ライフサイエンスコーパス: keratitis

1 ections model and in vivo model of bacterial keratitis.

2 n early development of severe herpes stromal keratitis.

3 different from that of herpes simplex virus keratitis.

4 ngals in the treatment of filamentous fungal keratitis.

5 for novel therapeutics against P aeruginosa keratitis.

6 contact lens use are associated with MDR-PA keratitis.

7 contact lens use were associated with MDR-PA keratitis.

8 lymicrobial keratitis and 60 cases of fungal keratitis.

9 y elevated in neutrophils from patients with keratitis.

10 icans infection in an animal model of fungal keratitis.

11 itis, postoperative aspergillosis and fungal keratitis.

12 to treat, with a poorer outcome than fungal keratitis.

13 can be targeted for preventing P. aeruginosa keratitis.

14 adosporium keratitis, a rare cause of fungal keratitis.

15 been considered as an idiopathic autoimmune keratitis.

16 s compared with drug-sensitive P. aeruginosa keratitis.

17 ical moxifloxacin hydrochloride in bacterial keratitis.

18 vitro and in a model of Aspergillus-induced keratitis.

19 thamoeba keratitis from bacterial and fungal keratitis.

20 o the initial misdiagnosis of AK as herpetic keratitis.

21 el of chemical injury or in late mustard gas keratitis.

22 lues from 221 patients with monocular fungal keratitis.

23 inical management of patients with microbial keratitis.

24 sus voriconazole for the treatment of fungal keratitis.

25 moeba keratitis than for bacterial or fungal keratitis.

26 corneal neovascularization in patients with keratitis.

27 eristic skin lesions, hearing deficiency and keratitis.

28 rticosteroids in the therapy of any indolent keratitis.

29 to the mediation of protection during ocular keratitis.

30 r resistance in patients with herpes simplex keratitis.

31 17) and IFN-gamma in murine models of fungal keratitis.

32 There were no cases of microbial keratitis.

33 e present study tested its role in bacterial keratitis.

34 ate of culture-positive bacterial and fungal keratitis.

35 of endophthalmitis resulting from infectious keratitis.

36 (CRAMP) in a murine model of Fusarium solani keratitis.

37 us is particularly associated with recurrent keratitis.

38 e elderly patients presented with unilateral keratitis.

39 costeroid treatment on outcomes in bacterial keratitis.

40 e organisms and clinical outcome in bacteria keratitis.

41 edia in the laboratory diagnosis of nonviral keratitis.

42 nd antibody to PVL in pathogenesis of murine keratitis.

43 yed the onset of vascularization and stromal keratitis.

44 ame cornea at the end of therapy for her VRE keratitis.

45 rticosteroids and oral acyclovir for stromal keratitis.

46 developing world for treatment of bacterial keratitis.

47 l microscopy performed at the acute stage of keratitis.

48 oriconazole on clinical outcomes in Fusarium keratitis.

49 oplasty (PPK) for herpes simplex virus (HSV) keratitis.

50 detachment, stromal necrosis, and infectious keratitis.

51 laments and acanthamoeba cysts in infectious keratitis.

52 tis, corneal neovascularization, and stromal keratitis.

53 ologist from patients suspected of microbial keratitis.

54 nderwent diagnostic testing for Acanthamoeba keratitis.

55 rpes simplex virus keratitis or Acanthamoeba keratitis.

56 he development of HSV-1-induced neurotrophic keratitis.

57 cleritis (1.8%), and 3 cases of interstitial keratitis (0.9%).

58 Of 95 patients with bacterial keratitis, 103 patients with fungal keratitis, and 93 pa

59 Of a total of 224 patients with bacterial keratitis, 114 patients were randomized to group A, wher

60 15 patients with laboratory-proven bacterial keratitis, 115 patients with laboratory-proven fungal ke

61 vitreous amyloid (26/26, 100%), neurotrophic keratitis (2/26, 8%), glaucoma (5/26, 19%), and tortuous

62 in young people; and sequellae of infectious keratitis (20%).

