ライフサイエンスコーパス: karyotype

1 31 linkage groups (LGs; consistent with the karyotype).

2 human and mouse with virtual karyotyping (e-karyotyping).

3 n phenotypic female patients with the 46, XY karyotype.

4 be, have descended from the proto-Calepineae Karyotype.

5 n situ hybridization, and 54% with a complex karyotype.

6 ng results showed discordance with the fetal karyotype.

7 d 3 years, overall and stratified by age and karyotype.

8 can generate mutagenesis and changes to the karyotype.

9 phase cells was consistent with the host sex karyotype.

10 total of 48/66 (72.7%) cases had an abnormal karyotype.

11 inate the fusions and maintain a telocentric karyotype.

12 imary amenorrhea, short stature, and a 46,XX karyotype.

13 , proliferation (MKI67 and PCNA), and normal karyotype.

14 h multipotent cell fate potential and normal karyotype.

15 d XF substrate preference, pluripotency, and karyotype.

16 odiploidy, high hyperdiploidy, and a complex karyotype.

17 tigated risk for developing a specific tumor karyotype.

18 and in some cases is better than a metaphase karyotype.

19 them are found in individuals with a normal karyotype.

20 s associated with low Ki67 index and diploid karyotype.

21 icism, and trisomy 20 diagnosed by metaphase karyotype.

22 these iPSCs are pluripotent and have normal karyotype.

23 ch mutations have occurred, or the resulting karyotype.

24 The remaining three metaphases were normal karyotype.

25 ymptoms, large splenomegaly, and unfavorable karyotype.

26 o the molecular landscape of AML with normal karyotype.

27 of human ES cell lines with a normal haploid karyotype.

28 ied translocations, and 19.5% showed complex karyotypes.

29 y subgroups, including complex and monosomal karyotypes.

30 trials for patients with high-risk C-IPSS-R karyotypes.

31 retain full pluripotency and exhibit normal karyotypes.

32 ted in fusion events in species with smaller karyotypes.

33 further insight into the evolution of avian karyotypes.

34 and 166 (39.7%) were classified as composite karyotypes.

35 onal profiles, differentiation potential and karyotypes.

36 418 (32.8%) of 1,274 patients with aberrant karyotypes.

37 lution of distinct male (XY) and female (XX) karyotypes.

38 growth of advanced malignancies with complex karyotypes.

39 , the resulting tumors evolved subtetraploid karyotypes.

40 ges through senescence, gene expression, and karyotyping.

41 are intractable, or cryptic, to both CMA and karyotyping.

42 ntent in four Afrotherian species using flow karyotyping.

43 marker chromosome-negative complex aberrant karyotypes (1/34).

44 For stratified analysis according to karyotype, 108 additional primary MDS patients registere

45 Of 37 T. mirus individuals that were karyotyped, 23 (62%) were chromosomally additive of the

46 53 mutation (27%), del11q (33%), and complex karyotype (29%).

47 The ancestral karyotype (2n = 16) has two terminal 35S sites and two i

48 Pigeon has a typical avian karyotype (2n = 80), while falcon (2n = 50) is highly re

49 .4%; 95% CI, 37%-44%): 26 of 59 (44.1%) with karyotyping, 32 of 188 (17.0%) with microarrays, 31 of 1

50 's Leukemia Group (CLG) trial, identified by karyotype (446 patients) and by DNA index (DI) (490 pati

51 th no evidence of lymphoma and a normal male karyotype (46, XY).

52 Among those, 252 karyotypes (60.3%) displayed a defined number of distinc

53 No population was fixed for a particular karyotype; 76% of the individuals showed intergenomic tr

54 An unbalanced karyotype, a condition known as aneuploidy, has a profou

55 in CLL patients that shows a role of complex karyotype aberrations as an independent prognostic facto

56 o single cells for long periods, without any karyotype abnormalities.

57 se, are found in approximately 30% of normal karyotype acute myeloid leukemia (AML) cases.

58 ficantly elevated in primary FLT3-ITD normal karyotype acute myeloid leukemia (NK-AML) compared with

59 ncluding 29 normal karyotype AML, 8 abnormal karyotype AML and 8 AML without karyotype informaiton.

