like tissues; however, it is unclear how heterotypic interactions affect lineag

80 Absent cooperativity, it is unclear how HIV can temporarily remain in an off-s

81 However, even in this well-studied model, it is unclear how homolog pairing in diploids or environ

82 It is unclear how human apolipoprotein E4 (ApoE4) increa

83 secrete IL-1 while retaining viability, yet it is unclear how IL-1 can be secreted from living cells

84 It is unclear how important drinking water instead of DB

85 biting fairly severe meiotic phenotypes, and it is unclear how important homeostasis is under normal

86 nd enhanced levels of estradiol (E2), though it is unclear how increased E2 promotes deterioration of

87 It is unclear how individual drug prices change over tim

88 It is unclear how iNKT terminal maturation is regulated

89 onsequences for induced cleavage, and so far it is unclear how intracellular signals address cleavage

90 at dictate CNS function are multifaceted and it is unclear how irradiation induces persistent alterat

91 oxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the

92 and triggers transcription termination, but it is unclear how its various enzymes are coordinated an

93 ete membranes interact at fertilization, and it is unclear how Juno - which was previously named fola

94 ut also by surrounding cell types [6-9], and it is unclear how large, possibly insoluble protein comp

95 However, it is unclear how LC coordinates disparate behavioral fu

96 However, it is unclear how LC-NE neurons divide up their brain-wi

97 However, it is unclear how leukocytes interact mechanically with

98 Currently it is unclear how lineages are regulated during kidney o

99 l excitatory neurons remains incomplete, and it is unclear how local excitatory and inhibitory synapt

100 However, it is unclear how Lrp4 deficiency in OBs impairs osteocl

101 However, it is unclear how LVEF improvement affects subsequent ri

102 It is unclear how M. bovis is able to survive in the env

103 It is unclear how magma mushes are mobilized to create l

104 Despite pioneering works in yeast, it is unclear how mammalian cells counteract Ku at seDSB

105 It is unclear how many cis-regulatory elements exist, wh

106 It is unclear how many patients achieve MR(4.5) under di

107 ositive clinical studies have been reported, it is unclear how many purported therapies have become e

108 However, it is unclear how MIA disrupts fetal brain gene expressi

109 However, it is unclear how microglia influence neuronal activity

110 However, it is unclear how might fluctuations in resource availab

111 interconnectivity between these structures, it is unclear how mPFC projections to each subcortical s

112 g protein and the molecular motors involved, it is unclear how mRNAs are connected to membranes durin

113 However, it is unclear how Msi2 recognizes and regulates mRNA tar

114 It is unclear how mtDNA deletions are tolerated or how t

115 However, it is unclear how much biodiversity is needed to deliver

116 In particular, it is unclear how much current actually reaches the brai

117 plain a small proportion of the genetic risk it is unclear how much is left to be detected by other,

118 pically proceed in parallel, and accordingly it is unclear how much of skill acquisition is a reflect

119 development, especially during amelogenesis, it is unclear how mutant forms cause ARS dental anomalie

120 es changes in SCN neuronal excitability, but it is unclear how mutations affecting post-translational

121 However, it is unclear how mutations of hnRNP U may cause such di

122 However, it is unclear how Nanos translation is regulated in deve

123 It is unclear how natural regulation of inflammation aff

124 In particular, it is unclear how natural selection can specifically mod

125 networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memor

126 It is unclear how networks that control critical cell-fa

127 Yet, it is unclear how neural activity in the medial prefront

128 However, it is unclear how NHEJ factors organize to repair divers

129 In particular, it is unclear how non-photosynthetic proteins in the anc

130 be important for centrosome separation, but it is unclear how nuclear dynein forces are organized in

131 However, it is unclear how nutrient overload regulates PFKFB3 exp

132 tural adaptation than any other species, but it is unclear how observational learning can give rise t

133 However, it is unclear how often sepsis readmissions are for rela

134 us promotes cardiovascular disease; however, it is unclear how or which proteins encoded at this locu

135 systemic lupus erythematosus (SLE); however, it is unclear how Ox40L contributes to SLE pathogenesis.