63 f whom 2124 (87.84%) had only one episode of keratitis, 294 (12.15%) at least two, 88 (3.63%) at leas

64 (9 eyes), corneal melt (5 eyes), infectious keratitis (3 eyes), endophthalmitis (3 eyes), GDD erosio

65 iral medications for presumed herpes simplex keratitis; 4 patients underwent diagnostic testing for A

66 llow-up for uveitis were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34

67 In fungal keratitis, 61 of 62 cases (98.38%) were diagnosed using

68 Thirty-eight out of 44 cases of bacterial keratitis (86.36%) were diagnosed by solid media alone (

69 l role for AMPs in defense against F. solani keratitis, a potentially blinding corneal disease.

70 ngal agents, we were faced with Cladosporium keratitis, a rare cause of fungal keratitis.

71 Acanthamoeba keratitis, a rare eye disease primarily affecting contac

72 oil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the e

73 rvival, and determining factors of microbial keratitis after penetrating keratoplasty (PK).

74 rds of all patients diagnosed with microbial keratitis after penetrating keratoplasty at the National

75 Infectious keratitis after penetrating keratoplasty leads to a high

76 Amoebic keratitis (AK) is a potentially blinding infection, the

77 Acanthamoeba keratitis (AK) is a very painful and vision-impairing in

78 diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as

79 d by the investigator to be vaccine related (keratitis; amnesia).

80 ate to placebo in the treatment of bacterial keratitis among 500 patients with culture-positive ulcer

81 included 21 patients with filamentous fungal keratitis and 24 patients with bacterial keratitis (as c

82 re 34 eyes of 34 patients with polymicrobial keratitis and 60 cases of fungal keratitis.

83 icularly before making a diagnosis of herpes keratitis and before the use of topical corticosteroids

84 In patients with viral keratitis and central neovascularization, a significant

85 significantly reduced in patients with viral keratitis and central neovascularization.

86 festation of HZO was dermatitis, followed by keratitis and conjunctivitis.

87 steurella multocida include: endophtalmitis, keratitis and corneal ulcers, Parinaud's oculoglandular

88 All patients showed superficial punctate keratitis and dry eye in the NK eye and a healthy contra

89 A complete resolution of keratitis and healing of ulcers occurred in 90 patients

90 of infection, including necrotizing stromal keratitis and herpes simplex encephalitis.

91 rophils was examined in patients with fungal keratitis and in uninfected individuals in southern Indi

92 associated with an increased risk for fungal keratitis and infectious keratitis overall.

93 present in 2 patients mimicking interstitial keratitis and limbal stem cell deficiency.

94 nts had rapid resolution of their infectious keratitis and noted no pain or discomfort attributed to

95 rget for clinical treatment of P. aeruginosa keratitis and other infectious diseases.

96 as an adjunctive therapy to treat microbial keratitis and other mucosal infections.

97 ghts the need for nationwide study on fungal keratitis and precise identification of the causative fu

98 dy was to determine the prevalence of fungal keratitis and spectrum of fungi implicated in causing th

99 Patients with non-Nocardia keratitis and those having no topical antibiotic use bef

100 for subgroups of patients with non-Nocardia keratitis and those with no topical antibiotic use befor

101 filamentous fungi in patients with microbial keratitis and to evaluate the effect of observer's imagi

102 lammatory response, such as diffuse lamellar keratitis and transient light-sensitivity syndrome.

103 or younger who were diagnosed with microbial keratitis and treated at our hospital between July 2008

104 plasma IL-17 and IL-23 between patients with keratitis and uninfected individuals; however, combined

105 , 115 patients with laboratory-proven fungal keratitis, and 115 patients with laboratory-proven acant

106 acterial keratitis, 103 patients with fungal keratitis, and 93 patients with acanthamoeba keratitis w

107 tics remain the best treatment for bacterial keratitis, and a recent review found all commonly prescr

108 perforates) model of Pseudomonas aeruginosa keratitis, and also significantly downregulates HMGB1 ex

109 ficantly different from herpes simplex virus keratitis, and further studies using this model should g

110 uce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuva

111 ries from this center, the rate of microbial keratitis as a complication of treatment has been reduce

112 a during the development of herpetic stromal keratitis as a means to alleviate further neovasculariza

113 gal keratitis and 24 patients with bacterial keratitis (as controls).

