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1 nd-binding domain of a light-gated mammalian kainate receptor.
2 1 prevents kainate-evoked endocytosis of the kainate receptor.
3 ivity for effectively blocking both AMPA and kainate receptors.
4 s that can potentially inhibit both AMPA and kainate receptors.
5 combinant homomeric and heteromeric AMPA and kainate receptors.
6 discharges in BLA slices in vitro via GluK1 kainate receptors.
7 rgic ACs do not appear to express functional kainate receptors.
8 tly the activity of both the GluK1 and GluK2 kainate receptors.
9 on structure currently exists of heteromeric kainate receptors.
10 e involvement of Ca(2+)/calcineurin and AMPA/kainate receptors.
11 ties by having subnanomolar IC(50) values at kainate receptors.
12 st that Neto2 modulates the function of most kainate receptors.
13 ferent from those of the homologous AMPA and kainate receptors.
14 es that contained GluK1, GluK1/5, or GluK2/5 kainate receptors.
15 hyl-4-isoxazolepropionic acid receptors, and kainate receptors.
16 c currents in neurons expressing recombinant kainate receptors.
17 for recombinant NMDA receptors over AMPA and kainate receptors.
18 tion of inhibitory presynaptic terminals via kainate receptors.
19 rter version (55 nt) inhibited both AMPA and kainate receptors.
20 oxicity, mediated through activation of AMPA/kainate receptors.
21 n the activation properties of the remaining kainate receptors.
22 m that resembles desensitization at AMPA and kainate receptors.
23 or sodium in order for glutamate to activate kainate receptors.
24 r dissection of ligand binding and gating in kainate receptors.
25 positive for mGluR5 and GLU(K5-7)-containing kainate receptors.
26 luR3 for AMPA, and KA2>GluR5>GluR7>GluR6 for kainate receptors.
27 y selective antagonist of GLU(K5)-containing kainate receptors.
28 ions are essential structural components of kainate receptors.
29 chemic axonal injury is not mediated by AMPA/kainate receptors.
30 , ischemic axonal damage is mediated by AMPA/kainate receptors.
31 nsures a high level of GluR6/KA2 heteromeric kainate receptors.
32 YM 2081, was used to confirm the presence of kainate receptors.
33 to the unique kinetic properties of AMPA and kainate receptors.
34 F bipolar cells were exclusively mediated by kainate receptors.
35 -hydroxy-5-methyl-4-isoxazolepropionic acid)/kainate receptors.
36 e granule cells and operate via postsynaptic kainate receptors.
37 found in all vertebrate NMDA but not AMPA or kainate receptors.
38 xcitability through their actions on AMPA or kainate receptors.
39 roxy-5-methyl-4-isoxazolepropionic acid] and kainate receptors.
40 ontaining NMDA receptors as well as AMPA and kainate receptors.
41 about the role of protein kinase C (PKC) in kainate receptor actions by demonstrating that direct po
44 We therefore investigated the effects of kainate receptor activation on GABA release in rat prefr
45 ggest that the balance between NMDA and AMPA/kainate receptor activation regulates the axonal arboriz
46 ed antidepressant-like effects required AMPA/kainate receptor activation, as evidenced by the ability
47 in GluK5 expression is sufficient to enhance kainate receptor activity by modulating receptor channel
48 at loss of synaptic AMPA receptors increased kainate receptor activity in cerebellar granule cells wi
49 acological inhibition or genetic ablation of kainate receptor activity reduces pain behaviors in a nu
50 e demonstrate that the desensitized state of kainate receptors acts as a deep energy well offsetting
52 nals at synapses that contain either AMPA or kainate receptors, all with different temporal propertie
53 ed EPSCs, whether they were mediated by AMPA/kainate receptors alone or in combination with NMDA rece
55 ochemistry, and pharmacology to identify the kainate receptor and auxiliary subunits in ground squirr
56 lation of GluR6 regulates endocytosis of the kainate receptor and modifies synaptic transmission.
