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1                                              It is unknown whether a neurotrophic deficit or patholog
2                                              It is unknown whether a similar association exists in li
3                                              It is unknown whether a similar functional organization
4 nance of contractile endurance in rat muscle it is unknown whether a similar regulation exists in hum
5                                              It is unknown whether a single transcription factor is a
6                                     However, it is unknown whether a synergistic effect exists.
7  abdominal fat mass before pregnancy because it is unknown whether abdominal fat mass, independently
8 ated with health outcomes and mortality, yet it is unknown whether accounting for SES can improve ris
9         Because fMRI data are correlational, it is unknown whether activity increases in core network
10                                     However, it is unknown whether AD is associated with central obes
11                                              It is unknown whether adding triglyceride-lowering treat
12 equivalent to those with cuticular suturing, it is unknown whether adhesive strips provide additional
13                                     However, it is unknown whether adiponectin is causally implicated
14                                 Furthermore, it is unknown whether AFF1 and AFF4 function similarly i
15                                 Furthermore, it is unknown whether African- and Asian-lineage ZIKV ha
16                                              It is unknown whether AHR also contributes earlier in hu
17                                     However, it is unknown whether all CD8(+) T cell specificities el
18                                              It is unknown whether alleles near NPC1L1 are associated
19                                              It is unknown whether alterations in ICN maturational pr
20  are impaired in most psychiatric disorders, it is unknown whether alterations in the dopamine system
21  MDmc projects to areas in addition to pOFC, it is unknown whether amygdalar pathways in MDmc innerva
22                                              It is unknown whether anatomical specializations in the
23 tenin have been well characterized; however, it is unknown whether and how a deubiquitinase is involv
24 s, and while specific peaks can be favoured, it is unknown whether and how early a commitment to fina
25                                              It is unknown whether and how estrogen modifies endothel
26 buted semantic processing network [4-6], but it is unknown whether and how individual neurons in the
27 h PAM recognition is essential for cleavage, it is unknown whether and how PAM binding activates Cas9
28                                     However, it is unknown whether and how RanBP9 transmits Abeta-ind
29                                     However, it is unknown whether and how the PINK1/Parkin pathway r
30                                              It is unknown whether and to what extent neuronal activi
31 ate memory-forming hippocampal synapses, yet it is unknown whether (and how) these hormones interact
32 nocular information for computing 3D motion, it is unknown whether (and how) these two signals intera
33                                   Similarly, it is unknown whether, and how, various proteins regulat
34                                              It is unknown whether antiarrhythmic drugs are safe and
35                                              It is unknown whether any mitotic kinases positively reg
36                                     However, it is unknown whether any of the components within the Q
37                                              It is unknown whether any of these domains in KDM5A have
38                                  At present, it is unknown whether APP family proteins function as ce
39                                              It is unknown whether asthma contributes to the childhoo
40                                              It is unknown whether AT may impact the outcome of bleed
41 nst RPCs might develop and induce RPC death, it is unknown whether autoantibodies against cell-surfac
42                                              It is unknown whether autoantigens with weak cross-linki
43 rlying mechanisms are poorly understood, and it is unknown whether autophagy affects only whether or
44 esize BChl e but accumulate BChl c; however, it is unknown whether BciD is sufficient to convert BChl
45 pression and antidepressant action, although it is unknown whether BDNF and TrkB in the dorsal raphe
46                                     However, it is unknown whether BDNF release and TrkB activation o
47  to suppress VLDL production from the liver, it is unknown whether brain insulin signaling independen
48                                              It is unknown whether CAC progression over time carries
49                                     However, it is unknown whether CAFs uniformly carry out these tas
50  may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA
51  will be tumor-associated Ag (TAA) specific, it is unknown whether CD8(+) T cells with specificity fo
52 ce embryos die before the first HSCs emerge, it is unknown whether Cdh5 has a direct role in HSC emer
53 hythms are vital to human mental health, but it is unknown whether circadian rhythms "entrained" to t
54                                Consequently, it is unknown whether clinical sequencing can be of bene
55          As the general population has aged, it is unknown whether clinical trial enrollment has chan
56                                     However, it is unknown whether CNP signaling regulates aortic val
57                          However, in humans, it is unknown whether cognitive function and brain struc
58 eficits and alpha-syn accumulation; however, it is unknown whether combining humoral and cellular imm
59 are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate
60 er SCI in association with axons and myelin, it is unknown whether complement proteins affect axon gr
61                                     However, it is unknown whether concomitant stimulus-induced chang
62                                              It is unknown whether cortical signals are stable for mo
