ライフサイエンスコーパス: key molecule

1 inase (ROP18 and ROP16, respectively) is the key molecule.

2 to future structure-function studies of this key molecule.

3 s elicit pathogenesis and platelet CD40 is a key molecule.

4 "jumpstarted" by the selective activation of key molecules.

5 A key molecule, alpha-gustducin, a primarily taste-specifi

6 idation of distinct neuronal roles played by key molecules already well known to immunologists (e.g.,

7 in imaging technology with probes that image key molecules and molecular based events that are fundam

8 These findings provide insight into key molecules and pathways involved in innate recognitio

9 complex remodelling process, with a focus on key molecules and pathways that might be suitable target

10 es is characterized by altered metabolism of key molecules and regulatory pathways.

11 elegans model should yield new insights into key molecules and their possible implications in parasit

12 3 (IRF3) and nuclear factor (NF)-kB, that is key molecules and transcription factors involved in the

13 Cells in this knot express sets of key molecules, and as such have been proposed to act as

14 ty is associated with selective exclusion of key molecules, and that manipulation of transport can en

15 build a presynaptic terminal has been made, key molecules are recruited to assemble synaptic vesicle

16 A key molecule associated with the IS is protein kinase C

17 d alopecia, we examined expression levels of key molecules associated with hair follicle differentiat

18 of the stress response kinase p38-MAPK, both key molecules associated with ultraviolet radiation derm

19 nteresting implications for the synthesis of key molecules at the threshold of life.

20 le fundamental regulators, such as SOX9, are key molecules both in mice and humans, the way in which

21 onging to the TNF family (BAFF) represents a key molecule by which macrophages and DCs directly regul

22 xp3 and the surface protein CD25 are the two key molecules characterizing Tregs.

23 tor of mitochondrial calcium uniporter, as a key molecule conferring cancer cells with resistance to

24 therapeutic dosing of AE, whereas IGF-1 is a key molecule coupled to gene expression of other molecul

25 eptor interacting protein 3 kinase (RIP3), a key molecule critical for the assembly of the necrosome

26 Genetic knock-down of these key molecules decelerated the proliferation of lymphoma

27 Dishevelled (Dvl) is a key molecule downstream of Fz receptors.

28 creasing evidence have pointed out CD25 as a key molecule during this transdifferentiation process, h

29 ha (P<0.01) and TGF-beta1 (P<0.01) which are key molecules during the onset of pregnancy.

30 During the last year, one key molecule, dystrophin, has been shown to be disrupted

31 Recently, key molecules expressed at the initial-segment synapses

32 ning the GC response in mice have identified key molecules expressed on follicular dendritic cells th

33 f 5hmec in zygotes indicating that TET3 is a key molecule for 5hmec synthesis.

34 Thus, our findings establish IKK-gamma as a key molecule for adapting an oncoprotein-specific signal

35 llular process is still unclear, Beclin 1, a key molecule for autophagy, has been suggested to play a

36 r memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help.

37 id organ homeostasis and identify RANKL as a key molecule for controlling the plasticity of the immun

38 In the retina, dopamine is a key molecule for daytime vision.

39 th 5' AMP-activated protein kinase (AMPK), a key molecule for energy sensing that negatively regulate

40 Cyclin B1 is a key molecule for G2-M-phase transition during the cell c

41 Thus, Bcl-X(L) is a key molecule for hypoxia selection of death resistance.

42 have previously identified fibronectin as a key molecule for incorporation of LTBP1 and TGF-beta int

43 We identified IL-12/IL-23p40, a key molecule for innate immune responses to commensal ba

44 These results identify SOAP as a key molecule for ookinete-to-oocyst differentiation in m

45 d cyclophilin ligand interactor (TACI), is a key molecule for plasma cell maintenance and is required

46 IKKalpha is a key molecule for the activation of the alternative NF-ka

47 These findings implicate sFRP2 as a key molecule for the biogenesis of a superior regenerati

48 Importantly, STING is the key molecule for the systemic baculovirus-induced IFN-I

49 ne (and related phytochelatins) could act as key molecules for ensuring the effective formation of HM

50 iced leader (SL) RNA and the large rRNAs are key molecules for mRNA maturation and protein synthesis,

51 roteins (TRAPs) that have been implicated as key molecules for parasite motility and adhesion onto ho

52 ese results suggest that IRS-1 and IRS-2 are key molecules for the TbetaR-V/LRP-1-mediated growth inh

53 We propose that myosin VI, by removing key molecules from developing hair bundles, is required

54 ts the acquisition of adaptation by removing key molecules from the hair bundle that serve a temporar

55 ing chemical logic to remind how these seven key molecules function as mobile packets of cellular cur

56 These findings have identified HDAC6 as a key molecule gating the effects of acute stress on synap

57 mRNA changes enabled us to predict ZEB1 as a key molecule governed by Galpha12.

