ライフサイエンスコーパス: junctional

1 Synaptopodin depletion prevents junctional accumulation of alpha-actinin-4, vinculin, an

2 We show that junctional actin assembly is maintained by contractility

3 ed result reflects a more dynamic and mobile junctional actin in EEF1A-depleted cells.

4 on assembly, but rather is needed for proper junctional actin regulation during elongation.

5 ceptivity including modulation of epithelial junctional activity.

6 ext, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor excha

7 ons in junction length, regulated in part by junctional actomyosin.

8 HH is a risk factor for esophageal and junctional adenocarcinoma (EGJA).

9 In platelets, junctional adhesion molecule (JAM)-A was previously iden

10 of one such transcript, F11R (also known as junctional adhesion molecule 1, JAM1), in hypoxia is dep

11 Mammalian orthoreoviruses use glycans and junctional adhesion molecule A (JAM-A) as attachment rec

12 Junctional adhesion molecule A (JAM-A) is a broadly expr

13 trocyte TJs of claudin 1 (CLDN1), CLDN4, and junctional adhesion molecule A (JAM-A) subunits is induc

14 Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold trans

15 Reovirus binds to cell surface glycans, junctional adhesion molecule A (JAM-A), and the Nogo-1 r

16 urface glycans or the proteinaceous receptor junctional adhesion molecule A (JAM-A).

17 Junctional adhesion molecule C (JAM-C) is an immunoglobu

18 the main proteins associated with it such as junctional adhesion molecule-1 and vascular endothelial

19 protein sigma1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to

20 Junctional adhesion molecule-A (JAM-A) is a tight juncti

21 Junctional adhesion molecule-A (JAM-A) is an adherens an

22 We have recently shown that junctional adhesion molecule-A (JAM-A) renders protectio

23 aged myofibres through the modulation of the junctional adhesion molecule-A.

24 g integrin alpha3beta1, VE-cadherin, ICAM-2, junctional adhesion molecule-B (JAM-B), laminin, and cel

25 ns and/or transmembrane adhesions, including junctional adhesion molecule-C (JAM-C) and myelin-associ

26 ed expression and/or functionality of the EC junctional adhesion molecule-C (JAM-C).

27 and Adenovirus Receptor (CAR) that binds to Junctional Adhesion Molecule-like (JAM-L) expressed on l

28 ross the ventral face of the somite and that junctional adhesion molecules (JAMs) mediate this requir

29 pond to elevated contractility by increasing junctional afadin.

30 alternative Crumbs isoform recapitulates the junctional aggregation and centrosome positioning defect

31 nt role of the V(D)J recombination-generated junctional and allele-specific residues for achieving hi

32 unctional disassembly are periodic pulses of junctional and medial myosin II that result in progressi

33 These observations argue that the balance of junctional and nuclear beta-catenin activity has a profo

34 r fluids of patients affected by dystrophic, junctional, and simplex EB.

35 hology of AJs and TJs but attenuated de novo junctional assembly.

36 Junctional association of YAP inhibits nuclear transloca

37 ry neuroepithelium, especially at the apical junctional belt of the sustentacular cells.

38 results demonstrate that LPA induces loss of junctional beta-catenin, stimulates clustering of beta1

39 n assembly, and loss of Rap1B led to loss of junctional border organization.

40 ists of scaffold proteins that interact with junctional cadherins, polarity proteins and the cytoskel

41 RQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiothe

42 nts because of a dose-limiting toxicity (ie, junctional cardiac rhythm).

43 To more accurately mimic the junctional CCC, we designed a constitutively monomeric c

44 ecognized molecular mechanism for inhibiting junctional CDC-42 to control actin organization and AJ p

45 onitor Ca(2+) transients in neurons and post-junctional cells of the murine colon evoked by exogenous

46 brates whose proteins mainly function as non-junctional channels on the cell surface.

47 ppear to be involved on the cone side of the junctional channels.

