ライフサイエンスコーパス: juxtanuclear

1 cytoplasmic inclusions appear as a distinct juxtanuclear accumulation at the centrosome and this req

2 y, Anxa6 knockdown also abrogated PE-induced juxtanuclear accumulation of secretory granules (SG) con

3 ts led to increased superoxide anion levels, juxtanuclear accumulation of ubiquitin- and p62/SQSTM1-p

4 e that undergoes a rapid condensation into a juxtanuclear aggregate during chemokine-induced polariza

5 Of note, abnormal juxtanuclear aggregates of mitochondria were observed, a

6 roteasome activity elicited the formation of juxtanuclear aggregates with characteristics of aggresom

7 , trafficking of a folding mutant that forms juxtanuclear aggregates, EGFP/SP-C(C122/186G), was not c

8 ese severe defects developed gradually after juxtanuclear aggresome formation and were not associated

9 /-) cells with prosaposin localized to large juxtanuclear aggresome-like inclusions, which is indicat

10 racellular degradative capacity is exceeded, juxtanuclear aggresomes are formed to sequester misfolde

11 Juxtanuclear aggresomes form in cells when levels of agg

12 nd caused redistribution of the receptors to juxtanuclear aggresomes, significantly more so for TPbet

13 ubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, without affecting 20S proteasom

14 of microtubules eliminated the formation of juxtanuclear and intranuclear inclusion bodies by HtEx1.

15 osomes and mitochondria were enriched in the juxtanuclear area and co-aggregate into a compact inclus

16 n also causes clustering of lysosomes in the juxtanuclear area of the cell, but the mechanisms respon

17 ining the redistribution of lysosomes to the juxtanuclear area.

18 ts and HeLa cells result in the formation of juxtanuclear bodies containing SSBP2.

19 ogenous SSBP2 protein and sequesters it into juxtanuclear bodies in adenovirally transformed human em

20 microtubules to retain the integrity of the juxtanuclear bodies suggests them to be E1B55K containin

21 ower rate and did not rapidly concentrate in juxtanuclear bodies.

22 en fluorescent protein, hLnk is found at the juxtanuclear compartment and also appears to be localize

23 s, while the 75-kDa protein localized to the juxtanuclear compartment and was packaged into virion pa

24 betaII (PKC betaII) translocated to a novel juxtanuclear compartment as observed in several cell typ

25 n the plasma membrane, but not in a distinct juxtanuclear compartment in which NHE3 is predominantly

26 In addition, the SDYQRL-TR-containing juxtanuclear compartment is more acidic than the recycli

27 zed together with other virion proteins in a juxtanuclear compartment termed the assembly compartment

28 rane, while E3-7.7K localized primarily to a juxtanuclear compartment that could not be identified.

29 This juxtanuclear compartment was localized close to the Golg

30 ation, and ErbB2 was observed to move into a juxtanuclear compartment where it colocalized with PKC-a

31 uitinated misfolded proteins accumulate in a juxtanuclear compartment where proteasomes are concentra

32 The juxtanuclear compartment, however, is a bona fide recycl

33 umulation of internalized cargo in a compact juxtanuclear compartment, Rabenosyn-5-RNAi caused its re

34 ate the targeting of misfolded proteins to a juxtanuclear compartment.

35 THP-1 cells at the plasma membrane and in a juxtanuclear compartment.

36 -HT receptor (5-HT2AR) into a Rab11-positive juxtanuclear compartment.

37 sical PKC isoenzymes, alpha and betaII, to a juxtanuclear compartment.

38 egress from the nucleus and associate with a juxtanuclear cytoplasmic assembly compartment, where vir

39 one (perivacuolar) or two (perivacuolar and juxtanuclear) dot-like aggregates per cell.

40 such membrane interactions are identified at juxtanuclear endocytic recycling compartments.

41 ly causing the observed retention of BST2 in juxtanuclear endosomes and stimulating its degradation i

42 ible and only partially affects STIM1 in the juxtanuclear ER compartment.

43 g microtubule depolymerization, the central, juxtanuclear Golgi apparatus scatters to multiple periph

44 All Golgi region proteins examined lost juxtanuclear Golgi apparatus-like distribution as scored

45 nhibited the transport of Shiga toxin to the juxtanuclear Golgi apparatus.

46 d dynein for its retrograde transport to the juxtanuclear Golgi complex and that STB increases MT ass

47 with antimannosidase II and anti-p200 in the juxtanuclear Golgi complex.

48 fragments tracked outward from the compact, juxtanuclear Golgi complex.

49 lgi enzymes gradually redistributed from the juxtanuclear Golgi or Golgi ministacks to the ER in cell

50 gp75 associates with GIPC, primarily in the juxtanuclear Golgi region.

51 al markers accumulated at the same rate in a juxtanuclear Golgi.

52 duce two distinct types of aggregates: large juxtanuclear inclusion bodies and small punctate aggrega

53 S reactivity of the fractions show that the juxtanuclear inclusion bodies are filled with amyloid-li

54 d cells and prevented the formation of large juxtanuclear inclusion bodies.