58 TRPM7 serves as a key molecule governing cellular Mg(2+) homeostasis in ma

59 s, stem cells and mitochondria interact with key molecules governing genome integrity, 'stemness' and

60 Previously, we identified that key molecules (IL6, CSF2, CCL5, VEGFA, and VEGFC) secret

61 owever, the regulatory role of miRNAs on the key molecules implicated in kidney fibrosis remains poor

62 The expression of key molecules implicated in osteoclastogenesis (NFATc1,

63 ifferences in the expression or induction of key molecules implicated in viral induction of interfero

64 Our results have identified p11 as a key molecule in a specific cell type that regulates stre

65 Hydrogen peroxide (H2O2) is known as a key molecule in a variety of biological processes, as we

66 ol regulatory element-binding protein 2 is a key molecule in aggravating proinflammatory responses in

67 e lectin receptor CLECSF8 (CLEC4D, MCL) as a key molecule in anti-mycobacterial host defense.

68 Hydrogen peroxide (H2O2) is a key molecule in biology.

69 plasticity, and prostaglandin E2 (PGE2) is a key molecule in COX-2-meduated synaptic modification.

70 , PfCRT, was recently demonstrated to be the key molecule in CQ resistance.

71 and degraded poly ADP ribose polymerase-1 (a key molecule in DNA repair and cell survival), leading t

72 tion of poly-ADP ribose polymerase (PARP), a key molecule in DNA repair, led to ovarian cancer patien

73 osure in CD8 T cells, with STAT4 acting as a key molecule in driving optimal antigen-specific respons

74 in gene, Rax, was previously identified as a key molecule in early eye formation in mice and humans.

75 nicotinamide adenine dinucleotide (NAD(+), a key molecule in energy and redox metabolism) decrease wi

76 n vitro and induce the expression of nNOS, a key molecule in gastrointestinal motility regulation.

77 mania spp., the spliced-leader (SL) RNA is a key molecule in gene expression donating its 5'-terminal

78 report that mice deficient in lymphotoxin, a key molecule in gut immunity, were resistant to DIO.

79 ated candidate genes and select one, EGR1, a key molecule in hippocampus-related learning and memory,

80 ld the acyl-NAD adduct which is considered a key molecule in INH action, providing a better understan

81 y endocytic proteins, it is not considered a key molecule in mediating the major forms of endocytosis

82 immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type

83 ported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine bios

84 can be ameliorated by expression of Drp1, a key molecule in mitochondrial fission.

85 the DRGs of diabetic mice at 8 mo of age, a key molecule in pain signaling, and this effect was also

86 We thus identify Sdf1 as a key molecule in pigment pattern formation, adding to the

87 r data suggest that myocardial MDA5 may be a key molecule in protecting the heart from direct viral i

88 These data suggest that ABCA12 is a key molecule in regulating keratinocyte differentiation

89 vator receptor (uPAR) has been shown to be a key molecule in regulating plasminogen-mediated extracel

90 helial growth factor A (VEGFA, rs3025033), a key molecule in retinal angiogenesis.

91 Importantly, PRDI-BF1 is defined as the key molecule in silencing CIITA and thus MHC-II in multi

92 These data strongly suggest that Cas-L is a key molecule in T cell migration induced by the ligation

93 r (DR)-dependent signals, it appears to be a key molecule in TG-regulated mitochondrial events.

94 Par3 therefore emerges as a key molecule in the coupling of the early and late event

95 nsforming growth factor-beta (TGF-beta) as a key molecule in the development and progression of hepat

96 itously expressed cell surface protein and a key molecule in the etiology of Alzheimer disease.

97 ese results demonstrate that galectin-3 is a key molecule in the host defense against pneumococcal in

98 xia-inducible-factor 1alpha (HIF1alpha), the key molecule in the hypoxic response.