136 Nevertheless, it is unclear how p53 orchestrates its activities in mul

137 romatic hydrocarbons (PAHs) increases atopy; it is unclear how PAH exposure is linked to increased se

138 It is unclear how partial resection might affect Ku enga

139 It is unclear how past outcomes influence future decisio

140 It is unclear how patients hospitalized for acute heart

141 However, it is unclear how pausing affects the initiation of new

142 To date, it is unclear how PD affects the ability to react and ad

143 However, it is unclear how phosphate could have assumed these cen

144 It is unclear how physical activity stimulates new bone

145 ha and Pin1 have multiple cellular partners, it is unclear how Pin1 assists in the regulation of ERal

146 mmunity and effector-triggered immunity, and it is unclear how plants inactivate these effectors to e

147 Yet, it is unclear how Plasmodium avoids the deleterious effe

148 uch approaches often have mixed results, and it is unclear how polyvalency alters the fine specificit

149 nt for fitness in temperate environments but it is unclear how progeny gain their initial seasonal en

150 It is unclear how proliferating cells elicit suppression

151 nditure (EE) increases with overfeeding, but it is unclear how rapidly this is related to changes in

152 It is unclear how Ras causes repression of Bmi1 in prima

153 However, it is unclear how RAS-ERK signals integrate time and spa

154 It is unclear how recent trends in "green" building affe

155 However, it is unclear how receptors and G proteins meet, interac

156 hery and prevention of Cu over-accumulation, it is unclear how regulation of ATP7A contributes to Cu

157 It is unclear how regulatory genes establish neural circ

158 largely to peripheral blood-derived T cells, it is unclear how representative the peripheral T cell r

159 It is unclear how reproducible or predictable adaptive e

160 ess evolves under stabilizing selection, but it is unclear how robustness and evolvability will emerg

161 However, it is unclear how self-organization by this mechanism re

162 It is unclear how sensory information from the bladder a

163 It is unclear how septic shock causes acute kidney injur

164 oposed for synapse-to-nuclear communication, it is unclear how signaling is coordinated at both subco

165 It is unclear how specific ARKs are activated at specifi

166 nce identity of rRNA genes within a species, it is unclear how specific rRNA genes are reproducibly c

167 However, currently it is unclear how specification of phloem cells is contr

168 ein kinase C (PKC) phosphorylation, although it is unclear how store depletion stimulates this gating

169 In plants, it is unclear how stress affects the production and fate

170 sive structures called invadopodia; however, it is unclear how Stx4 function is regulated during tumo

171 Given this contrast, it is unclear how such consistency in organ scale can em

172 Although it is unclear how such intergenerational transfer of inf

173 cleoli actively consume chemical energy, and it is unclear how such nonequilibrium activity might imp

174 However, it is unclear how such population-level data relate to t

175 eting for resources and instilling fear, but it is unclear how suppression of mesopredators varies wi

176 It is unclear how TACC3 interacts with chTOG.

177 However, it is unclear how task-relevant neural populations coord

178 e Th17 chemoattractant CCL20, and therefore, it is unclear how Th17 cells are recruited to the cervic

179 Yet, it is unclear how the 5'nuclease mechanisms of DNA disto

180 However, it is unclear how the abnormality in the hippocampal cir

181 synthesis enzymes and the cytoskeleton, but it is unclear how the activities of individual proteins

182 aking involving risk of punishment; however, it is unclear how the BLA is recruited at different stag

183 In particular, it is unclear how the brain distinguishes predictive rel

184 It is unclear how the brain interprets these signals.

185 It is unclear how the brain represents such pdfs or comp

186 gh aspects of this process are well studied, it is unclear how the cell controls the coordination of

187 It is unclear how the cell manages the plasticity of the

188 congestion is a major goal of acute therapy, it is unclear how the clinical components of congestion

189 In particular, it is unclear how the complement system communicates wit

190 lthough nucleic acids are potent activators, it is unclear how the contact system is regulated to pre

