ライフサイエンスコーパス: ketoglutarate

1 b's cycle intermediates (succinate and alpha-ketoglutarate).

2 B-04 is not a competitive inhibitor of alpha-ketoglutarate.

3 the concentration of its co-substrate alpha-ketoglutarate.

4 roducing 2-hydroxyglutarate (2HG) from alpha-ketoglutarate.

5 of O(2)-regulated metabolites such as alpha-ketoglutarate.

6 nverted to 3-deoxy-2-keto-hexarate and alpha-ketoglutarate.

7 hlorite oxidation afforded the 1-monooctyl 2-ketoglutarate.

8 4PE and a noncompetitive inhibitor vs alpha-ketoglutarate.

9 er than that towards the natural substrate 2-ketoglutarate.

10 ase in GDH affinity for its substrate, alpha-ketoglutarate.

11 n of saccharopine to give l-lysine and alpha-ketoglutarate.

12 equentially converted to glutamate and alpha-ketoglutarate.

13 rg428 contributes mainly to binding of alpha-ketoglutarate.

14 ng stimulation by glucose, leucine, or alpha-ketoglutarate.

15 II, and this effect was antagonized by alpha-ketoglutarate.

16 o catalyse conversion of isocitrate to alpha-ketoglutarate.

17 itric acid cycle intermediates, mostly alpha-ketoglutarate.

18 pyridine dicarboxylate, an analogue of alpha-ketoglutarate.

19 ementation with TCA cycle intermediate alpha-ketoglutarate.

20 tion of 2-hydroxyglutarate and reduced alpha-ketoglutarate.

21 genases, efficiently oxidized D-2HG to alpha-ketoglutarate.

22 ive carboxylation of glutamine-derived alpha-ketoglutarate.

23 mate to pyruvate, yielding alanine and alpha-ketoglutarate.

24 cy compared with that of KDM5B at 1 mm alpha-ketoglutarate.

25 ioxygenases using the essential metabolite 2-ketoglutarate (2KG) as a cofactor.

26 ion due to the increased production of alpha-ketoglutarate, a critical substrate for prolyl hydroxyla

27 ate export and that supplementation of alpha-ketoglutarate, a key downstream metabolite of glutamate,

28 transcription and, thus, production of alpha-ketoglutarate, a key metabolite in the regulation of ESC

29 f Nrd1 or Ogdh leads to an increase in alpha-ketoglutarate, a substrate for OGDH, which in turn leads

30 alpha-Ketoglutarate (AKG) is a key intermediate of tricarboxyl

31 resent, the antagonism between ADP and alpha-ketoglutarate allowed each of these effectors to influen

32 However, HPV was not increased by 1 mm alpha-ketoglutarate alone, and HPV in the absence of alpha-ket

33 and IDH2, decarboxylate isocitrate to alpha-ketoglutarate (alpha-KG) and reduce NADP to NADPH.

34 mechanism is steady state ordered with alpha-ketoglutarate (alpha-Kg) binding prior to acetyl-CoA (Ac

35 G) is an oncometabolite generated from alpha-ketoglutarate (alpha-KG) by mutant isocitrate dehydrogen

36 nthase (HOAS), the E1 component of the alpha-ketoglutarate (alpha-KG) dehydrogenase complex (KDHC), d

37 Mononuclear nonheme Fe(II) (MNH) and alpha-ketoglutarate (alpha-KG) dependent halogenases activate

38 genes necessary for the utilization of alpha-ketoglutarate (alpha-KG) in Pseudomonas aeruginosa PAO1.

39 was also activated by induction of an alpha-ketoglutarate (alpha-KG) paracrine signaling system.

40 oup from branched-chain amino acids to alpha-ketoglutarate (alpha-KG) thereby regenerating glutamate,

41 osphate (NADPH)-dependent reduction of alpha-ketoglutarate (alpha-KG) to 2-HG.

42 condensation of acetyl-CoA (AcCoA) and alpha-ketoglutarate (alpha-KG) to give homocitrate and CoA.

43 hed-chain amino acids while converting alpha-ketoglutarate (alpha-KG) to glutamate.

44 Glutaminolysis converts Gln into alpha-ketoglutarate (alpha-KG), a critical intermediate in the

45 Here we show that alpha-ketoglutarate (alpha-KG), a tricarboxylic acid cycle int

46 Fe(II)- and alpha-ketoglutarate (alpha-KG)-dependent dioxygenases are a la

47 tion is catalyzed by the non-heme iron alpha-ketoglutarate (alpha-KG)-dependent SnoK in the biosynthe

48 of D-2-hydroxyglutarate (D-2-HG) from alpha-ketoglutarate (alpha-KG).