60 s downregulated in AML, especially in normal karyotype AML patients with CEBPA mutations.

61 Different outcomes of normal karyotype AML suggest that this subgroup of AML could be

62 analysis in 45 AML cases including 29 normal karyotype AML, 8 abnormal karyotype AML and 8 AML withou

63 vered a novel poor-outcome subtype of normal-karyotype AML, which allowed for the generation of a hig

64 remendous hidden diversity in sex chromosome karyotypes among flies.

65 who had not been evaluated with bone-marrow karyotype analyses before therapy.

66 mparative genomic hybridization and spectral karyotype analysis reveal that genomic copy number loss

67 Karyotype analysis revealed that this phenotype was sign

68 me instability might drive tumour evolution, karyotype analysis using single-cell sequencing technolo

69 ssessment of pluripotency factor expression, karyotype analysis, and pathogen/sterility testing was c

70 Comparative karyotyping analysis revealed that chromosome organizati

71 mined by metaphase spread assay and spectral karyotyping analysis.

72 leukemia, acute myeloid leukemia with normal karyotype and acute T-ALL samples.

73 lastoma tumor cells have a relatively stable karyotype and currently the circumstances in which pRB i

74 strawberry (Fragaria vesca) with a conserved karyotype and few notable structural rearrangements.

75 y strains of S. cerevisiae, we evaluated the karyotype and gene expression studies performed by Hose

76 t human neural stem cells (hNSC) with normal karyotype and high proliferation potential under XF cond

77 n results that are discordant with the fetal karyotype and improve maternal clinical care.

78 ds in stratifying AML patients with aberrant karyotype and in identifying common aberrant transcripti

79 te the human disease, including the aberrant karyotype and metastatic behavior.

80 In patients with normal karyotype and no FLT3 internal tandem duplication (n = 1

81 fusion, a process that restores the parental karyotype and protects cells from rare accidental telome

82 female phenotype in an individual with an XY karyotype and testes producing age-appropriate normal co

83 The presence of monosomal karyotype and various genetic and molecular markers have

84 venetoclax refractory, and 23 had a complex karyotype and/or 17p deletion.

85 isease or can be explained by differences in karyotype and/or age.

86 cktail was developed with which to study the karyotypes and chromosome evolution of peanut and its wi

87 s derived from ST zygotes had normal euploid karyotypes and contained exclusively donor mtDNA.

88 Patients with the copresence of complex karyotypes and deletions/mutations involving TP53 demons

89 Whole-genome sequencing revised 93% of karyotypes and demonstrated complexity that was cryptic

90 d that chromosomal translocations or complex karyotypes and distinct somatic mutations may impact out

91 LIF-3i-reverted hPSCs retained normal karyotypes and genomic imprints, and attained defining m

92 after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells.

93 NT-ESCs displayed normal diploid karyotypes and inherited their nuclear genome exclusivel

94 ognosis compared with other non-CBF aberrant karyotypes and led to lower remission rates (complete re

95 In multivariate models, complex karyotypes and POT1 mutations (8.1% of patients) represe

96 t tissue sarcomas is characterized by simple karyotypes and recurrent chromosomal translocations, the

97 the applicability of the method using tumor karyotypes and somatic hypermutation data sets.

98 ns (P < .001) and lower in AMLs with complex karyotypes and t(8;21) translocations (P < .001).

99 sent hypotheses on how they may create novel karyotypes and thus affect chromosome evolution.

100 Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at hi

101 l abnormalities is typically investigated by karyotyping and array-based detection of microscopically

102 High-resolution molecular karyotyping and comparative genomics with Setaria italic

103 Cells were investigated by karyotyping and gene expression analysis of the CD34(+)

104 Utilizing spectral karyotyping and locus-specific fluorescence in situ hybr

105 Karyotyping and multiplex ligation-dependent probe ampli

106 We performed metaphase karyotyping and next-generation sequencing (NGS) of 85 g

107 single nucleotide polymorphism array (SNP-A) karyotyping and parallel sequencing of 22 genes frequent

108 Spectral karyotyping and short tandem repeat analysis of the UISO

109 the genetic basis of SAMS, we used molecular karyotyping and whole-exome sequencing (WES) to study sm

110 malities (45%) than controls (despite normal karyotypes), and most (80%) had teenage onset, with no d

111 -mutated AML patients for the impact of MLD, karyotype, and additional mutations.

