ライフサイエンスコーパス: ketogenic

1 e body metabolism, along with an increase in ketogenic amino acids and glycine.

2 fatty liver morphology and higher levels of ketogenic and branched-chain amino acids (BCAA).

3 hepatocytes failed to express gluconeogenic, ketogenic, and urea pathway enzymes.

4 es to a high-protein, low-carbohydrate [(LC) ketogenic] and those to a high-protein, medium-carbohydr

5 trast, we observed an increased abundance of ketogenic beta-hydroxybutyryl-CoA, in association with i

6 butyrate (BHB), a metabolite produced during ketogenic conditions, is also an FFA3 agonist.

7 enesis in the liver under chronic fasting or ketogenic conditions, leading to hepatosteatosis; liver-

8 Ketogenic conditions-starvation or ketogenic diet-increa

9 A commonly used rodent ketogenic diet (Bio-Serv F3666) that is very high in fat

10 The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats

11 We asked whether a high-fat ketogenic diet (KD) increases UCP levels and activity in

12 A ketogenic diet (KD) is a high-fat, low-carbohydrate meta

13 The ketogenic diet (KD) is a high-fat, low-carbohydrate, and

14 gated whether an isocaloric low-carbohydrate ketogenic diet (KD) is associated with changes in EE, re

15 g or treatment with the high-fat antiseizure ketogenic diet (KD).

16 increases with fasting and consumption of a ketogenic diet (KD).

17 Additional animals received the ketogenic diet (starting at 20 or 60 d old).

18 nged deprivation of food or consumption of a ketogenic diet activates the IRE1alpha-XBP1 pathway in m

19 The ketogenic diet also may facilitate mechanisms by which t

20 ldren were available for analysis: 54 on the ketogenic diet and 49 controls.

21 73 children were assigned to the ketogenic diet and 72 children to the control group.

22 ch for a 4-wk period-an LC (4% carbohydrate) ketogenic diet and an MC (35% carbohydrate) diet-randomi

23 Dietary therapies, including the ketogenic diet and its variations, have been available f

24 lating FGF21 in response to starvation and a ketogenic diet and that FGF21 is required for behavioral

25 he epigenome gives us an appreciation of the ketogenic diet and the potential for bioenergetic therap

26 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF

27 In addition, the ketogenic diet appears to favor the synthesis of glutami

28 usions, general anesthesia, hypothermia, and ketogenic diet as treatment for uncontrolled status epil

29 In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1b

30 profiling demonstrates that maintenance on a ketogenic diet causes a 25% reduction of myocardial (13)

31 A ketogenic diet consisting of a high ratio of fat to carb

32 e, we have explored whether treatment with a ketogenic diet could lead to a similar rescue through in

33 Weaning mice to a ketogenic diet extends viability to 8.5 wk.

34 s induced by an overnight fast or short term ketogenic diet feeding.

35 esions in Eker rats (Tsc2+/-) subjected to a ketogenic diet for 4, 6 and 8 months.

36 by parents of some children treated with the ketogenic diet for epilepsy control, although this side

37 The ketogenic diet had no effect in these models.

38 A ketogenic diet has also been found to induce mitochondri

39 The ketogenic diet has been widely and successfully used to

40 creased availability of anticonvulsants, the ketogenic diet has re-emerged as a therapeutic option.

41 therapy for pediatric epilepsy known as the ketogenic diet has seen a revival in its clinical use du

42 f this study was to test the efficacy of the ketogenic diet in a randomised controlled trial.

43 Here, we report that a ketogenic diet in Kmt2d(+/betaGeo) mice modulates H3ac a

44 onsible for the antiepileptic effects of the ketogenic diet in mice.

45 ning could in part explain the effect of the ketogenic diet in reducing epileptic seizures.

46 Strikingly, a ketogenic diet increased lysine acetylation in Cpt2M(-/-

47 tion of a high fat, low carbohydrate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor

48 The ketogenic diet is a high-fat, adequate protein, low carb

49 The medium chain triglyceride ketogenic diet is an established treatment for drug-resi

50 ingly, the use of therapeutic hypothermia or ketogenic diet is described as a strategy for super-refr

51 A ketogenic diet is used as anti-seizure therapy i.a. in t

52 The mechanisms underlying the ketogenic diet might also have roles in other disorders,

53 o mediate the stimulatory effect of an HF-LC ketogenic diet on FGF21 expression.

