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1 eta's binding sites both for Ran-GTP and for karyopherin alpha.
2 ing is also involved in the association with karyopherin alpha.
3 nt of the cellular nuclear import machinery, karyopherin alpha.
4 S cargo that is imported into the nucleus by karyopherin alpha.
5 b2p NLS substrate in vitro in the absence of karyopherin alpha.
6 inhibited import, did not inhibit export of karyopherin alpha.
7 rt assays, we have mapped binding regions of karyopherin alpha.
8 x and is modulated through interactions with karyopherin alpha.
9 beta to karyopherin alpha covers the NLS of karyopherin alpha.
10 ich together comprise the NPI-1 subfamily of karyopherin alphaS.
11 own assays indicate interaction of APE1 with karyopherin alpha 1 and 2, which requires the 20 N-termi
12 uclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membra
13 t mutations in the C terminus no longer bind karyopherin alpha 2 or block the nuclear import of STAT1
14 We also show that N-terminal deletions of karyopherin alpha 2 that no longer bind to karyopherin b
15 mbinant SARS-CoV lacking ORF6 did not tether karyopherin alpha 2 to the ER/Golgi membrane and allowed
16 We mapped the region of ORF6, which binds karyopherin alpha 2, to the C terminus of ORF6 and show
17 ns that interact with the NLS and identified karyopherin alpha 3 (KPNA3 or Kap-alpha3) and karyopheri
19 aryopherin alpha 3 (KPNA3 or Kap-alpha3) and karyopherin alpha 4 (KPNA4 or Kap-alpha4) as key binding
22 egulatory role in this process by binding to karyopherin alpha, a cellular receptor for nuclear local
23 ions as a molecular bridge between VirE2 and karyopherin alpha, allowing VirE2 to utilize the host ce
24 (pendulin/Rch1/alpha-P1/hSrp1alpha and Srp1/karyopherin-alpha/alpha-S1/NPI-1) which function in nucl
26 g as an 'adapter' molecule between VirE2 and karyopherin alpha and 'piggy-backing' VirE2 into the hos
31 ng region for Ran-GTP overlaps with that for karyopherin alpha and comprises at least one of the two
32 karyopherin beta1/importin beta, which binds karyopherin alpha and mediates the nuclear import of the
36 hese sequences can mediate direct binding to karyopherin-alpha and are essential for the passage of i
37 cargoes and their import receptor proteins, karyopherin-alpha and karyopherin-beta, can be robustly
38 Using truncated forms of recombinant yeast karyopherins alpha and beta in in vitro binding assays,
39 n shown to act as general transport factors (karyopherin alpha) and nuclear pore-docking proteins to
41 red by indirect immunofluorescence with anti-karyopherin alpha antibodies, we found that karyopherin
46 binding results, karyopherin beta2 inhibited karyopherin alpha/beta1-mediated import of a classical N
48 one of the two acidic clusters required for karyopherin alpha binding in addition to further downstr
52 -karyopherin alpha antibodies, we found that karyopherin alpha export was stimulated by added GTPase
55 model in which Rch1 or another member of the karyopherin-alpha family, through the recognition of the
58 This association increased the affinity of karyopherin alpha for basic-type NLSs, including that of
61 assay in which export of endogenous nuclear karyopherin alpha from nuclei of digitonin-permeabilized
62 monstration that a glutathione S-transferase-karyopherin alpha fusion interacts with ORF29p, but not
64 ar localization signal (NLS) is dependent on karyopherin alpha/importin alpha, which acts as the NLS
65 ure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha, in the absence and presence of a mono
66 factor Srp1 (also known as importin alpha or karyopherin alpha) is required for ubiquitin-independent
67 lves of the ring are structurally related to karyopherin-alpha (Kap-alpha) and beta-karyopherin famil
69 IFN) signaling by binding to NPI-1 subfamily karyopherin alpha (KPNA) nuclear import proteins, preven
72 of Ebola virus (EBOV) VP24 protein with host karyopherin alpha (KPNA) proteins blocks type I interfer
76 of hRch1/hSrp1alpha/importin-alpha and hSrp1/karyopherin alpha/NPI-1, respectively, and show consider
77 ed in sequestration of most of the cytosolic karyopherin alpha or karyopherin beta, respectively, in
81 cled efficiently in a reaction that involves karyopherin alpha, RanBP1, RanGAP, and the C terminus of
84 ta's binding region for alpha and Ran-GTP or karyopherin alpha's binding region for beta resulted in
86 gous to those previously shown to constitute karyopherin alpha's binding site to karyopherin beta.
91 tro binding assays, we mapped the regions of karyopherin alpha that bind to karyopherin beta and the
92 of matrix antigen and prevent its binding to karyopherin alpha, the cellular receptor for nuclear loc
93 ransferase pull-down assays, TDP-43 bound to karyopherin-alphas, thereby confirming the classical nuc
94 explains the observed cooperative binding of karyopherin alpha to a heterologous NLS protein in the p
95 the Bag6 nuclear localization sequence from karyopherin alpha to retain Bag6 in the cytosol but also
96 There was a correlation between binding of karyopherins alpha to different NLSs and their ability t
101 hereas karyopherin beta's binding region for karyopherin alpha was localized to an internal region co
102 ed to the creation of conditional alleles of karyopherin alpha with well characterized defects in NLS
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