ライフサイエンスコーパス: juxtamembrane

1 ction critically depends on an extracellular juxtamembrane 23-amino acid sequence of p75(NTR).

2 untethering of the SERT C terminus from the juxtamembrane actin cytoskeleton.

3 e alpha-helix, joined by a short linker to a juxtamembrane alpha-helix, which is associated with the

4 We found that replacing syndecan-1 juxtamembrane amino acid residues A243-S-Q-S-L247 with h

5 The interactions between the juxtamembrane amphipathic helix of one monomer and its n

6 Abs to juxtamembrane and central region constructs were both DR

7 viously identified ezrin binding motifs, the juxtamembrane and the (1176)YRSLE regions, we have disco

8 ormational change is transmitted through the juxtamembrane and transmembrane domains, leading to acti

9 ed cysteine-scanning mutagenesis in the EpoR juxtamembrane and transmembrane domains.

10 17 is released by ectodomain shedding at the juxtamembrane and/or intramembrane motif and to show tha

11 containing the extracellular, transmembrane, juxtamembrane, and kinase domains are overexpressed and

12 studies affirm the importance of the kinase, juxtamembrane, and transmembrane domains of PknA.

13 cysteines, a transmembrane glutamine, and a juxtamembrane aspartic acid.

14 A clasp to mimic juxtamembrane association between the integrin alpha and

15 mechanism of activation is disruption of the juxtamembrane autoregulatory domain by internal tandem d

16 Mutation of juxtamembrane basic residues in the plasma membrane SNAR

17 mechanism in which W515 at the intracellular juxtamembrane boundary inhibits dimerization of the TpoR

18 f the intracellular domain that includes the juxtamembrane, Box 1, and Box 2 regions.

19 igh level of flexibility and disorder in the juxtamembrane chopper domain of p75NTR, which results in

20 This shedding is performed by way of juxtamembrane cleavage and is mediated by a sheddase, wh

21 ursors to Pmel17 amyloid, depends on a novel juxtamembrane cleavage at amino acid position 583 betwee

22 and occurs predominantly or exclusively via juxtamembrane cleavage at the previously identified shed

23 mpts conformational changes in the cytosolic juxtamembrane coiled-coil region.

24 dimer formation and oncogenic activation of juxtamembrane cysteine mutants of RET, and explains the

25 4-subunit is S-acylated (palmitoylated) on a juxtamembrane cysteine residue (Cys-193) in the intracel

26 that JAM-C undergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys-264 and Cys-265.

27 ACE1 is modified by S-palmitoylation at four juxtamembrane cysteine residues.

28 indicate that DHHC5 palmitoylates PLM at two juxtamembrane cysteines, C40 and C42, although C40 is th

29 in Kv2.1 is governed by a 34 aa motif in the juxtamembrane cytoplasmic C terminus, and a 17 aa motif

30 with a cadherin 11 construct that lacked the juxtamembrane cytoplasmic domain was diminished to the l

31 Here we report that the conserved juxtamembrane cytoplasmic tyrosine motif ((612)YIY(614))

32 e D2, directly phosphorylating the conserved juxtamembrane DEGSY motif of the syndecan cytosolic doma

33 complex (alphabeta(2)) linked through native juxtamembrane disulfide bonds could be produced from iso

34 al tandem duplication (ITD) mutations in the juxtamembrane domain (23%) and point mutations in the ty

35 n the ligand N-terminal ELR and the receptor juxtamembrane domain (J-domain) residues (site II).

36 amino-terminal portion binds the receptor's juxtamembrane domain (J-domain).

37 a mutant cadherin-11 lacking the cytoplasmic juxtamembrane domain (JMD) diminished the turnover of al

38 The juxtamembrane domain (JMD) of S is an aromatic amino aci

39 lmodulin (Ca/CaM) binds to the intracellular juxtamembrane domain (JMD) of the epidermal growth facto

40 hly conserved tryptophan residues within the juxtamembrane domain (JMD) of the vesicular SNARE Synapt

41 Either activation loop Y807F or juxtamembrane domain (JMD) Y559F mutations severely comp

42 Its juxtamembrane domain (JX), the region located between th

43 ain (E168D, L299F, S323G, and N375S) and the juxtamembrane domain (R988C, R988C + T1010I, S1058P, and

44 phorin domain (N375S, M431V, and N454I), the juxtamembrane domain (T1010I and G1085X), and an alterna

45 ndocytosis, but p120 binding to the cadherin juxtamembrane domain acts as a master regulator guarding

46 residues 765-958 of PTPmu, which include the juxtamembrane domain and 35 residues of the first phosph

47 Longer forms of RET containing the juxtamembrane domain and C-terminal tail exhibited simil

48 ive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c

49 of EGF receptor mutants in the intracellular juxtamembrane domain and demonstrate that the most membr

50 ion of Pref-1 and fibronectin via the Pref-1 juxtamembrane domain and fibronectin C-terminal domain.

