ライフサイエンスコーパス: key component

1 nals via voltage-gated calcium channels as a key component.

2 ses, the binding specificity of the TCR is a key component.

3 rrors and adverse drug events addressing the key components.

4 tion mediated by NgRs and T-type channels as key components.

5 can be plagued with contaminants and loss of key components.

6 cludes the homeobox genes Hoxa9 and Meis1 as key components.

7 le forms of locomotion, and scratching share key components.

8 ugh gene silencing or chemical inhibition of key components.

9 Based on three key components: 1) environment and patients, 2) the medi

10 Two key components account for this synergy: (i) a self-vacc

11 that the phospholipase Dalpha1 protein is a key component and modulator of the G-protein complex in

12 ts are widely distributed in eukaryotes, but key components are absent in some lineages.

13 Two key components are centrosomes and the spindle assembly

14 o apply also to higher eukaryotes, since the key components are conserved in structure and function t

15 ADAMTS13 is a prime example for such a key component as it cleaves von Willebrand factor multim

16 the histone H4 tail is then identified as a key component by which DNA-sequence, histone modificatio

17 The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytopl

18 We begin this review by discussing key components (cells, electrodes, solvents, and electro

19 We investigated the key components controlling As accumulation and tolerance

20 coverage can be achieved by targeting three key components: demand-side interventions that improve r

21 and theoretical study shows that the missing key component for achieving the experimentally observed

22 The key component for catalytic turnover is the reoxidation

23 s of neutralizing antibodies and represent a key component for immunogen design.

24 Microorganisms are key components for plant biomass breakdown within rumen

25 We then review key components for successful execution of inhaled gene

26 of factors affecting the risk of spread are key components for surveillance planning and resource al

27 The key components for the signaling of stomatal defense and

28 tative RT-PCR analyses (validation set), the key components haptoglobin (HP), cluster of differentiat

29 platform is mainly composed of the following key components: i) internalizing RGD (iRGD) to enhance t

30 new NP platform is composed of the following key components: (i) polyprodrug inner core that can resp

31 ial resistance against a Li metal anode is a key component in all-solid-state Li metal batteries, but

32 A key component in any sex-specific model is the "mating f

33 r spinal repair, and may have potential as a key component in combinatorial strategies for spinal rep

34 Our findings suggest synaptic adhesion as a key component in compulsive behaviors, and show that tar

35 dendritic cell (DC) immunoreceptor (DCIR), a key component in DC homeostasis, is required to modulate

36 ls immunolabeled for tyrosine hydroxylase, a key component in dopamine synthesis.

37 Electrolytes, which are a key component in electrochemical devices, transport ions

38 er resident macrophages and hepatocytes is a key component in liver innate immunity.

39 eraction between a ligand and a protein is a key component in minimizing off-target effects in drug d

40 prion-like behavior of alpha-synuclein is a key component in Parkinson's disease pathogenesis.

41 Since tRNASec is a key component in selenoprotein biosynthesis, its efficie

42 The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing,

43 ilitates translation, has been shown to be a key component in the formation of long-term memory.

44 The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic le

45 Dexamethasone is a key component in the treatment of pediatric acute lympho

46 The other key component in this framework, the query gene signatur

47 g that the increase in HIF2alpha levels is a key component in tumor response to AZA+RA.

48 Nanoporous materials are key components in a vast number of applications from ene

49 of a coordinate set of transcripts encoding key components in cortical, brainstem and spinal axon gu

50 ular mechanisms of cocaine's contribution to key components in HIV pathogenesis and highlights novel

51 implicate intrinsically disordered proteins, key components in mRNP architectures, in the embryonic f

52 However, key components in the assembly of the MAVS mitochondrial

53 Environmental and genetic factors represent key components in the establishment/maintenance of the i

54 ctivity mapping mainly focused on two of the key components in the framework, namely, the reference g

55 e shown that calcineurin Abeta and SORLA are key components in the phosphoregulation of NKCC2.

56 compound extrusion (MATE) transporter, is a key component involved in colibactin activity and transp

57 The key component is a medical wire coated with a multilayer

58 The key component is a multifunctional electrode; light pass

59 The key component is an NTPase protein that cycles between n

60 A key component is the Rubisco-containing pyrenoid that is

61 ermline-encoded residues in contact with the key component, l-rhamnose.

