1 embly of nuclear-associated ER stacks called karmellae.

2 ly of nuclear-associated ER membranes called karmellae.

3 s in karmellae assembly, suggesting that the karmellae assembly defect reflected alteration of ER str

4 mutants tested, although the severity of the karmellae assembly defect varied depending on the partic

5 e screened temperature-sensitive mutants for karmellae assembly defects.

6 s well correlated with pronounced defects in karmellae assembly, suggesting that the karmellae assemb

7     To identify additional genes involved in karmellae assembly, we screened temperature-sensitive mu

8  the carboxyl terminus were unable to induce karmellae assembly.

9 in of Hmg1p was not sufficient to signal for karmellae assembly.

10 s causing defects in secretion also affected karmellae assembly.

11 nsitive strains that were also defective for karmellae biogenesis carried mutations in VPS16, a gene

12                                              Karmellae biogenesis was defective in all 13 other vacuo

13 he features of HMG-CoA reductase that signal karmellae biogenesis would provide useful insights into

14 s of HMG-CoA reductase can profoundly affect karmellae biogenesis.

15 tosolic domain prevents proper signaling for karmellae by interfering with the required tertiary stru

16  at this band during interphase and abnormal karmellae-like nuclear membrane structures.

17 n from small invaginated spherules to large, karmellae-like, multilayer stacks of appressed double me

18 ssion of these proteins induced formation of karmellae, whorls, and crystalloid OSER structures.