48 f integration between hard-wired synaptic or junctional circuits and extrasynaptic signals wirelessly

49 atter was restricted by accessibility of non-junctional claudin molecules such as claudin-4 at apical

50 icromolar [Ca(2+) ]i , in the submembrane or junctional cleft space, is not required to maximize [Ca(

51 uenced by the number of functional RyRs in a junctional cluster (which is reduced by tetracaine or ru

52 d by voltage-gated calcium signaling and gap-junctional communication.

53 naling cascade leading to enhancement of gap junctional communication.

54 etaV was invariably detected near the apical junctional complex and above the cuticular plate, a dens

55 lls but also generates changes in the apical junctional complex and loss of epithelial barrier functi

56 eoglycan with HS chains that is critical for junctional complex assembly and regulating the flow resp

57 f transporters and specialized intercellular junctional complex components.

58 revealed that Notch signaling induces apical junctional complex genes that regulate cell adhesion and

59 fficking, which were present near the apical junctional complex in the hair cells of mammalian ancest

60 thelial flow mechanotransduction through the junctional complex is mediated by a specific pool of VE-

61 nents of the cardiac area composita, a mixed junctional complex responsible for electromechanical cou

62 ibutes to the maturation and assembly of the junctional complex.

63 58 is essential for flow sensing through the junctional complex.

64 when NPCs normally acquire organized apical junctional complexes (AJCs) in the zebrafish hindbrain.

65 formation revealed that disruption of apical junctional complexes (AJCs) was responsible for PH in Ne

66 such as E-cadherin enrichment in epithelial junctional complexes and CD45 exclusion from the signali

67 oteins essential to maintain normal cellular junctional complexes and tissue homeostasis.

68 geometric graph, with nodes corresponding to junctional complexes and with edges corresponding to spe

69 -1 and stabilin-1 and was facilitated by the junctional complexes between HSECs.

70 Unique intercellular junctional complexes between the central nervous system

71 transient or stable breakdown of epithelial junctional complexes to permit programmed migration, inv

72 er, enter the next cell by traveling through junctional complexes without being intercepted by a neut

73 g imaginal discs are organized into distinct junctional complexes, including separate distributions f

74 vary glands due to disruptions of epithelial junctional complexes, likely secondary to elevated activ

75 at a number of levels, including epithelial junctional complexes, mucus production, and mucosa-deriv

76 secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to ac

77 lipid bilayer by ankyrin and by actin-based junctional complexes.

78 luding cell differentiation, the presence of junctional complexes/desmosomes and microvilli, and the

79 where they interact with the essential glial junctional component neurofascin 155.

80 We establish that the junctional components alpha-catenin, beta-catenin, and c

81 Imaging of junctional components and genetic analyses suggest that

82 reases cortical tension and locally enriches junctional components to facilitate apical constriction.

83 tension-induced sequential incorporation of junctional components.

84 simulation and eliminate noise in simulated junctional conductance (gj) records, we transformed an S

85 ated that such asymmetry strongly depends on junctional conductance and can lead to the unidirectiona

86 In C57BL/6 mice, the median junctional conductance between dark-adapted rods is appr

87 model can account for dynamic modulation of junctional conductance during the spread of electrical s

88 ice that under circadian conditions, the rod junctional conductance has a median value of 98 pS durin

89 Adaptation to bright light decreases the rod junctional conductance to approximately 0 pS, regardless

90 odel allowed us to replicate the kinetics of junctional conductance under different levels of intrace

91 tion potentials, can induce a rapid decay of junctional conductance, thus demonstrating spiking activ

92 signalling and the organization of adherens junctional contacts.

93 la adherens (ZA) in these cells, its role in junctional contractility and its mode of regulation are

94 nolayer, coronin 1B is also recruited to the junctional cortex at the apoptotic/neighbor cell interfa

95 sts by approximately 20 mV and increased gap junctional coupling between myofibroblasts and cardiomyo

96 a factor of 4 by physiological levels of gap junctional coupling between sister MCs at the same glome

97 m gap junction plaques and produce levels of junctional coupling similar to those for wild-type Cx32.

98 urons was not related to the strength of gap junctional coupling, and was still prevalent in connexin

99 The effect of gap junctional coupling, sodium ion channel distribution, an

100 tentials and cardiomyocyte-cardiomyocyte gap junctional coupling, TGF-beta1 depolarized cardiomyocyte

101 if they do, produce little or no detectable junctional coupling.

