ライフサイエンスコーパス: key

1 olved to improve the perception of formants, key acoustic components of animal calls that encode impo

2 ompounds that match the pharmacophore of the key actin residues of Pfn1-actin interaction and therefo

3 at ambient conditions over large areas, with key advantages over strategies based on liquid phase (fu

4 respectful modeling' framework which has two key aims: (i) respecting the models themselves and facil

5 n-nitrogen bond formation proceeds through a key aminium radical cation intermediate that is generate

6 We discuss how growing understanding of key anatomic sanctuaries for the virus can inform future

7 y stochastic processes.Adelie penguins are a key Antarctic indicator species, but data patchiness has

8 work showed that Unc-104 (a kinesin-3) is a key anterograde DCV motor.

9 cle structure, definition of E dimers as the key antigenic target, and deep understanding of neutrali

10 nB supports Th17 cell identity by regulating key AP-1 complex constituents.

11 he importance of biting midges as vectors, a key area of future research is to establish the impact o

12 Elongation of the body axis is a key aspect of body plan development.

13 built with carbon nanotubes have overlooked key aspects of a practical logic technology and have sta

14 In this review, we highlight the key aspects of the 2016 update with particular importanc

15 This large-scale study investigating key aspects of the PANDAS hypothesis found that individu

16 Increased key BAs were associated with higher grades of steatosis

17 Key behavioral outcomes, including susceptibility, were

18 coexistence and abundance, we assessed four key belowground traits - root diameter, root branching i

19 finding uncovers Vangl2-Dvl interaction as a key bi-functional switch that underlies the central logi

20 d nociceptors revealed oxidative stress as a key biological process.

21 d lincRNA co-expression networks, unraveling key biological processes where lincRNAs might be involve

22 In sum, our data demonstrate that pCRY is a key blue light receptor in Chlamydomonas that is involve

23 Since seedlings represent a key bottleneck in the demographic cycle of trees, effort

24 erebral blood flow and metabolic activity in key brain areas compared with control subjects.

25 Here, we review the key breakthroughs and remaining obstacles to the develop

26 rlining the role of epigenetic regulation of key cardiac transcription regulators.

27 ly hydrolyzed, confirming the TE domain as a key catalytic bottleneck.

28 cycle checkpoint under hypoxia and analyzed key cell cycle related proteins for their potential role

29 ors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts.

30 TP) by oxidative phosphorylation and mediate key cellular processes such as apoptosis.

31 fication and functional maturation remains a key challenge that hampers the routine application of hP

32 cost reduction to $0.20, and is a critical, key challenge.

33 emoval of tritium from nuclear waste are the key challenges in separation of light isotopes.

34 s simple chemical approach addresses several key challenges, such as control over phase purity, unifo

35 Here, we summarize some of the key characteristics of appetite circuits that are emergi

36 These findings provide key clinical and preclinical relevance to the conformati

37 curved membranes are CME hotspots, and that key CME proteins, clathrin and dynamin, show a strong pr

38 dendritic cell (DC) immunoreceptor (DCIR), a key component in DC homeostasis, is required to modulate

39 losses from soil microbial respiration are a key component of global carbon cycling, resulting in the

40 Major Histocompatibility Complex (MHC) is a key component of the adaptive immune system of all verte

41 Airway mucin concentrations may quantitate a key component of the chronic bronchitis pathophysiologic

42 Nanoporous materials are key components in a vast number of applications from ene

43 rom our results reinforces the benefits of 2 key components of the Mediterranean diet (wine and VOO).

44 The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytopl

45 eward-prediction errors that function as the key computational signatures of two distinct classes of

46 cytoskeletal components and demonstrate the key consequences of HIs for the mechanics of pronuclear

47 Optimum surface chemistry is a key consideration to modulate the formation of the serum

48 In this Perspective, we highlight the key contributions of these synthetic approaches and how

49 Neutrophils were recognized as key contributors in early animal models of GN, at a time

50 Despite being key contributors to biogeochemical processes, archaea ar

51 ulation of cellular resource allocation is a key control parameter for synthetic circuit design.

52 of the TNF receptor superfamily (TNFRSF) are key costimulators of T cells during infection, and there

53 Exclusion criteria were missing key data, death sooner than 24 h after the index date, t

54 Thus, this work provides key details into how an EV71 IRES structure adapts to hi

55 Maternal nutritional status is a key determinant of small for gestational age (SGA), but

56 echanical property of the central stalk is a key determinant of the rate of ATP turnover.

57 Key determinants of water scarcity are found to be the c

58 onal design of training and validation sets, key diastereoselectivity outliers were identified.