112 of patient's age, IPSS-R category, monosomal karyotype, and HCT-CI, the 5-year probability of surviva

113 sing additional cytogenetic profile testing, karyotyping, and genetic and protein profiling, we concl

114 ates that IPSS-R risk category and monosomal karyotype are important factors predicting transplantati

115 Common inverted and standard karyotypes are genetically divergent and account for mos

116 Single-locus karyotypes are very common, even in polyploids.

117 ized by unbalanced chromosome stoichiometry (karyotype), are associated with cancer malignancy and dr

118 of large CLL cohorts, as well as stimulated karyotyping, are discussed.

119 netic characteristics of sSMC delineated the karyotype as 47,XY,+der(15)(pter->p11.2::q11.1->q11.2::p

120 iploid (2n = 32) and have the Apis mellifera karyotype as revealed by Giemsa stain.

121 oved the prognosis of patients with subclone karyotypes as shown in landmark analyses.

122 ce, via a dynamic visualization on the human karyotype, as a downloadable tab-delimited file and as a

123 perform karyotype-based genome assembly and karyotype-assisted genome synteny analyses with preset k

124 This feature allows users to perform karyotype-based genome assembly and karyotype-assisted g

125 for excellent outcome was ploidy assessed by karyotype because patients with 58-66 chromosomes stood

126 population doublings, and maintain a diploid karyotype before arresting in G1.

127 ing method (biome representational in silico karyotyping [BRiSK]) were applied in parallel to samples

128 offers similar information as a traditional karyotype but with the benefit of DNA sequence resolutio

129 and unbalanced rearrangements identified on karyotyping but did not identify balanced translocations

130 al house mouse populations that have changed karyotype by accumulating metacentric fusions.

131 ly on morphologic analysis and assessment of karyotype by chromosome banding analysis.

132 , it is possible to obtain a fetal molecular karyotype by MPS of maternal plasma cfDNA that is equiva

133 We analyzed 57 AML patients with normal karyotype by using Illumina's 450k array and showed that

134 chromosomal microarray analysis or standard karyotype can be offered for prenatal diagnosis with a p

135 cates that selection of a specific aneuploid karyotype can result in the adaptation of hepatocytes to

136 in some populations, leading to fixation and karyotype change, while other populations preferentially

137 s multiple PSC lines and can proceed without karyotype change.

138 We discovered a correlation between karyotype changes and phylogeny branch lengths.

139 This tool will greatly facilitate karyotype, chromosome, and genome evolution studies usin

140 Complex karyotype (CK) is the poorest risk factor in patients wi

141 tcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed integrative analysis us

142 tients into those defined as having a normal karyotype (CN-AML).

143 orescence in situ hybridization (FISH)-based karyotyping cocktail was developed with which to study t

144 potent and benign and have relatively normal karyotype compared with ESCs knocked out for p53.

145 s, 13q deletions, 17p deletions, or a normal karyotype compared with normal CD19(+) cord blood and pe

146 .001), platelet count (HR, 1.41; P < .001), karyotype complexity (CK [three abnormalities]: HR, 1.81

147 BM blast percentage (HR, 1.12; P < .001) and karyotype complexity (CK: HR, 2.53; P = .002; very CK: H

148 After accounting for karyotype complexity, MK was not associated with OS or e

149 aracterized by a particularly high degree of karyotype complexity, TP53 mutations, and dismal prognos

150 This pilot study showed a 100% SNP-A karyotype concordance and a 97% mutation concordance bet

151 ch revealed that the ancestral Cucurbitaceae karyotypes consisted of 12 protochromosomes with 18 534

152 ally have XY sex chromosomes and a conserved karyotype consisting of six chromosomal arms (five large

153 There are examples of massive karyotype conversion, from mostly telocentric (centromer

154 The abnormal karyotype correlated with shorter time to first treatmen

155 heterogeneous telomeres with a more complex karyotype correlating also with distinct chromosomal cha

156 Some individuals with a 46,XX karyotype develop testes or ovotestes (testicular or ovo

157 Adverse-risk karyotypes displayed a higher frequency of marker chromo

158 Combined data from karyotype, DNA index, fluorescence in situ hybridization

159 sh between these explanations and to examine karyotype dynamics in chromosome instable lymphoma, we u

160 ll samples from human and mouse with virtual karyotyping (e-karyotyping).

