ライフサイエンスコーパス: kallistatin

1 RNA oligonucleotide abolished the effect of kallistatin.

2 llikrein is a specific target proteinase for kallistatin.

3 nhibitor, affected vasorelaxation induced by kallistatin.

4 Infusion of purified kallistatin (0.07-1.42 nmol/kg) into cannulated rat jugu

5 Here, we report that circulation levels of kallistatin, a member of the serine proteinase inhibitor

6 Renal expression of kallistatin, a potent vasodilator, was down-regulated in

7 Kallistatin, a serine proteinase inhibitor (serpin), is

8 d region between the H helix and C2 sheet of kallistatin acquired heparin-suppressed inhibitory activ

9 Kallistatin also caused dose-dependent vasodilation of t

10 Kallistatin, an endogenous plasma protein, exhibits plei

11 PTBN1 express much less of the Wnt inhibitor kallistatin and exhibit decreased beta-catenin phosphory

12 inhibition of Wnt/beta-catenin signaling by kallistatin and rescued the wound-healing deficiency in

13 Conversely, adenovirus-mediated transfer of kallistatin antisense cDNA into cultured VSMCs inhibited

14 rmore, local delivery of adenovirus carrying kallistatin antisense cDNA significantly downregulated k

15 stimulated A549 human lung epithelial cells, kallistatin attenuated apoptosis, down-regulated Fas/Fas

16 Kallistatin attenuated VEGF- or bFGF-induced capillary d

17 Sequence analysis revealed that kallistatin-binding protein is human Kruppel-like factor

18 To isolate a kallistatin-binding protein that mediates the vascular a

19 In summary, we identified KLF4 as a kallistatin-binding protein, which has a novel role in m

20 Specific kallistatin-binding sites were identified in rat aorta b

21 ular modeling of the reactive center loop of kallistatin bound to the reactive crevice of tissue kall

22 that an intravenous bolus injection of human kallistatin caused a rapid, potent, and transient reduct

23 s, we prepared adenovirus carrying the human kallistatin cDNA (Ad.HKBP) and evaluated the effect of k

24 esponse markers (HR6 model), including SYWC, kallistatin, complement C9, gelsolin, testican-2, and al

25 KLF4 and kallistatin complex formation was identified in endothel

26 e region between the H helix and C2 sheet of kallistatin, comprise a major heparin-binding site respo

27 The loop between the H helix and C2 sheet of kallistatin containing clusters of basic amino acid resi

28 hibitory characteristics similar to those of kallistatin demonstrates that the loop between the H hel

29 h regions were substituted to generate three kallistatin double mutants K187A/K188A (mutations in the

30 listatin in lung by gene transfer with human kallistatin-encoding plasmid ameliorated acute lung inju

31 We observed an induction of kallistatin expression by platelet-derived growth factor

32 Restoration of kallistatin expression in these cells reversed the obser

33 indings suggest the therapeutic potential of kallistatin for sepsis-related ALI/ARDS.

34 ion library by using an alkaline phosphatase-kallistatin fusion protein binding assay.

35 n cDNA (Ad.HKBP) and evaluated the effect of kallistatin gene delivery on spontaneous angiogenesis in

36 Local kallistatin gene delivery significantly reduced capillar

37 kallistatin levels, and decreased SPTBN1 and kallistatin gene expression is associated with decreased

38 Mouse survival was improved by kallistatin gene transfer or recombinant human kallistat

39 The aim of this study is to evaluate if kallistatin has a direct effect on the vasculature and o

40 in the SERPINA4 gene, whose protein product, kallistatin, has been linked to apoptosis in the kidney.

41 study, we investigated the potential role of kallistatin in angiogenesis in vitro and in vivo.

42 To further investigate the role of kallistatin in angiogenesis, we prepared adenovirus carr

43 -activated protein kinase (MAPK) activity by kallistatin in cultured VSMCs.

