ライフサイエンスコーパス: ivermectin

1 orm infection were 57% (moxidectin) and 56% (ivermectin).

2 glycine, or glycine and ivermectin (glycine/ivermectin).

3 lexed with the positive allosteric modulator ivermectin.

4 ectin starting from the structure with bound ivermectin.

5 eported to be successfully treated with oral ivermectin.

6 for moxidectin compared to 95.2% (59/62) for ivermectin.

7 e patient was treated successfully with oral ivermectin.

8 laricidal and possibly sterilizing effect of ivermectin.

9 s are the site of action of the anthelmintic ivermectin.

10 h-level resistance to the antiparasitic drug ivermectin.

11 se in the affinity for nodulisporic acid and ivermectin.

12 to receive placebo or standard- or high-dose ivermectin.

13 annual or 3-monthly (quarterly) exposures to ivermectin.

14 d for 3 days after a single systemic dose of ivermectin.

15 n prevalence by mass distribution of donated ivermectin.

16 hieved in some areas following many years of ivermectin.

17 t serve as an alternative to the widely used ivermectin.

18 d current and was modulated significantly by ivermectin.

19 wed desensitization and was not modulated by ivermectin.

20 ctures of C. elegans GluCl in the absence of ivermectin.

21 se to the P2X4R-specific allosteric enhancer ivermectin.

22 y Cu(2+), and the P2X4 modulators Zn(2+) and ivermectin (0.3-3 microM) each increased intracellular [

23 Oral ivermectin, 12 mg, was given, and the eruption cleared w

24 total) from Manaus, Brazil, with single-dose ivermectin (200 microg/kg).

25 efficacy and safety of moxidectin (8 mg) vs ivermectin (200 mug/kg) against S. stercoralis infection

26 P2X4 receptor-selective allosteric enhancer ivermectin (3 microM), the 2-meSATP-stimulated current i

27 testing, a total of 15,522 (95.5%) received ivermectin, 340 (2.1%) were excluded from ivermectin dis

28 Ivermectin, 4-vynilpiridine and ethylene glycol dimethac

29 proaches to include the mass distribution of ivermectin - a drug donated by Merck & Co. for disease c

30 This formulation is designed to release ivermectin, a mosquito-killing drug for 10 days after a

31 The compounds considered are ivermectin, abamectin, emamectin, eprinomectin, doramect

32 Treatment with a single dose of oral ivermectin achieved resolution of her symptoms.

33 g direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.

34 these individuals may be excluded from mass ivermectin administration campaigns against onchocercias

35 a single or repeated dose (200 microg/kg) of ivermectin (AL-IVM1 and AL-IVM2, respectively).

36 hs following treatment with a single dose of ivermectin-albendazole, some of these defects were rever

37 significantly between children who received ivermectin alone and those who were treated with ivermec

38 lacebo, 22 [76%] albendazole alone, 17 [61%] ivermectin alone remained positive; p = 0.004).

39 Treatment with ivermectin, an importin inhibitor, blocked HE4/importin-

40 ), or a combination of 200-400 micrograms/kg ivermectin and 400 mg albendazole (n = 24).

41 0 microL blood among those who received both ivermectin and albendazole (p = 0.0001).

42 mectin alone and those who were treated with ivermectin and albendazole [corrected].

43 ng the efficacy and tolerability or combined ivermectin and albendazole in Haitian schoolchildren.

44 fti microfilaraemia, combined treatment with ivermectin and albendazole was more effective than treat

45 ed to inform other studies on anthelmintics (ivermectin and emodepside) that act on ion channels.

46 x was determined with the allosteric agonist ivermectin and in additional structures with the endogen

47 cyclic lactones (ML) (abamectin, doramectin, ivermectin and moxidectin) in butter, using liquid chrom

48 pha antibodies immunoprecipitated all of the ivermectin and nodulisporic acid receptors solubilized b

49 In the near future, ivermectin and other endectocides could serve as potent

50 nd channel block, and the mechanism by which ivermectin and related molecules stabilize the open stat

51 activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providin

52 nistrations, potentially in combination with ivermectin and vaccination, mass screening and treatment

53 treat filariasis include diethylcarbamazine, ivermectin, and albendazole, which are used mostly in co

54 hese two ligands was modulated by glutamate, ivermectin, and antagonists of invertebrate gamma-aminob

55 d 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decrease

56 There are limited data on the activity of ivermectin as a topical lousicide.

57 esults revealed the cytotoxins etoposide and ivermectin as potent inducers, allowing us to isolate an

58 that topical brimonidine, azelaic acid, and ivermectin, as well as oral doxycycline and isotretinoin

59 sociated with the initiation and severity of ivermectin-associated adverse reactions.