161 c gene expression to read the sex chromosome karyotype, early embryos must remain gender-naive; our f

162 For decades, pretreatment karyotype evaluation has served to identify subgroups fo

163 genomic blocks lead to conserved patterns of karyotype evolution among species of the same family.

164 e rearrangements might have had an impact on karyotype evolution and homoploid speciation in Ae. mark

165 e strength dictates meiotic success, driving karyotype evolution and reproductive isolation in mice.

166 Here we analyzed karyotype evolution in Agrodiaetus using phylogenetic co

167 ure studies on the chromosome homoeology and karyotype evolution of duckweed species.

168 nce and prerequisite to study the genome and karyotype evolution of other duckweed species.

169 olved in meiosis may be associated with fast karyotype evolution.

170 recombination landscapes and between-species karyotype evolution.

171 ell biological basis of centromere drive and karyotype evolution.

172 wledge of Equus chromosome rearrangement and karyotype evolution.

173 ion, some organisms demonstrate high rate of karyotype evolution.

174 ts, predicts a high degree of punctualism in karyotype evolution.

175 We further show that cells with complex karyotypes exhibit features of senescence and produce pr

176 the DNA crosslinking agent mitomycin C, and karyotypes feature genomic instability.

177 en assessed by chromosome counting, spectral karyotyping, fluorescence in situ hybridization, and DNA

178 cular genetic analyses, such as conventional karyotyping, fluorescence in situ hybridization, reverse

179 omes derive from the ancestral Cucurbitaceae karyotypes followed by 19 chromosomal fissions and 20 fu

180 only known example, in mammals, of altering karyotype for functional adaptation.

181 is as a first-tier test in place of standard karyotype for the evaluation of fetal chromosomes when o

182 romosomal abnormalities (BCAs) still require karyotyping for clinical detection.

183 his method for RNA-Seq data and present eSNP-Karyotyping for the detection of chromosomal aberrations

184 he mass of chromosomes and perform a partial karyotype from the results.

185 054 adult patients with MDS with an abnormal karyotype from the Spanish Registry of MDS.

186 We analysed 2949 karyotypes, from 1791 species and 86 plant families, and

187 We propose that cells with abnormal karyotypes generate a signal for their own elimination t

188 gh frequency of cells with the same abnormal karyotype (>5-10%; presumably of clonal origin) in the p

189 normalities, including complex and monosomal karyotypes, had no prognostic value in these intensive p

190 we conclude that the ancestral lepidopteran karyotype has been n=31 for at least 140 My.

191 es with post-HCT outcome, with the patient's karyotype having the strongest impact.

192 .21]; P < .001) and del(17p) by conventional karyotyping (hazard ratio, 7.96 [1.02-61.92]; P = .048)

193 cell leukaemias reveals different levels of karyotype heterogeneity in these cancers.

194 Monosomal karyotype (HR, 2.01; 95% CI, 1.65 to 2.45) and age 50 ye

195 Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer.

196 er, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by

197 ehensive spectrum of the heterogeneous tumor karyotype in human tumors.

198 Aneuploidy-or an unbalanced karyotype in which whole chromosomes are gained or lost-

199 study, we found that 3% of random aneuploid karyotypes in yeast disrupt the stable inheritance of si

200 demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations

201 med by SuperTAG methylation-specific digital karyotyping, in order to identify genes differentially m

202 , 8 abnormal karyotype AML and 8 AML without karyotype informaiton.

203 However, karyotype information has not been well utilized in geno

204 e features of CrusView is its integration of karyotype information when comparing two genomes.

205 Importantly, FDF could classify normal karyotype intermediate risk patients into two groups wit

206 d mRNA transcription are lineage, tissue and karyotype-invariant, and that models trained on matched

207 Importantly, our results reveal that karyotype is a key factor: Smaller autosomes and heterom

208 from most other catarrhine primates, in whom karyotype is highly conserved.