99 These data suggest that CD7 is a key molecule in the inflammatory response leading to LPS

100 APPL1 binds to AKT2, a key molecule in the insulin signaling pathway, thereby e

101 Akt is a key molecule in the insulin/insulin-like growth factor s

102 oid protein (Abeta) has been implicated as a key molecule in the neurodegenerative cascades of Alzhei

103 inal development, was studied as a potential key molecule in the pathogenesis of BM.

104 Finally, Jab1 may constitute a key molecule in the pathogenesis of dysmyelinating neuro

105 G protein-coupled receptor (KSHV-GPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma, pl

106 alpha-Synuclein is a key molecule in the pathogenesis of synucleinopathy incl

107 inositol-4,5-bisphosphate (PtdIns-4,5-P2), a key molecule in the phosphoinositide signalling pathway,

108 lted in expression and activation of Akt1, a key molecule in the PI3 kinase signaling pathway.

109 Our study identifies lanosterol as a key molecule in the prevention of lens protein aggregati

110 L-selectin has become established as a key molecule in the recirculation of naive T cells from

111 expression of Lyn, indicating that Lyn is a key molecule in the regulation of BCR-mediated signaling

112 is a G-protein-coupled receptor (GPCR) and a key molecule in the regulation of energy homeostasis.

113 Cardiac troponin (cTn) is a key molecule in the regulation of human cardiac muscle c

114 Nitric oxide (NO) is a key molecule in the regulation of tumor-microenvironment

115 -associated protein of 25 kDa (SNAP-25) is a key molecule in the soluble N-ethylmaleimide-sensitive f

116 f cytokinesis, Plo1p is thus implicated as a key molecule in the spatial and temporal coordination of

117 main-containing adaptor protein (TIRAP) is a key molecule in the TLR4 and 2 signaling.

118 AR signaling and suggest that betaARK1 is a key molecule in the transition of myocardial hypertrophy

119 our data suggest that C5a(desArg) acts as a key molecule in the triggering of local inflammation as

120 ypes in NOD mice and indicate that CCR7 is a key molecule in their development.

121 A key molecule in this immune pathway is the intracellular

122 adenosine triphosphatase (ATPase) ISWI as a key molecule in this process.

123 kin 1 receptor-associated kinase 1(IRAK1), a key molecule in TLR/IL-1R-mediated signaling, is phospho

124 ynthesis of S-adenosylmethionine (AdoMet), a key molecule in transmethylation reactions and polyamine

125 der (SL) RNA, a trans splicing substrate and key molecule in trypanosome mRNA maturation.

126 Taken together, Smac may serve as a key molecule in vivo to selectively reduce the protein l

127 To validate and quantitate the expression of key molecules in a wide range of samples, we have develo

128 helper T cells and actively decreased these key molecules in antigen-activated T(FH) cells.

129 (cysteine-aspartate-specific proteases) are key molecules in apoptosis and require proteolytic remov

130 ctivated protein kinase, that alterations in key molecules in both GLUT4 trafficking and insulin sign

131 The cytokines IL-1 and IL-18 are key molecules in both the innate and the adaptive immune

132 To understand the role of key molecules in determining the strength and nature of

133 Noncoding RNAs (ncRNAs) are emerging as key molecules in human cancer, with the potential to ser

134 summary, this study identifies SREBPs as the key molecules in regulating angiogenesis in response to

135 ogical or genetic inhibition of ROCK1 and 2, key molecules in Rho signaling, resulted in neuroblastom

136 Thus, these cytokines are key molecules in several disease processes.

137 creasingly important to the functionality of key molecules in signaling, cell growth, and cell death.

138 scription initiation sites of genes encoding key molecules in TCR rearrangements.

139 aromatic hydrocarbons (PAHs) are regarded as key molecules in the astrochemical evolution of the inte

140 the intracellular concentrations of several key molecules in the bone formation cascade, we examined

141 ew risk loci could lead to identification of key molecules in the development of Barrett's oesophagus

142 Antibodies are key molecules in the fight against infections.

143 d protein kinase Clambda (PKC-lambda), three key molecules in the insulin-signaling pathway, and was

144 ENU (N-ethyl-N-nitrosourea), have disclosed key molecules in the TLR signaling pathways and helped u

145 ponses is poorly understood, in part because key molecules in this mode of signal transduction, the m

146 habditis elegans have implicated a number of key molecules in this process, including the nutrient-se

147 netic mechanism studies have identified more key molecules (including Osterix, beta-catenin, and soni

148 tial to life because of its role in numerous key molecules, including DNA and RNA; indeed, organisms

149 Prognostic genes are key molecules informative for cancer prognosis and treat

150 ip between sleep and beta-amyloid (Abeta), a key molecule involved in AD pathogenesis.