60 lly, positive allosteric modulation of P2X4 (ivermectin) augmented ATP-mediated CXCL5 secretion.

61 Implementation of an ivermectin-based community treatment strategy for the el

62 idiasis, but required a course of parenteral ivermectin because of malabsorption from severe gastroin

63 It increased the K(d) for radiolabeled ivermectin binding from 0.35 +/- 0.1 to 2.26 +/- 0.78 nM

64 Ivermectin binding was composed of at least two kinetica

65 produced no detectable channel activity, but ivermectin binding was similar to wild-type.

66 ) had no effect on l-glutamate activation or ivermectin binding: one (T300S) produced no detectable c

67 revent pumping, in the absence of the AVR-15 ivermectin-binding channel on pharynx muscle, is to targ

68 P2X4, the lysosomal P2X4 was potentiated by ivermectin but insensitive to suramin and PPADS, and it

69 nel modified to be activated by low doses of ivermectin (but not glutamate) is highly effective in si

70 However, ivermectin can also inhibit pumping in the absence of th

71 In such cases, treatment with ivermectin can be beneficial.

72 This study indicates that parenteral ivermectin can be used safely and effectively in patient

73 ite evidence that single-dose treatment with ivermectin can greatly reduce the concentration of Wuche

74 sis in areas where loiasis is co-endemic and ivermectin cannot be safely mass administered.

75 omprehensive multiple-dose clinical trial of ivermectin, comparing 3-monthly with annual treatments a

76 st-bound open channel state, and the glycine/ivermectin complex adopts a potentially desensitized or

77 in a variety of systems, we question whether ivermectin could have additional modes of action on para

78 We propose that one of the ways ivermectin could prevent pumping, in the absence of the

79 Treatment with either albendazole or ivermectin cured all patients with most responding withi

80 maximal ivermectin response, indicating that ivermectin depolarizes the muscle by the same ionic mech

81 smission; and (ii) a nematocidal property of ivermectin derives from its activity as an agonist of gl

82 However, one dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) has bee

83 ed ivermectin, 340 (2.1%) were excluded from ivermectin distribution because of an L. loa microfilari

84 abled the reimplementation of community-wide ivermectin distribution in a heretofore "off limits" hea

85 Switching from annual to biannual ivermectin distribution may accelerate progress toward t

86 utic or preventative modality (separate from ivermectin distribution or vector control), elimination

87 al African countries have adopted a biannual ivermectin distribution strategy in some foci to control

88 erious adverse events, and exclude them from ivermectin distribution.

89 ted severe posttreatment reactions following ivermectin distribution.

90 crucially depends on the effects of multiple ivermectin doses on Onchocerca volvulus.

91 channels responded to low concentrations of ivermectin (estimated EC(50) = approximately 0.1 +/- 1.0

92 ress this question, 14 patients treated with ivermectin for onchocerciasis acquired >10 years ago dur

93 ght be a safe and efficacious alternative to ivermectin for the treatment of S. stercoralis infection

94 Samples, fortified with ivermectin from 50 to 500 mug kg(-1), were used to build

95 haracterized and used for direct analysis of ivermectin from bovine meat samples, in a two-dimensiona

96 lyR with strychnine, glycine, or glycine and ivermectin (glycine/ivermectin).

97 CI, 35 to 73), and from 24.6% to 8.0% in the ivermectin group (relative reduction, 67%; 95% CI, 52 to

98 CI, 49 to 75), and from 32.1% to 1.9% in the ivermectin group (relative reduction, 94%; 95% CI, 83 to

99 ild and were reported more frequently in the ivermectin group than in the permethrin group (15.6% vs.

100 roup), or mass administration of ivermectin (ivermectin group).

101 In the ivermectin group, there was a significant correlation be

102 ups, with the greatest reduction seen in the ivermectin group.