54 information is available on the effect of a ketogenic diet on plasma lipoproteins in children with d

55 and had not been treated previously with the ketogenic diet participated in a randomised controlled t

56 The ketogenic diet produced good seizure control.

57 A high-fat ketogenic diet produced significant increases in the ath

58 bgroup of the 371 patients accepted into the ketogenic diet program between 1994 and 2001.

59 Prolonged feeding of a ketogenic diet promotes the growth of renal tumors by re

60 Anticonvulsant mechanisms of the ketogenic diet remain incompletely understood.

61 A low-carbohydrate ketogenic diet remains one of the most effective (but my

62 All three patients who tried the ketogenic diet responded well to this treatment, and fut

63 At 6 months, the high-fat ketogenic diet significantly increased the mean plasma l

64 consideration of dietary choline content in ketogenic diet studies in rodents to limit hepatic mitoc

65 Analysing medium-chain fatty acids in future ketogenic diet studies will provide further insights int

66 The results from this trial of the ketogenic diet support its use in children with treatmen

67 R in mice suppressed the ability of an HF-LC ketogenic diet to induce hepatic FGF21 gene expression.

68 Depletion of glucose levels using a ketogenic diet to lower lactate production by glycolytic

69 mised cells points to the potential use of a ketogenic diet to treat patients with heteroplasmic mtDN

70 A 4:1 ketogenic diet was maintained for 15 mo, and whole-body

71 Only a decade ago the ketogenic diet was seen as a last resort; however, it ha

72 In 2009, two controlled trials of the ketogenic diet were published, as well as an Internation

73 and adults with G1D who were not receiving a ketogenic diet were selected on a first-come, first-enro

74 esponds to dietary manipulation such as the 'ketogenic diet'.

75 of GLUT1 deficiency has important treatment (ketogenic diet) and genetic counseling implications.

76 (24 h of fasting and a very low carbohydrate ketogenic diet) to demonstrate that heart muscle engages

77 n of the diet (the medium-chain triglyceride ketogenic diet), have been shown to directly inhibit AMP

78 as the modified Atkins diet) other than the ketogenic diet, (2) the relatively frequent occurrence (

79 tabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflamma

80 , not only as the mechanism of action of the ketogenic diet, but also as a potential target of future

81 Ketogenic diet, diazepam, valproate, potassium bromide a

82 Children were randomly assigned to receive a ketogenic diet, either immediately or after a 3-month de

83 ermia, magnesium, pyridoxine, immunotherapy, ketogenic diet, emergency neurosurgery, electroconvulsiv

84 ion, pyridoxine, steroids and immunotherapy, ketogenic diet, hypothermia, emergency resective neurosu

85 es that several mechanisms may exist for the ketogenic diet, including disruption of glutamatergic sy

86 er 80 years ago with the introduction of the ketogenic diet, is required.

87 d be suppressed by a carbohydrate-restricted ketogenic diet, MEDICA treatment suppressed tumor growth

88 ll now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified

89 as the perceived absolute requirement for a ketogenic diet, the assumed lack of structural brain def

90 y pharmacological stimulation of PDH or by a ketogenic diet, two treatments used for PDH deficiencies

91 bohydrates are restricted in patients on the ketogenic diet, we evaluated the effects of limiting car

92 g opinions about the anticancer actions of a ketogenic diet, we have shown that this anti-seizure the

93 duals with epilepsy benefit from consuming a ketogenic diet, which is similar to the more commonly kn

94 at liver were dramatically up-regulated by a ketogenic diet, which lowered HNE basal level.

95 tant adjunct to pharmacologic therapy is the ketogenic diet, which often improves seizure control, ev

96 compared with littermate control mice fed a ketogenic diet, yet it did not improve cardiac hypertrop

97 ncentrations are higher within the hearts of ketogenic diet-fed mice challenged with ketones compared

98 mpared with chow-fed C57BL/6 mice, fasted or ketogenic diet-fed mice displayed increased hepatic TG c

99 Ketogenic conditions-starvation or ketogenic diet-increase K8(+/+) HMGCS2, whereas this res

100 Here we focus on a novel hypothesis that a ketogenic diet-induced change in energy metabolism incre

101 These data suggest that a ketogenic diet-related bleeding tendency occurs in about

102 tely reversed in GF mice by consumption of a ketogenic diet.