102 labyrinthine structures adjoining the PM at junctional couplings (JCs).

103 here is a reduction in the early peak of the junctional current during the upstroke of the action pot

104 ined that although GJ channel gating reduces junctional current, it does not significantly alter cond

105 more stable and contains a high level of gap-junctional Cx43 whereas that formed with hypoxic cells i

106 oxic melanoma cells selectively degrades gap-junctional Cx43, leading to the destabilization of the i

107 nd contains a significant lower level of gap-junctional Cx43.

108 cteria were observed in the absence of tight junctional damage.

109 ngiocytes to lipopolysaccharide, rescued the junctional defect in vitro, and significantly attenuated

110 e of calcium signaling rescues the cell-cell junctional defects.

111 ngthen junctions to override Snail-dependent junctional disassembly and postpone EMT during Drosophil

112 A major driver of apical constriction and junctional disassembly are periodic pulses of junctional

113 In both cases, junctional disassembly can be blocked by simultaneous in

114 ter embryos to assess apical domain loss and junctional disassembly.

115 analiculi in LKB1(-/-) mice, confirming that junctional disruption resulted in paracellular exchange

116 After junctional disruption with the FBA, dilatation was simil

117 oblastic morphology, increased intercellular junctional distance, and induced paracellular permeabili

118 Similarly, immunoglobulin junctional diversification is impaired in cells.

119 key antigen-binding region, which arise from junctional diversity rather than differential VH gene us

120 r of N-nucleotides has a great effect on the junctional diversity, and thereby on the total diversity

121 function might be necessary for normal CDR3 junctional diversity.

122 olarity (PCP) is the formation of restricted junctional domains containing Frizzled/Dishevelled/Diego

123 es, larger unitary channel conductances, low junctional dye permeability/permselectivity, and an over

124 pathway might be involved to alter cellular junctional dynamics for breast cancer invasive progressi

125 cytoskeletal network may contribute to cell junctional dynamics.

126 ctivation by Wnt4a-Cdc42 signaling increases junctional E-cadherin in maturing pouches.

127 sruption, however, increased the mobility of junctional E-cadherin.

128 dred five children were recruited, 8.6% with junctional EB, 34.3% with simplex EB, 34.3% with autosom

129 nds, particularly dominant in dystrophic and junctional EB.

130 ively in 76 patients with severe generalized junctional epidermolysis bullosa born in the years 2000-

131 Treatment of severe generalized junctional epidermolysis bullosa by SCT is a last-ditch

132 ncidence of 1 of 150,000, severe generalized junctional epidermolysis bullosa occurred more often tha

133 port on two patients with severe generalized junctional epidermolysis bullosa treated with allogeneic

134 Severe generalized junctional epidermolysis bullosa, a lethal hereditary bl

135 s (AP) crest, as well as between the CEJ and junctional epithelium (JE) level, were measured; the num

136 -lymphocytic cells and T-helper cells in the junctional epithelium of SPF mice compared with GF mice

137 ngival inflammation, apical migration of the junctional epithelium, periodontal pocket formation, alv

138 ils that migrate from the vasculature to the junctional epithelium.

139 Junctional epitope antibodies, like VHH6, not only offer

140 Here we introduce VHH6, a junctional epitope antibody capable of specifically reco

141 ical techniques have been used to prove the "junctional epitope" nature of VHH6, a camelid single dom

142 c-1 embryos exhibit dynamic accumulations of junctional F-actin and an increase in AJ protein levels.