49 roduces 2-hydroxyglutarate (2-HG) from alpha-ketoglutarate (alpha-KG).

50 levels of the Krebs cycle intermediate alpha-ketoglutarate (alpha-KG).

51 drogenases (IDH) convert isocitrate to alpha-ketoglutarate (alpha-KG).

52 decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent re

53 dent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes.

54 To investigate the role of alpha-ketoglutarate (alphaKG) in the epimetabolic control of D

55 a physiologic plasma concentration of alpha-ketoglutarate (alphaKG) influences the kinetic interacti

56 atic activity allowing them to convert alpha-ketoglutarate (alphaKG) to 2-hydroxyglutarate (2HG), whi

57 atic halogenases activate O(2), cleave alpha-ketoglutarate (alphaKG) to CO(2) and succinate, and form

58 y of enzymes that use Fe(2+), O(2) and alpha-ketoglutarate (alphaKG) to perform a variety of halogena

59 ivity that catalyzes the conversion of alpha-ketoglutarate (alphaKG) to the oncometabolite D-(2)-hydr

60 ad can reverse the direction of apical alpha-ketoglutarate (alphaKG) transport in the proximal tubule

61 Glutamine is catabolyzed to alpha-ketoglutarate (alphaKG), a tricarboxylic acid (TCA) cycl

62 alphaKG oxygenases and require Fe(II), alpha-ketoglutarate (alphaKG), and O(2) for activity.

63 ongs to a recently discovered class of alpha-ketoglutarate (alphaKG), non-heme Fe(II)-dependent halog

64 bic conditions containing iron(II) and alpha-ketoglutarate (alphaKG), to dioxygen initiates oxidation

65 talyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG), whereas conferring a gain of a

66 he citric acid(TCA) cycle intermediate alpha-ketoglutarate (alphaKG), which via its OXGR1 receptor pl

67 use models to ask if inhibition of the alpha-ketoglutarate (alphaKG)-dependent dioxygenase Egln1, whi

68 FIH is a non-heme Fe(II), alpha-ketoglutarate (alphaKG)-dependent dioxygenase that inhib

69 His-1-carboxylate) facial triad in the alpha-ketoglutarate (alphaKG)-dependent dioxygenases clavamina

70 s (P4Hs) are mononuclear non-heme iron alpha-ketoglutarate (alphaKG)-dependent dioxygenases that cata

71 r (HIF) prolyl hydroxylases (PHDs) are alpha-ketoglutarate (alphaKG)-dependent dioxygenases that func

72 g hypoxia-inducible factor (FIH) is an alpha-ketoglutarate (alphaKG)-dependent enzyme which catalyzes

73 discovered class of nonheme Fe(II) and alpha-ketoglutarate (alphaKG)-dependent halogenases, catalyzes

74 nase (tauD) is one of the best-studied alpha-ketoglutarate (alphaKG)-dependent nonheme iron oxygenase

75 (Th1) were regulated by glutamine and alpha-ketoglutarate (alphaKG)-induced events, in part through

76 hrough reductive carboxylation (RC) of alpha-ketoglutarate (alphaKG).

77 DH1) reversibly converts isocitrate to alpha-ketoglutarate (alphaKG).

78 ive decarboxylation of isocitrate into alpha-ketoglutarate (alphaKG).

79 maintain a high level of intracellular alpha-ketoglutarate (alphaKG).

80 boxylic acid cycle (TCA) intermediate, alpha-ketoglutarate, also blocks the transcriptional activity

81 ate pathway, which generates cytosolic alpha-ketoglutarate, also known as 2-oxoglutarate (2OG).

82 The use of alpha-ketoglutarate (alternatively termed 2-oxoglutarate) as a

83 is is a cell-permeable prodrug form of alpha-ketoglutarate, an important intermediate in the tricarbo

84 (CD) studies using a non-decarboxylatable 2-ketoglutarate analog and determined the distribution of

85 tes to mtDNA loss by acting as a toxic alpha-ketoglutarate analog.