103 ups, with the greatest reduction seen in the ivermectin group.

104 532 in the permethrin group, and 716 in the ivermectin group.

105 Ivermectin has been on the veterinary market for almost

106 Ivermectin has controlled transmission of microfilariae,

107 The discovery of the drug ivermectin has provided humankind with a powerful new me

108 Multiple doses of ivermectin have a partial macrofilaricidal and a modest

109 pproved drug available for mass treatment is ivermectin, however, drug resistance is beginning to eme

110 The efficacy of ivermectin in ameliorating behavioural hypersensitivity

111 e found in samples of bovine muscle and only ivermectin in bovine liver.

112 o monitoring withdrawal period specified for ivermectin in cattle.

113 ependently by three approaches: analogy with ivermectin in the GluCl crystal structure, automated doc

114 3)-mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X

115 Ivermectin is a widely used anthelmintic drug whose nema

116 hocerciasis with diethylcarbamazine (DEC) or ivermectin is associated with a posttreatment reaction c

117 The nematocidal drug ivermectin is believed to kill worms by opening a glutam

118 field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underly

119 Ivermectin is one of the most important drugs in veterin

120 Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate hu

121 permethrin group), or mass administration of ivermectin (ivermectin group).

122 Ivermectin (IVM) has been the drug of choice for the tre

123 The endectocide ivermectin (IVM) induces a similar, but larger current t

124 We show that ivermectin (IVM) is a specific positive allosteric effec

125 Ivermectin (IVM) is widely used in both human and veteri

126 Ivermectin (IVM) may reduce malaria transmission by kill

127 eceptors is the presence of the large ligand ivermectin (IVM) positioned between all five subunits.

128 lRs) are ion channels serving as targets for ivermectin (IVM), a broad-spectrum anthelmintic drug use

129 inding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent.

130 Ivermectin (Ivm), a glycine receptor (GLR) agonist, was

131 We probed these motions using ivermectin (IVM), a macrocyclic lactone that stabilizes

132 antifilarial drugs diethylcarbamazine (DEC), ivermectin (IVM), and albendazole (ALB) for LF are unkno

133 Ivermectin (IVM), used alongside mass treatment strategi

134 ne (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administrat

135 lly in mouse striatum a modified heteromeric ivermectin (IVM)-gated chloride channel from C. elegans

136 We express invertebrate ivermectin (IVM)-sensitive chloride channels (Caenorhabd

137 urons upon exposure to the anthelmintic drug ivermectin (IVM).

138 ubsequent protein exocytosis was enhanced by ivermectin (IVR).

139 es, we compared a single application of 0.5% ivermectin lotion with vehicle control for the eliminati

140 Multiple doses of ivermectin may cumulatively and permanently reduce the f

141 29), a single 200-400 micrograms/kg dose of ivermectin (mean, 273 micrograms/kg, n = 28), 400 mg alb

142 brane pore markedly attenuates the effect of ivermectin on Ca(2+) current and channel gating.

143 To assess the effect of ivermectin on the morbidity caused by hookworm-related c

144 The potency of ivermectin on the pharynx was greater than at any of the

145 per 20 microL blood among those who received ivermectin only (p = 0.032); from 14.1 to 5.1 per 20 mic

146 azole was more effective than treatment with ivermectin only, with no measurable increase in severity

147 A tube of topical ivermectin or vehicle control was dispensed on day 1, to

148 of this strategy and quantified responses to ivermectin over 2 consecutive rounds of treatment in 10

149 nt strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis can

150 microfilariae was significantly lower in the ivermectin plus albendazole group (four [17%]), but ther

151 hR evoked by PAMs, including potentiation by ivermectin, PNU-120596, and TQS, as well as activation b

152 0 also effectively suppresses ATP-evoked and ivermectin-potentiated membrane permeabilization induced

153 Ivermectin potently and irreversibly depolarized the mus

154 therapy for onchocerciasis with intermittent ivermectin prevents the development of pathology in ende

155 Because solubilized nodulisporic acid and ivermectin receptors comigrated as 230-kDa complexes by

156 d that there also exists a distinct class of ivermectin receptors that contains the DmGluCl alpha sub

157 mRdl are components of nodulisporic acid and ivermectin receptors, and that there also exists a disti

158 receptors, but only approximately 70% of the ivermectin receptors.

