ライフサイエンスコーパス: keto group

1 orphan (2b), and MCL-101 (2c) lacking the 10-keto group.

2 noid onto the oxygen atom of the neighboring keto group.

3 t C-9, and the product is then oxidized to a keto group.

4 MutT of guanine nucleotides, which have a 6-keto group.

5 ther strict structural specificity for the 5-keto group.

6 boxylate rather than the C-1 carboxylate/C-2 keto groups.

7 orophylls a and b, which bear 3-vinyl and 13-keto groups.

8 rbing than the amide of asparagine (nitro or keto groups allow function) or if a compensating backbon

9 the potential functional role of cytosine's keto group and imino nitrogen.

10 cy in sulforaphane analogs: the sulfoxide or keto group and its appropriate distance to electrophilic

11 The 4-keto group and the 3-hydroxyl group of fisetin are hydro

12 lon-amino group of the enzyme and both the 8-keto group and the 4'-hydroxyl group of the ligand.

13 lpha-keto acid to an iron(II) center via the keto group and the carboxylate gives rise to metal-to-li

14 to C3-gem-diol obtained by hydration of the keto group and the exposed mercapto group attacks on C1

15 fective stacking involves only the exocyclic keto groups and amino groups of the cytidine bases.

16 teroatoms proximal to the carbon bearing the keto group, and a preferred thrombin inhibitor is 2-keto

17 The cyclic nature of the peptide, the C-8 keto group, and the tryptophan are all critical for the

18 rticles with functionalities such as amines, keto groups, and alkynes for post modification reactions

19 Chlorophylls bear a 3-vinyl group and a 13-keto group, as well as a full complement of substituents

20 acetyl-deoxynivalenol (3-ADON), it lacks the keto group at C-8 and hence is a type A trichothecene.

21 earing a C4-C5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar act

22 The reduction of the keto group at C3 via a Noyori protocol after Suzuki coup

23 A substituent at C6 and a keto group at C8 are required for cleavage.

24 the ring, as well as the presence of a beta-keto group at the C4 position.

25 released by this enzyme contain a C4 gemdiol/keto group at the nonreducing end.

26 duce functional receptors harboring reactive keto groups at three specific positions.

27 group (2,3-pentanedione) or the absence of a keto group (butanone) are not ODR-10 agonists.

28 Hydrogenation of the C(4) keto group by NADH, assisted by Tyr(147) as catalytic pr

29 A gyrase inhibitor, and the reduction of the keto group by SimC7 was shown to be crucial for high-aff

30 rmate), and alteration of the 3-hydroxy to a keto group (cholestanone).

31 e hydroxyl group of L-3-hydroxyacyl-CoA to a keto group, concomitant with the reduction of NAD+ to NA

32 ate and stabilize the newly forming hydroxyl/keto group during catalysis.

33 nooxygenase catalyses the incorporation of a keto group forming spheroidenone.

34 forms an oxime derivative with the aldehyde/keto group found in oxidatively modified proteins.

35 e oxidases responsible for production of the keto groups found in many of these diterpenoids have lar

36 Removal of the 11-keto group from the lead compound 1 and replacement of t

37 tion of exocyclic amino and keto groups, the keto group having the greater effect; and free energies

38 rate thioester carbon atom by binding of the keto group in an oxyanion hole.

39 ces may be due to steric hindrance by the 11-keto group in CF3DODA-Me, which prevents Michael additio

40 tion of an MTM derivative with an additional keto group in the 3-side chain.

41 , which is attributed to the location of the keto group in the reduced ring (rather than in the isocy

42 t the positions of the extracyclic amino and keto groups in the major groove.

43 rmed a 3,4-desaturation and introduced a C-2 keto group into neurosporene derivatives in the presence

44 n oxygen is present the incorporation of the keto group into spheroidene, forming spheroidenone, reco

45 inc chlorins to zinc oxochlorins wherein the keto group is located in the reduced ring (17-position)

46 In ALDH2, the 3-keto group is surrounded by the adjacent Cys301/303.

47 Although the keto group is the most versatile of the functional group

48 ester production, i.e., the reduction of the keto group of (phenol)phthiodiolones.