86 By increasing intracellular alpha-ketoglutarate and activating PHDs we trigger PHD-depende

87 ; these proteins are direct sensors of alpha-ketoglutarate and adenylylate energy charge and control

88 Signaling of alpha-ketoglutarate and adenylylate energy charge by these het

89 PII proteins are sensors of alpha-ketoglutarate and adenylylate energy charge that regulat

90 he role of the three binding sites for alpha-ketoglutarate and adenylylate nucleotide in the PII trim

91 ate conditions, the antagonism between alpha-ketoglutarate and ADP allowed each of these effectors to

92 re also used to examine the effects of alpha-ketoglutarate and ADP on PII activation of the adenylylt

93 arate alone, and HPV in the absence of alpha-ketoglutarate and cysteine was not attenuated by asparta

94 ents would ensure the replenishment of alpha-ketoglutarate and glutamate, which provide the carbon ba

95 yme, produces 2-hydroxy-3-oxoadipate using 2-ketoglutarate and glyoxylate.

96 P4H uses alpha-ketoglutarate and O2 as cosubstrates, and forms succinat

97 e in cell proliferation was rescued by alpha-ketoglutarate and overexpression of IDH2, whereas prolif

98 a-keto analog of asparagine), yielding alpha-ketoglutarate and oxaloacetate, respectively.

99 rnary complex of HygX with cosubstrate alpha-ketoglutarate and putative product hygromycin B identifi

100 he intracellular levels of its product alpha-ketoglutarate and subsequent metabolite fumarate.

101 re flushed in situ with histidine-tryptophan-ketoglutarate and subsequently preserved either by simpl

102 itric acid cycle intermediates such as alpha-ketoglutarate and succinate, NaDC3 transports other comp

103 Both alpha-ketoglutarate and the UDP-linked sugar bind in the WlbA

104 H1 R132H competitively with respect to alpha-ketoglutarate and uncompetitively with respect to NADPH.

105 lows to succinate both through citrate/alpha-ketoglutarate and via malate/fumarate.

106 substrate required addition of Fe(2+), alpha-ketoglutarate, and ascorbic acid, confirming that KdoO i

107 mitochondrial enzymes, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids.

108 (E3) is associated with the pyruvate, alpha-ketoglutarate, and glycine dehydrogenase complexes.

109 EI(Ntr) activity was not affected by alpha-ketoglutarate, and no binding between the EIGAF and alph

110 he enzyme in a complex with NAD(H) and alpha-ketoglutarate, and the enzyme in a complex with NAD(H) a

111 x enzymes are involved, including four alpha-ketoglutarate- and iron(II)-dependent dioxygenases that

112 ls, but causes a drop in the levels of alpha-ketoglutarate, another output of the pathway and a trica

113 BMDACs) with dimethyloxalylglycine, an alpha-ketoglutarate antagonist that induces hypoxia-inducible

114 its physiological concentration range, alpha-ketoglutarate apparently played a role in only the latte

115 els of TCA-cycle metabolites including alpha-ketoglutarate are high, and levels of the key regulatory

116 This enzyme has been shown to use alpha-ketoglutarate as an oxidant to regenerate the oxidized d

117 e phenazine reduction with pyruvate or alpha-ketoglutarate as electron donors.

118 rolyl 4-hydroxylases that use O(2) and alpha-ketoglutarate as substrates to hydroxylate conserved pro

119 ific activity of DapL using ll-DAP and alpha-ketoglutarate as substrates was 24.3 + or - 2.0 nmol min

120 vitro in the presence of Fe (2+), O 2, alpha-ketoglutarate, ascorbate, and Triton X-100.

121 used for GC-MS/MS analysis of alanine, alpha-ketoglutarate, asparagine, aspartic acid, cystathionine,

122 JmjC domain with conserved Fe(II) and alpha-ketoglutarate binding sites, and displays H3K9me1/2 deme

123 onstitutes the cofactor (metal ion and alpha-ketoglutarate) binding characteristics of other structur

124 n addition, reductive carboxylation of alpha-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2

125 Homocitrate synthase (acetyl-coenzyme A: 2-ketoglutarate C-transferase; E.C. 2.3.3.14) (HCS) cataly

126 pe IDH1, only hyperpolarized [1-(13)C] alpha-ketoglutarate can be detected.

