ライフサイエンスコーパス: it remains unclear how

1 decades of work on visual motion processing, it remains unclear how 3D directions-trajectories that i

2 It remains unclear how a brain that rapidly forgets, or

3 Currently it remains unclear how a cell population's growth rate a

4 It remains unclear how a dynein dimer is able to transpo

5 given that the BMP signal can be diffusible, it remains unclear how a local extracellular asymmetry i

6 protein 2 (MeCP2), but despite much effort, it remains unclear how a loss of MeCP2 function generate

7 It remains unclear how a mutation in a small fraction of

8 (PTM) involved in regulating chromatin, yet it remains unclear how acetylation modifies the disorder

9 It remains unclear how agonist binding to the ligand-bin

10 However, it remains unclear how alterations in cell adhesion coor

11 It remains unclear how ancient periods of climate change

12 lesions predominantly originate prenatally, it remains unclear how and when exactly MCT8 dysfunction

13 However, it remains unclear how and when the brain processes topo

14 It remains unclear how and when the nervous system solve

15 ominant role in these pCO2 fluctuations, but it remains unclear how and where in the ocean CO2 was st

16 However, it remains unclear how and where this molecule is formed

17 However, it remains unclear how and why the 7SK snRNP is assemble

18 It remains unclear how apical constriction is regulated

19 However, it remains unclear how astrocytes control the release of

20 hip is essential for astrocyte function, but it remains unclear how astrocytes establish their intric

21 However, it remains unclear how ATPase activity and MT binding ar

22 o inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestin

23 this pathway are increasingly well defined, it remains unclear how autophagy modulation impacts norm

24 ed breaks via homologous recombination (HR), it remains unclear how BMI1 regulates checkpoint activat

25 l, hematopoietic, and brain development, but it remains unclear how BRPF1 is linked to human developm

26 However, it remains unclear how cancer subtypes with different on

27 esicular endosomes with the plasma membrane, it remains unclear how cargos are selected for exosomal

28 However, it remains unclear how cells coordinate DNA synthesis wi

29 It remains unclear how cells overcome the deleterious ef

30 ived as a unified sensory object--a "smell." It remains unclear how chemical features encoded by dive

31 However, it remains unclear how ChlF and photosynthesis are linke

32 However, it remains unclear how cholinergic neurons in the brain

33 However, it remains unclear how circulating T-cells can escape fr

34 However, it remains unclear how cognitive impairments affect func

35 However, it remains unclear how 'cognitive' cortical representati

36 However, it remains unclear how cohesin-mediated interactions con

37 colonize and exploit particle resources, but it remains unclear how community dynamics emerge from th

38 It remains unclear how components of the NHEJ machinery

39 However, it remains unclear how consensus is achieved in stable g

40 It remains unclear how correlated variability affects th

41 It remains unclear how cortical anatomy might influence

42 to alter substrate choice by ClpXP; however, it remains unclear how CpdR influences its multiple targ

43 mmation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death.

44 It remains unclear how cytoskeletal filaments and motor

45 y extrathymic regulatory T (Treg) cells, yet it remains unclear how DCs regulate induction of such to

46 It remains unclear how deaminases access double stranded

47 Yet it remains unclear how deposit formation is restricted t

48 er an organism's metabolic requirements, and it remains unclear how development and metabolic demands

49 However, it remains unclear how diastolic Ca release contributes

50 It remains unclear how dietary intake can influence HDP

51 However, it remains unclear how differences in the TCR contribute

52 he clinical application of this information, it remains unclear how different cellular processes inte

53 However, it remains unclear how different conformations of the di

54 node in host cell stress responses, although it remains unclear how different forms of stress activat

55 additional transcription factor binding, yet it remains unclear how different pioneer factors achieve

56 It remains unclear how different subpopulations of cance

57 It remains unclear how different translocator protein (T

58 spite this, DP cells appear homogeneous, and it remains unclear how distinct TCR signalling instructs

59 lytical applications have been demonstrated, it remains unclear how DNA hybridization takes place in

60 and negative symptoms of schizophrenia, but it remains unclear how dopamine dysfunction could mechan

