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1 pecific enrichment of signaling pathways and key regulators.
2 elucidating regulatory networks, and finding key regulators.
3 endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important role
7 mmed for short-term responses, and targeting key regulators could promote long-term, tissue-targeted
8 tope tagging of the endogenous protein) as a key regulator for adhesion during gliding motility in th
9 we show that a zinc finger protein, ZIC2, a key regulator for central nervous system development, is
10 AK119 to USP7 and showed that USP7 is also a key regulator for monoubiquitination at H2A Lys-119 as b
11 Recently, it was demonstrated that Vps4, the key regulator for recycling of the ESCRT-III complex, is
12 iating SI in P. rhoeas pollen: PrMPK9-1 is a key regulator for SI in pollen and acts upstream of prog
13 thioredoxin and glutaredoxin systems are the key regulators for hSOD1 aggregation and may play critic
14 ntify ATG-dependent phagocytosis in DCs as a key regulator in driving autoimmune CD4(+) T cell-mediat
16 ing concept in which the gut microbiota is a key regulator in priming the neuroinflammatory response
17 ly, our data show that miR-27 functions as a key regulator in Treg development and function and sugge
18 findings identify F8 and the Tfpi/F3 axis as key regulators in determining thrombosis balance in the
19 tic and mechanistic approach for identifying key regulators in directed differentiation of pluripoten
21 his transcriptional repressor functions as a key regulator involved in maintenance of T cell quiescen
23 lectively, via transcriptional regulation of key regulators NAI1 for ER body formation and MYB51/122
24 We argue that BDNF-ERK1/2 in the mOFC is a key regulator of "online" goal-directed action selection
25 nuclear-encoded transcription factor GLK1, a key regulator of a light-induced transcriptional network
26 tor, high mobility group box 1 (HMGB1), is a key regulator of a range of liver injury conditions and
28 Collectively, these results identify TA as a key regulator of actin-dependent rearward nuclear moveme
29 trolled talin rod domain unfolding acts as a key regulator of adhesion structure and function and con
37 differentiation and plasticity, and NRF1, a key regulator of antioxidant response and mitochondrial
41 tracellular Ca(2+) is widely recognized as a key regulator of autophagy, acting through the modulatio
42 physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the auto
44 ated as an injury-specific kinesin that is a key regulator of axonal growth and regeneration by promo
47 nction of the ubiquitous c-di-GMP network, a key regulator of bacterial social traits associated with
48 t the contribution of CD69 as a nonredundant key regulator of BIC/miR-155-dependent Treg cell develop
49 lt transporters and cytochrome P450 7a1, the key regulator of bile salt synthesis, indicating that el
50 target of rapamycin complex 2 (mTORC2) as a key regulator of bladder cancer cell migration and invas
52 evidence implicates the gut microbiota as a key regulator of brain and behavior, yet it remains to b
56 to unveil the unknown relevance of SOX9 as a key regulator of cardiac fibrosis, pointing to SOX9 as a
58 s indicate that the Cox1 C-terminal end is a key regulator of CcO biogenesis and that it is important
59 ptor-interacting protein kinase 1 (RIPK1), a key regulator of cell death, NF-kappaB, and MAPK signali
60 ounding environment has been implicated as a key regulator of cell differentiation, migration, and pr
61 sociated protein lissencephaly 1 (Lis1) is a key regulator of cell division during stem cell renewal
63 e T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse
68 This study also implies that TRIM32 is a key regulator of cell viability and apoptosis in cardiom
70 The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeosta
71 ytosolic iron regulatory protein 1 (IRP1), a key regulator of cellular iron homeostasis in mammalian
73 egulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as
77 These results demonstrate that vri acts as a key regulator of clock output and suggest that the prima
80 mitotic substrate for the Aurora A kinase, a key regulator of critical mitotic events, like centrosom
84 thylation and active DNA demethylation, is a key regulator of EBV latency type DNA methylation patter
87 t novel non-canonical functions of PLK1 as a key regulator of EMT and cell motility in normal prostat
90 a glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum homeostasis and P
93 discovery of brown adipose tissue (BAT) as a key regulator of energy expenditure has sparked interest
95 nd supporting evidence that mutant TP53 is a key regulator of EOC progression, differentiation, and r
97 Collectively, our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and
100 ity and differential binding of HNF4alpha, a key regulator of expression of various fucosyltransferas
101 roliferator-activated receptor-alpha), and a key regulator of fat metabolism, and 2 downstream genes:
102 tivated receptor-gamma coactivator 1alpha, a key regulator of fatty acid metabolism, and that prolife
103 Together, these findings identify WNT5a as a key regulator of follicle development and gonadotropin r
104 t adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype
106 VPR-1 acts in parallel to Notch signaling, a key regulator of germline stem cell proliferation and di
107 response element binding protein (CREB) is a key regulator of glucose metabolism and synaptic plastic
108 he first to demonstrate that HIF-1alpha is a key regulator of glucose metabolism in skeletal muscle b
109 hese studies uncover a role for vigilin as a key regulator of hepatic Apob translation and demonstrat
112 fy the arginine methyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated
115 nulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is genetically linked
117 ate-binding protein in human platelets and a key regulator of integrin alphaIIbbeta3 outside-in signa
118 a Hydrolase Domain Containing 5 (ABHD5) is a key regulator of intracellular neutral lipids that has b
125 egulator Yes-associated protein 1 (YAP) is a key regulator of liver size, development, and function.