143 broad cohort of epithelial genes, including junctional factor dlg-1 Accumulation of DLG-1 protein is

144 R clusters became fragmented with diminished junctional folds and synaptic vesicles.

145 grin stimulus, but not on the development of junctional folds, another hallmark of mature postsynapti

146 To test junctional function, we used intravital microscopy to qu

147 kocytes actively contract the VECs to open a junctional gap and then push themselves across the gap b

148 leukocytes preferentially extravasate across junctional gaps in the endothelial monolayer (paracellul

149 ears to be the dominant kinase essential for junctional integrity and contractile tension at epitheli

150 ge in this area is that barrier function and junctional integrity are difficult to study in the intac

151 ctionally, CdGAP-Ajuba interaction maintains junctional integrity in homeostasis and diseases: (i) ga

152 ponses to laminar shear stress and regulates junctional integrity through modulation of calcium signa

153 We further showed that retention of adherens junctional integrity was caused by the up-regulation of

154 ewed toward loss of differentiation, reduced junctional integrity, and impaired innate defense.

155 ess, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression o

156 Butyrate restoration improved IEC junctional integrity, decreased apoptosis and mitigated

157 to inhibit ROCK activity, and to maintain EC junctional integrity.

158 rives expression of VE-cadherin and controls junctional integrity.

159 tial repair process that is dependent on gap junctional intercellular communication (GJIC).

160 ocytes, despite a lack of heterocellular gap junctional intercellular communication between the two c

161 s used to quantitatively investigate the gap junctional intercellular communication in several homoty

162 rences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phosphoryla

163 number of neighboring cells coupled via gap junctional intercellular communication, providing a mech

164 nt number of MSCs was down-regulated via gap junctional intercellular communication.

165 dock between adjacent cells to allow for gap junctional intercellular communication.

166 rapid intra-SR Ca diffusion, such that local junctional intra-SR [Ca] can be maintained by intra-SR d

167 +) store into the peripheral subsarcolemmnal junctional (j-SR) and the much more abundant central non

168 rtance, Fmnl3 expression is up-regulated and junctional localization increases during collective cell

169 s in a PLEKHA7-dependent manner, because its junctional localization is abolished by knock-out of PLE

170 re protein Frizzled, we show that its stable junctional localization is promoted by the core proteins

171 NL1 in epithelial cells results in decreased junctional localization of MgcRacGAP but not of ECT2, a

172 ld protein zonula occludens 1, and disrupted junctional localization of the structural transmembrane

173 binds to and requires VAV2 function for its junctional localization.

174 in TTX-insoluble fractions, consistent with junctional localization.

175 that leads to defective Tie2 clustering and junctional localization.

176 ar morphogenesis or express the foot process junctional markers nephrin and podocin.

177 ts, we identify time-dependent properties of junctional mechanics consistent with a simple viscoelast

178 VEGFR3 levels, a component of a junctional mechanosensory complex, mediate these differe

179 we now identify as another component of the junctional mechanosensory complex.

180 , reduced tension on VE-cadherin and loss of junctional mechanotransducers such as vinculin and PAK2,

181 Junctional membrane complexes (JMCs) in myocytes are cri

182 RATIONALE: Junctional membrane complexes (JMCs) in myocytes are cri

183 At homotypic contacts, junctional N-cadherin bonds downregulate Myosin-II contr

184 e of this interplay specifies the pattern of junctional network remodeling that changes wing shape.

185 Once engaged with the astrocyte gap-junctional network, brain metastatic cancer cells use th

186 neurulation events, we term this phenomenon junctional neurulation.

187 j-SR) and the much more abundant central non-junctional (nj-SR) SR.

188 CRISPR/Cas9 knockout of podocalyxin causes junctional organization defects in podocyte-like cells.

189 in loading order, resulting in many possible junctional outcomes from one DSB.

190 tions of these models revealed that this gap junctional/paracrine mechanism accounts for up to 23% of

191 Ringed junctional pattern and dermal nests were associated with

192 Aspecific junctional pattern, basaloid cords, and ulceration were

193 ecessary for trans-endocytosis, and adhesive junctional PCP complexes appear to be destined for degra

194 be of high medical relevance because loss of junctional Pg is a hallmark of arrhythmogenic cardiomyop

195 the total number of GJ channels clustered in junctional plaques, and it has the potential to describe

196 However, the mechanisms that control junctional plasticity are not fully understood.

197 polysaccharide secretion system known as the junctional pore complex (JPC).

198 le hormogonia corresponds to the site of the junctional pore complex.

