ライフサイエンスコーパス: keratin-8

1 s remained unaltered, including cyclin E and keratin 8.

2 ine-to-histidine mutations at position 53 of keratin 8.

3 Tumors were further classified by markers keratin 8/18 (K18, KRT18), keratin 14 (K14, KRT14) and e

4 n the tumor that express both luminal marker keratin 8/18 and basal marker keratin 5.

5 Ballooned hepatocytes were quantified by keratin 8/18 and ubiquitin (K8/18/Ub) staining.

6 e effect of small heat shock proteins on the keratin 8/18 intermediate filament cytoskeleton using a

7 Consistent with DNAJB6 dysfunction, keratin 8/18, a DNAJB6 client also accumulated in DNAJB6

8 rates expression of NP markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brac

9 Keratins 8/18 (K8/18) are phosphoglycoproteins and form

10 Keratins 8/18 (K8/K18) are established hepatoprotective

11 otein aggregates consisting of ubiquitinated keratins 8/18 (K8/K18).

12 blocked normal differentiation, and induced keratin 8, a marker of malignant conversion, but did not

13 Keratin 8 and 18 (K8/18) phosphorylation plays a signifi

14 Keratin 8 and 18 (K8K18) mutations are found in patients

15 runcates the last 14 amino acids; 8 missense keratin 8 and 18 alterations; and several new polymorphi

16 We identified 10 novel keratin 8 and 18 heterozygous variants in 44 of 467 expl

17 a time-dependent disassembly-degradation of keratin 8 and 18 proteins, which was associated with an

18 Keratin 8 and 18 variants in 17 of 467 liver disease exp

19 The overall frequency of keratin 8 and 18 variants was 12.4% in 467 liver disease

20 cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is associated with cir

21 We tested for mutations in the keratin 8 and keratin 18 genes in purified genomic DNA i

22 osis, but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is uncle

23 of TEC subsets during ontogeny, we analyzed keratin 8 and keratin 5 expression at several stages of

24 duction of epithelial markers E-cadherin and keratin-8 and down-regulation of mesenchymal markers N-c

25 patibility complex transcription factors and keratin-8 and therefore may allow immune evasion and est

26 Keratins 8 and 18 (K8/18) are intermediate filament phos

27 Keratins 8 and 18 (K8/18) are major constituents of Mall

28 Keratins 8 and 18 (K8/18) are simple epithelial cell-spe

29 Hepatocytes express keratins 8 and 18 (K8/18) as their only cytoskeletal int

30 Keratins 8 and 18 (K8/18) heteropolymers may regulate ce

31 eral liver diseases and consist primarily of keratins 8 and 18 (K8/K18) and ubiquitin that are cross-

32 Keratins 8 and 18 (K8/K18) are important hepatoprotectiv

33 Keratins 8 and 18 (K8/K18) are the intermediate filament

34 Keratins 8 and 18 (K8/K18) protect the liver from variou

35 major keratins in the pancreas and liver are keratins 8 and 18 (K8/K18), but their function seemingly

36 MBs consist primarily of keratins 8 and 18 (K8/K18), require a K8-greater-than-K1

37 -Denk bodies (MDBs), which are aggregates of keratins 8 and 18 (K8/K18), ubiquitin, and the ubiquitin

38 re composed primarily of hyperphosphorylated keratins 8 and 18 (K8/K18).

39 demonstrated the constitutive expression of keratins 8 and 18 and induced expression of keratin 19,

40 n, the transfectants containing vimentin and keratins 8 and 18 demonstrated an increase in focal adhe

41 nimal models, the absence of heteropolymeric keratins 8 and 18 or the presence of mutant keratins in

42 Keratins 8 and 18 protect the liver from stress.

43 ich included several keratins, in particular keratins 8 and 18 which are regulated through the ras si

44 h up-regulation of epithelial markers (i.e., keratins 8 and 18) and down-regulation of mesenchymal ma

45 elial tissues express keratins 5 and 14, and keratins 8 and 18, respectively.