61 Despite two decades of research, it remains unclear how dopamine neurons make this calcul

62 MtrD delivers drugs to the channel of MtrE, it remains unclear how drug delivery and channel opening

63 However, it remains unclear how dynamic DNA methylation relates t

64 It remains unclear how dynein coordinates this diverse s

65 However, it remains unclear how dynein is spatially and temporall

66 However, it remains unclear how each Pellino member distinctly re

67 strategy for removing pathological tau, but it remains unclear how effectively tau aggregates can be

68 polymerases as 5-FU in the genome; however, it remains unclear how either genomically incorporated U

69 iring of inhibitory hippocampal neurons, but it remains unclear how elevated inhibition could account

70 disease and non-compaction cardiomyopathies, it remains unclear how embryonic cardiomyocytes assemble

71 However, it remains unclear how EndoG binds and digests DNA.

72 ignals in tumor-host cell communication, yet it remains unclear how endogenously produced tEVs affect

73 However, it remains unclear how EP neurons encode information and

74 fection endured by sex-trafficked women, but it remains unclear how exposure to trafficking puts its

75 have helped define human NP cell phenotype, it remains unclear how expression of these markers is in

76 However, it remains unclear how EZH2 switches to this catalytic i

77 However, it remains unclear how far the field has progressed as a

78 Thus, it remains unclear how feedback from mature cells is con

79 However, it remains unclear how fibronectin (FN), type 1 collagen

80 of FTLD-Tau patient neuronal cells in vitro, it remains unclear how FTLD-Tau patient neurons degenera

81 is often implicated in the illness, although it remains unclear how functional alterations of the reg

82 lytic mechanism of bacterial NRPSs is known, it remains unclear how fungal NRPSs create products of d

83 However, it remains unclear how GAG structures are changed during

84 onrandomly organized within the nucleus, but it remains unclear how gene position affects gene expres

85 However, it remains unclear how generalizable this finding is in

86 Nonetheless, it remains unclear how genotypic information should be u

87 c and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysos

88 vidence for an alternating access mechanism, it remains unclear how H(+)- and sugar-binding trigger t

89 However, it remains unclear how healthy neurons regulate the dual

90 However, it remains unclear how HHIP contributes to COPD pathogen

91 related with overall gene expression levels, it remains unclear how histone modification enrichment a

92 It remains unclear how history of adaptation to one anti

93 /Meis families to control transcription, but it remains unclear how Hox:TALE complexes function.

94 Notably, it remains unclear how HVEM functions with each of its l

95 However, it remains unclear how hypoxia-induced transcription fac

96 es the risk of breast cancer in black women, it remains unclear how hysterectomy without ovary remova

97 are considered lineage-specific repressors, it remains unclear how identical combinations of transcr

98 st inhibition by normal cellular mechanisms, it remains unclear how important it is that the GHVs res

99 However, it remains unclear how individual family members partici

100 It remains unclear how individual groups of brainstem ne

101 However, it remains unclear how individual T cells integrate such

102 neural correlates of conscious experiences, it remains unclear how individuals exert control over th

103 However, it remains unclear how infection initially becomes laten

104 ncluding Slits and their Robo receptors, but it remains unclear how information from multiple cues is

105 However, it remains unclear how interactor selection, and thus fa

106 However, it remains unclear how intercellular signaling among som

107 It remains unclear how interleukin-21 receptor (IL-21R)

108 However, it remains unclear how IRF5 and Blimp-1 (a transcription

109 Free CSN is autoinhibited, and it remains unclear how it becomes activated.

110 s an important part of art appreciation, but it remains unclear how it can be applied to artworks for

111 ntrolling these developmental processes, but it remains unclear how it works.

112 recipient thalamus controls motor output but it remains unclear how its activity is regulated.

113 circuits underlying motivated behavior, but it remains unclear how its inputs from different sources

114 ver of B-ALL development in mice and humans, it remains unclear how its loss contributes to leukemoge

115 However, it remains unclear how kinesin-based transport could the

116 In contrast, it remains unclear how known regulators of innate immuni

117 However, it remains unclear how LAP shapes both the activation an

118 rain states have been studied for some time, it remains unclear how large-scale cortico-cortical func

