ライフサイエンスコーパス: keratin-18

1 Slug, and up-regulation of epithelial marker keratin 18.

2 as well as down-regulation of E-cadherin and Keratin-18.

3 In this study, keratins 18, 8, and 19 were identified to interact with

4 fected, but hsc hsp70, hsp90beta, keratin 8, keratin 18 and caveolin-1 were deregulated following tre

5 and the embryonic OCT-4, cytoskeletal genes keratin-18 and beta-actin, the cell cycle gene C-MOS, an

6 (beta-casein), CDH1 (E-cadherin), and KER18 (keratin-18)) and suppressed genes associated with stem c

7 biquitous cytoskeletal elements, beta-actin, keratin-18, and alpha-tubulin, were detected at the expe

8 in sensitivity increased, and serum level of keratin 18 decreased.

9 n 44 of 467 explants and 11 of 349 controls: keratin 18 deletion (delta64-71), a keratin 8 frameshift

10 However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increa

11 Plasma levels of total keratin 18, keratin 18 fragments, interleukin 6, tumor necrosis fact

12 total (M65) and caspase-cleaved (M30) serum keratin-18 fragments (n = 204) with histological paramet

13 have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis,

14 c stimulation, we have used a modified human keratin 18 gene to conditionally express the polyomaviru

15 We tested for mutations in the keratin 8 and keratin 18 genes in purified genomic DNA isolated from 1

16 importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear.

17 er enzymes, insulin resistance, adiponectin, keratin 18, high-sensitivity C-reactive protein, or hyal

18 optosis in HCT-15 or HT-29 cells but induced keratin 18 in both cell lines.

19 -5, suggesting that Krtap5-5 crosstalks with keratin 18 in E0771 cells.

20 amino acids on the alpha-helix 2B domain of keratin 18 in which two amino acids (Leu(366) and Lys(37

21 intestinal epithelial intermediate filament keratin 18 interact with the C-terminus of the Shigella

22 Keratin 8 (K8) and keratin 18 (K18) form intermediate filaments characteris

23 .3 kb and 3.5 kb of DNA that flank the human keratin 18 (K18) gene and synthetic nuclear matrix attac

24 The human keratin 18 (K18) gene is expressed in a restricted but d

25 or potential regulatory regions of the human keratin 18 (K18) gene.

26 bind the human intermediate filament protein keratin 18 (K18) in vivo, in a cell-cycle- and phosphory

27 expression, with a greater keratin 8 (K8)-to-keratin 18 (K18) ratio, which are critical for drug-indu

28 Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of

29 sion in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate f

30 t has been studied in terms of regulation is keratin 18 (K18).

31 Keratin 8 (K8) and keratin-18 (K18) are the major intermediate filament pro

32 f necrosis), full-length and caspase-cleaved keratin-18 (K18; markers of necrosis and apoptosis), and

33 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility group box-1 [HMGB1], and

34 intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is associated with cirrhosis in huma

35 Plasma levels of total keratin 18, keratin 18 fragments, interleukin 6, tumor n

36 Although 14-3-3sigma, keratin 18, keratin 19, ATP synthase beta, protein disul

37 We also cloned a Monodelphis gene, keratin 18 (KRT18), and characterized its expression pat

38 r complications, the implementation of total keratin 18 measurements in routine diagnostics after ort

39 Keratin 18 mutants where O-GlcNAcylation at Ser(30) was

40 vealed that this clone contains sequences of keratin 18 (nucleotides 568-1196).

41 We further demonstrate that knockdown of keratin 18 phenocopies the loss of Krtap5-5, suggesting

42 ure of human airway epithelial cells (A549), keratin 18, the 78-kD glucose-regulated protein, trans-1

43 lowing in vivo inhalation of an HDI aerosol, keratin 18 was also identified as the predominant diisoc

44 Total keratin 18 was demonstrated to be favorable in its progn

45 Dickkopf-1, Fibroblast Growth Factor 8, and Keratin-18) was further verified by reverse-transcriptio

46 arker cholecystokinin, and epithelial marker keratin 18 were up-regulated.

47 scriptional targets, including cyclin D1 and keratin 18, which show inverse expression in PAM212 base