63                                     However, it is unknown whether cortical thickness abnormalities r
64                                              It is unknown whether CPC dysfunction affects chromosome
65                                     However, it is unknown whether Cxxc1 plays a role in thymocyte de
66                                              It is unknown whether decreasing sodium intake to <2300
67                                              It is unknown whether diet quality is correlated with ac
68                               In particular, it is unknown whether different action categories follow
69 heir neighbouring membrane proteins, however it is unknown whether different membrane protein propert
70                                              It is unknown whether different visual acuity outcomes a
71 ed risk of adverse health outcomes; however, it is unknown whether discrimination is related to incid
72  and Epac2 activation can be arrhythmogenic, it is unknown whether distinct subcellular distribution
73 for alloimmune and autoimmune disorders, but it is unknown whether disturbances to T cell immunity ma
74                                     However, it is unknown whether dopamine is similarly involved wit
75                                     However, it is unknown whether DREAM is expressed in anucleate pl
76 mmon because of acute myocardial infarction, it is unknown whether early coronary angiography is asso
77                                              It is unknown whether EDAR stimulation in adults with XL
78  associated with disorders in childhood, but it is unknown whether effects persist into adulthood.
79 omatic cells has been demonstrated, however, it is unknown whether electrophysiologically-active soma
80                                              It is unknown whether elevated suPAR levels in patients
81                                     However, it is unknown whether endostatin p.D104N affects the ris
82                                   RATIONALE: It is unknown whether every ventricular myocyte expresse
83  improve S(I) in obese individuals; however, it is unknown whether exercise and RYGB surgery-induced
84                                              It is unknown whether exercise intolerance in PH coincid
85                                              It is unknown whether exposure of a 3D renal tissue mode
86 icator bacteria in urban coastal waters, but it is unknown whether exposure to seawater after rainsto
87                                              It is unknown whether exposure to selective serotonin re
88                                              It is unknown whether fingolimod affects microglial acti
89 synapses of cones and other retinal neurons, it is unknown whether Gbetagamma contributes to these ef
90                                              It is unknown whether genetic screening is indicated in
91 eratinocytes is incompletely understood, and it is unknown whether glycolytic regulation is essential
92 sclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infect
93                                              It is unknown whether habitual intake of dietary flavono
94                                 In contrast, it is unknown whether hereditary succession played a rol
95                                     However, it is unknown whether human CF macrophages have an indep
96                                     However, it is unknown whether hyperexcitability also occurs in M
97                                     However, it is unknown whether IL-10 also facilitates immune home
98 cytokine production in response to PGD2, but it is unknown whether ILC2s are active in patients with
99                                              It is unknown whether immunosuppression influences the p
100 ve pathway, is impaired in pancreatitis, but it is unknown whether impaired autophagy is a cause or a
101                                     However, it is unknown whether impairments are mediated by shared
102                                              It is unknown whether infants are predisposed to illness
103                                              It is unknown whether influenza vaccination of nonelderl
104                                              It is unknown whether inhibitory synapses at these two c
105  adult tissues, enhancers lack H3K27me3, and it is unknown whether intergenic H3K27me3 deposits affec
106 ibed in maturing mammalian granulocytes, but it is unknown whether IR occurs broadly in other hematop
107                                              It is unknown whether irradiation of the internal mammar
108                                     However, it is unknown whether IS patients are at increased risk
109 ry response is promptly activated after TBI, it is unknown whether it has a significant role in chron
110                                              It is unknown whether it is beneficial for patients to c
111                                              It is unknown whether it is necessary for beta-adrenergi
112  instruct map formation in sensory circuits, it is unknown whether it plays a role in the organizatio
113 rgic signaling alters histone modifications, it is unknown, whether it also affects other epigenetic
114                                    Moreover, it is unknown whether ketamine can be prophylactic again
115                                              It is unknown whether lactate contributes to energy meta
116                                  In insects, it is unknown whether LDs play any role during the devel
117                                              It is unknown whether levothyroxine treatment of women w
118                                              It is unknown whether local control is possible, for exa
119                                     However, it is unknown whether localized Ca(2+) release, such as
120 rosis (ALS) and frontotemporal dementia, but it is unknown whether loss of function, toxicity by the
121                                              It is unknown whether low levels of 1,5-anhydroglucitol
122 is shaped by localized growth responses, but it is unknown whether LPS influences these responses in
123                                              It is unknown whether LPS mediates ductular cell expansi
124 ssential role in auditory fear conditioning, it is unknown whether LTP is induced selectively in the