127 report we demonstrate that derivatized alpha-ketoglutarate can be used as a strategy for maintaining

128 We also show that derivatized alpha-ketoglutarate can permeate multiple layers of cells, red

129 proof-of-concept study, that [1-(13)C] alpha-ketoglutarate can serve as a metabolic imaging agent for

130 ive carboxylation of glutamine-derived alpha-ketoglutarate (catalyzed by reverse flux through isocitr

131 several cellular conditions where the alpha-ketoglutarate/citrate ratio is changed due to an altered

132 ions that result in an increase in the alpha-ketoglutarate/citrate ratio.

133 ne (DMOG, 200 mug/g), an antagonist of alpha-ketoglutarate cofactor and inhibitor for HIF PHD, on pos

134 /glutamine (10/2 mM) did not influence alpha-ketoglutarate concentrations but caused 120 and 33% incr

135 P was the sole adenylylate nucleotide, alpha-ketoglutarate controlled the extent of PII activation bu

136 , and no binding between the EIGAF and alpha-ketoglutarate could be detected.

137 the gamma-aminobutyric acid pathway or alpha-ketoglutarate decarboxylase/succinic semialdehyde dehydr

138 Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex is loca

139 rganization of the multienzyme complex alpha-ketoglutarate dehydrogenase (alpha-KGDH).

140 ound an increase in phosphorylation of alpha-ketoglutarate dehydrogenase (alphaKGDH) in female hearts

141 in amino acid dehydrogenase (BCDH) and alpha-ketoglutarate dehydrogenase (KDH).

142 such as pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydrogenase (KGDH), and the glycine clea

143 aperones and assists in the folding of alpha-ketoglutarate dehydrogenase (OGDH), a rate-limiting enzy

144 cofactor of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase and other mitochondrial targ

145 ons of regulation of the activities of alpha-ketoglutarate dehydrogenase and the aspartate-glutamate

146 proteins, including the E2 subunit of alpha-ketoglutarate dehydrogenase and the glutathione S-transf

147 The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an arguably

148 hyl transferase, and components of the alpha-ketoglutarate dehydrogenase complex in conjunction with

149 target DLST-the E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex, a rate-controlling

150 A to the reduction of NAD(+) using the alpha-ketoglutarate dehydrogenase complex.

151 , we demonstrate that the pyruvate and alpha-ketoglutarate dehydrogenase complexes directly catalyze

152 nslational lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes, resulting in dimi

153 nent of the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes.

154 xes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched-chain ketoacid

155 subunits of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, and Gcv3, the H protein of

156 le enzymes, pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.

157 ation was changed in 1797 genes [e.g., alpha-ketoglutarate dependent dioxygenase (FTO), interleukin 6

158 treatment promoted GBM survival in an alpha-ketoglutarate-dependent (alphaKG-dependent) manner.

159 172K mutant IDH2 resulted in increased alpha-ketoglutarate-dependent consumption of NADPH compared to

160 The KDM5/JARID1 family of Fe(II)- and alpha-ketoglutarate-dependent demethylases remove methyl group

161 s lipid-A by hydroxylation by the Fe2+/alpha-ketoglutarate-dependent dioxygenase enzyme (LpxO).

162 emethylation are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase family.

163 Inactivation of Fe(II)/alpha-ketoglutarate-dependent dioxygenase gene fr9P led to los

164 didomain protein, DdaD, and an Fe(II)/alpha-ketoglutarate-dependent dioxygenase homologue, DdaC.

165 for the archetypal non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase TauD.

166 , which encodes a putative Fe (2+)/O 2/alpha-ketoglutarate-dependent dioxygenase, abolishes S-2-hydro

167 ions or substrate taurine to TauD, an alpha-ketoglutarate-dependent dioxygenase, alters its UV absor

168 demethylation of thebaine by an Fe(II)/alpha-ketoglutarate-dependent dioxygenase.

169 The AlkB family of Fe(II)- and alpha-ketoglutarate-dependent dioxygenases is a class of ubiqu

170 Fumarate has been shown to inhibit alpha-ketoglutarate-dependent dioxygenases that are involved i

171 The PHDs are alpha-ketoglutarate-dependent dioxygenases that have low K(m)

172 ranslocation) proteins are Fe(ii)- and alpha-ketoglutarate-dependent dioxygenases that modify the met

173 igenetic effects through inhibition of alpha-ketoglutarate-dependent dioxygenases that require iron a

174 lutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases' by Xu and colleagu

175 endent methyltransferases, Fe(II)- and alpha-ketoglutarate-dependent dioxygenases, base excision glyc

176 proteins, a family of AlkB-like Fe(II)/alpha-ketoglutarate-dependent dioxygenases, can oxidize 5mC to

177 ly distinct bifunctional non-heme iron alpha-ketoglutarate-dependent enzyme responsible for the termi

178 by Cur halogenase, a non-haem Fe(ii), alpha-ketoglutarate-dependent enzyme.

