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2 ates using runs of homozygosity with a 1,000-kb window (correlation = 0.94 with the estimates provide
3 ecruits PR to the CK5 promoter near the -1.1 kb essential PRE, and also to a proximal region near -13
4 estingly, RARalpha was recruited to the -1.1 kb PRE and the -130 bp PRE/RARE regions with P4, but not
5 eletion analysis, we identified a region 1.1 kb upstream of the CK5 transcriptional start site that i
8 a spliced and polyadenylated lncRNA about 1 kb in length that is found in both the nuclear and cytop
9 ker plasmids which produce both 100 bp and 1 kb DNA ladders when digested with two common restriction
10 proximately 5 bp) and long ( approximately 1 kb) genomic distances, showing that mutation drives GC c
15 ic exchange often incorporates regions of <1 kb, and allelic gene conversion changes the frequency of
19 resolves repetitive structures longer than 1 kb, representing the largest repeat family and immune ge
20 atterns were predominantly observed within 1 kb from the transcription start site, where both histone
24 gle-nucleotide polymorphism approximately 10 kb downstream of myosin regulatory light chain interacti
27 ore technologies (ONT) produce reads over 10 kb in length, which have enabled high-quality genome ass
28 Rgamma2 promoter and an enhancer sequence 10 kb upstream that forms at the onset of PPARgamma2 expres
30 gene from 15 kb upstream of its 5'-end to 10 kb downstream of its 3'-end to determine SOX9 interactio
31 h can provide accurate sequences of up to 10 kb, allowing us to identify rare mutations below the det
36 we find that the rates of large-scale (>100 kb) de novo copy-number variants (CNVs) are significantl
37 We identified 33 hotspots of large (>100 kb) tandem duplications, a mutational signature associat
41 hisms (SNPs), corresponding to 1 marker/100 kb distributed across the genome for sex-linked variatio
49 e replacement of genomic DNA with long (>100-kb) synthetic DNA, through the in vivo excision of doubl
50 also lead to a refined ERBB2 amplicon of 106 kb and show that several cases of amplifications are com
51 e with destabilized GFP, we identified an 11-kb genomic region 3' of the Nkx3.1 transcription start s
53 ugh androgen receptor (AR) binding to the 11-kb region in both normal luminal cells and CARNs and dis
54 ts per ml when vector genomes harboured a 12 kb insert, approximately twice that reported for lentivi
55 ously unidentified cis-regulatory element 12 kb upstream of HLA-G with enhancer activity, Enhancer L
60 mitochondrial (mt) genomes of anisakids (~14 kb) from different fish hosts in multiple countries, in
62 y chromatin immunoprecipitation with the -14-kb Pu.1 or +37-kb Cebpa enhancers after stable expressio
64 repair deficiencies and hyper-resection 0.15 kb from the DSB that was dependent on the nuclease activ
65 OX9 antibody, covering the Ctgf gene from 15 kb upstream of its 5'-end to 10 kb downstream of its 3'-
67 -linked variants to sample approximately 150 kb of nuclear sequence, in addition to complete mitochon
68 n of B. turicatae genes localized on the 150 kb linear megaplasmid during the tick-mammalian transmis
69 ify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcrip
70 adapted this method to rapidly deliver a 152 kb herpes simplex virus 1 genome cloned in yeast into ma
72 nce that chromosomal looping, bypassing 1524 kb of linear genome, connects Auts2 to the Caln1 gene lo
74 METHODS AND We sequenced a approximately 158 kb region encompassing PRRX1 in 962 individuals with and
76 e that transgenically express the entire 160-kb human C19MC locus or lentivirally express C19MC miRNA
77 position of the large-size PB transposon (17 kb) encoding the full-length DYS and green fluorescence
80 ling, we show that CEBPA is located in a 170-kb topological-associated domain that contains 14 potent
81 e homogenates, we assembled a contiguous 174-kb genome sequence containing 128 unique predicted open
85 ys more than 10(8) DNA fragments, each 0.2-2 kb in size, for their ability to drive transcription aut
86 7095681 at 10q25.3, intron of SHTN1 and 27.2 kb downstream of VAX1, Pmeta = 3.80E-9, OR = 0.64) in Ch
87 functional analysis of HMS1, a region of 9.2 kb in chromosome 3 of Drosophila mauritiana, which resul
88 her, we programmed 4,342 overlapping 1 and 2 kb deletions that tiled 206 kb centered on HPRT1 (includ
90 nt required for gene regulation was mapped 2 kb upstream of the 12-HETER1 transcriptional start site.
