ライフサイエンスコーパス: keratin-5

1 f polzeta) was deleted in tissues expressing keratin 5.

2 luminal marker keratin 8/18 and basal marker keratin 5.

3 axome consists of a marginal ring containing keratin 5 10-nm-thick filaments and F-actin.

4 amous phenotype with increased expression of keratins 5/6 and beta-catenin.

5 tochemical staining showed that nestin, GFP, keratin 5/8, and keratin 15 colocalize in the hair folli

6 Here, we demonstrated that keratin 5, a 58 kD protein required for formation of 8 n

7 Because keratin 5, a keratin associated with basal cells, was de

8 creased and decreased promoter activities of keratin 5, a proliferative marker, and involucrin, a dif

9 The genes encoding keratin 5 and 14 are highly expressed in the basal cell

10 the undifferentiated epithelial cell markers keratin 5 and 14 but not the differentiation marker kera

11 y a role in the suprabasal repression of the keratin 5 and 14 genes because keratin 14 mRNA expressio

12 the expression of the proliferation markers keratin 5 and cyclin D1.

13 The keratin 5 and keratin 14 genes encode proteins that form

14 mSG cells exhibited progenitor cell markers (keratin 5 and nanog) as well as acinar-specific markers-

15 Keratins 5 and 14 (K5 and K14), the main pairing occurri

16 For IFs comprised of keratins 5 and 14 (K5 and K14), which occur in basal ker

17 For IFs comprised of keratins 5 and 14 (K5, K14), found in basal keratinocyte

18 Keratins 5 and 14 are expressed as a pair in basal cells

19 tified and simple epithelial tissues express keratins 5 and 14, and keratins 8 and 18, respectively.

20 is caused by dominant-negative mutations in keratins 5 and 14, which are specifically expressed in t

21 , and markers of keratinocyte proliferation (keratins 5 and 6), and differentiation (small proline-ri

22 disorder caused by mutations in keratins K5 (keratin 5) and K14 (keratin 14), with fragility of basal

23 in a dramatic redistribution of desmoplakin, keratin 5, and chromogranin A proteins.

24 on-sense mutation, overexpressed a truncated keratin 5, and showed a disorganized and collapsed kerat

25 Four-week-old keratin 5/AZ and wild-type (Wt) littermates were placed

26 Specifically, after low-dose IR, keratin 5(+) basal hair bulb progenitors, rather than bu

27 of IGF-1 is under the control of the bovine keratin 5 (BK5) promoter and is directed to either the m

28 driven by human keratin 14 (HK14) or bovine keratin 5 (BK5) promoters, respectively.

29 ress a subset of basal cell genes, including keratin 5, but no longer express high levels of either T

30 airway stem cells expressing Trp63 (p63) and keratin 5, called DASC(p63/Krt5), to this process.

31 We used a truncated keratin 5 (DeltaK5) promoter to assess the potential rol

32 opment in vivo with a doxycycline-inducible, keratin 5-driven transgene encoding TSLP (K5-TSLP).

33 expanding set of genetic variants including keratin 5 (encoded by KRT5), an intermediate filament-fo

34 mentation (mutation P25L in the V1 domain of keratin 5), epidermolysis bullosa simplex with migratory

35 ne or more layers of intermediate cells, and keratin 5-expressing basal cells (K5-BCs), which are con

36 Pten-deficient prostate lesions arising from keratin 5-expressing basal cells in a temporally control

37 Unchallenged mice developed tumors in keratin 5-expressing tissues with age, consistent with t

38 s during ontogeny, we analyzed keratin 8 and keratin 5 expression at several stages of fetal developm

39 ocervix and uterine cavity were monitored by keratin 5 expression with immunohistochemistry.