62 simulations indicated hydrogen bonding is a key component leading to propofol-selective binding with

63 ains the binding site for plasmin(ogen), the key component necessary for the rapid and efficient inhi

64 these advances enable our system to host the key components necessary to expand the use of nucleic ac

65 and direct molecular-level information for a key component needed for achieving carbon mass closure o

66 Honokiol is a key component of a medicinal herb, Magnolia bark.

67 for OBOC library screening, and represents a key component of a next-generation distributed small mol

68 y neutralizing antibodies are likely to be a key component of a protective vaccine.

69 alizing antibodies (bnAbs) is likely to be a key component of a successful vaccine response.

70 In this study, we show that Shank3 is a key component of a zinc-sensitive signaling system that

71 ogether, these data suggest that Shank3 is a key component of a zinc-sensitive signaling system, regu

72 Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help

73 Trastuzumab is a key component of adjuvant therapy for stage I to III hum

74 y of the surface is covered with it; it is a key component of all life; its vapour and droplets fill

75 ATG5 is a key component of an E3-like ATG12-ATG5-ATG16 protein com

76 gramming of host cells by F. tularensis is a key component of both inhibition of host defense mechani

77 Quality of life is a key component of cancer care; however, the factors that

78 In plants, L-arabinose (Ara) is a key component of cell wall polymers, glycoproteins, as w

79 ) by dehydrogenase enzymes to form NADH is a key component of cellular metabolism.

80 IFICANCE STATEMENT: Working memory (WM) is a key component of cognition.

81 the present study we conditionally removed a key component of complex IV, protohaem IX farnesyltransf

82 om inside to outside the nest, and is also a key component of division of labour.

83 e hepatitis C virus (HCV) NS5A protein are a key component of effective treatment regimens, but the g

84 Arousal is typically conceived as a key component of emotional response.

85 GINS is a key component of eukaryotic replicative forks and is com

86 at dysregulation of the T cell response is a key component of EVD pathophysiology.

87 Chitin is a key component of fungal cell walls and a potent inducer

88 ether, these data demonstrate that PmtA is a key component of GAS antioxidant defenses and contribute

89 Alternative splicing (AS) is a key component of gene expression programs that drive cel

90 losses from soil microbial respiration are a key component of global carbon cycling, resulting in the

91 Biological invasions are a key component of global change, and understanding the dr

92 and guide responding ("cue detection") is a key component of goal-directed behavior.

93 Adhesion is a key component of hematopoietic stem cell regulation medi

94 eveals that mTORC1-mediated translation is a key component of HH signaling and an important target fo

95 ich comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.

96 t processes, such as recruitment of Rad51 (a key component of homologous recombination) to DSBs, homo

97 Vertebrate gut microbiota form a key component of immunity and a dynamic link between an

98 A key component of influenza virus evolution is antigenic

99 The classical complement cascade, a key component of innate immune pathogen defence, mediate

100 As IRAK1 is a key component of innate immune signaling pathways that a

101 Complement is a key component of innate immunity in health and a powerfu

102 ic insight into how the complement system, a key component of innate immunity, regulates the developm

103 A key component of it is deriving an appropriate backgroun

104 A key component of its apparatus is a dialysis membrane in

105 ibition, highlighting the IRF4/MYC axis as a key component of its mechanism of action.

106 We show here that RNF31, the key component of LUBAC, interacts with LMP1 and IRF7 in

107 Sequence alignment algorithms are a key component of many bioinformatics applications.

108 ative of its clandestine production and is a key component of many modern forensic investigations.

109 in a wide range of functions, including as a key component of membranes, precursor of important molec

110 This pause is a key component of metazoan gene expression regulation.

111 A key component of mitochondrial Ca(2+) signalling is the

112 ne resulted in a depletion of cardiolipin, a key component of mitochondrial membranes, and compromise

113 t numerical seismic wavefield modelling is a key component of modern seismic imaging techniques, such

114 erational hospital safety surveillance and a key component of multifaceted research surveillance, pat

115 e dehydrogenase-6-phosphogluconolactonase, a key component of NADPH synthesis, potently synergizes MB

116 ed IGF1-RIT1-Akt-Sox2 signaling pathway as a key component of neurogenic niche sensing, contributing

117 Tissue inflammation is a key component of obesity-induced insulin resistance, wit

118 Empathy is a key component of our ability to engage and interact with

119 ted carbon (O3/BAC) is being considered as a key component of reverse osmosis-free advanced treatment

120 Here, we tested whether dopamine, a key component of reward-related circuitry, is also impli

121 General transcription factor TFIID is a key component of RNA polymerase II transcription initiat

122 ork identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals

123 In the dentate gyrus - a key component of spatial memory circuits - granule cells

124 ains, defective in sRNAs or in ARGONAUTE3 (a key component of sRNA-mediated gene silencing), did not

125 This study identifies Shank as a key component of synaptic Wnt signaling, defining a nove

126 Myosin II is a key component of the actomyosin ring, although whether i

127 Major Histocompatibility Complex (MHC) is a key component of the adaptive immune system of all verte

128 A key component of the analysis of microbiome datasets is

129 eins, including that of type I interferon, a key component of the antiviral response.