91 We determined sequences extending nearly 2 kb upstream of the transcription start site for 68 allel
92 icted to a chromatin domain extending only 2 kb either side of the DSB, and BRD2 does not spread into
94 in two variants, one consisting of a large 2-kb transcript composed of four exons and one consisting
96 als, meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots, whose positions and
97 AHR hotspots, PRS1 and PRS2, separated by 20 kb and located within the low-copy repeats NF1-REPa and
98 one intergenic SNP (rs11901793), which is 20 kb upstream of CXCR7 gene on chromosome 2, was associate
99 stance gene, mecA, is carried on a large (20 kb to > 60 kb) genomic island, staphylococcal cassette c
108 r for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1-Di
109 Hi-C data for budding yeast and identify 200-kb scale TADs, whose boundaries are enriched for transcr
111 rlapping 1 and 2 kb deletions that tiled 206 kb centered on HPRT1 (including 87 kb upstream and 79 kb
112 t, is a major contributor of the 16p11.2 220 kb BP2-BP3 CNV-associated neurodevelopmental phenotypes.
113 plication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are
114 ad size and body weight, a second distal 220 kb BP2-BP3 CNV is likewise a potent driver of neuropsych
116 s an enormous design space (1043 possible 23 kb constructs), from which an algorithm-guided 192-membe
117 onas applanata In fact, at approximately 230 kb, the ptDNA of P. uvella represents the largest plasti
118 Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene tra
122 ves direct iterative recombineering of 10-25 kb synthetic DNA constructs which are assembled in yeast
125 s mouse Ebeta element and its neighboring 25 kb region by independently tethering this TF without coi
127 ve earlier shown that a locus within an 250 kb haplotype block spanning the 5' untranslated region r
128 We construct a weighted network with 250-kb genomic regions as nodes and Hi-C interactions as edg
129 sms (tag-SNPs) within a region spanning 263 kb including SPINK5 ( 61 kb) in n=722 (n=367 food-allerg
132 ell-specific Gata3 enhancer (Tce1) lying 280 kb downstream from the structural gene and demonstrated
133 the ~48 kb risk haplotype) that spanned ~280 kb forming one risk haplotype carried by 35 % of the GSD
134 d vascular short telomere abundance (4.2-1.3 kb) 43.0 +/- 1.5 vs. 55.1 +/- 3.8%) in aged vs. young of
135 le-stranded RNA genome of approximately 13.3 kb encapsidated by multiple copies of the nucleoprotein
136 presentative M. musculus sequence (the 16.3 kb mitochondrial genome), at 100%, 100%, and 96.7% conse
138 with Fam20C (flox/flox) mice, we created 2.3 kb Col 1a1-Cre;Fam20C (foxl/flox) (cKO) mice, in which F
144 ority of open chromatin regions lie within 3 kb upstream of a transcription start site in all species
145 actional proviral expression of HIV RNA (1.3-kb fragment of p6, protease, and reverse transcriptase)
146 ance determinants via incorporation of a 5.3-kb mega cassette harboringmsrDandmefE Furthermore, durin
147 CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated en
153 ments at approximately 80% fidelity and a 31 kb plasmid from five fragments at approximately 50% fide
154 n rates, and histone modifications) in +/-32 kb of these ERVs' integration sites and in control regio
155 mbinant inbred strains, we found that the 33-kb Ltab-Ncr3 haplotype in MHC-III was linked to the indu
156 no origin, and a homozygous approximately 34 kb deletion affecting exons 3-9 was observed in two fami
157 nome sequencing to discover a pathogenic 346 kb inversion in multiple probands, and cDNA sequencing a
159 f the deletions revealed a approximately 350 kb critical region on chromosome 6q16.1 that encompasses
163 unoprecipitation with the -14-kb Pu.1 or +37-kb Cebpa enhancers after stable expression in 32Dcl3 cel
168 tions observed at a nearby approximately 374-kb region of complete LD containing three additional can
170 cus is thus refined to a shared region of 39 kb that contains DNAse hypersensitive sites active at a
171 us, which has a genome of approximately 13.4 kb and groups with aphid-transmitted viruses in the genu
176 generated knockin mice that replace the 1.4-kb proximal Selp promoter with the corresponding SELP se
177 digree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threon
179 ousands of mutations across approximately 40 kb of cis-regulatory genomic space and uses knock-in gre
181 en one region-specific SNP (rs10509852), 400 kb upstream of SORCS1 gene on chromosome 10, and the glo
182 oundary was highly resilient, and only a 400-kb deletion, including the whole-gene cluster, was event
186 ome, we selectively excised approximately 44 kb DNA spanning promoter region, transcription start sit
190 10(-25)), resides in an enhancer element 47 kb upstream of the transcription start site of c-Myc-int
191 19,086,778 (p = 1.4 x 10(-7)) and a rare ~48 kb risk haplotype overlapping the PKP2 gene and shared o
192 p-associated in GSDs and five within the ~48 kb risk haplotype) that spanned ~280 kb forming one risk
193 has a unique first exon (Ex1B) located 10.5 kb upstream of the first exon (Ex1A) for canonical MTP (
195 long PfKelch13 C580Y haplotype (-50 to +31.5 kb) lineage, which emerged in western Cambodia in 2008,
196 emblies of the 4.6 Mb E. coli genome, 48.5 kb lambda genome, and a representative M. musculus seque
198 e the causal variant(s) at this locus to a 5 kb region that overlaps a stretch-enhancer active in isl
205 as9-SunTag-DNMT3A is able to methylate a 4.5-kb genomic region and repress HOXA5 gene expression.