199 but the resting rate of miniature excitatory junctional potentials (mEJPs) is significantly lower in

200 tude of both evoked and miniature excitatory junctional potentials.

201 Our four-way junctional pre-catalytic structure differs significantly

202 Mg(2+) ions relative to a reported three-way junctional pre-catalytic structure of the twister-sister

203 The mechanosensitive junctional protein alpha-catenin acts through vinculin a

204 amentous actin and the redistribution of the junctional protein beta-catenin at the wound margin duri

205 s both structural changes in the actin-bound junctional protein complex and physical forces spanning

206 The contribution of the gap junctional protein connexin 36 (Cx36) to the regulation

207 Expression of the redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in the

208 mutant ADF reduces actin polymerization and junctional protein disassembly, attenuates both early- a

209 PLEKHA7 is a junctional protein implicated in stabilization of the ca

210 circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junctions (G

211 eased phosphorylation of p38 MAPK and of the junctional protein JAM-A.

212 Deltalens), show that loss of this cell-cell junctional protein leads to lens degeneration, necrosis

213 -cadherin, a major endothelial cell-specific junctional protein that controls vascular integrity.

214 ures correlating with mislocalization of the junctional protein, cingulin.

215 ed enterocyte TNF-alpha while it upregulated junctional protein-coding mRNAs.

216 titis, a finding supported by maintenance of junctional proteins and polarity markers.

217 into the post-translational modifications of junctional proteins and signaling pathways regulating pl

218 yers with similar levels and distribution of junctional proteins and transendothelial electrical resi

219 conserved redistribution of cytoskeletal and junctional proteins around the wound.

220 veal polarized dynamics, and organization of junctional proteins between the front of FAJs and their

221 Junctional proteins Neph1 and ZO-1 and their interaction

222 Although transcripts of junctional proteins such as connexin43, ZO-1, occludin,

223 hesion markers and lower levels of cell-cell junctional proteins when compared to lean mice.

224 ns and reduced the expression of endothelial junctional proteins when compared to lean serum.

225 actin polymerization and the disassembly of junctional proteins within microvascular endothelial cel

226 d mucosal inflammation, a loss of epithelial junctional proteins, and an increase in mucosal inflamma

227 tin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD

228 ithelial cells by lowering the expression of junctional proteins, such as zonula occludens-1, occludi

229 ed altered subcellular distribution of tight junctional proteins.

230 ore apically localized F-actin and BTB tight junctional proteins.

231 n and other plakins harbor binding sites for junctional proteins.

232 bind different sets of actin-regulating and junctional proteins.

233 barrier-associated transcription factors and junctional proteins.

234 KO mice revealed a reduced expression of BBB junctional proteins.

235 al permeability and the expression levels of junctional proteins.

236 Using a cutoff 5% allele fraction for junctional reads, 7 different rearrangements were presen

237 Actomyosin cable formation is accompanied by junctional rearrangements at the wound margin.

238 re thought to typically present as permanent junctional reciprocating tachycardia (permanent junction

239 ctional reciprocating tachycardia (permanent junctional reciprocating tachycardia), they may also be

240 ) DAP patients manifested clinical permanent junctional reciprocating tachycardia, and these patients

241 DAPs do not present with clinical permanent junctional reciprocating tachycardia.

242 h those with DAPs without clinical permanent junctional reciprocating tachycardia.

243 ZO-1 was required for junctional recruitment of JACOP, which, in turn, recruit

244 The junctional recruitment of nectin-1 and nectin-3 and thei

245 nsion on the E-cadherin complex promoted the junctional recruitment of the protein LGN, a core compon

246 90)BCR-ABL peptides derived from the BCR-ABL junctional region and alternative splicing, and of adopt

247 ently, App also recruits Dachs to the apical junctional region through protein-protein association, t

248 ification and recruiting Dachs to the apical junctional region, thereby promoting tissue growth.

249 n of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth by inhi

250 der of atrophy; Zone 2 as the center of this junctional region; Zone 3 at the border between the junc

251 occurs is found to be cablelike in that the junctional regions act like inverted cables.