130 Social communication deficits are a key component of the ASD diagnostic criteria, but the un

131 We used mice lacking Abcc8, a key component of the beta-cell KATP-channel, to analyze

132 isoforms, physically interacts with Axin1, a key component of the canonical Wnt pathway.

133 that the redox-sensing function of mNT is a key component of the cellular adaptive response to help

134 n the bed nucleus of the stria terminalis, a key component of the central extended amygdala.

135 Airway mucin concentrations may quantitate a key component of the chronic bronchitis pathophysiologic

136 Intrinsic high-level MDM2 expression is a key component of the cone precursor circuitry and is tho

137 Thus, LHX2 is a key component of the control network for producing neuro

138 line calibration approach can be useful as a key component of the control strategy for continuous man

139 that target the viral polymerase have been a key component of the current HIV-1 combination drug regi

140 lantic water and subsequent convection, is a key component of the deep southward return flow of the A

141 This consensus is a key component of the DNA sequence rules that specify tra

142 acts with Actin-related protein-1 (Arp-1), a key component of the Dynein/Dynactin complex.

143 the long-term impact of CeO2NPs to plants, a key component of the ecosystem, is still not well unders

144 A key component of the eukaryotic cell cycle is the protei

145 Munc18-1 is a key component of the exocytic machinery that controls ne

146 igh-yield method is developed to prepare the key component of the fiber-shaped zinc-air battery, i.e.

147 Interestingly, we identify nicastrin, a key component of the gamma-secretase complex, as a membr

148 ital carbon sources to marine bacteria, is a key component of the global sulfur cycle and effects atm

149 cells in the kidney glomeruli that act as a key component of the glomerular filtration barrier.

150 ized by endocrine cells of the stomach and a key component of the gut-brain axis, is involved in alco

151 HSP70 is a molecular chaperone and a key component of the heat-shock response.

152 receptor (GPCR) superfamily, constituting a key component of the Hedgehog signalling pathway.

153 The endoribonuclease Dicer is a key component of the human RNA interference pathway and

154 We identified the per operon as the key component of the hysteretic switch.

155 RPS caused by mutations in the gene IFT81, a key component of the IFT-B complex essential for anterog

156 In this study we defined the role of ILK, a key component of the IPP complex, in diet-induced muscle

157 Here, we report that METTL14, a key component of the m(6)A methyltransferase complex, is

158 beta2-Microglobulin (beta2m), a key component of the major histocompatibility class I co

159 The VPS35 gene, which encodes a key component of the membrane protein-recycling retromer

160 is greatly enhanced in cells lacking Glo1, a key component of the MG detoxification system.

161 ic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present str

162 ated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (T

163 These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosu

164 SIGNIFICANCE STATEMENT: Pericytes are a key component of the neurovascular unit and are essentia

165 Lamin B1, a key component of the nuclear lamina, plays an important

166 Lamin B1, a key component of the nuclear lamina, plays an important

167 The key component of the nuclear pore complex (NPC) controll

168 We identified Fgf1 signaling as a key component of the overnutrition-induced beta-cell dif

169 se is a multi-domain redox enzyme which is a key component of the P450 mono-oxygenase drug-metabolizi

170 on at the locus encoding microRNA miR-34A, a key component of the p53 regulatory network (adjusted P

171 to inducing anesthesia, propofol activates a key component of the pain pathway, the transient recepto

172 This asymmetric suppression may be a key component of the perceptual losses in amblyopia.

173 to conduct remote palpation, or touching, a key component of the physical exam, remains a major limi

174 n for the Kif13b kinesin in glial cells as a key component of the PI3K/AKT signaling pathway, which c

175 tems responsible for addiction, serving as a key component of the plasticity responsible for relapse

176 ranscriptome analysis, identifies HPAT5 as a key component of the pluripotency network.

177 nterferon-gamma (IFNgamma) was found to be a key component of the protective antibody response.

178 Hsp27, which is pivotal to its function as a key component of the proteostasis network in cells.

179 ependent NADH dehydrogenase (Na(+)-NQR) is a key component of the respiratory chain of diverse prokar

180 sensitivity to negative information may be a key component of the reward-seeking behaviours in behavi

181 neurons in the Drosophila central brain is a key component of the sleep homeostat.