114 inguish between bacterial, fungal, and viral keratitis, as the treatments are quite different.

115 kic bullous keratopathy (North America), and keratitis (Asia).

116 erapy in the management of severe infectious keratitis associated with corneal melting.

117 eal ectatic disorders, a history of herpetic keratitis, Avellino corneal dystrophy, significant catar

118 pert opinion on the best treatment of fungal keratitis before MUTT I results were available.

119 herpes simplex keratitis, then Acanthamoeba keratitis before referral.

120 did not increase the incidence of infectious keratitis, but prolonged vancomycin use was associated w

121 currence of any type of herpes simplex virus keratitis by approximately half.

122 promotes better resolution of P. aeruginosa keratitis by decreasing levels of proinflammatory mediat

123 Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin.

124 All cultured infectious keratitis cases from July 1, 2008, through December 31,

125 Twenty-three episodes of MDR-PA keratitis (cases) and 67 episodes of drug-sensitive P. a

126 We report an aggressive fungal keratitis caused by a putatively novel species of Lophot

127 single transient episode of HSV-1 epithelial keratitis causes long-term changes in the corneal microe

128 healing problems (sterile infiltrate, herpes keratitis, central haze, and stromal scar).

129 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation b

130 L) in patients with quiescent herpes simplex keratitis compared with control patients without ocular

131 Outcomes are worse in MDR-PA keratitis compared with drug-sensitive P. aeruginosa ker

132 Symptoms of fungal keratitis consist of blurred vision, redness, tearing, p

133 67 episodes of drug-sensitive P. aeruginosa keratitis (controls) were identified.

134 hthalmia or anophthalmia, retinal dysplasia, keratitis, corneal neovascularization, cataracts, and ca

135 in the murine model of herpes simplex virus keratitis, corneal pathology and lymphangiogenesis are a

136 d the causes were refractive errors (47.1%), keratitis/corneal opacity (16%), amblyopia (14.3%), ocul

137 The patient with VRE keratitis developed a consecutive Candida keratitis else

138 Fungal keratitis developed in 4 cases (5.6%), and all patients

139 Infectious keratitis develops in 13.6% of eyes after keratoprosthes

140 therapy for recalcitrant deep stromal fungal keratitis did not improve outcomes.

141 Viral keratitis differs from bacterial and fungal cases in tha

142 -2002, the leading risk factor for microbial keratitis during 2008-2012 was contact lens use, and the

143 Episodes of drug-sensitive P. aeruginosa keratitis during the same period were taken as controls.

144 . aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (

145 des in 52 eyes of culture-positive microbial keratitis during the study period.

146 RE keratitis developed a consecutive Candida keratitis elsewhere in the same cornea at the end of the

147 Both transmission and disease, such as keratitis, encephalitis, and neurodegeneration, have bee

148 s, the linear form of Thygeson's superficial keratitis, epithelial regeneration line, Acanthamoeba ke

149 nts with bacterial, fungal, viral, or immune keratitis featuring negative Acanthamoeba PCR results (c

150 In previous studies of fungal keratitis (FK) from temperate countries, yeasts were the

151 ts experience a single episode of epithelial keratitis followed by re-establishment of a clear cornea

152 tive culture result reduced the incidence of keratitis from 15.8% in untreated cases to 1.9% in treat

153 rease in the rate of orthokeratology-related keratitis from 9.9% to 19.1% (P = .011).

154 Ninety episodes of P. aeruginosa keratitis from a tertiary care eye institution from 2007

155 n be useful for differentiating acanthamoeba keratitis from bacterial and fungal keratitis.

156 Although there are several reports on fungal keratitis from developing and developed countries, funga

157 Out of 153 cases of microbial keratitis, fungi were recovered from 69 patients giving

158 e polymicrobial group compared to the fungal keratitis group (39.3% vs 73.7%, P = .0045).