125                                    Moreover, it is unknown whether M-P streams exist in human cortex.
126  inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial
127                                     However, it is unknown whether maternal pregnancy adiposity is as
128                                              It is unknown whether mature O. vulgatum sporophytes for
129                                     However, it is unknown whether mechanical force and Wnt signaling
130                                     However, it is unknown whether mindfulness-meditation-based analg
131                                              It is unknown whether miR-33b is induced during or invol
132                                              It is unknown whether more sensitive cardiac troponin (c
133 to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antige
134 tumours expressing highly stabilized mutp53, it is unknown whether mutp53 is a therapeutic target in
135                                     However, it is unknown whether nAb titers define protection in th
136                                              It is unknown whether neuronal injury begins during acut
137                                              It is unknown whether neurons can dynamically control th
138                                     However, it is unknown whether neurons in the dorsal cochlear nuc
139                                     However, it is unknown whether neurons with such selectivity actu
140                                              It is unknown whether newer-generation temporary circula
141                                     However, it is unknown whether NFkappaB is a driver or a conseque
142 e alcohol drinking in nondependent rats, yet it is unknown whether nicotine facilitates the transitio
143 on by nitric oxide (NO); in plants, however, it is unknown whether NO affects histone acetylation.
144                                     However, it is unknown whether or how subtle differences in spike
145  a mixture of stress-released molecules, yet it is unknown whether or how these interact to mediate t
146 e of host RNAi triggers by pathogenic fungi, it is unknown whether or not such an uptake mechanism ha
147                                  At present, it is unknown whether or not ZIKV can infect, disseminat
148                                     However, it is unknown whether organismal function requires that
149 scription and histone removal in spermatids, it is unknown whether other BET family proteins play a r
150                                     However, it is unknown whether other NLR proteins are also able t
151 d clinical adoption of novel anticoagulants, it is unknown whether outcomes differ among patients wit
152                                              It is unknown whether P is the oxidant in each step or w
153                                              It is unknown whether "paradoxical" ERK activation occur
154                                              It is unknown whether parameters describing reticulated
155 itis associate with cardiovascular risk, but it is unknown whether particular groups of patients have
156                                              It is unknown whether pathological processes preceding e
157 ons are common after major surgery, although it is unknown whether patients achieve improved outcomes
158                               In particular, it is unknown whether patients' behaviour results from e
159                                              It is unknown whether people who spontaneously control H
160                                              It is unknown whether people with genetic enrichment for
161 requency with which cultural concerns arise, it is unknown whether physician diversity reflects that
162 eby preventing further fertilization events, it is unknown whether plant gametes prevent polyspermy b
163 higher rates of waitlist mortality than men; it is unknown whether practices surrounding delisting fo
164 ent of peripartum cardiomyopathy (PPCM), but it is unknown whether preeclampsia impacts clinical or l
165   However, unlike in oncology or cardiology, it is unknown whether PROs are associated with survival
166                                     However, it is unknown whether RE-induced forgetting is common to
167                               In particular, it is unknown whether reconsolidation can reorganize the
168 ugh observed in other memory domains [5, 6], it is unknown whether reconsolidation leads to strengthe
169                                     However, it is unknown whether regions of the scene network suppo
170 f postoperative RVOT obstruction and PR, but it is unknown whether relief of the right ventricular vo
171 from inflammation to tissue repair; however, it is unknown whether resolvins play a role in tissue re
172                                     However, it is unknown whether RNAs play any role in this process
173 m for both B cells and epithelial cells, and it is unknown whether serum neutralizing antibodies agai
174 ing acute physiological challenges; however, it is unknown whether sex differences in LV mechanics ar
175 AMPARs in artificial expression systems, but it is unknown whether Shisa7 has a functional role in gl
176 itical regulator of metabolism in the liver, it is unknown whether SHP is necessary to coordinate met
177                                              It is unknown whether similar network abnormalities are
178                                              It is unknown whether similar risks exist for recently p
179                                 Importantly, it is unknown whether smoking-related brain changes are
180 ength and when localized onto particles, but it is unknown whether spatial localization of short-chai
181 s has not been studied for the H3R; further, it is unknown whether splice variants of the same recept
182                                              It is unknown whether structured in-home support would y
183                                              It is unknown whether substantial weight loss improves t