151 l 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling.

152 t also suppressed the expression of IL-7R, a key molecule involved in controlling intestinal ILC home

153 It was found that STAT3, a key molecule involved in IL-6 signaling, was constitutiv

154 The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) developmen

155 Since NF-kappaB is a key molecule involved in the regulation of several of th

156 Recently, another key molecule involved in this pathway was identified, sc

157 ancer metastasis; therefore, identifying the key molecules involved during this process promises to a

158 Recent studies have highlighted some of the key molecules involved in all of these pathogenic proces

159 to evaluate the expression and activation of key molecules involved in cell survival and proliferatio

160 and ZAP-70 also associated differently with key molecules involved in cytoskeletal and calcium signa

161 temic immunosuppression by downregulation of key molecules involved in DC differentiation and suppres

162 ess has been made in identifying some of the key molecules involved in each of these steps.

163 harmacological inhibition against a panel of key molecules involved in galvanotaxis further revealed

164 Sunitinib, an inhibitor of key molecules involved in neoangiogenesis, has an establ

165 ome biosynthetic aspects of T. cruzi mucins, key molecules involved in parasite protection and virule

166 he brain and thus controls the expression of key molecules involved in receptor signaling and spine m

167 t of NM, and (2) the expression of two other key molecules involved in regulating neuronal [Ca(2+)](i

168 r adapters capable of binding to enzymes and key molecules involved in signal transduction, maintaini

169 However, the key molecules involved in such regulation and the mechan

170 active zone formation and the scaffolding of key molecules involved in SV recycling.

171 Transcriptomics revealed downregulation of key molecules involved in T cell receptor (TCR) signalin

172 NA microarray analysis is starting to reveal key molecules involved in the accumulation of free chole

173 ated in part through increased expression of key molecules involved in the class II MHC pathway via i

174 in the striatum, we suggest that they may be key molecules involved in the expression of the dyskines

175 on on Th17 cells and inhibited expression of key molecules involved in the generation of pathogenic T

176 aken together, these results have identified key molecules involved in the group II mGluR-induced pot

177 Almost all of the key molecules involved in the innate and adaptive immune

178 Genes and protein expression of key molecules involved in the insulin signaling cascade

179 gnaling systems as well as the processing of key molecules involved in the pathology of the disease.

180 In addition, key molecules involved in the TRAIL/DR5 pathway during D

181 s, and progress has been made in identifying key molecules involved in this signaling.

182 wn mechanisms by which ATP and adenosine are key molecules involved in thrombosis by regulating the a

183 mad signaling pathway, and the production of key molecules involved in tissue repair, such as type I

184 e route to the identification of some of the key molecules involved.

185 The data suggest that CDX1 is a key molecule linking etiological agents of BM to the dev

186 Laminin appears to be a key molecule mediating the epithelial-mesenchymal intera

187 results indicate that the OAMB receptor is a key molecule mediating the octopamine's signal for appet

188 monstrating that Nemo-like kinase (NLK) is a key molecule modulating disease toxicity in spinocerebel

189 e forkhead transcription factor, FoxP3, is a key molecule necessary and sufficient for Tregs developm

190 r animal models, have identified some of the key molecules necessary for peripheral innervation and f

191 ed that Meis1 regulates the transcription of key molecules necessary for the endosomal machinery.

192 that RB deficiency altered the expression of key molecules needed for proper cellular organization an

193 ic, stochastic noise in small populations of key molecules (notably, Period mRNA near its daily minim

194 The synthesis of cysteine, the key molecule of any thiol metabolism, has been elucidate

195 One key molecule of T cell activation is the actin-remodelin

196 ylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system.

197 cell death converging at anoikis, including key molecules of interaction such as Beclin 1, reactive

198 nosaialic acids, is thought to be one of the key molecules of signal transduction in mammalian cells.

199 d small interfering RNAs (viRNAs), which are key molecules of the antiviral RNAi response.