51 ernal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of a

52 in, the transmembrane domain and the luminal juxtamembrane domain are required for efficient cleavage

53 interactions that are dependent on distinct juxtamembrane domain conformations, resulting in signifi

54 is thus a specific requirement for BTN3A1's juxtamembrane domain for correct gammadelta T cell-relat

55 A conserved juxtamembrane domain harbours disease mutations, which c

56 The intracellular juxtamembrane domain has previously been shown to be req

57 c domain Ia and (2) folding/unfolding of the juxtamembrane domain Ib of PLN.

58 Thus, the conformational change in the FLT3 juxtamembrane domain induced by the ITD activates the ki

59 These data suggest that the cytoplasmic juxtamembrane domain is involved not only in the transmi

60 on experiments revealed that the cytoplasmic juxtamembrane domain is necessary for maximal FERONIA ac

61 In contrast, Tyr-831 in the juxtamembrane domain is not essential for kinase activit

62 that dasatinib potently inhibits WT KIT and juxtamembrane domain mutant KIT autophosphorylation and

63 the PDGFRA mutation; for example, the V561D juxtamembrane domain mutation is more sensitive to imati

64 t cell line-1 (HMC-1)-HMC-1.1, harboring the juxtamembrane domain mutation V560G, and HMC-1.2, carryi

65 Juxtamembrane domain mutations are common in gastrointes

66 Whereas KIT juxtamembrane domain mutations seen in most patients wit

67 e membrane binding of the positively charged juxtamembrane domain of a reconstituted VAMP2 protein an

68 In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembran

69 p120(ctn) binds to the juxtamembrane domain of classical cadherins and has been

70 The 45-residue juxtamembrane domain of EGFR (JM), located between the t

71 TRIP6 binds to the cytoplasmic juxtamembrane domain of Fas and interferes with the recr

72 tion between FGFR3 and Pyk2, mediated by the juxtamembrane domain of FGFR3 and the kinase domain of P

73 encodes the switch and zipper regions of the juxtamembrane domain of FLT3.

74 model by inserting an ITD mutation into the juxtamembrane domain of murine Flt3.

75 ly mediated by the highly positively charged juxtamembrane domain of syntaxin.

76 The intracellular juxtamembrane domain of the EGF receptor has been shown

77 eonine 654 (PKC phosphorylation site) in the juxtamembrane domain of the receptor is considerably inc

78 ylation was inserted at the beginning of the juxtamembrane domain of the receptor.

79 known RON orthologs that encodes part of the juxtamembrane domain of the receptor.

80 oth the extracellular amino terminus and the juxtamembrane domain of the receptor.

81 me internal tandem duplications (ITD) at the juxtamembrane domain of the receptor.

82 specifically interacts with the cytoplasmic juxtamembrane domain of TrkA receptor and triggers its d

83 PDCL3 binds to the juxtamembrane domain of VEGFR-2 and controls the abundan

84 The juxtamembrane domain of vesicle-associated membrane prot

85 y internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop mutations in

86 f the activating length mutation (LM) in the juxtamembrane domain or point mutation in the kinase dom

87 ing internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine

88 tified, as being of particular importance, a juxtamembrane domain region of BTN3A molecules identifie

89 lung cancer, which encodes a deletion of the juxtamembrane domain resulting in the loss of Cbl E3-lig

90 ta show that aberrant MET regulation via the juxtamembrane domain subverts core MET receptor function

91 d 2 candidate STAT5 docking sites within the juxtamembrane domain that are disrupted by the ITD.

92 t a highly conserved motif in the E-cadherin juxtamembrane domain that determines apical-lateral pola

93 Mutation of residues within the juxtamembrane domain that reduce the VAMP2 net positive

94 y binds to phosphorylated Y(561) in the PERK juxtamembrane domain through its SH2 domain.

