ライフサイエンスコーパス: juxtamembrane

1 ction critically depends on an extracellular juxtamembrane 23-amino acid sequence of p75(NTR).

2 untethering of the SERT C terminus from the juxtamembrane actin cytoskeleton.

3 e alpha-helix, joined by a short linker to a juxtamembrane alpha-helix, which is associated with the

4 We found that replacing syndecan-1 juxtamembrane amino acid residues A243-S-Q-S-L247 with h

5 The interactions between the juxtamembrane amphipathic helix of one monomer and its n

6 Abs to juxtamembrane and central region constructs were both DR

7 viously identified ezrin binding motifs, the juxtamembrane and the (1176)YRSLE regions, we have disco

8 haride and ceramide moieties of GT1b and the juxtamembrane and transmembrane domains of synaptotagmin

9 ormational change is transmitted through the juxtamembrane and transmembrane domains, leading to acti

10 ed cysteine-scanning mutagenesis in the EpoR juxtamembrane and transmembrane domains.

11 17 is released by ectodomain shedding at the juxtamembrane and/or intramembrane motif and to show tha

12 containing the extracellular, transmembrane, juxtamembrane, and kinase domains are overexpressed and

13 studies affirm the importance of the kinase, juxtamembrane, and transmembrane domains of PknA.

14 cysteines, a transmembrane glutamine, and a juxtamembrane aspartic acid.

15 A clasp to mimic juxtamembrane association between the integrin alpha and

16 mechanism of activation is disruption of the juxtamembrane autoregulatory domain by internal tandem d

17 Mutation of juxtamembrane basic residues in the plasma membrane SNAR

18 mechanism in which W515 at the intracellular juxtamembrane boundary inhibits dimerization of the TpoR

19 f the intracellular domain that includes the juxtamembrane, Box 1, and Box 2 regions.

20 igh level of flexibility and disorder in the juxtamembrane chopper domain of p75NTR, which results in

21 ursors to Pmel17 amyloid, depends on a novel juxtamembrane cleavage at amino acid position 583 betwee

22 growth factor receptor beta gene (PDGFRB), a juxtamembrane-coding region.

23 mpts conformational changes in the cytosolic juxtamembrane coiled-coil region.

24 dimer formation and oncogenic activation of juxtamembrane cysteine mutants of RET, and explains the

25 4-subunit is S-acylated (palmitoylated) on a juxtamembrane cysteine residue (Cys-193) in the intracel

26 that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys-264 and Cys-265.

27 ACE1 is modified by S-palmitoylation at four juxtamembrane cysteine residues.

28 indicate that DHHC5 palmitoylates PLM at two juxtamembrane cysteines, C40 and C42, although C40 is th

29 in Kv2.1 is governed by a 34 aa motif in the juxtamembrane cytoplasmic C terminus, and a 17 aa motif

30 with a cadherin 11 construct that lacked the juxtamembrane cytoplasmic domain was diminished to the l

31 Here we report that the conserved juxtamembrane cytoplasmic tyrosine motif ((612)YIY(614))

32 e, we highlight the important role of the E2 juxtamembrane D-loop in mediating virus budding and part

33 e D2, directly phosphorylating the conserved juxtamembrane DEGSY motif of the syndecan cytosolic doma

34 complex (alphabeta(2)) linked through native juxtamembrane disulfide bonds could be produced from iso

35 al tandem duplication (ITD) mutations in the juxtamembrane domain (23%) and point mutations in the ty

36 a mutant cadherin-11 lacking the cytoplasmic juxtamembrane domain (JMD) diminished the turnover of al

37 The juxtamembrane domain (JMD) of S is an aromatic amino aci

38 lmodulin (Ca/CaM) binds to the intracellular juxtamembrane domain (JMD) of the epidermal growth facto

39 hly conserved tryptophan residues within the juxtamembrane domain (JMD) of the vesicular SNARE Synapt

40 Either activation loop Y807F or juxtamembrane domain (JMD) Y559F mutations severely comp

41 Its juxtamembrane domain (JX), the region located between th

42 ain (E168D, L299F, S323G, and N375S) and the juxtamembrane domain (R988C, R988C + T1010I, S1058P, and

43 phorin domain (N375S, M431V, and N454I), the juxtamembrane domain (T1010I and G1085X), and an alterna

44 ndocytosis, but p120 binding to the cadherin juxtamembrane domain acts as a master regulator guarding

45 residues 765-958 of PTPmu, which include the juxtamembrane domain and 35 residues of the first phosph

46 Longer forms of RET containing the juxtamembrane domain and C-terminal tail exhibited simil

47 ive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c

48 of EGF receptor mutants in the intracellular juxtamembrane domain and demonstrate that the most membr

49 ion of Pref-1 and fibronectin via the Pref-1 juxtamembrane domain and fibronectin C-terminal domain.