191 It is unclear how the continuous Wnt gradient along the

192 However, it is unclear how the CRD is removed.

193 However, it is unclear how the daily expression of circadian gene

194 on the molecular control of cell movements, it is unclear how the different observed modes of collec

195 a few decades, and, at the ice-sheet scale, it is unclear how the entire drainage network of ice str

196 ing motifs (MIMs) of ESCRT-III subunits, but it is unclear how the enzyme then remodels these substra

197 - DNA sequence changes during evolution, but it is unclear how the evolutionary dynamics of epigeneti

198 It is unclear how the H7N9 virus re-emerged and how it w

199 Furthermore, it is unclear how the high expression impacts global tra

200 to involve both encoding and retrieval, and it is unclear how the human hippocampus subserves both f

201 Yet, it is unclear how the identities of an unknown number of

202 It is unclear how the IGC impacts OB output to downstrea

203 It is unclear how the immune response in early life beco

204 However, it is unclear how the inhibitory function of Sufu toward

205 However, it is unclear how the kinase module is structurally regu

206 It is unclear how the low abundant Ire1alpha efficiently

207 However, it is unclear how the low temperature and high hydrostat

208 reduced local terrestrial biodiversity, but it is unclear how the magnitude of change relates to the

209 It is unclear how the misunderstanding that Rubus fruits

210 Particularly, it is unclear how the neurons in these cortical areas mu

211 It is unclear how the numerous odorant molecules and the

212 However, it is unclear how the particle's hydrodynamic drag and m

213 in humans and animal models of Parkinsonism, it is unclear how the pattern regularization would origi

214 adient is an important cue for polarization, it is unclear how the polarization is affected by cell d

215 ytic center of all Dus enzymes is conserved, it is unclear how the same protein fold can be reprogram

216 However, it is unclear how the small number of A3G molecules foun

217 eceptors controls specific signaling events, it is unclear how the spatiotemporal control of signalin

218 It is unclear how the specific activation of individual

219 (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection

220 finity of IgG1 Fc to Fc gamma receptors, but it is unclear how the structural modifications of N-glyc

221 Nevertheless, it is unclear how the terrestrial carbon sink will evolv

222 For example, it is unclear how the timing of individual phage infecti

223 erile injury response in the liver; however, it is unclear how the type of cells injured or the mecha

224 infection of certain target cells, although it is unclear how the virus replicates so robustly.

225 al frequencies has been fairly well studied, it is unclear how the visual system integrates this info

226 It is unclear how the Warburg effect that exemplifies en

227 However, it is unclear how their expression level in neurons is r

228 nown to have distinct reaction dynamics, but it is unclear how their kinetics affects the overall ele

229 It is unclear how these binding events are regulated.

230 lial cells do not express CD4 receptors, and it is unclear how these cells become productively infect

231 However, it is unclear how these cells mediate memory discriminat

232 ulation using artificial visual stimuli, and it is unclear how these descriptions map onto the encodi

233 However, it is unclear how these different types of appraisals ar

234 It is unclear how these enzymes cooperate to oxidise sul

235 It is unclear how these events control ER proteostasis a

236 hough oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombo

237 s can drive their membrane localization, yet it is unclear how these intracellular proteins are targe

238 It is unclear how these loci may contribute to AD pathol

239 However, it is unclear how these mechanisms influence transfer ac

240 ential for transcription regulation, and yet it is unclear how these multisubunit complexes coordinat

241 It is unclear how these mutations contribute to disease.

242 n disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease.