206 tions within the cardiac myocyte genome at 5-kb resolution, enabling examination of intra- and interc
207 e pairwise interactions of over 10 million 5-kb DNA segments in the B-lymphocyte cell line GB12878.
215 They positioned predominantly around 50-500 kbs from the transcription start sites of their nearby g
216 d over six loci spanning between 30- and 500-kb chromosomal regions have been described in two Iowa S
217 error rates as low as 10(-8) and average 500-kb-long DNA fragments that can be assembled into haploty
218 lized within an evolutionarily conserved 500-kb domain in human chromosome 19q13.4 and mouse proximal
219 cantly decreased eRNAs at ESEs -428 and -525 kb upstream of the MYC oncogene transcription start site
223 of commensal Escherichia coli harbor the 54-kb clb gene cluster which codes for small molecules name
229 design rules, and demonstrate folding of a 6-kb template by as few as 10 unique strand sequences bind
231 , mecA, is carried on a large (20 kb to > 60 kb) genomic island, staphylococcal cassette chromosome m
237 egion spanning 263 kb including SPINK5 ( 61 kb) in n=722 (n=367 food-allergic, n=199 food-sensitized
238 analysis of one such locus residing in a 610 kb gene desert on chr13q22.1 (marked by rs9543325).
241 rescuing transgenic mouse line bearing a 662-kb Gata3 yeast artificial chromosome (YAC), and these an
246 ns included deletions ranging from 75 to 2.7 kb in length, most of which appear to have occurred at r
249 s two canonical bipartite sites within a 0.7-kb transcriptional enhancer upstream of Mist1 that are e
251 of Boodlea composita are encoded on 1- to 7-kb DNA contigs with an exceptionally high GC content, ea
252 ure we identified two novel DREs located -70 kb upstream and +100 kb downstream from the NGB gene.
253 n immunoprecipitation suggested that the -70 kb region upstream of the NGB gene contained a neuronal-
254 e genomic distance range ( approximately 700 kb-1.5 Mb), while interactions involving actively marked
255 ble across individuals (sd: fetal LTL = 0.72 kb, MTL = 0.72 kb; children LTL = 0.81 kb, MTL = 0.82 kb
256 viduals (sd: fetal LTL = 0.72 kb, MTL = 0.72 kb; children LTL = 0.81 kb, MTL = 0.82 kb) but were high
258 inherited ASD and glaucoma to identify a 748-kb deletion in a gene desert that contains conserved put
260 that both siblings are homozygous for a 770-kb deletion on chr22q11.1 encompassing both IL17RA and c
261 pe localize the functional variation to a 78 kb region spanning the 3'end of MLH1 and the 5'end of th
262 ed on HPRT1 (including 87 kb upstream and 79 kb downstream) with median 27-fold redundancy per base.
265 ant for inhibiting long-range resection, 4.8 kb from the break, and for preventing the formation of l
266 e effect of overexpression of the entire 4.8 kb miR-183 family cluster, including the intergenic regi
269 e novo with paired-end and long-mate-pair (8 kb) libraries were first assembled and analyzed utilizin
278 0.72 kb, MTL = 0.72 kb; children LTL = 0.81 kb, MTL = 0.82 kb) but were highly correlated within ind
279 0.72 kb; children LTL = 0.81 kb, MTL = 0.82 kb) but were highly correlated within individuals (fetus
281 tiled 206 kb centered on HPRT1 (including 87 kb upstream and 79 kb downstream) with median 27-fold re
282 nctional lycopene biosynthetic pathway (11.9 kb encoding 10 genes) in Escherichia coli using a highly
287 wstonensis Each strain encodes a 9.8- to 9.9-kb linear double-stranded DNA (dsDNA) genome with large
288 e microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes
290 ion of Sult1d1 at a distance of more than 95 kb but not the more proximal and silent Sult1e1 gene.
291 UNX3 through a specific element within a -97 kb super-enhancer in a manner dependent on the expressio
292 ase D (PKD) family inhibitors CRT0066101 and kb NB 142-70 prevented the increase in YAP phosphorylati
293 e estimated the Ca(2+)-binding rate constant kb ( approximately 1.8 x 10(8) M(-1) s(-1)) for mSlo1 an
295 rustrated AFM interactions on the scale of J/kb approximately 30 K, but reveal no anomalies that woul
296 1 variant is on chromosome 10, 132 kilobase (kb) downstream from <em>CXCL12</em>, which encodes a che
297 ific segments at megabase (Mb) and kilobase (kb) resolutions of single average and ensemble structure
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