184                                              It is unknown whether such communication occurs in respo
185                                     However, it is unknown whether such deficits are present in youth
186 owever, in most higher-order cortical sites, it is unknown whether such M-P streams exist and/or what
187                                     However, it is unknown whether such rapid adaption also occurs fo
188                                              It is unknown whether such sensitivity to spatial patter
189                                     However, it is unknown whether such training effects can be intro
190 cromolecules between these compartments, but it is unknown whether surveillance mechanisms exist to r
191                                     However, it is unknown whether synaptotagmin-7-dependent asynchro
192                                              It is unknown whether TAVR can be safely introduced to l
193                                              It is unknown whether temporal changes in therapy are as
194                                        Thus, it is unknown whether Th17 cell plasticity merely reflec
195                                              It is unknown whether the ability to visually distinguis
196                                              It is unknown whether the appropriate use of percutaneou
197 as changed substantially in the last decade, it is unknown whether the burden of ESRD due to multiple
198                                     However, it is unknown whether the CBS/H2S axis plays a role in c
199                                              It is unknown whether the concomitant use of inhaled glu
200                                              It is unknown whether the difference is explained by inc
201         However, with new methods available, it is unknown whether the findings will be consistent, i
202                                Additionally, it is unknown whether the function of single muscles is
203                                     However, it is unknown whether the GPs of the currently and previ
204                                              It is unknown whether the human immune system frequently
205                                              It is unknown whether the increased risk of heart failur
206                                     However, it is unknown whether the increased risk of Parkinson's
207  at high risk for adverse outcomes; however, it is unknown whether the magnitude of troponin elevatio
208                                              It is unknown whether the membrane itself plays an activ
209                                 In contrast, it is unknown whether the parental reproductive age has
210                                     However, it is unknown whether the past 60 y of changes in Ca ava
211 f motion occurs within a 3D environment, and it is unknown whether the principles from 2D motion proc
212                                              It is unknown whether the process of memory consolidatio
213 quently divergently transcribed in vivo, but it is unknown whether the resultant antisense RNAs are a
214 t cardiac function following bacteremia, but it is unknown whether the same occurs in humans with sev
215                                              It is unknown whether the spatial location of this vesse
216                                     However, it is unknown whether the stimulus regulating hypoxia-in
217 ain insufficiently understood; specifically, it is unknown whether the unopposed activation of the im
218                                              It is unknown whether the use of hormonal therapy, espec
219             However, for many endosymbioses, it is unknown whether their evolutionary basis is mutual
220                                   Meanwhile, it is unknown whether there exists a potential antagonis
221                                   Presently, it is unknown whether there is a causal link between alt
222                                  At present, it is unknown whether there will be sufficient cross-rea
223 creased risk of infective endocarditis (IE), it is unknown whether these abnormalities are associated
224                                              It is unknown whether these benefits remain when NOACs h
225  (memory phenotype CD8(+) T cells [TM]), but it is unknown whether these cells retain memory function
226 espread changes within the motor cortex, but it is unknown whether these changes are ultimately funne
227                                              It is unknown whether these changes continue to affect h
228                                              It is unknown whether these clusters play a role in post
229                                              It is unknown whether these convulsants act as negative
230                                              It is unknown whether these effects differ across anti-V
231                                     However, it is unknown whether these glycolipids activate human i
232                                     However, it is unknown whether these improvements were consistent
233                                     However, it is unknown whether these late-segregating acentric fr
234                                              It is unknown whether these lesions persist and what dir
235 sion of information processing in noise, but it is unknown whether these markers are present in pre-r
236 m clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from mel
237 enes is associated with tobacco exposure but it is unknown whether these methylation changes translat
238 nt genetic changes in colorectal tumors, but it is unknown whether these mutations phenocopy gain-of-
239                                              It is unknown whether these patients have a prothromboti
240                                              It is unknown whether these pro-inflammatory lymphocytes
241                                              It is unknown whether these proinflammatory lymphocytes
242                                              It is unknown whether these receptors are interchangeabl