57 ; a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) tha
59 pathway requires the metabotropic action of kainate receptors and activation of G protein, protein k
60 3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors and of N-methyl-D-aspartate (NMDA) rec
61 ke-2 (Neto2) as a novel accessory subunit of kainate receptors and showed that Neto2 modulates the ga
62 d pentylenetetrazol is not mediated by GluK1 kainate receptors, and deletion of these receptors does
65 on treatment of an acutely administered AMPA/kainate receptor antagonist and delayed transplantation
66 These findings show that a highly selective kainate receptor antagonist can affect the deficits in s
68 no-3-hydroxy-5-methyl-4-isoxazole propionate/kainate receptor antagonist CNQX (0, .01, .03, .1 mug/si
69 sent experiments, administration of the AMPA/kainate receptor antagonist CNQX (0, 0.03, or 0.3 mug) i
70 finding that intracore injection of the AMPA/kainate receptor antagonist CNQX attenuated the ability
73 havioral responses to kainic acid and that a kainate receptor antagonist normalized altered behaviors
74 t work examined effects of another selective kainate receptor antagonist, (S)-1-(2-Amino-2-carboxyeth
75 further support for the idea that selective kainate receptor antagonists could be novel therapeutic
77 Compounds 18i and (-)-4 were the most potent kainate receptor antagonists, and 18i was selective for
79 l-4-isoxazolepropionic acid, and heteromeric kainate receptors are all downstream targets of GPCR sig
86 uK2 knock-out mice, demonstrating that GluK1 kainate receptors are not required for epileptogenesis o
90 g the different temporal signalling roles of kainate receptors, as cones release glutamate over a ran
91 ptically released zinc inhibits postsynaptic kainate receptors at mossy fiber synapses and limits fre
92 properties and kinetic behaviour of AMPA and kainate receptors at the level of single receptor molecu
94 ntly solved crystal structures for the GluK2 kainate receptor ATD as a guide, we performed cysteine m
98 al/pharmacological data showed that CeA AMPA/kainate receptor blockade attenuates cisplatin-induced p
99 n trained rabbits was injected with the AMPA/kainate receptor blocker, 1,2,3,4-tetrahydro-6-nitro-2,3
100 -5-methylisoxazol-4-yl)propanoate (AMPA) and kainate receptors bound to full and partial agonists.
102 -methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors, but only oscillations in the DP were
109 systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb
110 operties of single AMPA receptor (AMPAR) and kainate receptor channels present in CA1 cells in hippoc
111 d knockdown, we determine that Tm5c uses the kainate receptor Clumsy to receive excitatory glutamate
112 just through the NMDA but also mGlu and AMPA/Kainate receptors, completely reversed the cell death ph
113 We conclude that selective activation of kainate receptors containing the GluK1 subunit can trigg
118 tly as auxiliary proteins that slowed GluK2a kainate receptor current kinetics without impacting rece
124 show that sodium and chloride ions modulate kainate receptor dimer affinity as much as 50-fold, and
125 tor mutants and directly measured changes in kainate receptor dimer stability by analytical ultracent
126 the energetic effects of allosteric ions on kainate receptor dimer stability in solution, using a Gl
127 than other glutamate receptors, and synaptic kainate receptors display properties that differ from re
128 r, heterologous expression of the Drosophila kainate receptor DKaiR1D and the AMPA receptor DGluR1A r
132 ropic receptor with metabotropic properties (kainate receptors) failed to prevent depolarization-indu
136 us the plasma membrane localization of GluR6 kainate receptors following mutagenesis of the LBD.
137 aturated in CSF, and that the requirement of kainate receptors for Na(+) occurs simply because other
138 nglion cells confirmed the essential role of kainate receptors for signaling in both transient and su
139 or the high-affinity subunits for ionotropic kainate receptor function and further demonstrate that k
140 new roles for Neto1 and Neto2 in regulating kainate receptor function and identify domains within th
143 for the PKC-dependent regulation of synaptic kainate receptor function observed during various forms
146 densities for glutamatergic AMPA, NMDA, and kainate receptors; GABAA receptors; muscarinic M1 , M2 a
147 sitizing D776K mutant provides insights into kainate receptor gating and represents a potentially use
148 Here, by determining the structure of the kainate receptor GluK2 subtype in its desensitized state
150 entified some known SAP102 binding partners, kainate receptor GluR6/7 and inward rectifier potassium
151 n of Neto subunits with recombinant GluK2(Q) kainate receptors greatly reduced inward rectification w
153 good evidence that both heteromeric AMPA and kainate receptors have a 2:2 subunit stoichiometry and a
156 he present study highlights the role of AMPA-kainate receptor in IVH-induced white matter injury and
157 the desensitization properties of the GluR6 kainate receptor in response to glutamate application, a
158 pharmacogenetic findings also implicate the kainate receptor in the mechanism of topiramate's effect
159 sed 4.1N interaction with GluK2/3-containing kainate receptors in acute brain slices, an effect that
160 d with combined activation of muscarinic and kainate receptors in different subregions of the medial
164 eceptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling
166 previously unsuspected role for postsynaptic kainate receptors in the induction of functional and str
167 y, it was reported that inactivation of AMPA/kainate receptors in the IO produces extinction of condi
168 ceptors was mediated exclusively through the kainate receptors in the transient OFF bipolar cells, wh
169 ical studies demonstrated that activation of kainate receptors increased the frequency, but not the a
173 via AMPA receptor activation, and that AMPA-kainate receptor inhibition suppresses inflammation and
174 selectivity toward native GLU(K5)-containing kainate receptors (K(D) 0.105 +/- 0.007 microM vs kainat
179 Neto) 1 and Neto2, the auxiliary subunits of kainate receptor (KARs), are phosphorylated by multiple
187 mit high temporal frequency signals, whereas kainate receptors (KARs) are presumed to encode lower te
194 e classes of ionotropic glutamate receptors, kainate receptors (KARs) have a unique brain distributio
198 coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function.
