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1 ameters are variable within individuals, but it is unclear whether 1 semen sample could represent a m
5 ted with inferior outcomes and higher costs, it is unclear whether a similar association has been see
6 ans of beta-cell replacement in rodents (2), it is unclear whether a similar principle applies to hum
7 lly ventilated patients without lung injury, it is unclear whether a similar relationship holds for a
12 er, as effective therapeutics are developed, it is unclear whether additional symptoms will be uncove
14 from evaluative threats like peer rejection, it is unclear whether adolescents avail themselves of th
16 itope in the DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for ne
21 ANCE STATEMENT Despite substantial research, it is unclear whether and how individual neuroendocrine
23 ates with reduced patient survival; however, it is unclear whether and how NUP88 overexpression drive
24 jor cell type involved in encapsulation, but it is unclear whether and how stem cells contribute to t
29 ost consistent PCOS characteristic; however, it is unclear whether androgen excess, which is treatabl
30 he taste of Ca(2+) is poorly understood, and it is unclear whether animals such as Drosophila melanog
33 ex in PSAC/NPP establishment are unknown and it is unclear whether any of the RhopH proteins play a r
35 RPC despite the castrate level of androgens, it is unclear whether AR signaling is significantly repr
36 bleeding in patients undergoing surgery, but it is unclear whether aspirin should be stopped before c
37 developed to address cell line recognition, it is unclear whether available systems can perform suff
38 known as prison's "revolving door." However, it is unclear whether being sentenced to prison itself h
40 of N. cucumeris and T. putrescentiae exists, it is unclear whether both species share bacterial commu
42 vironmental stresses also activate AMPK, but it is unclear whether cellular energy status affects AMP
46 fatty acid amide hydrolase (FAAH), although it is unclear whether chronic dysregulation of CRF syste
49 ptors are bound by different picornaviruses, it is unclear whether common host factors are needed for
52 nism for P450 enzymes has been well studied, it is unclear whether CYP121 follows the general P450 me
54 cal for flexible adaptive behavior; however, it is unclear whether D2, D3, or both receptor subtypes
57 ryomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsibl
61 sed risk of postoperative AKI with TAVR, but it is unclear whether differences in patient risk profil
65 nsmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due
69 sociated with exposure to air pollution, but it is unclear whether effects might vary among air pollu
70 thylation/deamination and myeloperoxidation, it is unclear whether endogenous formaldehyde can initia
73 vo evidence that validates this finding, and it is unclear whether FAM20C is the only kinase for SIBL
78 niques are known to enhance alpha-diversity, it is unclear whether habitat restoration can re-establi
79 een beneficial following noncardiac surgery, it is unclear whether higher thresholds are appropriate
80 ions with the HSP90 chaperone machinery, but it is unclear whether HSP90 modulates the activity or ex
84 ent of astrocyte morphology are unknown, and it is unclear whether impairing astrocytic infiltration
86 athogenesis of congenital heart defects, but it is unclear whether individual common variants confer
88 of peripheral origin.SIGNIFICANCE STATEMENT It is unclear whether individual sodium channel isoforms
89 (RSFC) subnetworks and task-evoked activity, it is unclear whether individual variations in the conne
96 diposity predicts increased incidence of AD, it is unclear whether it affects AAO and severity of Alz
97 ower the risk of incident breast cancer, but it is unclear whether it affects malignant progression a
98 eased from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on
99 brane component for retro-translocation, but it is unclear whether it forms a protein-conducting chan
100 e in reducing the core symptoms of ADHD, but it is unclear whether it helps to improve academic outco
101 s associated with adverse birth outcomes but it is unclear whether it increases early delivery risk.
102 t-reported outcome (PRO) questionnaires, but it is unclear whether it is feasible to implement this a
103 attractiveness bias comes into question, and it is unclear whether it offers anything superior to ste
104 ease associated with helminth infection, but it is unclear whether it plays a similar role in radiati
105 t for patients with atrial fibrillation, but it is unclear whether it results in a lower risk of stro
106 teins into the bacterial outer membrane, but it is unclear whether it threads beta-strands into the l
109 s during axon growth is well understood, but it is unclear whether Kv channels control axon outgrowth
111 nitiation of allergic inflammation; however, it is unclear whether lipid mediators, such as cysteinyl
112 otein level alterations are inconsistent and it is unclear whether lipoprotein function is affected.