159 , combining medical subject headings (MESH) "Keratitis, Herpetic/" AND "Acyclovir/" limiting by the k

160 lude the blindness-inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex

161 or to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ul

162 infected corneas in a murine model of fungal keratitis; however, the ability to inhibit hyphal growth

163 th a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluati

164 Herpetic stromal keratitis (HSK) is an important vision-impairing lesion

165 Herpetic stromal keratitis (HSK) is characterized by an inflammatory resp

166 an trigger recurrent bouts of herpes stromal keratitis (HSK), an inflammatory response that leads to

167 tructive inflammatory disease herpes stromal keratitis (HSK).

168 n the development of severe herpetic stromal keratitis (HSK).

169 Keratitis-ichthyosis-deafness (KID) syndrome is an ectod

170 f suspected RM in the skin of a patient with keratitis-ichthyosis-deafness (KID) syndrome.

171 e is associated with disease pathogenesis in keratitis-ichthyosis-deafness (KID) syndrome.

172 ess associated with skin disorders, like the Keratitis-Ichthyosis-Deafness syndrome (KID).

173 lesions can also appear in individuals with keratitis-ichthyosis-deafness syndrome and finding somat

174 michannels with the mutation A88V, linked to Keratitis-Ichthyosis-Deafness syndrome, are both CO2 ins

175 ed regarding the risk of having a child with keratitis-ichthyosis-deafness syndrome.

176 own to cause the severe multisystem disorder keratitis-ichthyosis-deafness syndrome.

177 include AK in the differential diagnosis of keratitis in all contact lens users with keratitis, part

178 TAT-Cd degrees reduced the severity of keratitis in all of the delivery vehicles tested when tr

179 bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient.

180 pical antibiotics for treatment of bacterial keratitis in areas of the world where use of effective t

181 The long-term outcomes with PPK for HSV keratitis in children provide improvement in BCVA when n

182 ith pre-existing graft failure and microbial keratitis in clear graft on presentation.

183 cause of sporadic encephalitis and blinding keratitis in developed countries.

184 m developing and developed countries, fungal keratitis in Ethiopia is poorly known.

185 he occurrence of postkeratoplasty infectious keratitis in failed and clear grafts.

186 auses an early development of herpes stromal keratitis in NK1R(-/-) mice.

187 tis is one of the major causes of infectious keratitis in tropical countries.

188 reducing the immune response associated with keratitis include topical corticosteroids.

189 Contact lens-related microbial keratitis increased in Taiwanese children over time, esp

190 l tissue model representing clinical amoebic keratitis infection.

191 e strains (12/15) were recovered from equine keratitis infections; however, strains of F. keratoplast

192 Infectious keratitis is a major global cause of visual impairment a

193 Amoebic keratitis is a potentially blinding eye infection caused

194 Vaccinia virus (VACV) keratitis is a serious complication following smallpox v

195 Acanthamoeba keratitis is a serious vision-threatening disease.

196 Infectious keratitis is a sight-threatening condition for children.

197 Bacterial keratitis is a sight-threatening infection of the cornea

198 on of the nature of the pathogen that causes keratitis is achieved via microbial culture screening, w

199 Fungal keratitis is an important cause of corneal blindness all

200 The diagnosis of keratitis is based on visual exam, tissue cytology, and

201 Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration.

202 Fusarium keratitis is common and often results in poor outcomes.

203 Fungal keratitis is one of the major causes of infectious kerat

204 n the basis of these results, vaccinia virus keratitis is significantly different from herpes simplex

205 basis of our results, the pathology of VACV keratitis is significantly different from that of herpes

206 Deletion of prtS in clinical keratitis isolate K904 reduced, but did not eliminate, c

207 Ninety-nine percent of P aeruginosa keratitis isolates from SCUT produced Psl EPSs, and 100%

208 protease-positive strains was observed among keratitis isolates than among conjunctivitis isolates.