200 ons of the dorsal root ganglia (DRG) express kainate receptors (KARs), a subfamily of glutamate recep
201 urons in the neonatal DRG express functional kainate receptors (KARs), one of three subfamilies of io
208 c glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of excitatory neur
212 ne or PKA with either H89 or RpcAMPs blocked kainate receptor-mediated actions but did not prevent th
214 cologically isolated NMDA receptor- and AMPA/kainate receptor-mediated components of the fully develo
216 CT depolarisation evoked short-latency, AMPA/kainate receptor-mediated EPSCs in connected GCL neurons
217 Both cell types receive predominantly AMPA/kainate receptor-mediated excitatory synaptic input that
220 e activity of MSNs via a glutamatergic, AMPA/kainate receptor-mediated mechanism, indicated by increa
221 primarily controlled by two classes of AMPA/kainate receptor-mediated synaptic inputs derived from o
222 dings in hippocampal slices demonstrate that kainate-receptor-mediated excitatory postsynaptic curren
224 gate this, we constructed a library of GluR6 kainate receptor mutants and directly measured changes i
227 normal LTP, as did an artificially expressed kainate receptor not normally found at these synapses.
233 NMDAR antagonists, but not blockers of AMPA/kainate receptors or voltage-gated sodium channels, prev
234 ceptor function and further demonstrate that kainate receptor participation in metabotropic signaling
236 ndly slows the desensitization rate of GluK1 kainate receptors, promotes plasma membrane localization
237 receptor; GluR5-7 and KA1-2 subunits of the kainate receptor; PSD95), all but two (GluR4 and KA1) we
238 r results have revealed a mechanism by which kainate receptors regulate KCC2 expression in the hippoc
241 relate of this action - activation of PKC by kainate receptors - requires G alpha(i/o) proteins.
242 erface mutants, and that the deactivation of kainate receptor responses is dominated by entry into de
248 hly with expression of Ca(2+)-permeable AMPA/kainate receptors, shows a laminar pattern of distributi
251 oxy-5-methyl-4-isoxazole propionic acid) and kainate receptor subtypes in their major functional stat
252 resting and desensitized states of AMPA and kainate receptor subtypes, the ion channels are closed,
253 ubunits that combined segments from NMDA and kainate receptors, subtypes with distinct pharmacologica
254 of a single gene coding for a high-affinity kainate receptor subunit (i.e., grik4) in a limited area
255 g that fusing the N-terminal 150 residues of kainate receptor subunit 2 (KA2) to the recently discove
257 hippocampal neurons, we discovered that the kainate receptor subunit GluK2 and the auxiliary subunit
259 -I mRNA editing at the Q/R site of the human kainate receptor subunit GluR5 and was compared with two
260 d the splicing pattern and expression of the kainate receptor subunit GluR6 in human fibroblast cell
261 are present at synapses and we show that the kainate receptor subunit GluR6 is a SUMO substrate.
262 We conclude that GluK1 is the predominant kainate receptor subunit in cb1 and cb3 Off bipolar cell
263 as a critical mechanism for retention of the kainate receptor subunit KA2 in the endoplasmic reticulu
270 -expression of Neto1 and 2 with pore-forming kainate receptor subunits also increases the duration of
272 Here we report that the GluK1 and GluK2 kainate receptor subunits interact with the spectrin-act
273 ction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 ka
274 Xenopus oocytes injected with cRNA encoding kainate receptor subunits, we have observed that heterom
276 ained 25 genes involved in the regulation of kainate receptors, TGF-beta and Wnt signaling, as well a
277 1a/b cells were mediated by GluK1-containing kainate receptors that behaved differently from the rece
278 much less well understood, particularly for kainate receptors that exist as multiple subtypes with a
279 id (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in con
280 ty and by synaptic activation of presynaptic kainate receptors that increase release probability on s
281 xcitatory neurotransmitter that binds to the kainate receptor, the N-methyl-D-aspartate (NMDA) recept
282 could be related to increased sensitivity of kainate receptors to endogenous glutamate, effects of th
284 mately 21 A resolution, of full-length GluK2 kainate receptors trapped in antagonist-bound resting an
285 at an aberrant readout of synaptic inputs by kainate receptors triggered a long-lasting impairment of
287 erologous systems, the temporal responses of kainate receptors vary when different channel-forming an
289 ts the channel properties of the human GluK2 kainate receptor, we have systematically characterized t
290 fferent fibers express Ca(2+)-permeable AMPA/kainate receptors, we utilized kainate-stimulated uptake
293 ese findings place GluRdelta2 among AMPA and kainate receptors, where the dimer interface is not only
294 Hyperpolarizing bipolar cells express AMPA/kainate receptors, whereas depolarizing bipolar cells (D
296 promoting the insertion and stabilization of kainate receptors, which may be important for tuning neu
297 on of the CRH system following activation of kainate receptors, which may result in long-term changes
299 no-terminal domain tetramer in AMPA, but not kainate, receptors with a two-fold to four-fold symmetry
300 channel properties of recombinant and native kainate receptors without affecting trafficking of the r
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