50 ernal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of a

51 in, the transmembrane domain and the luminal juxtamembrane domain are required for efficient cleavage

52 interactions that are dependent on distinct juxtamembrane domain conformations, resulting in signifi

53 is thus a specific requirement for BTN3A1's juxtamembrane domain for correct gammadelta T cell-relat

54 A conserved juxtamembrane domain harbours disease mutations, which c

55 The intracellular juxtamembrane domain has previously been shown to be req

56 c domain Ia and (2) folding/unfolding of the juxtamembrane domain Ib of PLN.

57 Thus, the conformational change in the FLT3 juxtamembrane domain induced by the ITD activates the ki

58 These data suggest that the cytoplasmic juxtamembrane domain is involved not only in the transmi

59 on experiments revealed that the cytoplasmic juxtamembrane domain is necessary for maximal FERONIA ac

60 In contrast, Tyr-831 in the juxtamembrane domain is not essential for kinase activit

61 that dasatinib potently inhibits WT KIT and juxtamembrane domain mutant KIT autophosphorylation and

62 the PDGFRA mutation; for example, the V561D juxtamembrane domain mutation is more sensitive to imati

63 t cell line-1 (HMC-1)-HMC-1.1, harboring the juxtamembrane domain mutation V560G, and HMC-1.2, carryi

64 Juxtamembrane domain mutations are common in gastrointes

65 Whereas KIT juxtamembrane domain mutations seen in most patients wit

66 e membrane binding of the positively charged juxtamembrane domain of a reconstituted VAMP2 protein an

67 In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembran

68 p120(ctn) binds to the juxtamembrane domain of classical cadherins and has been

69 p120-catenin binds to the cytoplasmic juxtamembrane domain of classical cadherins and regulate

70 The 45-residue juxtamembrane domain of EGFR (JM), located between the t

71 TRIP6 binds to the cytoplasmic juxtamembrane domain of Fas and interferes with the recr

72 encodes the switch and zipper regions of the juxtamembrane domain of FLT3.

73 model by inserting an ITD mutation into the juxtamembrane domain of murine Flt3.

74 charged amino acids in the membrane-proximal juxtamembrane domain of substrates make them resistant t

75 ingolipid-binding motif in the extracellular juxtamembrane domain of synaptotagmins 1/2 and confirmed

76 ly mediated by the highly positively charged juxtamembrane domain of syntaxin.

77 The intracellular juxtamembrane domain of the EGF receptor has been shown

78 eonine 654 (PKC phosphorylation site) in the juxtamembrane domain of the receptor is considerably inc

79 ylation was inserted at the beginning of the juxtamembrane domain of the receptor.

80 known RON orthologs that encodes part of the juxtamembrane domain of the receptor.

81 oth the extracellular amino terminus and the juxtamembrane domain of the receptor.

82 specifically interacts with the cytoplasmic juxtamembrane domain of TrkA receptor and triggers its d

83 PDCL3 binds to the juxtamembrane domain of VEGFR-2 and controls the abundan

84 The juxtamembrane domain of vesicle-associated membrane prot

85 ing internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine

86 ed somatic-activating PDGFRB variants in the juxtamembrane domain or the kinase activation loop in 4/

87 tified, as being of particular importance, a juxtamembrane domain region of BTN3A molecules identifie

88 lung cancer, which encodes a deletion of the juxtamembrane domain resulting in the loss of Cbl E3-lig

89 ta show that aberrant MET regulation via the juxtamembrane domain subverts core MET receptor function

90 d 2 candidate STAT5 docking sites within the juxtamembrane domain that are disrupted by the ITD.

91 t a highly conserved motif in the E-cadherin juxtamembrane domain that determines apical-lateral pola

92 Mutation of residues within the juxtamembrane domain that reduce the VAMP2 net positive

93 y binds to phosphorylated Y(561) in the PERK juxtamembrane domain through its SH2 domain.