95 precursor (pro-HB-EGF), it is cleaved at the juxtamembrane domain to release the soluble form of HB-E

96 age the receptor tyrosine kinase Axl via its juxtamembrane domain to trigger ligand-independent autop

97 t results in a V559A substitution within the juxtamembrane domain was identified in three family memb

98 We found that whereas the Crb juxtamembrane domain was not required for adherens junct

99 rb has been proposed to interact through its juxtamembrane domain with Moesin (Moe), a FERM domain pr

100 d alternative splice product skipping entire juxtamembrane domain) of a NSCLC cell line and adenocarc

101 dent on p120's interaction with the cadherin juxtamembrane domain, but occurs independently of p120's

102 he integral membrane form of PMEL within the juxtamembrane domain, releasing the PMEL luminal domain

103 on of the activation loop, alphaC-helix, and juxtamembrane domain, which are all important domains fo

104 Activation of cFMS is also inhibited by the juxtamembrane domain, which interacts with residues of t

105 GFR2 TK construct inclusive of the important juxtamembrane domain.

106 ng require the presence of the intracellular juxtamembrane domain.

107 n of ACE is required for its cleavage at the juxtamembrane domain.

108 in PTH), which interacts with the receptor's juxtamembrane domain.

109 mportant regulatory role for the APP luminal juxtamembrane domain.

110 aling capacity of mouse and human RON to the juxtamembrane domain.

111 ependent colony formation that mapped to the juxtamembrane domain.

112 eceptor (MET(Delta14)) lacking a cytoplasmic juxtamembrane domain.

113 r mutant containing a distal mutation in the juxtamembrane domain.

114 e derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of

115 ion, understanding how the transmembrane and juxtamembrane domains contribute to transmembrane signal

116 ces a Ferris wheel-like translocation of two juxtamembrane domains in the dimer with essentially no c

117 he hydrophobic transmembrane and amphipathic juxtamembrane domains is important for stabilizing the t

118 creen exons encoding the activation loop and juxtamembrane domains of 85 tyrosine kinase genes in 188

119 systematic mutation of the transmembrane and juxtamembrane domains of a model transmembrane protein,

120 y threonine phosphorylation in the conserved juxtamembrane domains of EGFR and HER2.

121 nto RGCs reveals that both extracellular and juxtamembrane domains of EphB1 are required to efficient

122 , the interactions between the catalytic and juxtamembrane domains of VEGFR2 are studied.

123 inal segment to interact with the receptor's juxtamembrane domains to activate the receptor.

124 by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic int

125 s of the TM domains and of the intracellular juxtamembrane domains, paving the way for a comprehensiv

126 ceptor-tyrosine kinases via their respective juxtamembrane domains; additionally the binding mode of

127 ic Abs: those to 841-860 peptide with Abs to juxtamembrane epitopes, which appear early in prediabete

128 These so-called juxtamembrane expansion (JME) alleles consist of interna

129 A juxtamembrane FERM domain-binding motif is responsible f

130 Crb directly binds to Ex through its juxtamembrane FERM-binding motif (FBM).

131 The Ex-regulatory domain of Crb maps to the juxtamembrane FERM-binding motif (JM), a cytoskeletal in

132 3.8 A/amino acid), indicating that the three juxtamembrane fibronectin domains of gp130 are not neces

133 am isoforms that contain the TM2 cytoplasmic juxtamembrane flanking sequences.

134 nce shows that PC1 undergoes cleavage at the juxtamembrane G protein-coupled receptor proteolytic sit

135 A turn at the Gly of the juxtamembrane GFFKR motif caps the alpha TM helix and br

136 tured alpha-helix that closely resembles the juxtamembrane helical region of the analogous TM6 and th

137 ts that are held together noncovalently by a juxtamembrane heterodimerization (HD) domain.

138 R includes the 3 Lin12/Notch repeats and the juxtamembrane heterodimerization domain, the region of N

139 arly, only one receptor in the dimer needs a juxtamembrane hydrophobic L253 or W258 residue, essentia

140 We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that

141 Because the caveolin-1 scaffolding domain is juxtamembrane, it is tempting to suggest that Slo1-caveo

142 in, and transmembrane/extracellular loop, or juxtamembrane (J) regions of the receptor.

143 forms characterized by variant extracellular juxtamembrane (JM) and intracellular cytoplasmic (CYT) d

144 n this paper, we investigate the role of the juxtamembrane (JM) domain in EGFR signaling by replacing

145 een two conserved tryptophan residues in the juxtamembrane (JM) domain is required for kinase activat

146 Here we show that the XA21 juxtamembrane (JM) domain is required for kinase autopho

147 hout (VEGFR2-CD) and with (VEGFR2-CD/JM) the juxtamembrane (JM) domain were characterized by kinetic,

148 al tandem duplication (ITD) sequences in the juxtamembrane (JM) domain.