113 ipulated overall sound intensity; therefore, it is unclear whether looming bias is truly a perceptual
118 as late-onset Alzheimer's disease, although it is unclear whether mild traumatic brain injury, or co
124 rment than it is for dementia, and therefore it is unclear whether neuroinflammation is part of the p
127 luence phenotypes in future generations, but it is unclear whether offspring phenotypes represent spe
128 gh such collapse often unfolds unexpectedly, it is unclear whether one can detect the risk of cheater
133 limbic network supports reward learning, but it is unclear whether other choice features, such as eff
137 scle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute
139 e use after stroke have been recognized, but it is unclear whether patient or hospital characteristic
141 PD-L1 is also expressed on T cells; however, it is unclear whether PD-L1 on this population influence
143 overgrowth (Kosaki overgrowth syndrome), but it is unclear whether PDGFRB mutations alone are respons
145 s a common part of the physical examination, it is unclear whether performing screening pelvic examin
146 rine, cerebrospinal fluid) and brain tissue, it is unclear whether peripheral and central OT releases
147 ures have begun to shift flowering time, but it is unclear whether phenotypic plasticity can accommod
150 hough the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-rela
154 locally within the hemogenic niche; however, it is unclear whether production can adapt to fluctuatin
160 as a severe course of bipolar disorder, but it is unclear whether rapid cycling bipolar disorder is
161 on, vesicles are retrieved and recycled, and it is unclear whether recycling pathways for evoked and
162 iability provide a valuable prognostic tool, it is unclear whether reduced heart rate variability its
165 to induce plasticity of excitatory synapses, it is unclear whether rMS can also modify structural and
167 been associated with cognitive function but it is unclear whether RNFL thinning is secondary to cort
170 trials have found the procedure to be safe, it is unclear whether safe adaptation of this approach f
173 crovascular complications later in life, but it is unclear whether short period of poor glycemic cont
175 (SIT) is an effective allergy treatment, but it is unclear whether SIT is effective for atopic eczema
176 nerally direct slicing of their targets, but it is unclear whether slicer-independent mechanisms of t
177 ween trauma patients and uninjured controls, it is unclear whether some of these differences may be "
178 anslation of different subsets of mRNAs, yet it is unclear whether specialized ribosomes exist and if
180 ed with adverse cardiovascular outcomes, but it is unclear whether specific PM2.5 components, particu
182 of gestation) has become less invasive, but it is unclear whether such developments in care are asso
183 le those of previously executed actions, but it is unclear whether such effects depend strictly on ac
185 ediatric surgical population are scarce, and it is unclear whether such preclinical findings are rele
186 iets come to prefer less salt over time, but it is unclear whether sweet taste perception is modulate
187 ontinually produced in the dentate gyrus but it is unclear whether synaptic integration of new neuron
190 l nicotinic ACh receptors (nAChRs); however, it is unclear whether the accompanying efferent-mediated
196 THSD7A-Ab-positive patients is unknown, and it is unclear whether the clinical presentation differs
201 with allergic disease in young children, but it is unclear whether the effects persist to adolescence
202 the era of direct-acting antivirals (DAAs), it is unclear whether the efficacy of treatment achieved
203 ng the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppress
204 y to human immunodeficiency virus (HIV), but it is unclear whether the increased risk can reduce the
209 atalytic domain have not been described, and it is unclear whether the mechanism of amino acid recogn
210 ricans attempt to lose weight each year, and it is unclear whether the modality of acute, tightly con
211 e specificity of the mu rhythm, meaning that it is unclear whether the mu rhythm reflects mirror neur
213 wave sleep (USWS) and suppressed REM sleep, it is unclear whether the mysticete whales show a simila
227 ctly linked to protection against apoptosis, it is unclear whether the suppression of other cell deat
228 to increase after hysterosalpingography, but it is unclear whether the type of contrast medium used (
229 evolutionary history of CD4(+) T cells, and it is unclear whether their differentiation into special
230 iduals are present in many groups [1-8], but it is unclear whether their emergence is determined by t
231 onents appears to be hierarchical [3-5], yet it is unclear whether their production during embryogene
232 ributions in response to climate change, but it is unclear whether their productivity is being affect
234 quence divergence from the reference genome; it is unclear whether there is benefit from post-process
235 hiatric disorders such as schizophrenia, but it is unclear whether these abnormalities represent a ca
238 ting effects on root and microbial dynamics, it is unclear whether these biotic effects can translate
239 es contain several isoforms of NO synthases, it is unclear whether these can control respiration in a
241 d microbiota composition and metabolism, but it is unclear whether these changes precede inflammation
248 onds was observed in hybrid perovskites, but it is unclear whether these long-lived hot carriers can
249 ound within the gut are commensals, although it is unclear whether these organisms can elicit systemi
250 oportion of food products bear no label, and it is unclear whether these products are free from aller
251 esolvase, Escherichia coli RuvC protein, but it is unclear whether these substrates fully recapitulat
254 OSs) are also expressed in cardiac myocytes, it is unclear whether they control respiration in an int
255 MOG antibody disease are largely unknown and it is unclear whether they differ from those of multiple
257 OE and EUE tend to correlate positively, but it is unclear whether they reflect different aspects of
258 ce IFN-gamma, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in
259 een described in inactive awake animals, but it is unclear whether they shape sensory processing in n
261 tes AMP-activated protein kinase (AMPK), but it is unclear whether this activation occurs solely via
263 mended for high-HIV-prevalence settings, but it is unclear whether this approach is sufficient to ach
264 disease (CHD) in observational studies, but it is unclear whether this association is causal or the
266 ss disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cas
269 ese two structures significantly differ, and it is unclear whether this difference is due to an alter
272 o tend to use more addictive substances, but it is unclear whether this is due to shared genetic or e
273 re often re-treated with the same ACT though it is unclear whether this is the most suitable approach
274 ong patients undergoing cardiac surgery, but it is unclear whether this leads to improved outcomes.
275 disk at the planet's formation location, but it is unclear whether this level of depletion can actual
282 (AMI) than normal weight patients; however, it is unclear whether this relationship is explained by
283 MRSA) has declined over the past decade, but it is unclear whether this represents a decline in S. au
288 an meat eaters of some chronic diseases, but it is unclear whether this translates into lower mortali
289 s predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical u
290 in concentrations during pregnancy; however, it is unclear whether those relations are attributable t
292 in regulating DNA transaction processes, but it is unclear whether transcription-associated chromatin
293 e viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral r
294 onal organizations to screen for depression, it is unclear whether treatment of depression in patient
295 dge of gene risk may enhance dietary change, it is unclear whether varepsilon4 carriers would benefit
298 s has been shown for cross-sectional volume, it is unclear whether volume changes over time translate
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