ライフサイエンスコーパス: karyotypic

1 cations into the IgH locus (i) are frequent (karyotypic 14q32 translocations and/or illegitimate swit

2 ronic lymphocytic leukemia with normal FISH, karyotypic aberrations by conventional cytogenetics with

3 Karyotypic aberrations contribute to the understanding o

4 We evaluated the significance of karyotypic aberrations in a learning cohort (LC; n = 64)

5 aryotyping to provide a detailed analysis of karyotypic aberrations in the diverse group of cancer ce

6 The observed karyotypic aberrations probably reflect the progressive

7 cent cytogenetic studies of HESCs have shown karyotypic aberrations.

8 ptosis is accompanied by the accumulation of karyotypic abnormalites that often typify cancer cells,

9 y of MDS patients have either clonal somatic karyotypic abnormalities and/or gene mutations that aid

10 46% of T-PLL cases, but some cases also have karyotypic abnormalities at 11q, including 11q23.

11 offers low-resolution detection of balanced karyotypic abnormalities but cannot provide the precise,

12 IDH family mutations and additional cryptic karyotypic abnormalities can occur in advanced phase CML

13 Although specific karyotypic abnormalities have been linked to MDS for dec

14 nal evolution was defined as the presence of karyotypic abnormalities in addition to the Philadelphia

15 f leukemia was significantly correlated with karyotypic abnormalities in addition to trisomy 21 (P =

16 Karyotypic abnormalities in cultured embryonic stem cell

17 ients with intestinal juvenile polyposis and karyotypic abnormalities involving chromosome 10q.

18 Coupled with the karyotypic abnormalities observed in CIN tumors are the

19 n situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in

20 were independently correlated with specific karyotypic abnormalities on the resected specimens.

21 Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality

22 of chromosome 6 are among the most frequent karyotypic abnormalities that appear in human malignant

23 ws concurrent tracking of both mutations and karyotypic abnormalities throughout therapy and is able

24 spect to pluripotency as well as a subset of karyotypic abnormalities whose dynamic properties were m

25 Of 20 patients with karyotypic abnormalities, 11 had at least a 50 percent r

26 ups was in the proportion of patients having karyotypic abnormalities, an observation common only in

27 eterogeneity among cases in cell morphology, karyotypic abnormalities, and clinical course.

28 ity of T-lineage ALL patients, regardless of karyotypic abnormalities, and such features do not ident

29 translocations without extensive additional karyotypic abnormalities, and those without such signatu

30 y evidence of genomic instability, including karyotypic abnormalities, gene amplification, and hypers

31 A model containing karyotypic abnormalities, hemoglobin, platelet count, an

32 fic translocations, which generally have few karyotypic abnormalities, telomere lengths were similar

33 viously recognized genetic polymorphisms and karyotypic abnormalities, which collectively determine i

34 Cytogenetic analysis revealed clonal karyotypic abnormalities, which may contribute to pathog

35 oth humans and mice, occur in the absence of karyotypic abnormalities.

36 rmal karyotypes, but not in those with other karyotypic abnormalities.

37 apoptosis in ESCs and is a likely source of karyotypic abnormalities.

38 normal karyotype and 12% of those with other karyotypic abnormalities.

39 intact p53 response, and an absence of gross karyotypic abnormalities.

40 ttle is known about genes altered in complex karyotypic abnormalities.

41 at senescence before developing significant karyotypic abnormalities.

42 ere analysed by M-FISH to identify recurrent karyotypic abnormalities.

43 yotype and 12 percent among those with other karyotypic abnormalities; P=0.007) and patients with low

44 eletions of chromosome 5 are the most common karyotypic abnormality in myelodysplastic syndromes (MDS

45 her tumor cells do not, indicating that this karyotypic abnormality of c-myc occurs as a late event.

46 rimary MM tumors, some tumor cells contain a karyotypic abnormality of the c-myc locus, whereas other

47 o had de novo MDS with trisomy 8 as the sole karyotypic abnormality responded to ATG with durable rev

48 Trisomy 12, the most frequent karyotypic abnormality, is commonly found in a subset of

49 was associated with either a 13q- or a 20q- karyotypic abnormality.

50 - or int-1-risk MDS who lack the deletion 5q karyotypic abnormality.