94 precursor (pro-HB-EGF), it is cleaved at the juxtamembrane domain to release the soluble form of HB-E

95 age the receptor tyrosine kinase Axl via its juxtamembrane domain to trigger ligand-independent autop

96 t results in a V559A substitution within the juxtamembrane domain was identified in three family memb

97 We found that whereas the Crb juxtamembrane domain was not required for adherens junct

98 rb has been proposed to interact through its juxtamembrane domain with Moesin (Moe), a FERM domain pr

99 d alternative splice product skipping entire juxtamembrane domain) of a NSCLC cell line and adenocarc

100 fourth mutation, NTRK2R458G, residing in the juxtamembrane domain, activates TrkB via noncanonical me

101 arrangements of the DFG motif, alphaC-helix, juxtamembrane domain, and the activation loop to switch

102 dent on p120's interaction with the cadherin juxtamembrane domain, but occurs independently of p120's

103 he integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain

104 on of the activation loop, alphaC-helix, and juxtamembrane domain, which are all important domains fo

105 Activation of cFMS is also inhibited by the juxtamembrane domain, which interacts with residues of t

106 r mutant containing a distal mutation in the juxtamembrane domain.

107 GFR2 TK construct inclusive of the important juxtamembrane domain.

108 ng require the presence of the intracellular juxtamembrane domain.

109 n of ACE is required for its cleavage at the juxtamembrane domain.

110 in PTH), which interacts with the receptor's juxtamembrane domain.

111 mportant regulatory role for the APP luminal juxtamembrane domain.

112 aling capacity of mouse and human RON to the juxtamembrane domain.

113 eceptor (MET(Delta14)) lacking a cytoplasmic juxtamembrane domain.

114 de the first evidence that the extracellular juxtamembrane domains (JMDs) of ADAM17 and iRhom2 regula

115 e derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of

116 ion, understanding how the transmembrane and juxtamembrane domains contribute to transmembrane signal

117 he hydrophobic transmembrane and amphipathic juxtamembrane domains is important for stabilizing the t

118 creen exons encoding the activation loop and juxtamembrane domains of 85 tyrosine kinase genes in 188

119 systematic mutation of the transmembrane and juxtamembrane domains of a model transmembrane protein,

120 y threonine phosphorylation in the conserved juxtamembrane domains of EGFR and HER2.

121 nto RGCs reveals that both extracellular and juxtamembrane domains of EphB1 are required to efficient

122 , the interactions between the catalytic and juxtamembrane domains of VEGFR2 are studied.

123 inal segment to interact with the receptor's juxtamembrane domains to activate the receptor.

124 Coiled-coil and juxtamembrane domains within the matrix portion of the c

125 by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic int

126 s of the TM domains and of the intracellular juxtamembrane domains, paving the way for a comprehensiv

127 ceptor-tyrosine kinases via their respective juxtamembrane domains; additionally the binding mode of

128 ic Abs: those to 841-860 peptide with Abs to juxtamembrane epitopes, which appear early in prediabete

129 These so-called juxtamembrane expansion (JME) alleles consist of interna

130 A juxtamembrane FERM domain-binding motif is responsible f

131 Crb directly binds to Ex through its juxtamembrane FERM-binding motif (FBM).

132 The Ex-regulatory domain of Crb maps to the juxtamembrane FERM-binding motif (JM), a cytoskeletal in

133 3.8 A/amino acid), indicating that the three juxtamembrane fibronectin domains of gp130 are not neces

134 am isoforms that contain the TM2 cytoplasmic juxtamembrane flanking sequences.

135 nce shows that PC1 undergoes cleavage at the juxtamembrane G protein-coupled receptor proteolytic sit

136 A turn at the Gly of the juxtamembrane GFFKR motif caps the alpha TM helix and br

137 tured alpha-helix that closely resembles the juxtamembrane helical region of the analogous TM6 and th

138 ts that are held together noncovalently by a juxtamembrane heterodimerization (HD) domain.

139 R includes the 3 Lin12/Notch repeats and the juxtamembrane heterodimerization domain, the region of N

140 arly, only one receptor in the dimer needs a juxtamembrane hydrophobic L253 or W258 residue, essentia

141 We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that

142 Because the caveolin-1 scaffolding domain is juxtamembrane, it is tempting to suggest that Slo1-caveo

143 in, and transmembrane/extracellular loop, or juxtamembrane (J) regions of the receptor.