179 DdaC catalyzes Fe(II)- and alpha-ketoglutarate-dependent epoxidation of the covalently bo

180 We show that Fe(II)- and alpha-ketoglutarate-dependent fat mass and obesity-associated

181 The alpha-ketoglutarate-dependent hydroxylases and halogenases emp

182 d in vivo by hyperammonemia through an alpha-ketoglutarate-dependent inhibition of the mammalian targ

183 gillus fumigatus is the first reported alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme

184 Notably, we characterized an alpha-ketoglutarate-dependent non-heme Fe(II) dioxygenase that

185 5caC in three consecutive, Fe(II)- and alpha-ketoglutarate-dependent oxidation reactions.

186 caC) in three consecutive, Fe(II)- and alpha-ketoglutarate-dependent oxidation reactions.

187 om nucleic acids by a unique iron- and alpha-ketoglutarate-dependent oxidation strategy.

188 ied a conserved group of nonheme iron, alpha-ketoglutarate-dependent oxygenases likely responsible fo

189 of histone demethylases are Fe2+- and alpha-ketoglutarate-dependent oxygenases that are essential co

190 hich can be overcome by treatment with alpha-ketoglutarate derivatives.

191 Residue F159 in taurine alpha-ketoglutarate dioxygenase (TauD) is demonstrated to play

192 Taurine alpha-ketoglutarate dioxygenase (tauD) is one of the best-stud

193 uctive metabolism of glutamine-derived alpha-ketoglutarate even in normoxic conditions.

194 The Jumonji C domain Fe(II) alpha-ketoglutarate family of proteins performs the majority o

195 PHF2 belongs to a class of alpha-ketoglutarate-Fe(2)(+)-dependent dioxygenases.

196 The sequential activities of PhnY, an alpha-ketoglutarate/Fe(II)-dependent dioxygenase, and PhnZ, a

197 y 'ancient' CoA-dependent pyruvate and alpha-ketoglutarate ferredoxin oxidoreductases.

198 ive carboxylation of glutamine-derived alpha-ketoglutarate for de novo lipogenesis.

199 e and an assay procedure that measures alpha-ketoglutarate formation from alpha-ketoglutaramate in a

200 that steric constraints could prevent alpha-ketoglutarate from undergoing an "off-line"-to-"in-line"

201 AMPKalpha2 regulates alpha-ketoglutarate generation, hypoxia-inducible factor-1alph

202 Uniquely, after alpha-ketoglutarate has bound to the mononuclear iron centre i

203 Reducing O-GlcNAcylation increases alpha-ketoglutarate, HIF-1 hydroxylation, and interaction with

204 ylation covalent intermediate derived from 2-ketoglutarate; however, it decreases the abundance of th

205 olled trials (RCTs) and histidine-tryptophan-ketoglutarate (HTK) in two RCTs.

206 osomolar citrate (HOC), histidine-tryptophan-ketoglutarate (HTK), or University of Wisconsin (UW) sol

207 n solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tis

208 oxidative deamination of glutamate to alpha-ketoglutarate in a limited number of tissues in humans,

209 ent carboxylation of glutamine-derived alpha-ketoglutarate in hypoxia is associated with a concomitan

210 atalyze the oxidation of isocitrate to alpha-ketoglutarate in the citric acid cycle.

211 nvert glutamine-derived glutamate into alpha-ketoglutarate in the mitochondria to fuel the tricarboxy

212 increase in reductive carboxylation of alpha-ketoglutarate (increased concentrations of 2-hydroxyglut

213 the tricarboxyclic acid cycle product alpha-ketoglutarate, indicating the critical function of GLS1

214 e deficiency, through the reduction of alpha-ketoglutarate, inhibits the AlkB homolog (ALKBH) enzymes

215 ethanolamine, 2,4-diaminobutyrate, and alpha-ketoglutarate into achromobactin.