209 The ability of P aeruginosa keratitis isolates to form biofilms in vitro was correla

210 Antimicrobial resistance in the MDR-PA keratitis isolates was least for colistin and imipenem (

211 pecificity for diagnosing filamentous fungal keratitis, its sensitivity is moderate and highly depend

212 were modified in patients with neurotrophic keratitis (KN).

213 ed mice prevented the development of stromal keratitis lesions more effectively than did control iTre

214 s to the way in which they manifest herpetic keratitis, making rapid diagnosis and treatment even mor

215 d a benefit for all corneal ulcers, Fusarium keratitis may benefit from the addition of oral voricona

216 al study, patients with suspected infectious keratitis meeting traditional criteria for diagnostic co

217 e virulence of a subset of MRSA strains in a keratitis model.

218 , epithelial regeneration line, Acanthamoeba keratitis, mucus plaque keratopathy, medication-related

219 ewly occurred after DSAEK as a result of HSV keratitis (n = 2) or interface infection (n = 2).

220 CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (

221 thetic membrane formation (n=15), infectious keratitis (n=1), extrusion (n=2), and corneal melt (n=4)

222 Neurotrophic keratitis (NK) represents a sight-threatening complicati

223 es with culture-positive deep stromal fungal keratitis not responding to appropriate medical therapy

224 Ocular bacterial keratitis, often associated with Pseudomonas aeruginosa

225 orking hypothesis places blame for microbial keratitis on bacterial adaptation to ocular surface defe

226 of miR-155 in Pseudomonas aeruginosa-induced keratitis, one of the most common sight-threatening ocul

227 rficial cornea, such as herpes simplex virus keratitis or Acanthamoeba keratitis.

228 keratopathy, endophthalmitis, and infectious keratitis or corneal ulceration.

229 tment alone in moderate to severe infectious keratitis over a 30-day period.

230 sed risk for fungal keratitis and infectious keratitis overall.

231 e this risk in patients with traumatic/viral keratitis (P = 0.162) at day 90.

232 of keratitis in all contact lens users with keratitis, particularly before making a diagnosis of her

233 114 corneal scraping samples from infectious keratitis patients.

234 ompared to patients with bacterial or fungal keratitis, patients with acanthamoeba keratitis were mor

235 Compared to patients with fungal keratitis, patients with polymicrobial keratitis were si

236 Forty eyes of 40 patients with fungal keratitis (positive smear or culture results or both) la

237 Observations: A woman with recurrent keratitis presented with a corneal ulcer, which was cult

238 ere recovered from 69 patients giving fungal keratitis prevalence of 45.1.

239 High prevalence of fungal keratitis recorded in the present study, highlights the

240 lbicans inoculation had markedly ameliorated keratitis, reduced fungal load, and decreased polymorpho

241 Fungal keratitis remains a challenge for ophthalmologists as th

242 Scarring from bacterial keratitis remains a leading cause of visual loss.

243 ces thereof in patients with recurrent HSV-1 keratitis (rHK).

244 -associated neovascularization, postherpetic keratitis scarring, lipid keratopathy, and limbal stem c

245 er 16 years of age with history of microbial keratitis seen at a tertiary referral center.

246 patients with laboratory-proven acanthamoeba keratitis seen at Aravind Eye Hospital, Madurai, India,

247 epithelial keratitis without herpes stromal keratitis sequelae, possessed a significant leukocytic i

248 ruginosa inoculation significantly decreased keratitis severity, as evidenced by preserved epithelium

249 EK for failed TPK conducted for Aspergillus keratitis showed better outcomes in terms of graft clari

250 or T cells can be effective to limit stromal keratitis (SK) lesion severity.

251 sult in a chronic immunoinflammatory stromal keratitis (SK) lesion that is a significant cause of hum

252 onas aeruginosa and Staphylococcus aureus in keratitis; Streptococcus viridians, Streptococcus pneumo

253 ease of intraocular pressure (IOP), exposure keratitis, subconjunctival hemorrhage, a sore throat, an

254 on also had strong protection against fungal keratitis, suggesting a therapeutic window.