149 tural features of the transmembrane (TM) and juxtamembrane (JM) domains of APP that facilitate proteo

150 Its transmembrane domain (TMD) and juxtamembrane (JM) region are essential for signal trans

151 l growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory

152 is study demonstrates that the intracellular juxtamembrane (JM) region plays a vital role in the kina

153 position of the B30.2 domain relative to the juxtamembrane (JM) region.

154 Our results demonstrate that the juxtamembrane (JM) regions of RTKs are critical for indu

155 The transmembrane (TM) and juxtamembrane (JM) regions of the epidermal growth facto

156 ontaining the ErbB2 TM helix and some of the juxtamembrane (JM) residues were studied.

157 and an intracellular domain that includes a juxtamembrane (JM) sequence and a kinase domain.

158 Further, both the juxtamembrane (JMD) and beta-catenin binding domains (CB

159 rnal tandem duplication (ITD) of FLT3 at the juxtamembrane (JMD) and tyrosine kinase (TKD) domains (F

160 The juxtamembrane K54 residue in TCR-zeta was identified to

161 The formation of the activating juxtamembrane latch is prevented by the C-terminal tails

162 oximal fifth and sixth FNIII domains and the juxtamembrane linker and showed that a fragment containi

163 ce vesicle binding assay to characterize the juxtamembrane linker and to test the ability of reconsti

164 y, additional deletion of the remaining five juxtamembrane-located amino acids also abrogated ADAM10-

165 A juxtamembrane Lys residue in beta also has an important

166 balpha leucine-rich repeat domain (LRRD) and juxtamembrane mechanosensitive domain (MSD).

167 Oligomerization requires the juxtamembrane middle domain three-helix bundle, as does

168 2 activation due to mutations in a conserved juxtamembrane motif does lead to cytokine-independent ac

169 residues at a time revealed that a conserved juxtamembrane motif, MKKK, was the only region required

170 inhibit the growth of cell lines expressing juxtamembrane mutant KIT.

171 Wild-type Kit-and juxtamembrane-mutant-expressing cell lines required cons

172 Imatinib, which potently inhibits juxtamembrane mutants, is effective for the treatment of

173 c mastocytosis (SM); however, unlike the KIT juxtamembrane mutants, the activation loop mutants are i

174 aberrant proliferation is a consequence of a juxtamembrane mutation in the FLT3 gene (FMS-like tyrosi

175 canonical phosphorylation site (RETW) in the juxtamembrane N-terminal region of monoamine transporter

176 bodies bind to overlapping epitopes within a juxtamembrane negative regulatory region that protects N

177 Mutations in the juxtamembrane or C-terminal regions had only small obser

178 r loops and seven transmembrane helices (the juxtamembrane or J domain) could also antagonize the PTH

179 Here, by analyzing mice with juxtamembrane or kinase domain point mutations that incr

180 om oncogenic mutations in the extracellular, juxtamembrane, or kinase domains.

181 idogenesis, is initiated by S2 cleavage at a juxtamembrane position.

182 The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuron

183 oinositides, the function of Syx's polybasic juxtamembrane region (5RK) remains unclear.

184 nteracts specifically with the extracellular juxtamembrane region (JMR) and the transmembrane (TM) do

185 factor (GDNF), and its polymorphism at G691S juxtamembrane region (RETp) is a germline polymorphism.

186 Finally, EphA2 mutations in the juxtamembrane region (Y587F, Y593F, Y587E/Y593E), kinase

187 nd IGF1R are mediated by their intracellular juxtamembrane region and substrate binding to this regio

188 role in neurite branching, through both the juxtamembrane region and the RSLE region.

189 ested that an additional two residues in the juxtamembrane region and three sites in the activation l

190 Three modes of binding with the juxtamembrane region are characterized through a series

191 Sequence comparison of the juxtamembrane region identified similar palindromic sequ

192 like and suggesting a potential role for the juxtamembrane region in enzyme activity.

193 Deletion mutant analysis indicates that the juxtamembrane region including the GS domain of TbetaRI

194 A conserved aromatic/basic motif in the juxtamembrane region may be causing this relatively high

195 the autophosphorylation of EphB3 within the juxtamembrane region occurs in trans using a specific in

196 These results indicate that the luminal juxtamembrane region of APP is an important regulatory d

197 We have identified an amino acid in the juxtamembrane region of APP, lysine 624, on the basis of

198 we mutated 68 individual amino acids in the juxtamembrane region of CLR, a key region for activation

199 ese findings indicate that the extracellular juxtamembrane region of DDR1 is exceptionally flexible a

200 Furthermore, the extracellular juxtamembrane region of DDR1 tolerated large deletions a

201 In this study, we have shown that the juxtamembrane region of EGFR harbors a putative NLS with

202 . in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in sta

203 atalytic activity in a similar manner as the juxtamembrane region of EphB2.