59 tance and showed increased expression of the key downstream messenger insulin receptor substrate-1 ph

60 Bayesian network analysis revealed key driver genes within these modules.

61 ng in a TH17 immune response with IL-23 as a key driver.

62 This approach allows BA to be linked to the key drivers of fire in the region.

63 creatic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression.

64 enged efforts to link population dynamics to key drivers.

65 utoimmune pathology; however, defining their key effector functions in specific autoimmune diseases r

66 End binding protein 1 (EB1) is a key element in the complex network of protein-protein in

67 ndritic cell-mediated cross-priming, are the key elements.

68 Key eligibility criteria included measurable disease, fa

69 present study we explore the role of AP-2, a key endocytic adaptor protein complex, in the developmen

70 ) and Re-citrate synthase (Ccar_06155) was a key enzyme in its tricarboxylic acid cycle (TCA) pathway

71 Dihydrofolate reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate

72 how that BDV infection induces expression of key enzymes of the kynurenine pathway in brains of newbo

73 try and we provide an overview of one of the key enzymes of the pathway, PHGDH.

74 Here we define three key epochs in the transcriptome dynamics of human retina

75 which a conformational change in BTN3A1 is a key event of pAg sensing that ultimately leads to T cell

76 a biologically universal event, and yet the key events that drive aging are still poorly understood.

77 Furthermore, we discuss key experimental design considerations, including the ch

78 en its central role in formation of sebum, a key factor in acne pathogenesis.

79 Response to stress or external threats is a key factor in mood and anxiety disorder aetiology.

80 This is a key factor in the initiation of vaso-occlusive episodes,

81 e autoimmune regulator (AIRE) protein is the key factor in thymic negative selection of autoreactive

82 hese findings provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage v

83 metabolic COMT capacity for methylation are key factors for high HVAL concentrations.

84 esults identify a novel cross talk between a key family of miRNAs and proapoptotic Bcl-2 proteins in

85 by aberrant transcription factors (TF) is a key feature of cancer, but its global influence on drug

86 ecrosis factor (TNF) receptor signaling is a key feature of various inflammatory disorders.

87 Key features include the first catalytic asymmetric cycl

88 reated a theoretical model that captures the key features of the organ's morphogenesis.

89 The substrate structure incorporates three key features: (a) a bis(4-amino-3-hydroxyphenyl)squarain

90 n was related to population variation in the key female antagonistic trait (spine length, a defence a

91 ate brain connectivity are a transdiagnostic key finding in neurodevelopmental diseases, a characteri

92 One of the key findings of our study is the overall shift toward ex

93 de by highlighting shared themes that may be key for advancing future research in both fields.

94 ansition, suggesting that is most active and key for Bailinggu development.

95 y analyses confirmed coral recruitment to be key for coral persistence.

96 em point-spread function (PSF) serves as the key for encryption and decryption.

97 omechanisms that resist crack propagation is key for the observed leap in mechanical response.

98 acterial growth and survival, since they are key for uptake of nutrients on the one hand, and for def

99 ed by the relative lack of information about key free-living species.

100 The 4H(+)/4e(-) reduction of O2 to water, a key fuel-cell reaction also carried out in biology by ox

101 maize) seed development in order to identify key genes in a complex developmental process.

102 sponge orders, according to similarities in key genes such as 16S rRNA and polyketide synthase genes

103 This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblast

104 A mouse model that recapitulates key histopathological features of human melanomagenesis

105 Exosome based screening of key HPVOPC associated molecules could be beneficial for

106 A key hydrindanone was prepared in three steps and 48% ove

107 aplotype block and the expression pattern of key immune system genes.

108 A key implication of our work is that important nonequilib

109 lar catalyst on the semiconductor surface is key in controlling the selectivity for CO2 reduction ove

110 e has been less well studied, although it is key in the clearance of fungal pathogens.

111 Recent studies have identified key in vivo functions of ADAR enzymes, informing our und

112 ta through a focus group consultation and 19 key informant interviews.

113 Key ingredients (tryptophan and tyrosine) were shown not

114 lf-related and social considerations are two key inputs to the value calculation in both communicator

115 target and SCZ-related deficits and provide key insights into beneficial LoF mutations and potential

116 GEPIA provides key interactive and customizable functions including dif

117 ons that emphasize the role of astrocytes as key intermediaries between peripheral immune events, neu

118 de leading to o-quinodimethane, which is the key intermediate to benzocyclobutene-type products.