200 trate a sex-specific interaction between two key molecules of the human serotonergic system, and sugg

201 for characterizing the interactions between key molecules of the slit diaphragm that control glomeru

202 e of motor neurons in ALS and that targeting key molecules of this cascade may prove to be neuroprote

203 he muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ)

204 to bromodomain, testis-specific (Brdt) as a key molecule participating in chromatin remodeling durin

205 ve response may be determined, in part, by a key molecule, periostin, which maintains the integrity o

206 Tumor-derived PTHrP has emerged as a key molecule playing multiple roles in cachexia, from fa

207 Tumor-derived PTHrP has emerged as a key molecule playing multiple roles in cachexia, from fa

208 The contributions of key molecules predicted to align chromosomes at the cent

209 rtive activity, suggesting that IGF-2 is the key molecule produced by these cells that stimulates HSC

210 proach with the kinase hits identified other key molecules putatively involved in tau phosphorylation

211 AEG-1 might be a key molecule regulating initiation and progression of NA

212 This was spearheaded by the discovery of key molecules regulating body weight homeostasis.

213 However, the key molecules regulating homeostasis in central mammalia

214 MHC class II is a key molecule required for Ag presentation to Th cells, p

215 These findings identify LTBP4 as a key molecule required for the stability of the TGFbeta r

216 Thus, our study has shown that Dcc is a key molecule required for ventral migration of early-bor

217 el was developed to simulate the dynamics of key molecules required for LTP and LTD.

218 Thus, SAP affects expression of key molecules required for T-B cell collaboration by mec

219 Prestin is the key molecule responsible for OHC electromotility.

220 CD14 is a key molecule responsible for the innate host inflammator

221 ype NPCs, suggesting that TSP1 is one of the key molecules responsible for astrocyte-induced neurogen

222 However, the mechanosensory cells and key molecules responsible for sensing the physical prope

223 In this context, CD73 is a key molecule, since via degradation of adenosine monopho

224 apparently result in the down-regulation of key molecules, such as cyclin A, which may be responsibl

225 Key molecules, such as the transduction channel, may be

226 our knowledge, cyclin D3 is identified as a key molecule targeted by autoimmunity that plays a nonre

227 Here we demonstrate that IL-9 is a key molecule that affects differentiation of T(H)17 cell

228 e-acetylglucosaminyltransferase (LARGE) is a key molecule that binds to the N-terminal domain of alph

229 e identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness.

230 Studies were designed to characterize a key molecule that is involved in the dysregulation.

231 ty of cyclic AMP-dependent protein kinase, a key molecule that is known to be involved in L-LTP.

232 S, a member of the CD28 family, represents a key molecule that regulates adaptive responses to foreig

233 Delineation of key molecules that act epigenetically to transduce diver

234 Examination of key molecules that are known to be required for limb dev

235 Recent studies indicate that certain key molecules that are vital for various developmental p

236 were combined with RNA-seq data to identify key molecules that associate with long-term durable self

237 Thus, our study has identified several key molecules that control USP33 degradation within the

238 Identification of key molecules that drive angiogenesis is critical for th

239 istinct microenvironmental niches to provide key molecules that drive innate and adaptive immune resp

240 As key molecules that drive progression and chemoresistance

241 terations in the expression of Fgf8 and Shh, key molecules that establish a signaling center critical

242 y novel components of the pathway, including key molecules that function as positive or negative regu

243 ding proteins profilin and thymosin beta4 as key molecules that localize actin monomers to the leadin

244 pe 2 BBZDR/Wor rats changes in expression of key molecules that make up the nodal and paranodal appar

245 The absence of Msh2 or Mlh1, two key molecules that mediate mismatch repair in eukaryotic

246 ppaB kinase alpha (IKKalpha) and IKKbeta are key molecules that predominantly mediate noncanonical an

247 To address this problem, cyclins-key molecules that regulate cell cycle transition-have b

248 data demonstrate a functional link between 2 key molecules that regulate hypoxia preconditioning and

249 Identifying key molecules that regulate the crosstalk between the im

250 alian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients l

251 Three key molecules that sense nutrients and broadly affect ge

252 ll proliferation and differentiation and are key molecules that target retinoid and retinoic acid rec

253 , phosphorylate and regulate the activity of key molecules that ultimately control the expression of

254 depend on the precise and timely delivery of key molecules throughout life.

255 stence in their hosts while also revealing a key molecule to pursue while devising methods to improve

256 Taken together, we propose that Foxc2 is a key molecule to regulate PAI-1 gene expression.

257 of Trk, identifying Rac GTPase as one of the key molecules whose activity is critical for cell surviv

258 r applicability of this approach for linking key molecules with defined cellular functions in another

259 ion pathways and that, specifically, several key molecules within the mitogen-activated protein kinas