209 Metaphase karyotyping is an established diagnostic standard in acu

210 Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells

211 ontent that is not a multiple of the haploid karyotype, is associated with reduced fitness in all org

212 identifying chromosomes, a process known as karyotyping, is widely used to detect changes in chromos

213 In addition, as revealed by spectral karyotyping, LMP1 induced "outre" giant cells and hypopl

214 vent (PML-RARA) versus the genomes of normal karyotype M1-AML samples and the exomes of hematopoietic

215 and a small dot), but superficially similar karyotypes may conceal the true extent of sex chromosome

216 e shown that pluripotent cells with abnormal karyotypes may grow faster, differentiate less and becom

217 single-nucleotide polymorphism array (SNP-A) karyotyping may be used to find cryptic abnormalities an

218 It has recently been reported that monosomal karyotype (MK) worsens the prognosis of patients with CK

219 Cytogenetics revealed a normal female karyotype; molecular testing for NPM1, FLT3-ITD, and CEB

220 diagnostic yield of genomic tools (molecular karyotyping, multi-gene panel and exome sequencing) in a

221 hromosomes of the ancestral proto-Calepineae Karyotype (n = 7) through an unusually high number of pe

222 tella xylostella) indicates that the B. mori karyotype (n=28) is a phylogenetically derived state res

223 se resemblance to the ancestral lepidopteran karyotype (n=31) makes it a useful reference point for r

224 Mammalian karyotypes (number and structure of chromosomes) can var

225 We evaluated the molecular karyotype of 25 clinical-grade hESC lines by whole-genom

226 The inferred ancestral karyotype of clade E (CEK; n = 7) originated from an old

227 ome, which presumably reflects the ancestral karyotype of higher Diptera.

228 y research, which has the putative ancestral karyotype of n=31.

229 Results showed that karyotype of the nascent allopolyploid plants (AT2) is s

230 were found as robust cytogenetic markers for karyotyping of meadow fescue and ryegrass species and th

231 Karyotyping of the cord blood cells from 15 ARV-exposed

232 n 3 of 4 sex-mismatched specimens, tissue XY-karyotyping of the RPM interphase cells was consistent w

233 size; therefore, it is possible to perform a karyotype on chromosomes using their mass as an identify

234 y relapsed and refractory disease and normal karyotype or low risk cytogenetics, such as hyperdiploid

235 eatment failure, independent of conventional karyotype or mutation status.

236 onor/recipient pair (HR, 0.4; P = .009), and karyotype other than monosomy 7 (HR, 0.5; P = .02).

237 prognostication accuracy compared with FISH karyotype (P < .0001), and was externally validated in a

238 0(9)/L (P = .03), and those with unfavorable karyotype (P = .03).

239 h complex aberrant, monosomal, and abnl(17p) karyotypes (P < .001 each).

240 (P = .006) and lower incidence of high-risk karyotypes (P = .01 for AML and < .001 for MDS) compared

241 plex aberrant, and 41.2% in abnormality(17p) karyotypes, P < .0001 each).

242 f HeLa remains largely unexplored beyond its karyotype, partly because like many cancers, its extensi

243 %) of aberrant non-core-binding-factor (CBF) karyotype patients.

244 assisted genome synteny analyses with preset karyotype patterns of the Brassicaceae genomes.

245 l >100 x 10(9)/L at diagnosis, and monosomal karyotype predicted poorer EFS.

246 fied by presence of poor-prognosis (complex) karyotype (presence of at least three abnormalities, or

247 s >/= 60 years old and patients with adverse karyotype, previous MDS or tAML did not impact overall o

248 ical-grade hESC lines with defined molecular karyotypes provides a substantial starting platform from

249 frequent mitotic errors and possess complex karyotypes, recapitulating a common feature of human can

250 t covariates such as cytogenetics, monosomal karyotype, relapsed or refractory rather than newly diag

251 n (WGD) is usually followed by gene loss and karyotype repatterning.