119 aches also enable the monitoring of possible key intermediates as an essential prerequisite for propo

120 We observe the key intermediates in the singlet fission process, includ

121 en identified under coupling conditions, are key intermediates, and [Cu(II)(carb)3](-) serves as the

122 ottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate

123 between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and

124 paraginase, yet surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to in

125 that the combination of activity of several key kinases can predict the occurrence of long-lasting f

126 This article highlights key lessons learned during the introduction of inactivat

127 size and performance of the transmitter are key limiting factors.

128 d problems, with an objective of identifying key markers that could be investigated further to determ

129 vior supports social cohesion by providing a key mechanism for minimizing mutual interference.

130 lar degradation pathway and has emerged as a key mechanism of antiviral immunity in metazoans, includ

131 Insulin resistance is a key mediator of obesity-related cardiometabolic disease,

132 1 was regulated by NF-E2-related factor 2, a key mediator of the cellular antioxidant response.

133 Muscle is emerging as a key mediator of this homeostatic control through consump

134 Pancreatic stellate cells (PSCs) are key mediators in the production of this fibrotic stroma,

135 KEY MESSAGE: We have developed a unique male-sterility a

136 KEY MESSAGE: We have identified 39 proteins that interac

137 KEY MESSAGE: We identify proteins that associate with th

138 tests from 1486 rats identified BRaf as the key missing signaling effector in the common synaptic NM

139 nfection increases enzymatic activity of two key MMPs known to be secreted and activated in neuroinfl

140 tructure of the MOB1/NDR2 complex and define key MOB1 residues mediating MOB1's differential binding

141 ous studies indicates the importance of some key model aspects including climatic and temporal variat

142 ere, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expre

143 reveal that CPH1 functions as a hub linking key motor and structural proteins that contain intrinsic

144 e-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer.

145 a pars compacta (SNc) dopamine neurons are a key node in the circuitry that drives addiction and rela

146 As one of the key nodes in the metabolic network, the forkhead transcr

147 al reasoning on the RN causality to identify key-nodes.

148 racting partners, ground neural synchrony in key nonverbal social behaviors, and highlight the role o

149 2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, where

150 elop following random somatic alterations of key oncogenic genes, which are favoured by a number of r

151 in atomic detail, structural models of three key PANS: the hexasome (H2A.H2B).(H3.H4)2, the tetrasome

152 ce for the scientific community highlighting key paradigms of the type I IFN response.

153 strument demonstrate that the integration of key parallelizable components, including the line-focuse

154 ve stress, and mitochondrial dysfunction are key pathophysiological features of insulin resistance an

155 Door-to-needle time (DNT) is a key performance indicator for efficient use of intraveno

156 ge gene clusters that jointly encompass many key phenotypic regulatory Type II MADS-box gene clades (

157 In the retina, delay in up-regulation of key photoreceptor genes underlies delayed outer segment

158 he importance of nucleobase desolvation as a key physical feature that enhances the misreplication of

159 e (Ag NP) exposure, which was dependent upon key physicochemical properties.

160 layer of an electrolyte, which represents a key physicochemical surface property in various fields r

161 CD38 is an ectoenzyme and receptor with key physiological roles.

162 his study demonstrates that PGI2 can reverse key platelet functions after their initial activation an

163 arkedly reduced the activity of NF-kappaB, a key player in muscle inflammation and myogenesis.

164 power of large-scale proteomics to identify key players in liver regeneration and the importance of

165 These signals are potential key players in the activation of bulge melanocyte precur

166 KEY POINTS: A tonically active, muscarinic cholinergic i

167 KEY POINTS: Applications of transcranial direct current

168 KEY POINTS: In lean individuals, 6 weeks of extended mor

169 KEY POINTS: Intracellular pH regulation is vital to neur

170 KEY POINTS: Mammalian cells are frequently exposed to st

171 KEY POINTS: Severe aortic valve diseases are common card

172 KEY POINTS: Synaptic transmission at the endbulb of Held

173 KEY POINTS: The AMPA-type ionotropic glutamate receptors

174 KEY POINTS: Visceral thermoreceptors that modify thermor

175 During this process, key polarity proteins and receptors are recruited to the

176 ken up by plants, CIPK23 appears to occupy a key position in controlling ion balance and ion homeosta

177 STK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gen

178 e electronic structural effects of these two key principal amine compounds imposed by hydrogen bondin

179 r equation, keeping this ratio constant is a key principle for the power scaling of laser-induced fil

180 Sulfidation is a key process for silver nanoparticles released from consu

181 gulating kinase 1 (ASK1) in hepatocytes is a key process in the progression of nonalcoholic steatohep

182 Regulation of aquaporins is a key process of living organisms to counteract sudden osm

183 ins operating in the eukaryotic algal CCM, a key process that drives global carbon fixation.