204 ike GPI-AP1 (LLG1) bind to the extracellular juxtamembrane region of FER and show that this interacti

205 increase the surface accessible area at the juxtamembrane region of intracellular loop 3 that could

206 rikingly, replacement of leucine(973) in the juxtamembrane region of IR to phenylalanine, which is pr

207 avage of the labeled receptor identified the juxtamembrane region of its amino-terminal domain as the

208 In addition, we have shown that the juxtamembrane region of L1-CT has some binding affinity

209 e pleckstrin homology domain of Kal7 and the juxtamembrane region of NR2B preceding its cytosolic C-t

210 kA signaling in neurons and propose that the juxtamembrane region of p75(ICD) acts to cause a conform

211 Bioinformatics analysis of the juxtamembrane region of PelD suggests that it contains a

212 phorylating a Ser/Thr cluster (CL-II) in the juxtamembrane region of Smo carboxyl-terminal intracellu

213 , but the interaction requires the polybasic juxtamembrane region of syntaxin-1 and is not affected b

214 usly described another cleavage event in the juxtamembrane region of the ectodomain that generated a

215 tide corresponding to the calmodulin-binding juxtamembrane region of the EGFR on model membranes; W-7

216 hat charge-silencing mutagenesis within this juxtamembrane region of the epidermal growth factor rece

217 ent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus.

218 on 14-encoded sequences in the intracellular juxtamembrane region of the MET receptor.

219 ed that the Arg(131)-Lys(136) segment at the juxtamembrane region of the receptor amino terminus cont

220 of residues introduced in the extracellular juxtamembrane region of the receptor and not on the spec

221 f the NOTCH1 gene encoding the extracellular juxtamembrane region of the receptor.

222 ns of cysteine residues in the extracellular juxtamembrane region of the RET receptor tyrosine kinase

223 the predicted off-state of the corresponding juxtamembrane region of the third intracellular loop of

224 ed on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NG

225 an internal tandem duplication (ITD) of the juxtamembrane region or a point mutation of the Flt3 rec

226 ric arrangement involving an exchange of the juxtamembrane region proximal to the kinase domain.

227 marily responsible for shedding corin in its juxtamembrane region to release the approximately 180-kD

228 GISTs commonly contain mutations of the KIT juxtamembrane region while SM and AML harbor active site

229 in ligand recognition, and find the specific juxtamembrane region within the CYTO (A375-P394) mediate

230 e latter is thought to form an alpha-helical juxtamembrane region, an unstructured linker, and a C-te

231 nt helix II extends the SNARE motif into the juxtamembrane region, and the more stable helix III is t

232 without conformational coupling through the juxtamembrane region, but requires specific receptor int

233 of DDR1 takes place within the extracellular juxtamembrane region, generating a membrane-anchored C-t

234 n alpha-helical structure that breaks in the juxtamembrane region, leaving the cytoplasmic domain uns

235 tified S-838, S-858, T-872, and T-880 in the juxtamembrane region, T-982 in the kinase domain, and S-

236 mains of IA-2 and IA-2beta, but not the IA-2 juxtamembrane region, were less common in patients carry

237 edding occurs in the immediate extracellular juxtamembrane region, which is also where O-glycosylatio

238 e identified a specific sequence in the TrkA juxtamembrane region, which is distinct from that in Trk

239 The juxtamembrane region, which links the NTD and the cataly

240 CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets,

241 -BD of the receptor located at its cytosolic juxtamembrane region.

242 uses residues from the kinase domain and the juxtamembrane region.

243 nase domain and tyrosine residues within the juxtamembrane region.

244 -like domain in the PDGFbetaR autoinhibitory juxtamembrane region.

245 R O-glycosylation is found N-terminal to the juxtamembrane region.

246 ontain the palindromic CD163 sequence in the juxtamembrane region.

247 ergoes a conformational change involving the juxtamembrane region.

248 basic amino acid residues in the cytoplasmic juxtamembrane region.