51 fic region of chromosome 1 is thus the first karyotypic alteration that can be identified in hepatocy

52 tigate the basis of recent observations that karyotypic alterations are related to telomeric fusions,

53 A few karyotypic alterations can be directly linked to distinc

54 r could be a factor contributing to frequent karyotypic alterations observed in Chinese hamster cells

55 hibit extensive chromosomal instability, but karyotypic alterations will be significant in carcinogen

56 nses (DDRs) at the telomeres, culminating in karyotypic alterations with massive arrays of telomere f

57 ly account for the magnitude of the observed karyotypic alterations.

58 Karyotypic analyses demonstrate that reprogramming of hu

59 Karyotypic analyses of MEFs and lymphomas from DMP1-null

60 Karyotypic analyses performed in 28 patients showed clon

61 Flow cytometry and karyotypic analyses revealed increased polyploidy and an

62 re below the detection limit of conventional karyotypic analyses.

63 Karyotypic analysis further indicated that secondary gen

64 double minute chromosomes upon conventional karyotypic analysis indicated overt amplification of DNA

65 Karyotypic analysis of the stages of rat hepatocarcinoge

66 au susceptibility locus was undertaken after karyotypic analysis revealed no abnormalities.

67 Here we confirm by spectral karyotypic analysis that MYC-induced hematopoietic tumor

68 By spectral karyotypic analysis, we found that MYC even within one c

69 nd the absence of interstitial deletions, in karyotypic analysis.

70 previously been shown to be common sites of karyotypic and allelic loss in MM, our comparative genom

71 We use sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify

72 Using karyotypic and comparative genomic hybridization (CGH) a

73 ed region was confirmed to be within 1p22 by karyotypic and fluorescence in situ hybridization analys

74 Karyotypic and phenotypic analysis of human disseminated

75 nal analysis of fused cells reveals that the karyotypic and phenotypic potential of tumors formed by

76 zed Arabidopsis allohexaploids and monitored karyotypic and phenotypic variation in this population o

77 ed a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24

78 Here, we investigate the role of karyotypic change in homoploid hybrid speciation by gene

79 ygous deletions identified at 9p21, the only karyotypic change was a single case in which one entire

80 iated with normal karyotypes (IL3) or simple karyotypic changes (IL3R, FLT3).

81 Extensive karyotypic changes (tetrasomy) were observed in the hybr

82 Karyotypic changes accounting for these molecular alleli

83 n both preventing, and generating, oncogenic karyotypic changes are discussed.

84 Important similarities were noticed between karyotypic changes in cancer cell lines and that seen in

85 We have observed karyotypic changes involving the gain of chromosome 17q

86 All 21 strains were diploid, although karyotypic changes were present in eight of the 21 isola

87 Karyotypic changes, however, detect only gross alteratio

88 nonreciprocal translocations and additional karyotypic changes, indicating that genomic instability

89 on of SIR2 also produces a high frequency of karyotypic changes.

90 The karyotypic chaos exhibited by human epithelial cancers c

91 Clear differences between the karyotypic characteristics of B-lineage ALL and T-ALL we

92 ient co-detection and in situ phenotypic and karyotypic characterization as well as quantification of

93 the basis of these changes, we compared the karyotypic chromosomal abnormalities of primary pancreat

94 The results of karyotypic, clinical, and ERP investigations of this fam

95 n of these cell lines we defined and studied karyotypic complexity and heterogeneity (metaphase-to-me

96 We have asked whether we could use karyotypic complexity and instability as determinants fo

97 istinct therapeutic agents that target tumor karyotypic complexity has important clinical implication

98 Baseline karyotypic complexity, presence of del(17)(p13.1), and a

99 nifested by chromosomal reconfigurations and karyotypic complexity.

100 (snow leopard) provides further evidence for karyotypic conservation within felids, and demonstrates

101 tic patterns were heterogenous; a variety of karyotypic defects with numerical and structural abnorma

102 vorable prognosis than those with additional karyotypic defects, who tend to develop myeloproliferati

103 The karyotypic del(11)(q23) was a cryptic t(11;17).

104 Along with the karyotypic description of these cell lines we defined an

105 cies and progenitors primarily resulted from karyotypic differences between the species.

106 QTL analyses indicate that the karyotypic differences contribute to reproductive isolat

107 omic makeup of I. nelsonii), suggesting that karyotypic differences do not contribute substantially t

108 Karyotypic diversification is more prominent in Equus sp

109 f an "evolutionary trap" (ET) targeting both karyotypic diversity and fitness.