182 SON is a key component of the spliceosomal complex and a critical

183 Identifying and treating LTBI is a key component of the strategy for reducing the burden of

184 A key component of the system is the proteasomal adenosine

185 These results indicate that a key component of the TCR is essential for the developmen

186 GlcNAc residues on WTA were found to be the key component of the varphi11 receptor.

187 As a key component of the vertebrate neuroendocrine system, t

188 signaling caused by partial loss of axin, a key component of the Wnt cascade.

189 improve mitochondrial function by targeting key component of these signalling cascades could represe

190 Here, we report evidence that a key component of this phenotype is variable fate switchi

191 A key component of this structure is a glycoconjugate, the

192 vates RHOA, a small GTPase protein that is a key component of tight junctions and adherens junctions.

193 r-associated fibroblasts (CAFs), which are a key component of tumor microenvironment that provides ne

194 alpha (IRE1alpha), an ER stress sensor, is a key component of UPR.

195 y wavelength-dependent light scattering is a key component of visual communication in nature and acts

196 ping national sodium reduction strategies, a key component of which is a sodium reduction model that

197 Our results demonstrate that the key components of a core metabolic pathway central to en

198 Indeed, specific KLFs represent key components of a cross-regulating pluripotency networ

199 hat the PCC, thalamus, and basal ganglia are key components of a LC-noradrenergic arousal circuit.

200 Mast cells are versatile key components of allergy and inflammation known to resp

201 n the type IV subfamily of P-type ATPases as key components of antiviral RNAi.

202 Caspases are key components of apoptotic pathways.

203 bacterial secretion systems, which represent key components of bacterial pathogenicity.

204 oduced in this report can be used to predict key components of biological networks, with potentially

205 MPA and GABAA receptors, by interacting with key components of both excitatory and inhibitory postsyn

206 a, including alteration in the expression of key components of Ca(2+) handling and mitochondrial meta

207 emplified by 1,1'-bi-2-naphthol (BINOL), are key components of catalysts, natural products and medici

208 ntified sorting nexin-9 (SNX9) and dynamins, key components of clathrin-mediated endocytosis, as bind

209 xpensive, and stable electrode materials are key components of commercially viable electrochemical wa

210 The trajectories and familiality of 3 key components of community functioning--social activity

211 owed by sequencing revealed Irf8 and Gfi1 as key components of counteracting myeloid-gene-regulatory

212 The key components of CRISPR/Cas9 are guide RNAs (gRNAs) whi

213 Bayesian inference model, incorporating the key components of cue combination, causal inference, and

214 sations, and express themselves publicly-all key components of democratic politics-more often than th

215 -derived hydrocarbons, black carbon, and two key components of drilling mud, barium and olefins.

216 pressures provide experimental evidence for key components of eco-evolutionary feedbacks in wild pop

217 guanine nucleotide exchange factor Tiam2 as key components of EphB2 trans-endocytosis, a pathway pre

218 ted fatty acids (PUFA, n-3 fatty acids), the key components of fish and flaxseed oils, are increasing

219 Key components of FMT interventions, which are necessary

220 Collateral branches from axons are key components of functional neural circuits that allow

221 implementation of artificial synapses - the key components of high-performance, analog neuromorphic

222 ated to cohesin and condensin, which are the key components of higher-order chromatin structures.

223 , but bacterial metabolites are likely to be key components of host interactions.

224 e or xenobiotic transport between organs are key components of human metabolism that impact therapeut

225 rstanding of age-related changes that affect key components of immunity, including the effect of agin

226 epcidin or iron loading did not affect other key components of innate immunity, did not indiscriminat

227 Behavioural interactions are key components of interspecific competition between pred

228 Microbial communities are key components of lake ecosystems and play central roles

229 The morphometry of these structures, forming key components of limbic-cortical-striatal-pallidal-thal

230 tis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein sign

231 lating BMP-9 levels were associated with the key components of MetS and IR.

232 We examined the impact of several key components of miRNA stem loops and their flanking se

233 This review summarizes key components of NASH pathogenesis and discusses how in

234 ion and facilitates glutamatergic signaling, key components of opioid tolerance.

235 We discuss the key components of PHM in IBD.

236 vironment for caspase and nuclease activity, key components of programmed cell death.

237 Mutations in key components of protein trafficking and cellular degra

238 ntification and criticality assessments, two key components of Quality by Design.

239 odium chloride cotransporters NKCC2 and NCC (key components of salt reabsorption in the distal renal

240 ons, and topical anesthesia also have become key components of standard treatment.