49 ha-helix 1, approaches both Asp-99 and the 3-keto group of 19-NTHS while, from beta-strand 1, the car

50 ical 3-ketobutyryl chains but also the alpha-keto group of alpha-KIC-containing intermediates on the

51 rmed between this protein residue and the C9-keto group of BPhL in wild-type.

52 molecule may donate a hydrogen bond to the 3-keto group of Delta(5)-AD and thus help the thiolate of

53 es or deoxynebularine, suggesting that the 6-keto group of hypoxanthine in DNA is critical for stable

54 The alpha-keto group of OxGly interacts with Lys77 and His96, whic

55 reonine residue hydrogen-bonded to the 13(1)-keto group of P(A) with an alanine residue.

56 ing partners with the 17-hydroxy group and 3-keto group of testosterone are Asn705 and Thr877, and Gl

57 occurs by formation of an imine between the keto group of the alpha-keto acid, and the amino group o

58 a flavonoid A-ring and 2,3-double bond and 4-keto group of the C-ring were the main structural requir

59 to alanine to remove the H-bond to the 13(1)-keto group of the chlorophyll a' in Chlamydomonas reinha

60 g heart enzyme appeared to be close to the 3-keto group of the fatty acyl moiety of the substrate, Hi

61 In the first, the C6 keto group of the inhibitor forms a hemi-ketal adduct wi

62 ogen bond with glutamic acid L104 via the C9-keto group of the macrocycle.

63 dition, the nitro functionality mimics the 3-keto group of the natural ligand testosterone and is inv

64 In this last step of the MTM biosynthesis, a keto group of the pentyl side chain is reduced to a seco

65 9 interacts with the 1-carboxylate and the 2-keto group of the substrate to promote carbonyl polariza

66 acting as a hydrogen bond donor for the C-3 keto group of the substrate.

67 ods and NMR spectroscopy, suggests the gamma-keto group of the TCA intermediate plays a significant r

68 C2-type KRs to align the thioester and beta-keto groups of a polyketide intermediate to reduce the p

69 nvestigate the influence of the pyrimidine 2-keto group on selection of nucleotides for incorporation

70 A 4-keto group on the saturated ring is favored for receptor

71 talyze one or two chain extension reactions, keto group processing steps, acyl-ACP release, and cycli

72 the mechanistic details of chain extension, keto group processing, acyl chain release, and macrocycl

73 es catalyse two-carbon linear extensions and keto-group processing reactions on intermediates covalen

74 (S) hydroxyl group of prostaglandins to a 15-keto group resulting in a significant reduction of the b

75 me the hydrogen bond acceptor role of the 11-keto group, resulting in hydrogen bonding to Arg364.

76 no substituent, but addition of an exocyclic keto group results in a modest enhancement of hydrophobi

77 pharmacophores, naphthyl, morpholino, and 3-keto groups, shows that the morpholinyl ring of the mole

78 The incorporation of reactive keto groups such as Acp or Bzp into GPCRs allows their r

79 with the introduction of exocyclic amino and keto groups, the keto group having the greater effect; a

80 m proton transfer from the carboxylic to the keto group; thus, we name it an ol structure.

81 f charge-separated resonance forms of the C9-keto group to the electronic structure of the cofactor.

82 ide chain with three carbons (from the alpha-keto group up to and including the side chain carboxylat

83 ins show strong resonance enhancement of the keto group upon Soret excitation but not with Q(y)()-ban

84 l derivatives produced by reduction of the 4-keto group using borodeuteride.

85 The 3-keto group was discovered to regain the potent agonist a

86 e side chains of these amino acids contain a keto group, which can be uniquely modified in vitro and

87 The orientation of the 17-keto group with respect to the nicotinamide ring of NADP

88 To preserve coplanarity of the 4-keto group with the pyrimidine ring, the N1-C1' glycosid