110 The phenotypic diversity resulting from karyotypic diversity endows the cell population with sup

111 ay be a facilitator of dangerous genetic and karyotypic diversity in tumorigenesis.

112 ypes reveals a propensity for tumors of less karyotypic diversity to segregate from the more pleomorp

113 The gibbon genome exhibits extensive karyotypic diversity with an increased rate of chromosom

114 Although karyotypic events in follicular lymphoma and its transfo

115 e involving LCRs plays a significant role in karyotypic evolution accompanying primate speciation.

116 gests that isolation may arise through rapid karyotypic evolution and/or ecological divergence of hyb

117 ian karyotypes provides strong evidence that karyotypic evolution is driven by nonrandom segregation

118 the impact of cytogenetic abnormalities and karyotypic evolution on the outcome of 256 patients.

119 Karyotypic evolution was documented in the majority of t

120 nts with otherwise typical AA in whom clonal karyotypic evolution was observed during frequent period

121 otoroos), which exhibit recent and extensive karyotypic evolution, rearrangements involve chiefly the

122 omic duplication plays a significant role in karyotypic evolution.

123 aps provide a powerful tool for the study of karyotypic evolution.

124 except for body size; and (3) unpredictable karyotypic evolution.

125 with a predominant and predictably drugable karyotypic feature.

126 In general, karyotypic findings in splenic tissue (n = 92) were simi

127 pecific cell biological mechanism for Todd's karyotypic fission concept, "kinetochore reproduction th

128 The karyotypic fission idea by contrast posits that all medi

129 Karyotypic fission theory of Todd offers an explanation

130 eny of irradiated cells also included clonal karyotypic heterogeneity.

131 zed by non-recurrent genetic aberrations and karyotypic heterogeneity.

132 have shed light on the diverse effects that karyotypic imbalances have on cellular phenotypes, and s

133 om the proband was studied using microarray, karyotypic, immunohistochemical, and immunoblotting tech

134 the development of consensus in reporting of karyotypic information in clinical trials involving youn

135 Karyotypic information on multiple myeloma (MM) is less

136 Increased karyotypic instability and activation of tumor-promoting

137 ultiple myeloma is characterized by frequent karyotypic instability at the earliest stage, progressin

138 Thus, the karyotypic instability generated by aneuploidy emerges a

139 The mechanism causing this karyotypic instability is largely unknown, but recent ob

140 he horse, is a promising model for exploring karyotypic instability.

141 "gain-of-CIN" phenotype and led to profound karyotypic instability.

142 structure are linked to mitotic defects and karyotypic instability.

143 orient linkage groups relative to a standard karyotypic layout (short arms at top).

144 d that with new precise methods more cryptic karyotypic lesions can be uncovered that may show import

145 morphological and physiological traits) and karyotypic levels for around 30 generations of laborator

146 in the initial state, at both phenotypic and karyotypic levels; (2) predictable phenotypic evolution

147 ion can drive tumorigenesis through impaired karyotypic maintenance.

148 have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence.

149 d trial, we enrolled adults (>40 years) with karyotypic or clinically diagnosed Down's syndrome, with

150 em for the study of nuclear DNA replication, karyotypic plasticity and other aspects of chromosomal b

151 sp. carinii infecting rats differentiated by karyotypic profiles exhibit the same low level of geneti

152 istent with the elevated rate of speciation, karyotypic rearrangement, and mitochondrial DNA evolutio

153 We suggest that karyotypic rearrangement, drug resistance and homozygosi

154 combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cel

155 KARIBIN () is a karyotypic region-based integrated information resource

156 Both groups were balanced for age, karyotypic risk, and FLT3-internal tandem duplication an

157 wth requirements, cell-cycle checkpoints and karyotypic stability in telomerase-expressing cells are

158 pair mechanisms, cell cycle checkpoints, and karyotypic stability, and this is likely partially due t

159 tion may be necessary for the maintenance of karyotypic stability.

160 lomere maintenance pathway incapable of full karyotypic stabilization in pleomorphic sarcomas.

161 of heterozygosity (LOH) were associated with karyotypic structural anomalies.

162 The MRS affects karyotypic variation by expanding and contracting intern

163 at sequence (MRS) is known to play a role in karyotypic variation in Candida albicans.

164 ze sequence, stock, phenotype, genotypic and karyotypic variation, and chromosomal mapping data.

165 en rodent species, which were independent of karyotypic variation.