241 by MAST3 kinase inhibits PP2A and regulates key components of striatal signaling.

242 olve around possibilities and limitations of key components of such sensing platform including bottom

243 nd dynactin complexes separately mediate two key components of T cell-focused secretion, namely trans

244 ssion is caused by an impaired expression of key components of the antigen processing machinery (APM)

245 Our work identifies Oct-TyrR and Wtrw as key components of the astrocytic Ca(2+) signalling machi

246 Chemical probes are key components of the bioimaging toolbox, as they label

247 nctional and structural interactions between key components of the brain circuitry underlying human a

248 FTO led to the altered expression of several key components of the brain derived neurotrophic factor

249 SPDIR is controlled by key components of the cellular genome maintenance machin

250 est that in the presence of C22, one or more key components of the eggshell are inappropriately proce

251 e evidence supporting a relationship between key components of the external exposome in the prenatal

252 ctures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM).

253 recruit the host proteins LAMP-2A and Hsc73, key components of the host protein turnover pathway know

254 NK cells are key components of the immune system because of their rap

255 lity complex class II (MHC-II) molecules are key components of the immune system defense mechanism ag

256 ts that are not pathogenic in the absence of key components of the immune system such as might be fou

257 AMPs are key components of the innate immune system and can prote

258 although natural Abs (NA) and complement are key components of the innate immune system involved in t

259 at a mutation that prolongs the stability of key components of the intracellular clock, the cryptochr

260 Podocytes are key components of the kidney blood filtration barrier, a

261 n cyclization transition state as one of the key components of the large catalytic effect.

262 Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5

263 e and the associated LAMTOR1 phosphoprotein, key components of the lysosomal nutrient sensing (LYNUS)

264 Key components of the mechanism are small RNAs (sRNAs) o

265 rom our results reinforces the benefits of 2 key components of the Mediterranean diet (wine and VOO).

266 Macrophages and T cells are key components of the microenvironment, yet their phenot

267 of nuclear receptors RORalpha and RORgamma, key components of the molecular circadian clock, up-regu

268 tain an advantage from the downregulation of key components of the molecular machinery for necroptosi

269 Inhibition or depletion of key components of the neddylation machinery concomitantl

270 integrity between L-DLPFC and thalamus, two key components of the neuromodulatory network.

271 elated peptide (AgRP)-expressing neurons are key components of the neuronal circuits that control foo

272 We identified three key components of the Notch pathway, Notch1, Notch2, and

273 iated at least in part via interactions with key components of the Notch signaling pathway, and defec

274 omains and that it physically interacts with key components of the nuclear pore complex.

275 tered miRNAs during chlamydial infection are key components of the pathophysiological process of fibr

276 utations of Fig4, Pikfyve or Vac14, encoding key components of the PI(3,5)P2 biosynthetic complex, ea

277 iotensin II receptors AT1R and AT2R serve as key components of the renin-angiotensin-aldosterone syst

278 homolog is suppressed in vivo by mutation of key components of the retromer complex, which mediates r

279 isualize the transcriptional dynamics of two key components of the Rho signaling pathway in living em

280 The key components of the SPIROMICS QCT-LAS along with evide

281 etroelements, spliceosomal introns and other key components of the spliceosome.

282 The two key components of the store-operated calcium release-act

283 alteration during tumorigenesis, but compose key components of the stress response machinery in norma

284 er of this group, inhibits the expression of key components of the vesicular transport machinery, and

285 By determining high-resolution structures of key components of this motor, and characterizing the in

286 thway is linked to major human diseases, and key components of this pathway are targets for therapeut

287 interaction domain of the alpha subunit are key components of this recognition process.

288 The key components of this tool are a magnetoplasmonic nanop

289 MiDs), along with proteasome inhibitors, are key components of treatment regimens for multiple myelom

290 iet, exercise, and behavior modification are key components of treatment.

291 itectures which have the potential to become key components of various quantum devices.

292 sia are executed via the latter pathway, the key components of which remain unknown.

293 This article outlines the key components of WHO's strategy to tackle HIVDR and the

294 a central repressor of light signaling, is a key component required for seedlings to sense the depth

295 ilt a mathematical model while unveiling the key components that contribute to biomaterial-mediated i

296 he archaeal host cell already contained many key components that govern eukaryotic cellular complexit

297 Moreover, the polyyne core is a key component to several natural products.

298 Current definitions of paranoia include two key components: unfounded ideas of harm and the idea tha

299 g the ligandability of a protein target is a key component when defining hit-finding strategies or wh

300 Selective genomic deletion of key components within this module in mice resulted in lo