159 rily through the mass drug administration of ivermectin, remains challenging and has been heightened

160 The trajectory of GluCl with ivermectin removed shows a sequence of structural events

161 ch thresholds even within 50 years of annual ivermectin, requiring adoption of biannual treatment.

162 tion of maximal glutamate during the maximal ivermectin response, indicating that ivermectin depolari

163 The insecticide ivermectin reversibly activated homomeric HisCl1 channel

164 itis elegans as a model system to understand ivermectin's effects.

165 ed subunit forms a homomeric channel that is ivermectin-sensitive and glutamate-gated.

166 These results indicate that: (i) an ivermectin-sensitive chloride channel mediates fast inhi

167 Therefore, the GluCl-alpha2 subunit confers ivermectin sensitivity and a high-affinity desensitizing

168 We propose a model in which ivermectin sensitivity in C. elegans is mediated by gene

169 avr-15, a gene that confers ivermectin sensitivity on worms, is necessary postsynapt

170 macrofilaricidal and sterilizing effects of ivermectin should be incorporated into transmission mode

171 Albendazole plus ivermectin significantly reduced prevalence of elephanti

172 A single ivermectin (standard) dose clears the skin-dwelling micr

173 GluCl, which was simulated in the absence of ivermectin starting from the structure with bound iverme

174 in B. pahangi-infected gerbils treated with ivermectin, suggesting that the loss of circulating micr

175 ation, significantly more patients receiving ivermectin than patients receiving vehicle control were

176 After ivermectin therapy was introduced (during 1988-2001), on

177 antifilarial antibody levels decreased after ivermectin therapy, none of these parameters was useful

178 ld studies have highlighted the potential of ivermectin to control malaria parasite transmission if t

179 nt, peripheral eosinophil counts declined in ivermectin-treated groups (P<.001), whereas circulating

180 tentially practical approach to larger-scale ivermectin treatment for lymphatic filariasis and onchoc

181 Biannual ivermectin treatment improves the chances of reaching th

182 ogram cost, and program duration of biannual ivermectin treatment in different epidemiological and pr

183 The strategy of biannual ivermectin treatment in Ghana has reduced O. volvulus mi

184 t-treat strategy was used in the approach to ivermectin treatment in the Okola health district in Cam

185 ation of tissue inflammatory reactions after ivermectin treatment of onchocerciasis.

186 ezuela that were recorded before introducing ivermectin treatment.

187 ication of villages warranting priority mass ivermectin treatment.

188 Onchocerca volvulus-infected subjects after ivermectin treatment.

189 ry model of neuropathic pain was reversed by ivermectin treatment.

190 Ivermectin, used to treat river blindness, binds in the

191 ious adverse events (SAEs) after exposure to ivermectin, using thresholds of >5,000 mf/ml and >30,000

192 Transport was reduced by PSC 833, ivermectin, verapamil, CSA, and vanadate, but not by leu

193 This effect of ivermectin was abolished in the mutant avr-15, which lac

194 High-dose ivermectin was associated with more-severe reactions, mo

195 cent derivatives of cyclosporine A (CSA) and ivermectin was concentrative, specific, and energy-depen

196 Ivermectin was extracted from the minced meat samples th

197 trict in Cameroon, where the distribution of ivermectin was halted in 1999 after the occurrence of fa

198 A single, 10-minute, at-home application of ivermectin was more effective than vehicle control in el

199 stration, particularly the administration of ivermectin, was efficacious for the control of scabies a

200 s of abamectin, doramectin, eprinomectin and ivermectin were found in samples of bovine muscle and on

201 Responses to glutamate and ivermectin were inhibited by picrotoxinin and fipronil.

202 es of the insecticides nodulisporic acid and ivermectin were synthesized and demonstrated to bind wit

203 its sensitivity to the macrocyclic lactone, ivermectin, which allosterically modulates both ion cond

204 complex with the allosteric partial agonist ivermectin, which provided insights into the structure o

205 sly recognized as responding suboptimally to ivermectin-with statistically significantly high microfi

206 anded use of albendazole in combination with ivermectin would ensure improved drug efficacies against