119 However, it remains unclear how learning and consolidation requir

120 Therefore, it remains unclear how ligands modulate a GPCR's activit

121 It remains unclear how lipids directly affect these chan

122 It remains unclear how LKB1 inactivation coordinates tum

123 However, it remains unclear how Loc1p is recruited into this mRNP

124 It remains unclear how local chemical events in its ATPa

125 It remains unclear how localized radiotherapy for cancer

126 However, it remains unclear how long-term, chronic MJ use alters

127 However, it remains unclear how low- and high-salt taste percepti

128 own about the underlying signaling pathways, it remains unclear how macroscopic features of branched

129 e islands since the 5(th) century BCE [1-3], it remains unclear how many times, and by whom, the isla

130 used on how MDSCs promote tumor progression, it remains unclear how MDSCs develop and why the MDSC re

131 als are employed to control gene expression, it remains unclear how mechanical forces are transduced

132 the onset and duration of windows, although it remains unclear how mechanisms that shape synapse dev

133 Despite decades of research, it remains unclear how MeCP2 regulates transcription or

134 It remains unclear how microbial communities respond to

135 rtant component of gene regulatory networks, it remains unclear how microRNAs collaborate with transc

136 iated proteins can be found in mitochondria, it remains unclear how mitochondrial dysfunction and pro

137 Rs) in maintaining proper striatal function, it remains unclear how MSN collaterals are specifically

138 through a simple signaling pathway; however, it remains unclear how much of the diversity in auxin ef

139 However, it remains unclear how mutations that disrupt synapse fu

140 c amplification occurs in high-risk subsets, it remains unclear how MYCN expression is regulated in t

141 ocused on description of the phenomenon, but it remains unclear how NAHR occurs during meiosis and wh

142 However, it remains unclear how naive T cells survive for years w

143 However, it remains unclear how nanoscale bubbles manage to reach

144 onnectivity or stimulus-driven analyses, but it remains unclear how network properties change as syne

145 It remains unclear how neurons are able to dissociate pr

146 is has become increasingly evident; however, it remains unclear how Notch activities are regulated in

147 However, it remains unclear how Notch regulates the balance betwe

148 e to developing liver cancer than males, and it remains unclear how nutrition affects tumorigenesis i

149 It remains unclear, how often the CCI adds to standard r

150 olfactory responses to pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs)

151 n of left ventricular ejection fraction, yet it remains unclear how or whether DD affects cardiac hem

152 ity over a wide range of signal intensities, it remains unclear how other parameters such as adaptati

153 athway is involved in TSC pathology, however it remains unclear how other signaling pathways are pert

154 To date, it remains unclear how pancreatic lumens form and remode

155 twork assembly have been well characterized, it remains unclear how particle geometry and large-scale

156 ptional repression of pax6 and pax2 However, it remains unclear how Pax6 protein is removed from the

157 perception have been identified in the past, it remains unclear how perceptions of risk change when p

158 ly interacting TFs have been identified, but it remains unclear how pervasive this mechanism is durin

159 However, it remains unclear how phosphoproteomic changes occur an

160 However, it remains unclear how pilus expression is regulated and

161 However, it remains unclear how plant cells form well-organized c

162 It remains unclear how plants achieve retrograde cargo t

163 he engagement of glycoprotein VI (GPVI), but it remains unclear how platelets prevent inflammatory bl

164 , it lacks a pleckstrin homology domain, and it remains unclear how PLCzeta targets its phosphatidyli

165 But it remains unclear how PMO, a phenomenon limited to the

166 It remains unclear how PMv networks can flexibly link pe

167 stsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptor

168 to only a handful of mammalian origins, and it remains unclear how PR-Set7 and H4K20 methylation imp

169 However, it remains unclear how PRMT1 product specificity is regu

170 However, it remains unclear how protective MHC types can blunt au

171 olve the loss of intercellular adhesion, but it remains unclear how proteins that regulate alteration

172 nts are critical components of vaccines, but it remains unclear how prototypical adjuvants enhance th

173 fect components of the RAS/MAPK pathway, yet it remains unclear how PTPN11 mutations alter cellular s

174 (DBP) formation in finished water; however, it remains unclear how quality and quantity of overall a

175 icroorganisms residing in the human gut, but it remains unclear how rapidly and reproducibly the huma