216 r minireviews deal with aspects of the alpha-ketoglutarate/iron-dependent dioxygenases in this eighth

217 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-l

218 bolic fate of hyperpolarized [1-(13)C] alpha-ketoglutarate is studied in isogenic glioblastoma cells

219 s with the alpha-carboxylate moiety of alpha-ketoglutarate, is also uniquely positioned to bestow spe

220 (suc(2-)) through glutarate (glu(2-)), alpha-ketoglutarate (kglu(2-)), adipate (adi(2-)), pimelate (p

221 tion factor RTG1 Furthermore, elevated alpha-ketoglutarate levels also suppress 2HG-mediated respirat

222 of the IDH3 heterotetramer, decreased alpha-ketoglutarate levels and increased the stability and tra

223 Genetic modulation of alpha-ketoglutarate levels demonstrates a key regulatory role

224 DHs, which correlated with the reduced alpha-ketoglutarate levels.

225 iates with good sensitivity, including alpha-ketoglutarate, malate, fumarate, succinate, 2-hydroxyglu

226 novel pathogenicity island involved in alpha-ketoglutarate metabolism under anaerobic conditions.

227 increases the levels of glutamate and alpha-ketoglutarate, mitochondrial respiration rate, and GSH l

228 , carried by Dld3, to convert D-2HG to alpha-ketoglutarate, namely an FAD-dependent transhydrogenase

229 acid, confirming that KdoO is a Fe(2+)/alpha-ketoglutarate/O(2)-dependent dioxygenase.

230 hough two enzymes that catalyze Fe(2+)/alpha-ketoglutarate/O(2)-dependent hydroxylation of deoxyuridi

231 three coordination sites, a bidentate alpha-ketoglutarate occupying two sites, and an aquo ligand in

232 s to investigate the effect of ADP and alpha-ketoglutarate on the binding of PII to ATase and NRII.

233 phosphoenolpyruvate and the inhibitor alpha-ketoglutarate, on the structure and dynamics of EI using

234 h an NAD(+) precursor or its substrate alpha-ketoglutarate or treatment with a poly(ADP ribose) polym

235 or 30 hr CI in saline, histidine-tryptophan-ketoglutarate or University of Wisconsin preservation so

236 it forms with either the co-substrate (alpha-ketoglutarate) or the substrate (fumitremorgin B).

237 starved cells by the TCA intermediates alpha-ketoglutarate, oxaloacetate, and pyruvate, confirming th

238 te (SerC and PdxA), we have found that alpha-ketoglutarate, oxaloacetic acid, and pyruvate are equall

239 cluded an unexpected pathway bypassing alpha-ketoglutarate-oxidizing steps in the tricarboxylic acid

240 One such enzyme is the 2-oxoglutarate (alpha-ketoglutarate) oxidoreductase (OOR), which catalyzes the

241 k could be relieved by addition of the alpha-ketoglutarate precursor glutamate.

242 Histidine-tryptophan-ketoglutarate preservation solution slightly decreased i

243 atoms of N-oxalylglycine (an analog of alpha-ketoglutarate) provide four coordinations in the equator

244 the enzyme that converts isocitrate to alpha-ketoglutarate, providing mechanistic explanation for TCA

245 Glucose, galacturonic acid, alpha-ketoglutarate, pyruvate, acetoin and acetaldehyde were d

246 e characterized the stereochemistry of alpha-ketoglutarate reduction by showing that d-2-HGA, but not

247 Prior studies showed that alpha-ketoglutarate regulated the ability of PII to control th

248 ere, we show that a similar pattern of alpha-ketoglutarate regulation was obtained with another PII r

249 Mechanistically, addition of exogenous alpha-ketoglutarate replenishes TCA intermediates and rescues

250 on of KIC and glutamate to leucine and alpha-ketoglutarate, respectively.

251 ochondria via glutamate synthesis from alpha-ketoglutarate resulting in cataplerosis.

252 A cell-permeable ester of alpha-ketoglutarate reversed the low TCA cycle intermediates a

253 inhibitor Meloxicam via histidine-tryptophan-ketoglutarate showed the best graft-protective attribute

254 NEVKP or in 4 degrees C histidine-tryptophan-ketoglutarate solution (SCS), followed by kidney autotra

255 Histidine-Tryptophan-Ketoglutarate solution could have an economically superi

256 ither preserved in cold histidine-tryptophan-ketoglutarate solution for 8 hours (n = 5), or subjected

257 of Wisconsin solution, histidine-tryptophan-ketoglutarate solution, and Belzer-machine perfusion sol

258 3 hr of cold storage in histidine-tryptophan-ketoglutarate solution.

