ライフサイエンスコーパス: keto acid

1 and freeze-dried meat depending on the alpha-keto acid).

2 itant oxidative decarboxylation of the alpha-keto acid.

3 n and the carboxylate derived from the alpha-keto acid.

4 the respective commercially available delta-keto acids.

5 nsamination between primary amines and alpha-keto acids.

6 terial conversion of chiral epoxides to beta-keto acids.

7 dehydes or hydroxy acids, nor does it reduce keto acids.

8 y L-amino acids from the corresponding alpha-keto acids.

9 y for the catabolism of branched-chain alpha-keto acids.

10 D-amino acids into their corresponding alpha-keto acids.

11 isulfide and the site of activation by alpha-keto acids.

12 nit sulfhydryl/disulfide system and by alpha-keto acids.

13 ized from amino alcohols or amino thiols and keto acids.

14 carboxylation of aliphatic epoxides to beta-keto acids.

15 condensation of acetyl-CoA and certain other keto acids.

16 kaemia cells by aminating the branched-chain keto acids.

17 ons without the toxicity of phenols, such as keto acids.

18 t instead catalyzes the decarboxylation of 3-keto acids.

19 some of which are relatively labile such as keto acids.

20 hemical reaction, i.e., decarboxylation of 2-keto acids.

21 e nonoxidative decarboxylation of aromatic 2-keto acids.

22 ate, alpha-ketoglutarate, and branched chain keto-acids.

23 e biosynthetic pathway of the 9-carbon alpha-keto acid, 2-keto-3-deoxy-d-glycero-d-galactonononic aci

24 rence and highest activity with the aromatic keto-acid, 4-hydroxyphenylpyruvate.

25 d the five-coordinate [Fe(II)(Tp(Ph2))(alpha-keto acid)] (6-Me(3)-TPA = tris[(6-methyl-2-pyridyl)meth

26 fhydryl residue being the site both of alpha-keto acid activation and of the regulatory sulfhydryl/di

27 sensitive to pyruvate, consistent with alpha-keto acid activation occurring through a thiohemiacetal.

28 ermination and identification of eight alpha-keto acids (alpha-ketoglutaric acid, pyruvic acid, 4-hyd

29 g the conversion of the branched-chain alpha-keto acids an intermediate was always detected extracell

30 ibition studies using aliphatic and aromatic keto acid analogues have been carried out to gain insigh

31 aramate and alpha-ketosuccinamate (the alpha-keto acid analogues of glutamine and asparagine, respect

32 ysine-binding site has a higher affinity for keto acid analogues than does the alpha-Kg site or that

33 -hydroxylation, which would ultimately yield keto acid and hydroxy acid as urinary metabolites.

34 te, which can lead to both the desired alpha-keto acid and the 1,4-homofragmentation, with the produc

35 are extended to produce abiotic longer chain keto acids and alcohols by engineering the chain elongat

36 eutral and aromatic l-amino acids into alpha-keto acids and ammonia.

37 of d-amino acids to the corresponding alpha-keto acids and ammonia.

38 of the products from the reduction of gamma-keto acids and esters and delta-keto esters were convert

39 al capacity of respiration on branched-chain keto acids and fatty acids.

40 ed in the oxidative decarboxylation of alpha-keto acids and glycine.

41 oton at C(4)' of the cofactor to yield alpha-keto acids and the pyridoxamine phosphate (PMP) form of

42 onent catalyzes the decarboxylation of alpha-keto acids and the subsequent reductive acylation of the

43 These reactions yield alpha-keto acids and thiols.

44 metal-ion bridge between the quinolone C3-C4 keto-acid and amino acids in helix-4 of the target prote

45 ne dose as 4-oxo-4-(3-pyridyl)butanoic acid (keto acid) and 4-hydroxy-4-(3-pyridyl)butanoic acid (hyd

46 and freeze-dried meat depending on the alpha-keto acid) and linear (R>0.99) over several orders of ma

47 he six-coordinate [Fe(II)(6-Me(3)-TPA)(alpha-keto acid)](+) and the five-coordinate [Fe(II)(Tp(Ph2))(

48 Malonate semialdehyde is analogous to a beta-keto acid, and enzymes that catalyze the decarboxylation

49 an imine between the keto group of the alpha-keto acid, and the amino group of the amino acid.