184 y a few hundreds of protein kinases regulate key processes in human cells, and protein kinases play a

185 idence for the implication of lnc-KDM5D-4 in key processes related to fatty liver and cellular inflam

186 n both canonical and noncanonical autophagy, key processes that control the presentation of antigens

187 Key properties of the calcium signatures are not intuiti

188 therapeutic/theranostic capabilities), their key properties, and critically their likelihood to be cl

189 This obscures answers to key questions, such as how tetrapods attained their trem

190 ions may thus alter metal uptake by blocking key reactive sites.

191 h an Fe-H intermediate is postulated to be a key reactive species.

192 se findings strongly indicate that A2AR is a key receptor for the hypnotic effects of ethanol, and pr

193 a revised model of long-patch BER and a new key regulation point for pathway choice in BER.

194 Beclin 1 (BECN1) is a key regulator of autophagy, a critical catabolic homeost

195 ounding environment has been implicated as a key regulator of cell differentiation, migration, and pr

196 a Hydrolase Domain Containing 5 (ABHD5) is a key regulator of intracellular neutral lipids that has b

197 Apolipoprotein C-III (apoC-III) is a key regulator of lipoprotein metabolism.

198 nce recognizes the beta-arrestin system as a key regulator of not only GPCRs, but also receptor tyros

199 ly, we have found here that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, cau

200 F or knockdown of the expression of NSF, the key regulator of the SNARE system, significantly affecte

201 Several key regulators of ciliogenesis and ciliary signaling are

202 MicroRNAs are key regulators of vascular smooth muscle cells (VSMCs) p

203 leosome and the DNA conformation can provide key regulatory signals.

204 Here, we demonstrate a key requirement for the steroid hormone 20-hydroxyecdyso

205 Only when all the contacts between these key residues are eventually formed can the protein reach

206 ing and protein-protein interactions because key residues are truncated.

207 To identify key residues crucial for MjAgo function, we analysed the

208 Key residues in the polymerase are located in similar po

209 hen constructed two RBDs mutated in multiple key residues in the receptor-binding motif (RBM) of RBD

210 Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emer

211 s two RPA-binding motifs and ascertained the key residues required for these interactions.

212 lar extravasation and diffusive transport as key RF-modulated parameters, with transport being domina

213 nonperfusion of more than 10 DA remains the key risk factor for new vessel development compared to a

214 he Tyr181Cys mutation in HIV-1 RT has been a key roadblock in the discovery of nonnucleoside RT inhib

215 This peroxidase function plays a key role during apoptosis.

216 ng intermediaries (Smads), we demonstrated a key role for ALK2 in the BMP9/BMP10-induced surface expr

217 recognized in ecological studies, reveals a key role for cryptic diversity in structuring communitie

218 Thus, these results demonstrate a key role for HDAC1 in PU.1 gene transcription and, more

219 Emerging evidence implicates a key role for non-mutational drug resistance mechanisms u

220 The IPS plays a key role in attention orienting and may contribute to th

221 h.Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth,

222 ) homotypic interaction motifs (RHIM) play a key role in cell death and inflammatory signalling(1-3).

223 t a model in which this IDR of Med13 plays a key role in controlling a molecular switch that dictates

224 ges in the filter conformation, which play a key role in defining both selectivity and permeation.

225 Calcium plays a key role in determining the specificity of a vast array

226 of contractile cytoskeletal networks plays a key role in force generation, while on the tissue level

227 Friction plays a key role in how ruptures unzip faults in the Earth's cru

228 d/l-Amino acid mixtures play a key role in human physiology and pathology; thus, the in

229 sodium-coupled citrate transporter, plays a key role in importing citrate from the circulation into

230 ity-dependent mechanisms are known to play a key role in learning and memory.

231 cific social information transfer can play a key role in many aspects of animal ecology from foraging

232 g techniques, we now show that NMDARs have a key role in mediating the effect of leptin to modulate b

233 body, including in the brain, where it has a key role in membrane trafficking, vesicle secretion, and

234 findings show that the sigma receptor has a key role in METH dysregulation of dopamine release and d

235 ) genes promote elongation growth and play a key role in PM H(+)-ATPase activation by inhibiting PP2C

236 us of the mammalian hypothalamus and plays a key role in regulating food consumption and energy homeo

237 elson tyrosine-protein kinase 2 (Abl2) has a key role in regulating myofiber length, as a loss of Abl

238 fic transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion

239 igma(70)-holoenzyme (Esigma(70)) and plays a key role in the transcriptional reprogramming upon shift

240 The lymphatic system plays a key role in tissue fluid homeostasis, immune cell traffi

241 up-regulation of Cox-1 expression may play a key role in tissue homeostasis and wound healing during

242 a multi-unit molecular complex that plays a key role in transferring signals from transcriptional re

243 his review article, we will first review the key role of Ca(2+) in normal cardiac function-in particu

244 ysis of these vanadate compounds reveals the key role of VO4 structural motifs and electronic band-ed

245 Hsp70 molecular chaperones play key roles in cellular protein homeostasis by binding to

246 also enriched in the brain, where they play key roles in neuronal development and neurotransmission.