176 However, it remains unclear how readily cross-feeding interaction

177 It remains unclear how receptors such as Srs2 specifical

178 Despite the ubiquity of these networks, it remains unclear how regions within these large-scale

179 However, it remains unclear how respiratory surfaces and associat

180 However, it remains unclear how REV1 is recruited to the sites wh

181 It remains unclear how RICD sensitivity is calibrated in

182 With the inhibitory impact of RIF1 relieved, it remains unclear how RNF168-induced ubiquitylation inf

183 It remains unclear how robust SAOMs are to missing data

184 However, it remains unclear how SCF+G-CSF repairs the brain in ch

185 It remains unclear how sedentary behaviour and different

186 However, it remains unclear how selectivity for these stimulus pr

187 y on morphological and cytological data, but it remains unclear how Sequoia became polyploid and why

188 Unlike kinases, it remains unclear how serine/threonine phosphatases eng

189 esses more than 40 c-di-GMP-related enzymes, it remains unclear how signaling specificity is maintain

190 It remains unclear how single neurons in the human brain

191 It remains unclear how SMCs structure chromosomes and ho

192 Yet, it remains unclear how social experience shapes pro-soci

193 It remains unclear how specific interactions of Myo5B wi

194 However, it remains unclear how specific target genes are regulat

195 es of this pathway are now well established, it remains unclear how specificity of the pathway is con

196 It remains unclear how spontaneous and evoked transmissi

197 However, it remains unclear how SSRIs, which inhibit the plasma m

198 been studied in these and other cell types, it remains unclear how stem cells and progenitors change

199 However, it remains unclear how STUbLs interact with other protei

200 ted that GPCRs adopt multiple conformations, it remains unclear how subtle conformational changes are

201 into disease spread and pathogen adaptation, it remains unclear how successfully they may be used to

202 s can bind and possibly activate N-WASP, but it remains unclear how such binding events relieve autoi

203 evidence of sudden changes in behavior, but it remains unclear how such epiphanies occur.

204 s are needed in a defined stoichiometry, and it remains unclear how such production is achieved since

205 It remains unclear how sustained DCS affects ongoing syn

206 nce the ICM exists only transiently in vivo, it remains unclear how sustained propagation of naive ES

207 However, it remains unclear how synaptic transmission changes at

208 CD70 is also expressed on activated T cells, it remains unclear how T cell-derived CD70 affects T cel

209 hanges in plant and animal biodiversity, but it remains unclear how temperatures affect microbial bio

210 has proved to be frustratingly elusive, and it remains unclear how the 5-HT signalling effects of an

211 Yet, it remains unclear how the aberrant mRNAs are recognized

212 However, it remains unclear how the activity of ACF7 is regulated

213 However, it remains unclear how the APOE genotype affects plaque

214 In particular, it remains unclear how the auditory brain is able to ext

215 It remains unclear how the brain consolidates early labi

216 o the human experience of panic anxiety, but it remains unclear how the brain dynamically represents

217 It remains unclear how the brain represents external obj

218 Particularly, it remains unclear how the cascade components collective

219 h is known about protein folding in buffers, it remains unclear how the cellular protein homeostasis

220 However, it remains unclear how the coordinated behaviour of cyto

221 ensive studies have focused on this protein, it remains unclear how the dimeric full-length TDP-43 is

222 However, it remains unclear how the DNA damage checkpoint is acti

223 holesterol insufficiency are well described, it remains unclear how the ER senses and effectively def

224 rotubule nucleation in eukaryotic cells, but it remains unclear how the gamma-TuC becomes active spec

225 It remains unclear how the GPIb-IX-V complex is assemble

226 susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325),

227 mbryogenesis from hemogenic endothelium, but it remains unclear how the HSC lineage is initially esta

228 However, it remains unclear how the Hsp70 conformational ensemble

229 It remains unclear how the interaction of gamma with spe

230 However, it remains unclear how the interactions between TAL1 and

231 by the S1pr2/Galpha13 signaling pathway, but it remains unclear how the movements of the two tissues

232 one specific type of salience independently, it remains unclear how the NAcc concurrently differentia

233 However, it remains unclear how the OCM is subsequently converted

234 onent has been studied in detail previously, it remains unclear how the physiological parameters are

235 ion of Rh1 is internalized and degraded, but it remains unclear how the rhabdomeric Rh1 pool is reple

236 ecialized adaptation of limb morphology, yet it remains unclear how the specification of digit-innerv

237 However, it remains unclear how the speech signal is transformed

238 identified during rest and task states, yet it remains unclear how the two relate.