50 he beta-hydroxy acid is oxidized to the beta-keto acid, and this residue participates in all three of

51 tivation of the alternative oxidase by alpha-keto acids appears to involve the formation of a thiohem

52 r E1b-catalyzed decarboxylation of the alpha-keto acid are higher in these E1b mutants than in wild-t

53 ds and uses many biologically relevant alpha-keto acids as amino group acceptors.

54 non-heme iron dioxygenases that employ alpha-keto acids as cofactors, CDO was shown to be the only di

55 r degradation, and analyse the role of alpha-keto acids as intermediate compounds in the formation of

56 s studies have identified these seleno-alpha-keto acids as potent histone deacetylase inhibitors.

57 urs by a carboxylation reaction forming beta-keto acids as products and provide evidence for the invo

58 ndent carboxylation reaction that forms beta-keto acids as products.

59 This feature allows access to a trans keto-acid as the major product in high enantioselectivit

60 e oxidative decarboxylation of various alpha-keto acids, as well as the cleavage of glycine into CO(2

61 ldehyde to a significant extent by all alpha-keto acids assayed; glyoxylic acid being the most reacti

62 to lower BCAA and their corresponding alpha-keto acids (BCKA) in patients with classic and variant l

63 revealed increased levels of branched-chain keto acids (BCKA), and BCAA in plasma of T2D patients, w

64 This leads to buildup of branched-chain keto-acids (BCKA) and branched-chain amino acids (BCAA)

65 Branched-chain keto acids (BCKAs) are associated with increased suscept

66 ymes (BCATs) to produce branched-chain alpha-keto acids (BCKAs).

67 The keto acid binding pocket is relatively large and flexibl

68 ve been carried out to gain insight into the keto acid binding pocket.

69 TRAP-PBP (the Rhodobacter sphaeroides alpha-keto acid-binding protein) where quaternary structure fo

70 icant changes in amino acids, aldehydes, and keto acids but not fatty acids and sugars.

71 re synthesized in plants from branched-chain keto acids, but their metabolism is not completely under

72 of human liver microsomes with nicotine gave keto acid by using aminoketone as an intermediate; keto

73 This aromatic keto acid can be reduced by MDH, albeit at a somewhat sl

74 ion of alpha-ketoisovalerate and other alpha-keto acids, catalyzed by PanB.

75 the deaminated product branched-chain alpha-keto acids, catalyzed by the mitochondrial branched-chai

76 nt of these two features to the Fe(II)(alpha-keto acid) chelate mode and the nu(C==O) of the keto car

77 lyzes the isomerization of unsaturated alpha-keto acids, converting unconjugated ketones to the conju

78 However, rather than utilizing the typical keto-acid cosubstrates, 2-oxoglutarate, pyruvate, and ox

79 Branched-chain keto acids, D-valine, and D-isoleucine did not promote t

80 ive E. coli xylonate dehydratase (yjhG), a 2-keto acid decarboxylase from Pseudomonas putida (mdlC) a

81 ts, associated with the branched-chain alpha-keto acid decarboxylase/dehydrogenase (E1), dihydrolipoa

82 ction was also improved by overexpression of keto-acid decarboxylases (KDC) and alcohol dehydrogenase

83 e catalyzed by the same branched-chain alpha-keto acid dehydrogenase (BCDH) complex.