144 forms characterized by variant extracellular juxtamembrane (JM) and intracellular cytoplasmic (CYT) d

145 n this paper, we investigate the role of the juxtamembrane (JM) domain in EGFR signaling by replacing

146 een two conserved tryptophan residues in the juxtamembrane (JM) domain is required for kinase activat

147 Here we show that the XA21 juxtamembrane (JM) domain is required for kinase autopho

148 hout (VEGFR2-CD) and with (VEGFR2-CD/JM) the juxtamembrane (JM) domain were characterized by kinetic,

149 tural features of the transmembrane (TM) and juxtamembrane (JM) domains of APP that facilitate proteo

150 Its transmembrane domain (TMD) and juxtamembrane (JM) region are essential for signal trans

151 gated the function of the long intracellular juxtamembrane (JM) region of human DDR1 and found that t

152 l growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory

153 is study demonstrates that the intracellular juxtamembrane (JM) region plays a vital role in the kina

154 position of the B30.2 domain relative to the juxtamembrane (JM) region.

155 Our results demonstrate that the juxtamembrane (JM) regions of RTKs are critical for indu

156 The transmembrane (TM) and juxtamembrane (JM) regions of the epidermal growth facto

157 ontaining the ErbB2 TM helix and some of the juxtamembrane (JM) residues were studied.

158 TM domain and a portion of the intracellular juxtamembrane (JM) segment.

159 and an intracellular domain that includes a juxtamembrane (JM) sequence and a kinase domain.

160 Further, both the juxtamembrane (JMD) and beta-catenin binding domains (CB

161 rnal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (F

162 The juxtamembrane K54 residue in TCR-zeta was identified to

163 The formation of the activating juxtamembrane latch is prevented by the C-terminal tails

164 oximal fifth and sixth FNIII domains and the juxtamembrane linker and showed that a fragment containi

165 ce vesicle binding assay to characterize the juxtamembrane linker and to test the ability of reconsti

166 y, additional deletion of the remaining five juxtamembrane-located amino acids also abrogated ADAM10-

167 etween MCU and EMRE as well as pinpoints the juxtamembrane loop of MCU and extended linker of EMRE as

168 A juxtamembrane Lys residue in beta also has an important

169 balpha leucine-rich repeat domain (LRRD) and juxtamembrane mechanosensitive domain (MSD).

170 Recently, we have discovered a juxtamembrane mechanosensory domain (MSD) within the GPI

171 Oligomerization requires the juxtamembrane middle domain three-helix bundle, as does

172 2 activation due to mutations in a conserved juxtamembrane motif does lead to cytokine-independent ac

173 residues at a time revealed that a conserved juxtamembrane motif, MKKK, was the only region required

174 Wild-type Kit-and juxtamembrane-mutant-expressing cell lines required cons

175 c mastocytosis (SM); however, unlike the KIT juxtamembrane mutants, the activation loop mutants are i

176 aberrant proliferation is a consequence of a juxtamembrane mutation in the FLT3 gene (FMS-like tyrosi

177 canonical phosphorylation site (RETW) in the juxtamembrane N-terminal region of monoamine transporter

178 bodies bind to overlapping epitopes within a juxtamembrane negative regulatory region that protects N

179 Mutations in the juxtamembrane or C-terminal regions had only small obser

180 Here, by analyzing mice with juxtamembrane or kinase domain point mutations that incr

181 idogenesis, is initiated by S2 cleavage at a juxtamembrane position.

182 exposure of a cryptic protease site within a juxtamembrane proteolytic switch domain to activate tran

183 The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuron

184 oinositides, the function of Syx's polybasic juxtamembrane region (5RK) remains unclear.

185 nteracts specifically with the extracellular juxtamembrane region (JMR) and the transmembrane (TM) do

186 factor (GDNF), and its polymorphism at G691S juxtamembrane region (RETp) is a germline polymorphism.

187 Finally, EphA2 mutations in the juxtamembrane region (Y587F, Y593F, Y587E/Y593E), kinase

188 nd IGF1R are mediated by their intracellular juxtamembrane region and substrate binding to this regio

189 role in neurite branching, through both the juxtamembrane region and the RSLE region.

190 ested that an additional two residues in the juxtamembrane region and three sites in the activation l

191 Three modes of binding with the juxtamembrane region are characterized through a series

192 Sequence comparison of the juxtamembrane region identified similar palindromic sequ

193 like and suggesting a potential role for the juxtamembrane region in enzyme activity.

194 Deletion mutant analysis indicates that the juxtamembrane region including the GS domain of TbetaRI

195 oss-linking, we found that the extracellular juxtamembrane region is reordered after ligand binding.