259 ersity of Wisconsin and Histidine-Tryptophan-Ketoglutarate solutions are clinically equivalent.

260 was dependent on the concentration of alpha-ketoglutarate substrate in glioma cell lines and could b

261 , which is suppressed by glutamate and alpha-ketoglutarate supplementation.

262 tricarboxylic acid cycle intermediate alpha-ketoglutarate through glutaminase and alanine aminotrans

263 Variation of the concentration of alpha-ketoglutarate through its physiological range provided d

264 neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate" by Ward and colleag

265 neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate".

266 acquisition of the ability to convert alpha-ketoglutarate to 2HG.

267 c enzymatic activity: the reduction of alpha-ketoglutarate to d-2-hydroxyglutaric acid, which is prop

268 osynthesis pathway, in addition reduce alpha-ketoglutarate to D-2HG using NADH and represent major in

269 ion of E78A, which exhibits binding of alpha-ketoglutarate to E and E.NADH.

270 enzymes needed to convert glutamine to alpha-ketoglutarate to enter the TCA cycle.

271 stimulated reductive carboxylation of alpha-ketoglutarate to generate citrate via retrograde TCA cyc

272 ucine catabolism and transamination of alpha-ketoglutarate to glutamate, with impaired TCA anaplerosi

273 versible transamination of leucine and alpha-ketoglutarate to KIC and glutamate, the first step of le

274 olysis, the conversion of glutamine to alpha-ketoglutarate to maintain the TCA cycle (anaplerosis) an

275 combination of 1 mm cysteine and 1 mm alpha-ketoglutarate to promote sulphide synthesis via the cyst

276 alyse the NADPH-dependent reduction of alpha-ketoglutarate to R(-)-2-hydroxyglutarate (2HG).

277 onvert substantially more glutamine to alpha-ketoglutarate to replenish the tricarboxylic acid cycle

278 OR), which catalyzes the conversion of alpha-ketoglutarate to succinyl coenzyme A (succinyl-CoA) and

279 uman cells use reductive metabolism of alpha-ketoglutarate to synthesize AcCoA for lipid synthesis.

280 alteration that leads to catalysis of alpha-ketoglutarate to the oncometabolite D-2-hydroxyglutarate

281 ain-of-function activity by converting alpha-ketoglutarate to the oncometabolite R-2-hydroxyglutarate

282 addition of the TCA cycle intermediate alpha-ketoglutarate to the Rb TKO MEFs reversed the inhibitory

283 ears to be increased by Histidine-Tryptophan-Ketoglutarate-use (p = 0.018), this effect could not be

284 The ammonia is transferred to alpha-ketoglutarate via glutamate dehydrogenase, yielding glut

285 Only Meloxicam in histidine-tryptophan-ketoglutarate was demonstrated to be a safe drug without

286 Apparently, alpha-ketoglutarate was generated from unlabeled glutamate via

287 ation, net synthesis of glutamate from alpha-ketoglutarate was impaired in GDH-deficient islets.

288 Although alpha-ketoglutarate was required for the binding of PII to NRI

289 I equally well as the concentration of alpha-ketoglutarate was varied through its physiological range

290 Subsequent binding of the substrate, alpha-ketoglutarate, was characterized by a rapid equilibrium

291 pparent K(m)s of MJ1391 for ll-DAP and alpha-ketoglutarate were 82.8 + or - 10 microM and 0.42 + or -

292 lutaminolysis catabolites particularly alpha-ketoglutarate, which are generated in an mTORC2-dependen

293 increasing production of glutamate and alpha-ketoglutarate, which in turn results in enhanced mitocho

294 enase expression and the production of alpha-ketoglutarate, which negatively regulate hypoxia-inducib

295 e metabolism of glutamine/glutamate to alpha-ketoglutarate, which, in turn, is metabolized to produce

296 he enzyme (conversion of isocitrate to alpha-ketoglutarate) while conferring a new enzymatic function

297 tion with the mitochondrial metabolite alpha-ketoglutarate, whose synthesis is regulated by RIP1/RIP3

298 outcomes when comparing histidine-tryptophan-ketoglutarate with either of the University of Wisconsin

299 s a Stetter-like conjugate addition of alpha-ketoglutarate with isochorismate.

300 by Q-derived glutamate is converted to alpha-ketoglutarate with the concomitant conversion of oxaloac