84 ha and E1beta components of a branched-chain keto acid dehydrogenase (BCKAD) multienzyme complex invo

85 otransferase (BCAT) and branched-chain alpha-keto acid dehydrogenase (BCKD) complex--were determined

86 The branched-chain alpha-keto acid dehydrogenase (BCKD) kinase (abbreviated as BC

87 the 4-megadalton human branched-chain alpha-keto acid dehydrogenase (BCKD) metabolic machine is a th

88 and provide evidence that the branched-chain keto acid dehydrogenase (BCKDH) complex is performing th

89 ng mutants deficient in branched-chain alpha-keto acid dehydrogenase (BKD), an enzyme complex involve

90 involve increased activity of branched-chain keto acid dehydrogenase and the ubiquitin-proteasome pro

91 E1alpha subunit of the branched-chain alpha-keto acid dehydrogenase complex (BCKDC).

92 nt of the mitochondrial branched-chain alpha-keto acid dehydrogenase complex (BCKDC).

93 n and expression of the branched-chain alpha-keto acid dehydrogenase complex and beta-keto acyl-acyl

94 he NADH produced by the branched-chain alpha-keto acid dehydrogenase complex was required for complet

95 ipoic acid is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHCs).

96 l protein that is shared among several alpha-keto acid dehydrogenase complexes and the glycine cleava

97 e, aconitate hydratase, branched-chain alpha-keto acid dehydrogenase E1 component, biotin carboxylase

98 Branched chain alpha-keto acid dehydrogenase enzyme activity was significantl

99 e BCKAs mediated by the branched-chain alpha-keto acid dehydrogenase enzyme complex (BCKD complex).

100 transferase (BCATm) and branched-chain alpha-keto acid dehydrogenase enzyme complex (BCKDC).

101 Genes encoding a branched-chain alpha-keto acid dehydrogenase from Enterococcus faecalis 10C1,

102 l inhibitor of Sln1 and branched-chain alpha-keto acid dehydrogenase kinase (BCKDHK) and propose a me

103 ine expression of human branched-chain alpha-keto acid dehydrogenase kinase (BCKDK), the key enzyme t

104 Sln1 and the mammalian, branched-chain alpha-keto acid dehydrogenase kinase are very similar to that

105 odes the four proteins of the branched-chain keto acid dehydrogenase multienzyme complex of Pseudomon

106 abolism is regulated by branched-chain alpha-keto acid dehydrogenase, an enzyme complex that is inhib

107 c regulates the expression of branched-chain keto acid dehydrogenase, glucose-6-phosphate dehydrogena

108 ress any of the components of branched-chain keto acid dehydrogenase, were found to contain missense

109 inducible multienzyme complex branched-chain keto acid dehydrogenase, which is regulated in both spec

110 sing the bkd operon, encoding branched-chain keto acid dehydrogenase.

111 sed by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme.

112 yl)pyruvate dioxygenase (HPPD) are two alpha-keto acid dependent mononuclear non-heme iron enzymes th

113 HPPD is a unique member of the alpha-keto acid dependent oxygenases that require Fe(II) and a

114 HPPD is a member of the alpha-keto acid dependent oxygenases that require Fe(II) and a

115 strate has also been suggested for the alpha-keto acid-dependent enzyme clavaminate synthase 2.

116 Correlations over alpha-keto acid-dependent enzymes and with the extradiol dioxy

117 Like other alpha-keto acid-dependent enzymes, TfdA utilizes a mononuclear

118 ionality plays in oxygen activation by alpha-keto acid-dependent iron enzymes.

119 ndensation of aldehyde 5 with the enolate of keto acid derivatives to form the C6-C7 bond, selective

120 Although the reduction of delta-keto acids does not proceed under the same reaction cond

121 and isotope exchange occurs with some alpha-keto acids (e.g., pyruvate and alpha-ketobutyrate), resu

122 ith a variety of nucleophiles, provide gamma-keto acids, esters, and amides.

123 elopment of a process that affords the alpha-keto acid exclusively and should be generally applicable

124 In addition to POR, three other 2-keto acid ferredoxin oxidoreductases are involved in pep

125 se, ferredoxin:NADP oxidoreductase, or the 2-keto acid ferredoxin oxidoreductases specific for pyruva

126 glyoxylic acid being the most reactive alpha-keto acid for this reaction.