252 levels, vasopermeability, and alteration in junctional-related proteins were observed in the retinas

253 Pg-mutant S665A abrogated both cAMP-mediated junctional remodeling and increase of cohesion.

254 results indicate that the role of LET-502 in junctional remodeling is likely to be independent of its

255 ases, E-cadherin endocytosis, and epithelial junctional remodeling, as bona fide IRF6 partner protein

256 pression and a corresponding increase in gap-junctional resistivity.

257 ions involved in the spatial localization of junctional RhoA signaling.

258 Transient accelerated junctional rhythm during injections, and transient noctu

259 to enhanced Ca(2+) release from central non-junctional sarcoplasmic reticulum (SR) and centripetal p

260 3) reverted ultrastructural abnormalities of junctional sarcoplasmic reticulum and transverse tubules

261 ganized in a lattice to form clusters in the junctional sarcoplasmic reticulum membrane.

262 spryn, minispryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyoc

263 KCNQ1 mainly resides in the jSR (junctional sarcoplasmic reticulum), whereas KCNE1 reside

264 cking and parallel to the Scribble module of junctional scaffolding proteins.

265 relative NHEJ efficiency and analyze ligated junctional sequences for various types of DNA ends, incl

266 Lnp subsequently moves into the junctional sheets and forms oligomers.

267 ptic effects can be quite significant in the junctional spaces between cells, and that the cell activ

268 consistent with the STIM1 localizing to the junctional SR (jSR).

269 ted more often in central regions of the non-junctional SR compared to normal cells.

270 s is too large, the depletion of Ca from the junctional SR terminates the release; and 3) very long r

271 and calsequestrin (CSQ) localization to the junctional SR, and increases endoplasmic reticulum (ER)

272 he SR network, diffusion between network and junctional SR, cytosolic Ca diffusion, SERCA uptake acti

273 rs as major transcriptional regulators of EC junctional stability, guaranteeing physiological functio

274 not due to secondary effects on polarity or junctional structures.

275 ilize GTP-RhoA at the ZA, thereby sustaining junctional tension and inhibiting intraepithelial cell m

276 actin nucleation apparatus is necessary for junctional tension and integrity.

277 adhesion plays an active role in generating junctional tension by promoting actin assembly and corti

278 IA responds to Rho-ROCK signaling to support junctional tension in MCF-7 cells.

279 aling to drive the polarized organization of junctional tension necessary to build an in vivo epithel

280 dherin localizes and tunes EGFR activity and junctional tension to inhibit premature TJ complex forma

281 toinhibitory conformation, in the absence of junctional tension, and biophysical studies have shown t

282 ytes and the VECs can separately perturb the junctional tensions of VECs to result in the opening of

283 hototype 1 skin types; RCM features, such as junctional thickening, dense dermal nests, and nucleated

284 At steady-state, junctional transmission of lactate (a chemical base) fro

285 malemma), which can explain the advantage of junctional transmission over MCT in vivo.

286 itment of patients with lower oesophageal or junctional tumours planned for an oesophagogastric resec

287 nced oesophageal cancer or type I/II Siewert junctional tumours, histologically confirmed squamous-ce

288 structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme.

289 to myofibroblasts during pharmacological gap junctional uncoupling.

290 drive VE-cadherin expression and stabilized junctional VE-cadherin complexes through associated phos

291 nal region; Zone 3 at the border between the junctional zone and adjacent "normal" retina.

292 differentiate and expressed markers of both junctional zone and labyrinth trophoblast subtypes in a

293 a-HPV field cancerization arises from the HF junctional zone and predispose to squamous cell carcinom

294 The retinal sensitivity in the bulk of the junctional zone is similar to apparently uninvolved dist

295 ntal labyrinth (L) had a higher sO2 than the junctional zone plus decidua region (JZ+D) in C57Bl/6 mi

296 The junctional zone, a ring 500 mum in width, surrounding th

297 P1 led to FGR, increased karyorrhexis in the junctional zone, and decreased proliferation of labyrint

298 oise, sharpness, and ability to evaluate the junctional zone, myometrium, and musculoskeletal structu

299 owed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral

300 further induced overgrowth of the placental junctional zone.