127 phosphorylation of myosin light chain-20, a key regulator of lymphatic muscle contraction, was obser
133 ether, these findings identify miR-31 as the key regulator of MaSC activity and breast tumorigenesis.
134 tinct mechanisms, demonstrating that it is a key regulator of meiotic splicing in S. cerevisiae.
137 Taken together, our findings reveal K14 as a key regulator of metastasis and establish the concept th
142 ily of RNA-binding proteins has emerged as a key regulator of mRNA transport and local translation re
145 nhibition, demonstrating that betagamma is a key regulator of multiple pathways that impact Golgi mor
146 cle mitochondrial redox environment is not a key regulator of muscle fiber atrophy during sarcopenia
147 ulatory factor MyoD has been implicated as a key regulator of myogenesis, and yet there is little inf
148 endent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy
149 human dopamine (DA) transporter (hDAT) is a key regulator of neurotransmission and a target for anti
150 ngs demonstrate a new role for TNFalpha as a key regulator of neutrophil trafficking into and within
152 nce recognizes the beta-arrestin system as a key regulator of not only GPCRs, but also receptor tyros
153 ntegrin and metalloproteinase 10 (ADAM10), a key regulator of Notch signaling, survived into adulthoo
156 dependent and independent of Tpl2 kinase, a key regulator of nuclear factor kappaB1-mediated MAPK ac
158 r activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expre
170 hat target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative ep
171 fferentiation, demonstrating that Runx1 is a key regulator of several genes required for iNKT17 diffe
173 ar signaling pathway is hypothesized to be a key regulator of striatal activity via modulation of syn
175 e of biological processes, including being a key regulator of synaptic vesicle recycling at nerve ter
176 results reveal a critical role for ATF3 as a key regulator of the acinar cell transcriptional respons
177 e mouse, membrane cofactor protein (CD46), a key regulator of the alternative pathway of the compleme
178 ke receptor (TLR) adaptor protein MYD88 as a key regulator of the antiproliferative effects of HDAC i
179 cation of the histone demethylase KDM5A as a key regulator of the bromodomain protein ZMYND8 and NuRD
184 romyces cerevisiae protein kinase Rad53 is a key regulator of the DNA damage checkpoint and uses its
187 is suggests that modifying the activity of a key regulator of the fibrinolytic system, like alpha2-an
191 ve breast cancer (TNBC) cells, (2) acts as a key regulator of the proliferation and viability of TNBC
192 ly, we have found here that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, cau
194 x-sensitive transcription factor that is the key regulator of the response to oxidative and inflammat
195 F or knockdown of the expression of NSF, the key regulator of the SNARE system, significantly affecte
198 cteria, the PhoQ/PhoP signalling system is a key regulator of this antimicrobial peptide defence.
201 identify the transcription factor Runx3 as a key regulator of TRM cell differentiation and homeostasi
202 e identify the pluripotency factor Oct4 as a key regulator of trunk length in vertebrate embryos.