127 ron, TdcE, has recently been shown to be a 2-keto acid formate-lyase that can accept pyruvate as an e

128 alyze the oxidative decarboxylation of alpha-keto acids, forms the central core to which the other co

129 rally applicable to the preparation of alpha-keto acids from alpha,alpha-dichloroesters or acids.

130 at allows channeling of branched-chain alpha-keto acids from BCATm to E1.

131 rations to form a thioether linkage to a BEL keto acid hydrolysis product.

132 photochemical reaction mechanisms for alpha-keto acids in aqueous solution are robust and generaliza

133 o accurately quantify the abundance of alpha-keto acids in biological matrices.

134 is the first report of the presence of alpha-keto acids in both pork meats and Iberian hams.

135 d to measure mass isotopomers of these alpha-keto acids in tracer studies with stable isotopes.

136 transport of short chain monocarboxylic and keto acids, including pyruvate and lactate, to support b

137 alpha-Keto acids, including those formed by TATase-catalyzed t

138 methionine implicated an alpha-dimethyl-beta-keto acid intermediate in the biosynthesis of TMC-86A.

139 acid biosynthetic pathway and diverts its 2-keto acid intermediates for alcohol synthesis.

140 entially converts ureidoglycine and an alpha-keto acid into oxalurate and the corresponding amino aci

141 In turn, this keto acid is a substrate for YwfG, which promotes transa

142 -C2 unit and the C5 carboxylate of the alpha-keto acid is also important for binding; the alpha-oxo g

143 hyde and the amino acid from which the alpha-keto acid is derived.

144 y of the hydroxy acids from the reduction of keto acids is dependent only on the enantiomer of the re

145 arboxylation of short-chain epoxides to beta-keto acids is proposed to serve as the physiological rea

146 tive decarboxylation of branched-chain alpha-keto acids, is essentially devoid of the constituent dih

147 dehydration of (R)-phenylglycinol with omega-keto acids, lactams 4-6 were obtained as separable diast

148 In addition, alpha-keto acids may act as intermediates for the Strecker deg

149 ihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DH

150 e metabolites identified, the branched-chain keto-acid metabolite 3-methyl-2-oxovalerate was the stro

151 nthesize in situ either CH3SeH and/or seleno-keto acid metabolites.

152 roduction of 0.5 mol of ATP per mol of alpha-keto acid metabolized.

153 n is strengthened by the ability of an alpha-keto acid model compound, trimethylpyruvate, to act as a

154 ate constants for the reactions of amino and keto acids of several substrates decrease logarithmicall

155 e effects of pH, Tris, amino acids and alpha-keto acids on the activity of the enzyme.

156 ein-based supplements, amino acids and their keto acid or hydroxyacid analogues), discusses the ratio

157 Five of these compounds are either alpha-keto acids or alpha,beta-unsaturated acids, while the si

158 valent complexes of dinucleotides with alpha-keto acids originating from the reductive tricarboxylic

159 iron (III) complex ferricyanide, and 3) the keto-acids oxaloacetate and pyruvate (and phosphoenolpyr

160 to provide accurate assessments of the alpha-keto acids oxaloacetic acid, pyruvate, and glyoxylate be

161 ntain three distinct ferredoxin-dependent, 2-keto acid oxidoreductases, which use pyruvate, aromatic

162 actions of the following alpha-hydroxy-alpha-keto acid pairs: (S)-sulfolactic acid and sulfopyruvic a

163 otopic composition of some of the meteoritic keto acids points to interstellar or presolar origins, i

164 ntributes to the plasma branched-chain alpha-keto acid pool.

165 Fe(2+)-dependent ARD' produces the alpha-keto acid precursor of methionine and formate and allows

166 icin gamma(1)(I), including the elusive beta-keto acid precursor to a previously described C15 methyl

167 Starting from a linear keto acid precursor, the fused gamma-lactam beta-lactone

168 alpha-Ketoadipate, the other alpha-keto acid previously shown to support TauD activity, and

169 d BEL hydrolysis to a diffusible bromomethyl keto acid product that reacts with distant thiols.