252 te Miocene that was followed by considerable karyotype reshuffling and chromosome number reduction an

253 Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has

254 kers, formed teratomas in vivo, had a normal karyotype, retained and expressed mutant or normal CSF2R

255 uorescent in-situ hybridization and spectral karyotyping revealed that nine out of nine lymphomas con

256 ole for Pten and Tp53 suppression in complex karyotype sarcomas while establishing Notch as an import

257 Whilst 86.57% of karyotypes show S-type organisation (ancestral condition

258 In two of these cases in which the metaphase karyotype showed additional material of unknown origin,

259 Karyotypes showed the typical railroad appearance of a c

260 Spectral karyotyping (SKY) and fluorescent-in-situ hybridization

261 sarcomas we show that human-derived complex karyotype solid tumors: (1) can be reprogrammed into a p

262 Tolerance mechanisms can be karyotype-specific or general.

263 show that deletion of UBP3 exacerbates both karyotype-specific phenotypes and global stresses of ane

264 Such long-term karyotype stability after polyploidization has not been

265 oncogenic Aurora-A during mitosis to ensure karyotype stability remained an open question.

266 alysis including clinical variables, complex karyotype status, and candidate genes, mutations in TP53

267 romosome is identified in the female arowana karyotype, suggesting that the sex is determined by a ZW

268 rDNA was found in about 25% of single-locus karyotypes, suggesting that terminal locations are not e

269 wo putative progenitors using our FISH-based karyotyping system.

270 Using a novel karyotyping technique, we demonstrate that complete disr

271 at (2n = 2x = 14), has a highly asymmetrical karyotype that is indicative of chromosome rearrangement

272 nies obtained from binucleate founders had a karyotype that matched the parental cell type.

273 chromosomes that resemble the ancestral fly karyotype that originated approximately 100 million yr a

274 In a karyotype the chromosomes are identified by their size a

275 In multivariable analysis, an abnormal karyotype, the presence of FLT3-internal tandem duplicat

276 irectly on all cases with negative molecular karyotyping, the diagnostic yield of exome sequencing wa

277 Given the potential of cells with abnormal karyotypes to become cancerous, do pathways that limit t

278 , but the specific contributions of abnormal karyotypes to cancer, a disease characterized by aneuplo

279 y for the transition from traditional fungal karyotyping to more comprehensive chromosome biology stu

280 n 13 of 14 FLT3/ITD AML patients with normal karyotype treated with quizartinib, we observed terminal

281 XY-karyotyping using fluorescence in situ hybridization was

282 ethnically diverse (ED) origins with normal karyotype, verified teratoma formation, pluripotency bio

283 The hyperdiploid leukaemia karyotype was highly over-represented in ALL cases harbo

284 rescence in situ hybridization, and spectral karyotyping, we identified structural aberrations and co

285 g/d), fludarabine refractoriness and complex karyotype were associated with progression (hazard ratio

286 ostic Scoring System (IPSS-R), and monosomal karyotype were independently associated with relapse and

287 Karyotypes were constructed in cultivated peanut and its

288 some 7q were confined to group A and complex karyotypes were more frequent in group B.

289 aBMSCs exhibited multipotency, and karyotypes were normal up to 30 PDs, with significant ce

290 Karyotypes were prepared, showing the reproducibility of

291 Birth outcomes or karyotypes were the reference standard.

292 Chromosomal aberrations as assessed by karyotyping were observed in 68.8% of 154 patients, 31.2

293 - were associated with high hyperdiploid ALL karyotypes, whereas 11q23/MLL-rearranged AML or MDS was

294 our work identified biomarkers of aneuploid karyotypes, which suggest insights into the underlying m

295 in the maternal circulation to predict fetal karyotype with greater sensitivity and specificity than

296 his NR5A1 mutation was found to have a 46,XY karyotype with partial testicular dysgenesis.

297 than sequenced grass genomes and a conserved karyotype with seven chromosomes from before the rho dup

298 Osteosarcoma has a complex karyotype, with loss of p53 in the vast majority of case

299 pecies, N. caerulescens has the most derived karyotype, with species-specific inversions on chromosom

300 Here, in a cohort of 354 humans with varying karyotypes (XX, XY, XXX, XXY, XYY, XXYY, XXXXY), we inve