204 entified CCL2 as a novel KIT D816V-dependent key regulator of vascular cell migration and angiogenesi
205 related with significant downregulation of a key regulator of vascular homeostasis, Fli1, whereas TLR
207 show that in pericytes, MyD88 and IRAK4 are key regulators of 2 major injury responses: inflammatory
208 relationship of HPF and HflX and uncover the key regulators of 70S and 100S ribosome homeostasis that
209 ght studies demonstrating that microRNAs are key regulators of allergic inflammation and potential ta
210 ate that microenvironmental interactions are key regulators of AML and that disrupting these signals
212 or of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signal
216 ), collectively referred to as (p)ppGpp, are key regulators of bacterial growth, stress adaptation, p
217 rdered phase-like domains capable of sorting key regulators of BCR activation, and present a minimal,
218 e host microRNAs (miRNAs), which function as key regulators of beta-cell biology, we investigated the
220 between T1 vs T2 bladder cancer to identify key regulators of bladder cancer progression and/or inva
221 wever, brain-derived signals have emerged as key regulators of bone metabolism, although their mechan
223 calcium, actin, Ras, Raf1, PI3K, and JAK as key regulators of cardiac mechano-signaling and characte
224 als some TFs including Egr2 as new candidate key regulators of cardiovascular-associated (CV) genes.
227 cription factors (E2F7 and E2F8) function as key regulators of cell cycle progression and their inact
228 tiapoptotic proteins of the BCL-2 family are key regulators of cell survival and are frequently overe
233 regulation of bridge stability by anillins, key regulators of cytokinetic rings and cytoplasmic brid
236 ong noncoding RNAs (lncRNAs) have emerged as key regulators of diverse cellular processes in mammals
237 Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, altho
240 K) and the homologous yeast SNF1 complex are key regulators of energy metabolism that counteract nutr
246 at GCs increase the transcription of several key regulators of glucose metabolism that contain HREs,
247 folding domain of PAQR11 was associated with key regulators of Golgi compaction and vesicle transport
248 As) are increasingly recognized as potential key regulators of heart development and related diseases
249 ls achieved this effect via the targeting of key regulators of hepatic gluconeogenesis, protein phosp
251 activated macrophages, highlighting them as key regulators of inflammatory response and regenerative
253 ponse, and neprilysin and the STAT family as key regulators of intrinsic remote conditioning for prev
255 nsive human validation, we uncovered several key regulators of metastatic ability, including an actio
258 Moreover, despite the potential for several key regulators of muscle metabolism to explain an incomp
261 est that Lsh exerts epigenetic regulation at key regulators of neural stem cell fate ensuring adequat
262 e-gated CaV1.2 calcium channels (CaV1.2) are key regulators of neuronal excitability, synaptic plasti
263 relied on nicotinic receptor activation and key regulators of NRG3 signaling: (1) release of intrace
264 ntify COMMD1 and an E2F-metabolic pathway as key regulators of osteoclastogenic responses under patho
265 L3), SMXL4, and SMXL5 act as cell-autonomous key regulators of phloem formation in Arabidopsis thalia
266 y coordinating the expression of hundreds of key regulators of photosynthesis, the circadian clock, p
267 N1 (LEC1) and LEC2 transcription factors are key regulators of plant cell totipotency, as ectopic ove
268 190RhoGAP proteins, p190RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential
273 I cGMP-dependent protein kinases (PKGs) are key regulators of smooth muscle tone, cardiac hypertroph
275 lopment but also in synaptic function and as key regulators of synapse formation, synaptic activity,
278 inase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabo
279 These results demonstrate that AtPCP-Bs are key regulators of the hydration 'checkpoint' in establis
280 ing RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularl
282 of Science, Al Jord et al. (2017) show that key regulators of the mitotic cycle are redeployed in di
283 e pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, al
285 ticotrophin releasing hormone (crh) neurons, key regulators of the stress axis, develop abnormally, a
287 ranslational modifications of stressorins as key regulators of their activity and propose that target
292 s (miRNAs) recently have been established as key regulators of transcriptome reprogramming that defin
294 MicroRNAs (miRNAs) have been established as key regulators of various biological processes with poss
296 ced by OA-NO2 Inasmuch as ET-1 is one of the key regulators of vascular tone, we chose to examine in
297 r, nutrients, and signals suggests that some key regulators of vein formation may be genetically redu
299 cytokine and insulin signaling pathways with key regulator STAT3, which was also upregulated in the r
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