255 g features were more common for acanthamoeba keratitis than for bacterial or fungal keratitis.

256 SV-1 infections may lead to herpetic stromal keratitis that may advance to corneal blindness.

257 findings for 9 patients with history of HSV keratitis that underwent PPK and were followed in a sing

258 es simplex keratitis, varicella-zoster viral keratitis, the linear form of Thygeson's superficial ker

259 e diagnosed sequentially with herpes simplex keratitis, then Acanthamoeba keratitis before referral.

260 eak of contact lens (CL)-associated Fusarium keratitis, there may have been a rise in CL-associated f

261 P13 activity may contribute to P. aeruginosa keratitis through basement membrane degradation, and its

262 ing HMGB1 for the treatment of P. aeruginosa keratitis to avoid delivery and other issues associated

263 be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements,

264 We randomized 172 individuals with bacterial keratitis to topical treatment with povidone-iodine or a

265 All cases of bacterial keratitis treated at the University of Illinois Eye and

266 rganism in culture and culture-proven fungal keratitis treated with natamycin alone were retrieved fr

267 opical natamycin and voriconazole for fungal keratitis treatment.

268 rm keratopathy, such as prior herpes simplex keratitis, varicella-zoster viral keratitis, the linear

269 y were misdiagnosed as having herpes simplex keratitis versus 59 (41.8%) patients who did not require

270 Patients whose recurrent keratitis was associated with S. aureus had a higher rat

271 routes (1mg/ml and 200mg respectively), the keratitis was controlled.

272 Acanthamoeba keratitis was defined as the presence of AK with concurr

273 Acanthamoeba keratitis was diagnosed on microbiological culture in 94

274 While C. albicans keratitis was more severe in the corneas treated with Ch

275 Fungal keratitis was significantly associated with farmers (P =

276 Fungal keratitis was statistically associated with trauma (P =

277 Keratitis was the primary indication in Asia (32.3%).

278 n clinical diagnosis of bacterial and fungal keratitis, we recommend inclusion of both solid and liqu

279 Patients with suspected bacterial keratitis were identified from microbiological requests

280 n=28), fungal (n=15), or Acanthamoeba (n=13) keratitis were included in the study.

281 fungal keratitis, patients with acanthamoeba keratitis were more likely to be younger and to have a l

282 patients with moderate to severe infectious keratitis were randomized to receive either standard tre

283 ungal keratitis, patients with polymicrobial keratitis were significantly older (50.03 +/- 9.81 years

284 Episodes of MDR-PA keratitis were taken as cases.

285 ecovered from patients with confirmed fungal keratitis were used in the experiments.

286 almology Department for clinically suspected keratitis, were cultured on non-nutrient agar examined b

287 ghly plastic and capable of inducing stromal keratitis when adoptively transferred into Rag1(-/-) mic

288 can be considered for treatment of bacterial keratitis when antibiotic treatment is not practical.

289 ns such as herpes and Pseudomonas aeruginosa keratitis where IL-17A exacerbates corneal pathology and

290 rious adverse events (pharyngeal abscess and keratitis), which were not considered drug related by th

291 to explore the role of miR-155 in bacterial keratitis, which may provide a promising target for clin

292 Identifying patients with infectious keratitis who are at risk of experiencing a poor outcome

293 keratitis, and 93 patients with acanthamoeba keratitis who had medical records available for review,

294 Polymicrobial keratitis with fungus and bacteria was more common and m

295 elected and divided into 2 groups, microbial keratitis with pre-existing graft failure and microbial

296 Consecutive cases of microbial keratitis with significant growth of more than 1 organis

297 e displayed more resistance to P. aeruginosa keratitis, with a higher inducible nitric oxide synthase

298 atment for smear-positive filamentous fungal keratitis, with much of the difference attributable to i

299 S, which induces transient herpes epithelial keratitis without herpes stromal keratitis sequelae, pos

300 mfort to the blinding disease herpes stromal keratitis, yet most patients experience a single episode