196 A conserved aromatic/basic motif in the juxtamembrane region may be causing this relatively high

197 the autophosphorylation of EphB3 within the juxtamembrane region occurs in trans using a specific in

198 These results indicate that the luminal juxtamembrane region of APP is an important regulatory d

199 We have identified an amino acid in the juxtamembrane region of APP, lysine 624, on the basis of

200 we mutated 68 individual amino acids in the juxtamembrane region of CLR, a key region for activation

201 ese findings indicate that the extracellular juxtamembrane region of DDR1 is exceptionally flexible a

202 Furthermore, the extracellular juxtamembrane region of DDR1 tolerated large deletions a

203 ne phosphorylation site in the intracellular juxtamembrane region of DDR1b displayed positive signals

204 In this study, we have shown that the juxtamembrane region of EGFR harbors a putative NLS with

205 . in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in sta

206 atalytic activity in a similar manner as the juxtamembrane region of EphB2.

207 ike GPI-AP1 (LLG1) bind to the extracellular juxtamembrane region of FER and show that this interacti

208 increase the surface accessible area at the juxtamembrane region of intracellular loop 3 that could

209 rikingly, replacement of leucine(973) in the juxtamembrane region of IR to phenylalanine, which is pr

210 avage of the labeled receptor identified the juxtamembrane region of its amino-terminal domain as the

211 In addition, we have shown that the juxtamembrane region of L1-CT has some binding affinity

212 e pleckstrin homology domain of Kal7 and the juxtamembrane region of NR2B preceding its cytosolic C-t

213 kA signaling in neurons and propose that the juxtamembrane region of p75(ICD) acts to cause a conform

214 Bioinformatics analysis of the juxtamembrane region of PelD suggests that it contains a

215 phorylating a Ser/Thr cluster (CL-II) in the juxtamembrane region of Smo carboxyl-terminal intracellu

216 tive sorting requires lysine residues in the juxtamembrane region of Snc1 and is mediated by the Rsp5

217 , but the interaction requires the polybasic juxtamembrane region of syntaxin-1 and is not affected b

218 dues, H348 and H352, located in an external, juxtamembrane region of the E2 protein termed the D-loop

219 usly described another cleavage event in the juxtamembrane region of the ectodomain that generated a

220 tide corresponding to the calmodulin-binding juxtamembrane region of the EGFR on model membranes; W-7

221 hat charge-silencing mutagenesis within this juxtamembrane region of the epidermal growth factor rece

222 ent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus.

223 on 14-encoded sequences in the intracellular juxtamembrane region of the MET receptor.

224 ed that the Arg(131)-Lys(136) segment at the juxtamembrane region of the receptor amino terminus cont

225 of residues introduced in the extracellular juxtamembrane region of the receptor and not on the spec

226 f the NOTCH1 gene encoding the extracellular juxtamembrane region of the receptor.

227 ns of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase

228 the predicted off-state of the corresponding juxtamembrane region of the third intracellular loop of

229 ed on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NG

230 ric arrangement involving an exchange of the juxtamembrane region proximal to the kinase domain.

231 marily responsible for shedding corin in its juxtamembrane region to release the approximately 180-kD

232 Replacement of some residues in the juxtamembrane region with cysteine resulted in ligand-in

233 in ligand recognition, and find the specific juxtamembrane region within the CYTO (A375-P394) mediate

234 e latter is thought to form an alpha-helical juxtamembrane region, an unstructured linker, and a C-te

235 nt helix II extends the SNARE motif into the juxtamembrane region, and the more stable helix III is t

236 without conformational coupling through the juxtamembrane region, but requires specific receptor int

237 of DDR1 takes place within the extracellular juxtamembrane region, generating a membrane-anchored C-t

238 n alpha-helical structure that breaks in the juxtamembrane region, leaving the cytoplasmic domain uns

239 tified S-838, S-858, T-872, and T-880 in the juxtamembrane region, T-982 in the kinase domain, and S-

240 mains of IA-2 and IA-2beta, but not the IA-2 juxtamembrane region, were less common in patients carry

241 edding occurs in the immediate extracellular juxtamembrane region, which is also where O-glycosylatio

242 The juxtamembrane region, which links the NTD and the cataly

243 CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets,

244 basic amino acid residues in the cytoplasmic juxtamembrane region.

245 -BD of the receptor located at its cytosolic juxtamembrane region.

246 -dependent sorting signal located within its juxtamembrane region.

247 ergoes a conformational change involving the juxtamembrane region.