46 ns were present in the remaining 10 exons of keratins 8 and 18.

47 5P (of low invasive ability), with cDNAs for keratins 8 and 18.

48 ue-type plasminogen activator (tPA), AFP and keratins 8 and 19 is inhibited, whilst brachyury and myo

49 position 61 (a highly conserved glycine) of keratin 8, and 2 had tyrosine-to-histidine mutations at

50 actor) was both necessary and sufficient for keratin 8 cleavage in chlamydia-infected cells, suggesti

51 A cleavage fragment of keratin 8 corresponding to the central rod region was de

52 increase in p62 and Hsp25 levels as well as keratin 8 cross-linking that is normally associated with

53 After temporally ablating Pten in keratin 8-expressing luminal cells, luminal-derived Pten

54 ontrols: keratin 18 deletion (delta64-71), a keratin 8 frameshift that truncates the last 14 amino ac

55 others decreased keratin 8 phosphorylation (keratin 8 G433S).

56 Mutations that introduced disulfide bonds (keratin 8 G61C or R453C) decreased keratin solubility, p

57 Mutations in the keratin 8 gene may predispose people to liver disease an

58 Since keratin 8 is a major component of the intermediate filam

59 Furthermore, the C-terminal tail domain of keratin 8 is shown to be essential for this effect.

60 Exposure of keratin 8 (k-8) expressing human breast cancer cells (MC

61 The intermediate filament protein keratin 8 (K8) and its cross-linking by transglutaminase

62 Keratin 8 (K8) and keratin 18 (K18) form intermediate fi

63 Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate fi

64 ated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-spec

65 Keratin 8 (K8) and keratin-18 (K18) are the major interm

66 Using stable CACO-2 transfectants expressing keratin 8 (K8) antisense RNA under a tetracycline-respon

67 Absence of keratin 8 (K8) in mice leads to colitis, decreased Na/Cl

68 Keratin 8 (K8) is a major intermediate filament protein

69 The intermediate filament protein keratin 8 (K8) is critical for the development of most m

70 aining "particles," mostly containing either keratin 8 (K8) or 18 (K18), but not both.

71 n kinase C delta-mediated phosphorylation of keratin 8 (K8) Ser-73.

72 Keratin 8 (K8) serine 73 occurs within a relatively cons

73 ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epidermis.

74 Keratin 8 (K8) variants predispose to human liver injury

75 We investigated the regulation of keratin 8 (K8), a type II simple epithelial IF, by lysin

76 of intestinal keratins is unknown, although keratin 8 (K8)-null mice develop colitis, hyperplasia, d

77 Keratins are essential for MDB formation and keratin 8 (K8)-overexpressing transgenic mice are predis

78 2 and keratin overexpression, with a greater keratin 8 (K8)-to-keratin 18 (K18) ratio, which are crit

79 ne sites on the simple epithelial IF protein keratin 8 (K8).

80 atin in "simple type" glandular epithelia is keratin 8 (K8).

81 Keratins 8 (K8) and 18 (K18) are major components of int

82 l tissues such as liver and pancreas express keratins 8 (K8) and 18 (K18) as their major intermediate

83 Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate

84 Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate

85 was not affected, but hsc hsp70, hsp90beta, keratin 8, keratin 18 and caveolin-1 were deregulated fo

86 ents in simple epithelial cells, cleavage of keratin 8 may increase the solubility of the host cell c

87 -associated mutations have been described in keratin 8 or 18 (K8/18) which are the major keratin pair

88 ach to identify proteins that associate with keratins 8 or 18 (K8/K18) in a pervanadate-dependent man

89 r oxidative stress, whereas others decreased keratin 8 phosphorylation (keratin 8 G433S).

90 ge-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary glan

91 The most common variant, keratin 8 R340H, at the highly conserved R340 was found