40 Expression of mutant ras from a truncated keratin 5 gene promoter, which directs expression to the

41 subsets regulate the expression of IL-7 and keratin 5 in adult cortical epithelium, suggesting that

42 k of keratin filaments (with type II partner keratin 5) in skin keratinocytes analyzed by static and

43 xpression decreased the promoter activity of keratin 5, increased that of keratin 10 and enhanced the

44 The pattern of expression of keratin 1 and keratin 5 indicated that epidermal differentiation was n

45 proliferating cell nuclear antigen and mouse keratin 5 indicated that these increases were due to a m

46 t cases of EBS, point mutations occur in the keratin 5 (K5) and K14 genes expressed in the basal laye

47 One mTEC subset expresses keratin 5 (K5) and K14, but fails to bind Ulex europaeus

48 c disorders of the basal epidermal keratins, keratin 5 (K5) and keratin 14 (K14).

49 in mouse skin carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to d

50 al dominant condition caused by mutations in keratin 5 (K5) or K14.

51 s in the intermediate filament (IF) proteins keratin 5 (K5) or keratin 14 (K14) cause epidermolysis b

52 lex (EBS) results from dominant mutations in keratin 5 (K5) or keratin 14 (K14) genes, encoding the i

53 aithfully recapitulate the strong endogenous keratin 5 (K5) promoter and/or enhancer activity.

54 The keratin 5 (K5) promoter drives transgenic expression to

55 tic protein (BMP) antagonist noggin from the keratin 5 (K5) promoter in the epidermis.

56 ressing the E2F4 gene under the control of a keratin 5 (K5) promoter were developed, and their phenot

57 c mice expressing Myc under the control of a keratin 5 (K5) promoter were generated.

58 mice expressing E2F1 under the control of a keratin 5 (K5) promoter were generated.

59 ressing the E2F1 gene under the control of a keratin 5 (K5) promoter, we previously demonstrated that

60 targeted to squamous epithelial tissues by a keratin 5 (K5) promoter.

61 f transgenic mice expressing E2F3a through a keratin 5 (K5) promoter.

62 chieved by Cre recombinase expression from a keratin 5 (K5) promoter.

63 f the Cre recombinase under the control of a keratin 5 (K5) promoter.

64 produce BCCs when overexpressed by use of a Keratin 5 (K5) promoter.

65 regulated the expression of p63, Trim29, and keratin 5 (K5), which serve as diagnostic markers for hu

66 y breeding conditional Perp knockout mice to keratin 5 (K5)-Cre transgenic mice.

67 combinase expressed under the control of the keratin-5 (K5) promoter resulted in a delay in the first

68 ade a series of point substitutions with the keratin 5/keratin 14 IF system.

69 ares features with normal urothelium such as keratin 5 (KRT5), P-cadherin (P-Cad), and epidermal grow

70 in pigmentation associated with mutations in keratin 5 (KRT5), protein O-fucosyltransferase 1 (POFUT1

71 R-196a with its in silico-predicted targets, keratin 5 (KRT5), small proline-rich protein 2C (SPRR2C)

72 We identified type II keratin 5, lamin A, the cytoplasmic domain of integrin b

73 change predicts the synthesis of a truncated keratin 5, missing 119 amino acids, including the entire

74 ignificantly accelerate tumor development in keratin 5 Myc transgenic mice.

75 Expression of an altered keratin 5, of predicted mass and pI for the product of t

76 ost cases of EBS are due to mutations in the keratin 5 or 14 gene (K5 and K14), whose products copoly

77 s caused by expression of either an abnormal keratin 5 or an abnormal keratin 14 protein, which compr

78 ound to harbor heterozygous mutations in the keratin 5 or keratin 14 genes, KRT5 and KRT14, respectiv

79 Mutant keratins 5 or 14 are implicated in the etiology of epide

80 heath of the hair follicle, as well as other keratin 5 positive tissues.

81 ing loss of gangliogenesis, innervation, and keratin 5-positive (K5+) epithelial progenitors in the S

82 mutants display premature differentiation of keratin 5-positive (Krt5(+)) basal cells and ectopic exp

83 ery of the PNA-Antp, chromosomally modified, keratin 5-positive basal keratinocytes persist for at le

84 re decreased the number and morphogenesis of keratin 5-positive epithelial progenitor cells.