44 3-P2-P1 residues (residues 386-388) of human kallistatin in determining inhibitory specificity toward

45 udy introduces the potential significance of kallistatin in directly regulating blood pressure to red

46 ride (LPS)-treated mice, expression of human kallistatin in lung by gene transfer with human kallista

47 These results demonstrate a novel role of kallistatin in the inhibition of angiogenesis and tumor

48 The potential function of kallistatin in vascular biology was investigated by stud

49 Kallistatin increased endothelial nitric-oxide synthase

50 Exogenous kallistatin induced a >2-fold increase of VSMC prolifera

51 We showed that kallistatin inhibits tumor necrosis factor-alpha-induced

52 Kallistatin is a heparin-binding serine proteinase inhib

53 Kallistatin is a plasma protein that exhibits pleiotropi

54 These results indicate that kallistatin is a potent vasodilator which may function d

55 Kallistatin is a serine proteinase inhibitor (serpin) th

56 Kallistatin is a serine proteinase inhibitor which binds

57 Kallistatin is a serpin with a unique P1 Phe, which conf

58 Kallistatin is a unique serine proteinase inhibitor (ser

59 The inhibitory activity of kallistatin is abolished upon heparin binding.

60 The inhibitory activity of kallistatin is blocked upon its binding to heparin.

61 the loop between the H helix and C2 sheet of kallistatin is crucial in tissue kallikrein inhibition,

62 Moreover, a newly described serpin, kallistatin (KAL, gene symbol PI4), was also mapped with

63 eet of kallistatin was shown to suppress the kallistatin-kallikrein interaction through competition f

64 To test the hypothesis that elevated kallistatin levels could contribute to a wound-healing d

65 Here, we demonstrate that kallistatin levels were positively correlated with the c

66 is positively correlated with E-cadherin and kallistatin levels, and decreased SPTBN1 and kallistatin

67 ells of human blood vessels, suggesting that kallistatin may be involved in the regulation of vascula

68 These results indicate that kallistatin may play an important role in mediating PDGF

69 In balloon-injured vessels, endogenous kallistatin mRNA and protein levels increased up to 10-f

70 n antisense cDNA significantly downregulated kallistatin mRNA levels and attenuated neointima formati

71 Intense staining of kallistatin mRNA was identified in the proliferating VSM

72 Kallistatin mutants containing double Ala substitutions

73 Human kallistatin mutants with 19 different amino acid substit

74 S inhibitor abolished the blocking effect of kallistatin on vascular cell adhesion molecule-1 and mon

75 n between the H helix and C2 sheet), using a kallistatin P1Arg variant as a scaffold.

76 t of vasodilation mediated by the kallikrein-kallistatin pathway and vascular hypertrophy.

77 Our previous study showed that kallistatin plays a role in neointima hyperplasia.

78 t of the other chimera, which contained only kallistatin's P3-P2' sequence, and 2300-fold higher than

79 Purified human kallistatin significantly inhibited vascular endothelial

80 Like kallistatin, the binding activity of K187A/K188A to tiss

81 Lower ratio of kallistatin to total protein in BALF showed a significan

82 distinguishes the inhibitory specificity of kallistatin toward kallikrein versus chymotrypsin.

83 of Wnt/beta-catenin signaling, we generated kallistatin-transgenic (KS-TG) mice.

84 d a decreased number of blood vessels in the kallistatin-treated group as compared to the control.

85 llistatin gene transfer or recombinant human kallistatin treatment after LPS challenge.

86 empted to locate the heparin-binding site of kallistatin using synthetic peptides derived from its su

87 n mediating the anti-inflammatory actions of kallistatin via increasing eNOS expression in endothelia

88 Relaxation of isolated aortic rings by kallistatin was observed in the presence (ED50 of 3.4 x

89 sequence between the H helix and C2 sheet of kallistatin was shown to suppress the kallistatin-kallik

90 rotein that mediates the vascular actions of kallistatin, we screened and identified a positive clone

91 ion encompassing the H helix and C2 sheet of kallistatin, were used to assess their heparin binding a

92 , had no effect on the hypotensive effect of kallistatin yet it abolished the blood pressure-lowering