249 fusion, another points to possible roles of juxtamembrane regions (JMRs) and transmembrane domains (

250 imultaneous tandem alanine mutations of both juxtamembrane regions Arg(292)-Met(295) and Lys(311)-Lys

251 ich the positively charged VAMP and syntaxin juxtamembrane regions facilitate fusion by bridging the

252 tyrosine kinases (RTKs) revealed that their juxtamembrane regions negatively regulate their catalyti

253 dels by placing FRET probes at the cytosolic juxtamembrane regions of CD4 and the CD3 subunits to eva

254 We investigated the role of the juxtamembrane regions of IC3 by mutating amino acid cass

255 R activity, we determined that the cytosolic juxtamembrane regions of the CD3zetazeta subunits are sp

256 We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3

257 ing motifs, located in the N- and C-terminal juxtamembrane regions of the third intracellular loop of

258 nct Dscam functions can be attributed to the juxtamembrane regions of TMs that govern dendritic versu

259 B ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-depe

260 as well as aliphatic amino acids within both juxtamembrane regions were identified as important for E

261 actors (primary structures of TM domains and juxtamembrane regions, composition and phase of the loca

262 or for its activation, and that the key EpoR juxtamembrane regulatory motif essential for Epo-depende

263 We identified cysteine 306, a juxtamembrane residue on transmembrane domain 6 (TM6) of

264 ired PI3K recruitment and a newly identified juxtamembrane residue.

265 Similarly, substitution of the juxtamembrane residues of the TMD with alanines, or repl

266 ith site-directed mutagenesis identified two juxtamembrane residues, Lys-28 and Ser-26 (Abeta numberi

267 Mutagenesis studies demonstrated that the juxtamembrane secondary structure, not the primary amino

268 difference is located within the cytoplasmic juxtamembrane segment (JM) that links the kinase domain

269 l dimerization of the transmembrane helices, juxtamembrane segment dissociation and membrane burial,

270 ential intradimer coiled coil containing the juxtamembrane segment from each member of the receptor p

271 Efforts have been devoted to studying the juxtamembrane segment in order to understand the biologi

272 This study demonstrates that this juxtamembrane segment is highly conserved, alpha-helical

273 The C-terminal half of the juxtamembrane segment latches the activated kinase domai

274 We show that the intracellular juxtamembrane segment of the receptor, known to potentia

275 promotes an antiparallel interaction between juxtamembrane segments and release of inhibition by the

276 es near their N termini, dimerization of the juxtamembrane segments, and formation of asymmetric (act

277 gs highlight the importance of the polybasic juxtamembrane sequence in regulating the oncogenic poten

278 orm low affinity dimers in solution and that juxtamembrane sequences of Toll are critical for the act

279 olenoid and the other between the C-terminal juxtamembrane sequences.

280 ied: an amphipathic helix at the N-terminal (juxtamembrane) side, a nonessential C-terminal region, a

281 nal (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery.

282 Juxtamembrane signaling via the membrane growth factor K

283 f syndecan-1 is proteolytically cleaved at a juxtamembrane site by tissue inhibitor of metalloproteas

284 RR) that enables ADAM protease cleavage at a juxtamembrane site that otherwise lies buried within the

285 cleaved ACE at the same Arg-Ser bond in the juxtamembrane stalk as the constitutive secretase but wa

286 Substitution of the shorter pro-BTC juxtamembrane stalk or truncation of the pro-TGF-alpha s

287 residue at position 386, in the cytoplasmic juxtamembrane stalk.

288 dditionally, soluble TACE did not cleave the juxtamembrane stalks of either pro-BTC or pro-epiregulin

289 ied soluble TACE cleaved single sites in the juxtamembrane stalks of mouse pro-HB-EGF and pro-AR ecto

290 formation in which domain III (DIII) and the juxtamembrane stem pack against a central core trimer.

291 n outer layer composed of domain III and the juxtamembrane stem region.

292 pe protein (sE) that include portions of the juxtamembrane stem.

293 l change that couples to homodimerization of juxtamembrane structures in the Toll ectodomain C termin

294 Only the resulting juxtamembrane stub of the ectodomain is efficiently carr

295 tions in the semaphorin (T230M/E168D/N375S), juxtamembrane (T1010I/R988C), and tyrosine kinase (T1275

296 The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intra

297 r, we suggest that specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and

298 Mice containing a point mutation in the CD45 juxtamembrane wedge domain (E613R) develop a B cell-driv

299 ated mice containing a point mutation in the juxtamembrane wedge of CD45.

300 ated mice containing a point mutation in the juxtamembrane wedge of the receptor-like protein tyrosin