243 It is unclear how these noncoding sequence variants affe

244 However, at a systems-level it is unclear how these perturbations give rise to the o

245 cell-cell and cell-matrix interactions, but it is unclear how these physical cues influence stem cel

246 However, it is unclear how these plants access Fe in the rhizosph

247 heir fitness and disrupt their function, and it is unclear how these potentially harmful cells are ma

248 HR pathway is independent of RAD18 However, it is unclear how these processes are coordinated within

249 However, it is unclear how these processes are regulated and func

250 n activity are associated with tinnitus, but it is unclear how these relate to the phantom sound itse

251 However, it is unclear how these results translate to the biologi

252 Yet, it is unclear how these substances orchestrate state-dep

253 he encoding and retrieval of information but it is unclear how these two processes are achieved withi

254 It is unclear how these types of efficient coding relate

255 ction focus on initiation deficits; however, it is unclear how they account for deficits in the speed

256 endent on the cellular NXF1/TAP pathway, but it is unclear how they are recruited to the export machi

257 quently detected during medical imaging, but it is unclear how they form or progress to PDAC.

258 Many niche signals have been identified, but it is unclear how they influence the choice of stem cell

259 les in establishing tissue architecture, but it is unclear how they might be coordinated.

260 erns about the use of such technologies, and it is unclear how they might be implemented to deliver t

261 are predicted to be similar, and therefore, it is unclear how they recognize structurally distinct R

262 It is unclear how they use sensory signaling to detect a

263 It is unclear how this affective instability is associat

264 Mass bloom attracts pollinators and it is unclear how this affects the pollination and yield

265 ciate with cholesterol-rich lipid rafts, but it is unclear how this affects the properties of the rec

266 dent upon the ESCRT-III component CHMP7 [3], it is unclear how this complex is able to engage nuclear

267 Currently, it is unclear how this critical pathway unfolds, in part

268 However, it is unclear how this critical trait is acquired and re

269 ults in need of statin therapy; furthermore, it is unclear how this difference translates into number

270 It is unclear how this dually lipidated protein is trans

271 e of cortical receptive fields [2]; however, it is unclear how this fine-grain inhibition relates to

272 However, it is unclear how this flipping between chromatin states

273 cular crowding in the NPC transport channel, it is unclear how this impacts FG Nup barrier function o

274 chronic rejection of heart transplants, but it is unclear how this inflammation is initiated.

275 Currently, however, it is unclear how this influences host defenses against

276 me via its HAND-SANT-SLIDE (HSS) domain, yet it is unclear how this interaction enhances remodeling.

277 ) seems to inhibit pain processing, although it is unclear how this is achieved.

278 in labelling magnetic resonance imaging, but it is unclear how this is related to amyloid-beta pathol

279 lized communities of brain regions; however, it is unclear how this mechanism manifests over time.

280 It is unclear how this mitotic "centriole conversion" is

281 th ANE syndrome have fewer mature ribosomes, it is unclear how this mutation disrupts ribosome assemb

282 However, it is unclear how this process is neurally implemented.

283 ar to aggregate local neuronal activity, but it is unclear how this relationship affects information

284 Because it is unclear how this specialization for upright (compa

285 It is unclear how this urbanization disturbs the microbi

286 Yet, it is unclear how to advance an observation of comorbidi

287 However, it is unclear how to best conduct inference on the indiv

288 Secondly, it is unclear how to effectively delineate subnetworks,

289 a common eukaryotic centromere feature, yet it is unclear how transcription is linked to underlying

290 opoietic stem cell transplantation; however, it is unclear how Tregs mediate these effects.

291 smodium, is mediated by type I IFN; however, it is unclear how type I IFN suppresses immunity to bloo

292 However, it is unclear how ultrasound stimulates the splenic CAP.

293 Thus, it is unclear how useful can SCG be to address evolution

294 However, it is unclear how variation in 5-HTT gene expression imp

295 As such, it is unclear how visual and motor properties are repres

296 ctive GPCRs in these contexts is limited and it is unclear how well an opsin-chimera GPCR might mimic

297 n in the context of simple behavioral tasks, it is unclear how well each of these mechanisms can acco

298 he efficacy of latency-reversing agents, but it is unclear how well these models reflect HIV integrat

299 atosensory cortex (S1) of mice and rats, but it is unclear how whisker-related input is represented i

300 clines in heart attack and stroke incidence, it is unclear how women and men differ in first lifetime