247 ed between mouse and human and known to play key roles in neuronal function.

248 ally chicken, during processing represents a key route of transmission to humans.

249 Here we demonstrate that key RQC activities-Ltn1p-dependent ubiquitination and Rq

250 ssion, sharing positive messages to overcome key rumours, and strengthening community support for vac

251 nterval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; haz

252 l microfluidics to separate E. gracilis by a key shape parameter-cell aspect ratio (AR).

253 The key signal amplification reaction for the checkpoint is

254 sensus nucleotide triplet code constitutes a key signature providing PIC binding specificity in the h

255 he algorithm enables the construction of the key spatial searching data structure in our code, i.e.,

256 the heterogeneous ozonolysis of squalene, a key species in indoor air chemistry.

257 late cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by tr

258 with greater specificity against hRRM1 is a key step in the development of more effective treatments

259 Support is included for the key step in the process, reduction of U(VI) to U(V) .

260 Translation initiation is a key step in the regulation of gene expression.

261 Here, we provide first insight into the key step of MSP-mediated phosphotransfer in a eukaryotic

262 that maintaining structural stability is the key step towards high-voltage operation of layered-catho

263 The synthetic procedure involved two key steps: (1) the reaction of vinyl magnesium bromide w

264 ase (omega-TA) biocatalysts to establish the key stereocentres of these molecules.

265 ibitors of RAGE and concludes by identifying key strategies for future therapeutic intervention.

266 lunteer community mobilizers (VCMs) became a key strategy for interrupting polio transmission in the

267 ce cultivars through increasing biomass is a key strategy to meet rising global food demands.

268 The key structural changes to 1 include bioisosteric replace

269 osecond-long atomistic simulations elucidate key structural differences between monomeric ApoE3 and A

270 Key structural features interacting with KHK were discov

271 Key structural features of the catalysts are analyzed, a

272 deca-2,4,8-triene-7,10-diols, which form the key structural moieties of numerous natural biologically

273 Matriptase-2 (MT2) is a protease and key suppressor of hepatic hepcidin expression and cleave

274 inimum hourly urine output of 0.5 mL/kg is a key target guiding perioperative fluid therapy.

275 sample preparation microdevice establishes a key technology that intended to develop next generation

276 y coupled with tandem MS may render this the key technology to unravel complex glycomes.

277 dentifying the substrates of an E3 holds the key to elucidate its role in cell regulation.

278 the mechanical behavior of materials is the key to fundamental and engineering advances in materials

279 rug pharmacokinetic (PK) characteristics are key to generate an in vivo response, specifically whethe

280 results demonstrate that the G1MDR holds the key to HSPC maintenance and suggest that release from th

281 riation between places and services could be key to identifying targets for interventions to reverse

282 n atomic and molecular chains, which will be key to investigating numerous fundamental issues that th

283 tal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies.

284 T treatments can suppress viral load and are key to preventing transmission to the child.

285 p of capillaries and the renal epithelium is key to renal physiology, but how renal tubules regulate

286 sistance and metastatic dissemination is the key to successful treatment.

287 Key to the chaperone activity is an ATP-induced alloster

288 ribute to population growth rate (lambda) is key to understanding how animal populations will respond

289 ly linking movement behaviors and ecology is key to understanding the adaptive evolution of locomotio

290 Nevertheless, TS8 is key to understanding the potential energy surface; there

291 er canopy photosynthesis rates is one of the keys to increasing future crop production; however, this

292 nsfer of favorable gene clusters controlling key traits during selection breeding in Europe and China

293 irectly targeted Smad4, Hif1a, and Rora, all key transcription factors in the Th17 cell gene-expressi

294 interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell respo

295 between the symbiosis signaling pathway and key transcriptional regulators that direct AM-specific g

296 on CRY1 variant causes reduced expression of key transcriptional targets and lengthens the period of

297 Thus, HRI coordinates 2 key translation-regulation pathways, eIF2alphaP and mTOR

298 e pathogenesis of cancer either by silencing key tumor suppressor genes or by activating oncogenes.

299 Our analysis of the key uncertainties and open questions of and beyond the i

300 This work regulates several key variables of PbS NC assembly (e.g., NC concentration