103 after C75 injection in rats maintained on a ketogenic diet.

104 nd glycolysis), valproic acid (VPA), and the ketogenic diet.

105 cover possible therapeutic mechanisms of the ketogenic diet.

106 est in alternative therapies, especially the ketogenic diet.

107 mice consuming a high-fat, low-carbohydrate ketogenic diet.

108 ic action of a high fat and low carbohydrate ketogenic diet.

109 sant effect of the medium chain triglyceride ketogenic diet.

110 en fasted or fed a high-fat low-carbohydrate ketogenic diet.

111 nt antitumor mechanisms were launched by the ketogenic diet.

112 PHOS deficiency can be bypassed by feeding a ketogenic diet.

113 -intensity exercise, or the low-carbohydrate ketogenic diet.

114 to respond appropriately to consumption of a ketogenic diet.

115 asting or by maintaining a low-carbohydrate (ketogenic) diet might reduce epileptic seizures and offe

116 High-fat, low-carbohydrate ketogenic diets (KDs) have shown beneficial effects in m

117 d mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cance

118 gamma coactivator-1alpha pathway activation, ketogenic diets and other new strategies is required.

119 Ketogenic diets are also now being increasingly studied

120 Ketogenic diets are very efficient to control epilepsy a

121 how the well-recognized clinical effects of ketogenic diets can alter human behavior via the same ce

122 he mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still r

123 The use of ketogenic diets for weight loss is not warranted.

124 Second, common ketogenic diets lead to a therapeutically counterintuiti

125 flammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition

126 liver AQP9 levels were observed in rats fed ketogenic diets or high-protein diets, but AQP9 levels w

127 e short term, high-protein, low-carbohydrate ketogenic diets reduce hunger and lower food intake sign

128 High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological

129 ch as starvation, diabetic ketoacidosis, and ketogenic diets, play a potentially important role in re

130 iciency on the pleiotropic effects of rodent ketogenic diets, we studied four custom diets that diffe

131 LUT1-DS) who objected to or did not tolerate ketogenic diets.

132 olic and physiologic alterations provoked by ketogenic diets.

133 were 3-5 times those reported with high-fat ketogenic diets.

134 We describe the rate-limiting enzyme of the ketogenic energy metabolism pathway, mitochondrial 3-hyd

135 teraction between oncogenic BRAF V600E and a ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase (H

136 cogenic BRAF(V600E) stimulates expression of ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase an

137 e concomitantly decreasing gluconeogenic and ketogenic enzyme gene expression.

138 scles showed a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (

139 eceptor alpha-dependent induction of the key ketogenic enzyme HMGCS2.

140 ional mechanism, whereas L-FABP can activate ketogenic gene expression in fed mice.

141 nounced defect in ketone body production and ketogenic gene expression on fasting.

142 ation next to PPARA target genes and delayed ketogenic gene expression.

143 ha), the master transcriptional activator of ketogenic genes, and that suppression of NCoR1 (nuclear

144 Here we show that the prolongevity ketogenic hormone fibroblast growth factor 21 (FGF21), a

145 investigated the effects of adaptation to a ketogenic low carbohydrate (CHO), high fat diet (LCHF) d

146 Adaptation to a ketogenic low carbohydrate, high fat (LCHF) diet markedl

147 and biomarker change in adults adhering to a ketogenic low-carbohydrate (KLC) diet or a nonketogenic

148 itially to approximately 22% after 5 days in ketogenic medium and was accompanied by a dramatic impro

149 Conversely, the ketogenic module operates via a GR-induced TF cascade, w

150 l-CoA (HMG-CoA) lyase is a key enzyme in the ketogenic pathway that supplies metabolic fuel to extrah

151 gene expression of fatty acid oxidation and ketogenic pathways.

152 a function causes diversion of liver-trapped ketogenic precursors into triacylglycerol.

153 lation, and hypoglycemia, with an inadequate ketogenic response in adult mice lacking PPARalpha (PPAR

154 These include the ketogenic response of the liver to fasting and diabetes,

155 treatment with PPARgamma agonists and under ketogenic states.

156 To rescue the deficiency, we added ketogenic substrates to the water in which the embryos d