170 ica by catalyzing their hydrolysis to stable keto acid products.

171 The trans isomer of the keto-acid products is also observed at varying levels de

172 alpha-, beta-, and gamma-keto acids provide the corresponding hydroxy acids in 77

173 f three newly reported classes of compounds: keto acids (pyruvic acid and homologs), hydroxy tricarbo

174 The utilization of the alpha-keto acids resulted in a marked increase of biomass, equ

175 cur with other long-chain and branched alpha-keto acids, resulting in the stereospecific exchange of

176 tion products were formed, among which alpha-keto acids seemed to play a role in these reactions.

177 Formation of the alpha-keto acid semicarbazone is continuously monitored spectr

178 a variety of physiologically available alpha-keto acids serve as oxidants of PdxB to sustain multiple

179 The alpha-keto acid specificity of the enzyme is narrow, and the a

180 oxygenases that require Fe(II) and an alpha-keto acid substrate to oxygenate an organic molecule.

181 oxygenases that require Fe(II) and an alpha-keto acid substrate to oxygenate or oxidize an organic m

182 Pyruvate, a slow alternative keto acid substrate, exhibits competitive inhibition ver

183 Escherichia coli is highly specific for its keto acid substrate.

184 such as indolepyruvate, or branched-chain 2-keto acids such as 2-ketoisovalerate, as their primary s

185 doreductases, which use pyruvate, aromatic 2-keto acids such as indolepyruvate, or branched-chain 2-k

186 tochondria is known to be activated by alpha-keto acids, such as pyruvate, and by the reduction of a

187 Pure KGOR did not utilize other 2-keto acids, such as pyruvate, indolepyruvate, or 2-ketoi

188 (BCAA synthesis) and reverse (branched-chain keto acid synthesis) reactions.

189 a catabolic pathway for branched-chain alpha-keto acids that was previously unidentified in E. faecal

190 Instead of the wild-type alpha-keto acid, the new amine dehydrogenase now accepts the a

191 equires pyridoxal 5'-phosphate but not alpha-keto acid; therefore, the enzyme is not an aminotransfer

192 The bidentate coordination of an alpha-keto acid to an iron(II) center via the keto group and t

193 The ability of alpha-keto acids to covert amino acids into Strecker aldehydes

194 at is unable to convert branched-chain alpha-keto acids to ILV or to use ILV as a precursor for branc

195 t the conversion of the branched-chain alpha-keto acids to the corresponding free acids results in th

196 al N-tert-butanesulfinyl aldimines with beta-keto acids under basic conditions at room temperature pr

197 Benzyl esters of propiolic and beta-keto acids undergo catalytic decarboxylative coupling wh

198 cid by using aminoketone as an intermediate; keto acid was not formed from cotinine.

199 onverted into glyoxylic acid, and this alpha-keto acid was then able to convert phenylalanine into ph

200 pha-dichloroester to the corresponding alpha-keto acid was unexpectedly complicated by a novel 1,4-ho

201 An OPD-derivatized (13)C-labeled keto acid was used as an internal standard.

202 0 human liver samples, rates of formation of keto acid were 5.7% of those of cotinine and production

203 Using this methodology, alpha-keto acids were found to be present in pork meat to a lo

204 ed with enolate formation from aromatic beta keto acids were not detected.

205 e chemically synthesized alpha-dimethyl-beta-keto acid with a purified recombinant flavin-dependent e

206 e reductive amination of the corresponding 2-keto acid with ammonia.

207 olecular asymmetric reduction of a series of keto acids with (-)-diisopinocampheylborane and intermol

208 ugh the chemical derivatisation of the alpha-keto acids with dansylhydrazine is required), precise (<

209 tochemistry of a series of amphiphilic alpha-keto acids with differing linear alkyl chain lengths was

210 pha-hydroxy acids to the corresponding alpha-keto acids, with reduction of oxygen to H(2)O(2).