55 tein suffices to promote its delivery to the juxtanuclear inclusion.

56 d cells frequently leads to the formation of juxtanuclear inclusions that have been termed 'aggresome

57 sequently found to be enclosed within large, juxtanuclear, LAMP-1-positive vacuoles called Francisell

58 er, a large fraction of Hook3 maintained its juxtanuclear localization after Brefeldin A treatment, i

59 PKC-alpha knockdown impaired the juxtanuclear localization of ErbB2.

60 Fragmented Golgi membranes maintained their juxtanuclear localization, cisternal organization and ar

61 ding to IEV in size and shape, moving from a juxtanuclear location to the periphery of the cell, wher

62 o one in which filaments are aggregated in a juxtanuclear location, opposite to the direction of cell

63 lpha1, or N-cadherin, generate intracellular juxtanuclear membrane tubules when expressed in cells.

64 o focal adhesions in addition to cytoplasmic juxtanuclear membranes within infected cells.

65 During the process, juxtanuclear mitochondrial aggregates resembling a prote

66 y: peripheral lysosomes are less acidic than juxtanuclear ones despite their comparable buffering cap

67 lized SV5 HN in vesicle-like structures in a juxtanuclear pattern coincident with the localization of

68 isternae were still stacked and located in a juxtanuclear position.

69 G132-treated quiescent cells displayed fewer juxtanuclear protein aggregates, less apoptosis, and hig

70 the insoluble protein deposit (IPOD) and the juxtanuclear quality control (JUNQ).

71 s localize to one of these compartments, the juxtanuclear quality control compartment (JUNQ), and int

72 vented the translocation of PKCbetaII to the juxtanuclear region but not to the plasma membrane, thus

73 dosomes, which were less concentrated at the juxtanuclear region in mutant cells than in control fibr

74 at the deposition of the protofibrils in the juxtanuclear region is important in fibril formation.

75 tankyrase with GLUT4 storage vesicles in the juxtanuclear region of adipocytes.

76 ular membrane compartment emanating from the juxtanuclear region of cells, which resembled the compar

77 olgi apparatus and recycling endosome in the juxtanuclear region of resting peritoneal macrophages.

78 ular distribution of the gene product in the juxtanuclear region of the cells.

79 istically, translocation of PKCbetaII to the juxtanuclear region required kinase activity.

80 y demonstrated that virion movement from the juxtanuclear region to the periphery was saltatory with

81 es a dramatic redistribution of CAL from the juxtanuclear region to the plasma membrane where the two

82 FP-enriched vesicles rapidly travel from the juxtanuclear region to the plasma membrane.

83 C10 directs the trafficking of CFTR from the juxtanuclear region to the secretory pathway toward the

84 ER stress conditions, the QCVs converge in a juxtanuclear region, at the ERQC, as previously reported

85 KC) alpha and betaII become sequestered in a juxtanuclear region, the pericentrion.

86 AGS3 and AGS3-GFP from the cell cortex to a juxtanuclear region, where it co-localized with markers

87 r trafficking from the cell periphery to the juxtanuclear region, where they acquire EEA1.

88 to sequestration of recycling endosomes in a juxtanuclear region.

89 ing of B5-GFP to the site of wrapping in the juxtanuclear region.

90 and APPL to the early EEA1 endosomes in the juxtanuclear region.

91 tivity within HSFs was mostly present in the juxtanuclear region.

92 g COPII-associated membranes to cluster to a juxtanuclear region.

93 tacks in the pericentriolar and often in the juxtanuclear regions of the cell.

94 KCbetaI translocates to a recently described juxtanuclear site of localization for PKCalpha and PKCbe

95 ible fragmentation of the Golgi complex into juxtanuclear, stacked cisternal elements.

96 Immunofluorescent staining reveals striking juxtanuclear staining characteristic of the Golgi appara

97 e cycle of HCMV and accumulated in a stable, juxtanuclear structure late in infection.

98 essed, fluorescence began to accumulate in a juxtanuclear structure.

99 The morphology of the SDYQRL-TR-containing juxtanuclear structures is different from the recycling

100 ng pathway, colocalize with SDYQRL-TR in the juxtanuclear structures.

101 s and late endosomes into large (2-3 microm) juxtanuclear structures.

102 both necessary and sufficient for preventing juxtanuclear translocation of PKC betaII in response to

103 define a role for this pathway in regulating juxtanuclear translocation of PKC betaII.

104 F-7 cells but not in those cells that showed juxtanuclear translocation of PKC betaII.

105 Juxtanuclear translocation of PKC required an intact C1

106 onstrating a role for phospholipase D in the juxtanuclear translocation of PKCbetaII.

107 NFlank, shifting NFlank immunostaining to a juxtanuclear tubular array.

108 ells, the SDYQRL-TR construct accumulated in juxtanuclear tubules and vesicles that are in the vicini

109 GF receptors from peripheral compartments to juxtanuclear vesicles, and their subsequent degradation.

110 oprecipitate and colocalize with Dlg1 in the juxtanuclear zone.