248 uses residues from the kinase domain and the juxtamembrane region.

249 R O-glycosylation is found N-terminal to the juxtamembrane region.

250 ontain the palindromic CD163 sequence in the juxtamembrane region.

251 fusion, another points to possible roles of juxtamembrane regions (JMRs) and transmembrane domains (

252 imultaneous tandem alanine mutations of both juxtamembrane regions Arg(292)-Met(295) and Lys(311)-Lys

253 ich the positively charged VAMP and syntaxin juxtamembrane regions facilitate fusion by bridging the

254 tyrosine kinases (RTKs) revealed that their juxtamembrane regions negatively regulate their catalyti

255 itively charged pockets in the intracellular juxtamembrane regions of alpha1 subunits.

256 dels by placing FRET probes at the cytosolic juxtamembrane regions of CD4 and the CD3 subunits to eva

257 We investigated the role of the juxtamembrane regions of IC3 by mutating amino acid cass

258 strate that PS binding at the N-terminal and juxtamembrane regions of nSMase2 rather acts as a confor

259 R activity, we determined that the cytosolic juxtamembrane regions of the CD3zetazeta subunits are sp

260 We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3

261 nct Dscam functions can be attributed to the juxtamembrane regions of TMs that govern dendritic versu

262 findings indicate that the transmembrane and juxtamembrane regions of TRKA play key roles in its dime

263 B ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-depe

264 chanisms, for example engagement of receptor juxtamembrane regions or the surrounding lipid environme

265 as well as aliphatic amino acids within both juxtamembrane regions were identified as important for E

266 actors (primary structures of TM domains and juxtamembrane regions, composition and phase of the loca

267 or for its activation, and that the key EpoR juxtamembrane regulatory motif essential for Epo-depende

268 We identified cysteine 306, a juxtamembrane residue on transmembrane domain 6 (TM6) of

269 ired PI3K recruitment and a newly identified juxtamembrane residue.

270 Similarly, substitution of the juxtamembrane residues of the TMD with alanines, or repl

271 ith site-directed mutagenesis identified two juxtamembrane residues, Lys-28 and Ser-26 (Abeta numberi

272 Mutagenesis studies demonstrated that the juxtamembrane secondary structure, not the primary amino

273 difference is located within the cytoplasmic juxtamembrane segment (JM) that links the kinase domain

274 l dimerization of the transmembrane helices, juxtamembrane segment dissociation and membrane burial,

275 ential intradimer coiled coil containing the juxtamembrane segment from each member of the receptor p

276 This study demonstrates that this juxtamembrane segment is highly conserved, alpha-helical

277 The C-terminal half of the juxtamembrane segment latches the activated kinase domai

278 We show that the intracellular juxtamembrane segment of the receptor, known to potentia

279 promotes an antiparallel interaction between juxtamembrane segments and release of inhibition by the

280 es near their N termini, dimerization of the juxtamembrane segments, and formation of asymmetric (act

281 gs highlight the importance of the polybasic juxtamembrane sequence in regulating the oncogenic poten

282 olenoid and the other between the C-terminal juxtamembrane sequences.

283 ied: an amphipathic helix at the N-terminal (juxtamembrane) side, a nonessential C-terminal region, a

284 nal (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery.

285 Juxtamembrane signaling via the membrane growth factor K

286 f syndecan-1 is proteolytically cleaved at a juxtamembrane site by tissue inhibitor of metalloproteas

287 RR) that enables ADAM protease cleavage at a juxtamembrane site that otherwise lies buried within the

288 vents like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbe

289 residue at position 386, in the cytoplasmic juxtamembrane stalk.

290 formation in which domain III (DIII) and the juxtamembrane stem pack against a central core trimer.

291 n outer layer composed of domain III and the juxtamembrane stem region.

292 pe protein (sE) that include portions of the juxtamembrane stem.

293 l change that couples to homodimerization of juxtamembrane structures in the Toll ectodomain C termin

294 Only the resulting juxtamembrane stub of the ectodomain is efficiently carr

295 tions in the semaphorin (T230M/E168D/N375S), juxtamembrane (T1010I/R988C), and tyrosine kinase (T1275

296 The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intra

297 r, we suggest that specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and

298 Mice containing a point mutation in the CD45 juxtamembrane wedge domain (E613R) develop a B cell-driv

299 ated mice containing a point mutation in the juxtamembrane wedge of CD45.

300 ated mice containing a point mutation in the juxtamembrane wedge of the receptor-like protein tyrosin