243                                     However, it is unknown whether these shared manifestations of cog
244                                     However, it is unknown whether these three cytosolic carboxypepti
245 herapeutic drugs and confer drug resistance, it is unknown whether these transporters are expressed o
246  and visual perceptual performance; however, it is unknown whether these two dopamine-mediated phenom
247 rons by chronic manipulations of firing, but it is unknown whether they are coinduced by the same act
248                      For most RTKs, however, it is unknown whether they can exploit this new signalin
249 enger receptors (SR-As) mediate dsRNA entry, it is unknown whether they contribute to signaling beyon
250           However, for most C2H2-ZF proteins it is unknown whether they even bind DNA or, if they do,
251                                     However, it is unknown whether they exert their actions through s
252 high levels of CD44 accumulate with age, but it is unknown whether this accumulation reflects their p
253                                     However, it is unknown whether this action is unique to hERG1 cha
254                                              It is unknown whether this advantage extends to childhoo
255                                              It is unknown whether this association can be extrapolat
256 ated with a higher risk of suicide; however, it is unknown whether this association is also present i
257 of mortality of anaphylactic shock (AS), but it is unknown whether this association remains valid for
258  for the DAT endocytic brake is unknown, and it is unknown whether this braking mechanism is unique t
259                                     To date, it is unknown whether this clustering process can be dis
260 re depleted during ischemia-reperfusion, but it is unknown whether this depletion is a cause or an ef
261 y increases the risk of type 2 diabetes, but it is unknown whether this effect is specific to statins
262 ascular integrity at mid-gestation; however, it is unknown whether this enzyme contributes to later b
263  cognitive shifts could recruit the DMN, yet it is unknown whether this holds for nonhuman species.
264                                              It is unknown whether this hyperinflammatory response in
265 to have low-grade systemic inflammation, but it is unknown whether this inflammation starts before sy
266 tion has been observed in human cancers, yet it is unknown whether this is a bystander event or a dri
267                                              It is unknown whether this is because of low intake or a
268  with rhinovirus (RV) infections wheeze, but it is unknown whether this is due to more virulent strai
269 at AWR leads to improvement in function, but it is unknown whether this is specific to the abdominal
270                                     However, it is unknown whether this mechanism contributes to faci
271                                              It is unknown whether this neural signature predicts ris
272                                              It is unknown whether this preparatory activity is local
273 ) can be linked by apparent competition, but it is unknown whether this process is strong enough to b
274                                    Currently it is unknown whether this proliferative arrest presents
275                                     However, it is unknown whether this reactivity is beneficial or h
276                                      As yet, it is unknown whether this reduction precedes or results
277 ted with reduced dorsal striatal volume, but it is unknown whether this relationship extends to adole
278                                              It is unknown whether this relationship remains reliable
279                                              It is unknown whether this relationship stems from havin
280 ng necessary proteins at synaptic sites, but it is unknown whether this requires initiation or bypass
281                                              It is unknown whether this results in activation of coag
282                                     However, it is unknown whether this risk extends to the full year
283 ed risk of cardiovascular disease (CVD), but it is unknown whether this risk remains after adjustment
284 0-year risk of CVD in midadulthood; however, it is unknown whether this risk score is associated with
285 ed alga,Symbiodinium thermophilum Currently, it is unknown whether this symbiont originated elsewhere
286                                              It is unknown whether this systems-level pathophysiology
287 CU) beds in the United States is increasing, it is unknown whether this trend is consistent across al
288                                              It is unknown whether this was due to intrinsic TRAIL re
289 ociated with xeric/mesic ecotype divergence, it is unknown whether those traits evolve independently
290                                        Since it is unknown whether thyroid hormones (THs) regulate mi
291 ecreased risk of rejecting a maternal graft, it is unknown whether TME plays a role in development of
292 ARE proteins between opposing membranes, but it is unknown whether transmembrane domains (TMDs) of SN
293                                              It is unknown whether treatment with oral insulin can in
294                                              It is unknown whether tRNS on the atypically developing
295                                              It is unknown whether twins have shared in this reductio
296                                              It is unknown whether ubiquitous transcription is functi
297                                              It is unknown whether urine kidney injury biomarkers are
298 al S-adenosyl-l-methionine (SAM) enzyme, but it is unknown whether viperin actually exploits radical
299                                              It is unknown whether XEEL has the same ligand specifici
300                                     However, it is unknown whether ZIKV replicates in the vagina and

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