239 macological origins or following injury, but it remains unclear how the unaffected brain escapes this

240 However, it remains unclear how the visual cortex responds to rec

241 epends on microtubule attachment status, but it remains unclear how their assembly/disassembly is orc

242 nstream targets are often diverse, therefore it remains unclear how their expression is specialized w

243 However, it remains unclear how their sequence controls the physi

244 It remains unclear how these 2 opposite functions of p38

245 However, it remains unclear how these approaches compare when app

246 d with a variety of cognitive abilities, yet it remains unclear how these connectivity properties mig

247 It remains unclear how these cytokines are produced desp

248 It remains unclear how these DNA translocases harness ch

249 However, it remains unclear how these events are temporally coord

250 However, it remains unclear how these FMRP activities relate to e

251 However, it remains unclear how these forms of plasticity interac

252 ly observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities con

253 ROCK control distinct pools of cellular SFs, it remains unclear how these kinases differ in their reg

254 However, it remains unclear how these lesions compromise DNA repl

255 It remains unclear how these metalloregulator-DNA intera

256 n-2 (IL-2) by mature dendritic cells (mDCs), it remains unclear how these molecules participate in th

257 er cancers by targeting IDH mutant proteins, it remains unclear how these mutants affect tumor develo

258 It remains unclear how these mutations affect SNARE zipp

259 rmation relevant to emotional processes, but it remains unclear how these neurons are functionally an

260 genetic determinant for T2D risk in humans, it remains unclear how these noncoding variants affect d

261 It remains unclear how these opposing interactions are r

262 However, it remains unclear how these pathways interact during SA

263 s been implicated in lineage allocation, but it remains unclear how these processes are coordinated.

264 critical for proper protein homeostasis, yet it remains unclear how these processes are dynamically r

265 rlin has no known actin-regulatory activity, it remains unclear how these proteins work together to i

266 However, it remains unclear how these rapid shifts in behavior ar

267 However, it remains unclear how these signals are regulated and h

268 It remains unclear how these signals evolve.

269 nd share extensive neuronal connections, yet it remains unclear how these structures represent time.

270 FOXO genes are infrequent in human cancers, it remains unclear how these tumour suppressors are elim

271 the individual kinases have been identified, it remains unclear how they act in concert to ensure fai

272 the cornerstone of protective immunity, yet it remains unclear how they are durably maintained.

273 ve been implicated in GpIbalpha binding, but it remains unclear how they are involved.

274 phenomena have been investigated in detail, it remains unclear how they are related to each other an

275 Yet it remains unclear how they arise.

276 However, it remains unclear how they differentially interact with

277 eriplasm and link inner and outer membranes, it remains unclear how they operate efficiently without

278 key signaling pathways have been identified, it remains unclear how they work together to provide spe

279 However, it remains unclear how this circuit enables cells to def

280 It remains unclear how this common signaling pathway can

281 act in a mutually antagonistic fashion, but it remains unclear how this interaction generates polari

282 l-2 proteins during mitotic arrest; however, it remains unclear how this mechanism accounts for signi

283 It remains unclear how this network forms and how it aff

284 nnected to distributed regions in the brain, it remains unclear how this network is engaged in consti

285 However, it remains unclear how this pathway is affected, and whe

286 It remains unclear how this remarkable discrimination is

287 However, it remains unclear how tightly coupled eRNA production i

288 Nevertheless, it remains unclear how TIP60-mediated effects on p53 are

289 on algorithms were released in the last 3 y, it remains unclear how to benchmark them and how to asse

290 n 20-fold in tropical evergreen forests, but it remains unclear how to capture these variations using

291 presents an attractive therapeutic strategy, it remains unclear how to choose the microbiota repertoi

292 As a result, it remains unclear how to optimally synthesize and chemi

293 It remains unclear how Treg cells orchestrate their home

294 However, it remains unclear how TrmB dynamically regulates its ap

295 It remains unclear how TRPM6 affects divalent cation tra

296 It remains unclear how Twist induces gene expression.

297 of fungi and the plant Arabidopsis thaliana, it remains unclear how UPF1 is activated outside the met

298 However, it remains unclear how widespread these enhancements are

299 orient mitotic spindles in development, but it remains unclear how Wnt signaling is spatially contro

300 In many organisms, it remains unclear how X chromosomes are specified for d