85 elial morphogenesis and proliferation of the keratin 5-positive progenitor cells.

86 lumen layer of multi-ciliated and a layer of Keratin-5-positive basal cells.

87 to the gradual appearance of matriptase in a keratin-5-positive proliferative cell compartment during

88 in epidermis were generated using the bovine keratin 5 promoter (BK5).

89 al component of the NF-kappaB pathway, under keratin 5 promoter (K5-Ikkbeta).

90 xpressing RasGRP1 in the epidermis under the keratin 5 promoter (K5.RasGRP1) are prone to developing

91 wild-type TGFbeta1 in the epidermis using a keratin 5 promoter (K5.TGFbeta1(wt)) developed inflammat

92 Our recent study using a keratin 5 promoter (K5.TGFbeta1(wt)) showed that transge

93 ice overexpressing CDK4 under control of the keratin 5 promoter (K5CDK4 mice) develop epidermal hyper

94 sgenic mice carrying the CDK6 gene under the keratin 5 promoter (K5CDK6).

95 1 overexpression is controlled by the bovine keratin 5 promoter and recapitulates the paracrine expos

96 udy, we show that when Edn3 is driven by the keratin 5 promoter and thereby placed proximal to melano

97 Transgenic mice (K5-PKC alpha) in which the keratin 5 promoter directs the expression of protein kin

98 nic (Tg) mice over-expressing Cx26 driven by keratin 5 promoter had an unexpected mammary phenotype:

99 under the control of an epithelial-specific keratin 5 promoter to determine whether the absence of E

100 tional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycli

101 The keratin 5 promoter was used with a tetracycline-inducibl

102 a Cre transgene under control of the bovine keratin 5 promoter we achieved 100% recombination of the

103 l layer of the forestomach epithelium by the keratin 5 promoter were used to investigate whether AZ o

104 expression of COX-2, under the control of a keratin 5 promoter, is sufficient to cause transitional

105 ess a Smad7 transgene under the control of a keratin 5 promoter, were resistant to radiation-induced

106 arrying the CDK4 gene under the control of a keratin 5 promoter.

107 hich carry cyclin D2 or D3 genes driven by a keratin 5 promoter.

108 ators, tTA and rTA, are linked to the bovine keratin 5 promoter.

109 sal layer of mouse epidermis with the bovine keratin 5 promoter.

110 the human cyclin D1 gene driven by a bovine keratin 5 promoter.

111 1 to basal epidermal keratinocytes using the keratin 5 promoter.

112 ecific myosin light-chain 2 or skin-specific keratin 5 promoter.

113 follicles under the regulation of the bovine keratin 5 promoter.

114 ycline transactivator tTA from the epidermal keratin 5 promoter.

115 nocyte-specific CtBP1 transgenic mice with a keratin-5 promoter (K5.CtBP1) to probe the pathological

116 cyclin in squamous epithelia from the bovine keratin-5 promoter.

117 ng a desmoglein-3 mouse model (Dsg3(-/-)) or keratin 5-specific reporter mice, the investigators show

118 cantly higher total E-cadherin and decreased keratin 5 staining than epithelium of placebo-treated mi

119 mouse skin biopsies was determined based on Keratin 5 staining.

120 shift mutation c1649delG in the V2 domain of keratin 5), striate palmoplantar keratoderma (PPK), and

121 keratosis in both patients suggests that the keratin 5 tail domain may have unrecognized, but importa

122 e model that expresses an epidermal-targeted keratin-5-UCP3 (K5-UCP3) transgene and exhibits signific

123 sgenics to delete Fgfr2b in cells expressing keratin 5, we show that mice lacking epidermal Fgfr2b su

124 Basal cell markers such as p63 and keratin 5 were not expressed by the masses of PIN-like l

125 ressing the BMP antagonist noggin (promoter: keratin 5) were generated.