ライフサイエンスコーパス: key step

1 zed using a photocyclization reaction as the key step.

2 uses a Sharpless asymmetric epoxidation as a key step.

3 ons with the N-C(O) amide bond cleavage as a key step.

4 arrangement of cyclopentadienone epoxides as key step.

5 l-2-furfural from fructose was found to be a key step.

6 doketones with aldehydes was employed as the key step.

7 yzed homoconjugate addition chemistry in the key step.

8 n intramolecular Diels-Alder reaction as the key step.

9 ng cyclizations via aminoketyl radicals as a key step.

10 the particle class, radiolabeling remains a key step.

11 rom a neutral to a cationic pathway for this key step.

12 d using two successive Heck couplings as the key steps.

13 wo sequential Pd-catalyzed aminations as the key steps.

14 n and cyclopentanone ring cyclization as the key steps.

15 g opening of the resulting hemiacetal as the key steps.

16 wald amination and oxidative homocoupling as key steps.

17 t by ring-closing metathesis reaction as the key steps.

18 sis and a macrocyclic Glaser-Hay coupling as key steps.

19 selective Dieckmann-type macrocyclization as key steps.

20 hesis/enyne ring-rearrangement metathesis as key steps.

21 lective Pictet-Spengler cyclization were the key steps.

22 The synthetic procedure involved two key steps: (1) the reaction of vinyl magnesium bromide w

23 The key step, a ring-closing dienyne metathesis (RCDEYM) rea

24 As a key-step, a chiral auxiliary-mediated Diels-Alder cycloa

25 tis elegans and Ascaris suum have identified key steps and factors involved.

26 o carbon to the ortho carbon was proposed as key steps and verified using quantum mechanics.

27 Key steps are a palladium-catalyzed construction of the

28 Key steps are a totally diastereoselective nucleophilic

29 The key steps are an intramolecular Alder-ene (IMAE) reactio

30 complex and, not surprisingly, many of their key steps are exquisitely regulated by phosphorylation.

31 hesis of goadsporin is reported in which the key steps are the use of rhodium(II)-catalyzed reactions

32 ynthesis of (-)-actinophyllic acid, with the key step being a chiral phosphine-catalyzed [3 + 2] annu

33 of their amino-terminal domains (ATDs) is a key step controlling assembly.

34 e formation of Amadori products (APs) is the key step determining the development of the Maillard rea

35 he adhesion of Streptococcus pneumoniae is a key step during colonization of human respiratory tract

36 ic face of the nuclear pore complex (NPC), a key step during delivery of the viral genome into the nu

37 gioblasts to haemogenic endothelial cells, a key step during haematopoietic specification.

38 tion of skeletal muscle precursor cells is a key step during limb muscle development and depends on t

39 a4beta1-dependent T lymphocyte adhesion is a key step during lymphocyte trafficking.

40 inated polarization of epithelial cells is a key step during morphogenesis that leads to the formatio

41 Crushing is a key step during olive oil extraction.

42 ellular microbial hydrolases is considered a key step during the breakdown of biodegradable polyester

43 ut nonetheless take on such conformations at key steps during amyloid formation.

44 stigated lncRNAs differentially regulated at key steps during human cardiovascular development with a

45 e association of a PSC protocol focused on 3 key steps (early CSC notification based on clinical seve

46 d protonation of ethanol over the furan is a key step facilitating the Diels-Alder and dehydration re

47 This is achieved in two key steps: first, by exciting graphene plasmons within a

48 ed structurally and kinetically, but several key steps following phosphodiester bond formation remain

49 dination reaction has been incorporated as a key step for efficient synthesis of a potent neurokinin

50 bit uterine epithelial cell proliferation, a key step for embryo implantation.

51 orter function in N export from nodules is a key step for enhancing atmospheric N2 fixation and nodul

52 CO2-to-CO+O2 electrochemical splitting is a key step for liquid-fuel production for renewable energy

53 Dereplication represents a key step for rapidly identifying known secondary metabol

54 r spermatogonial differentiation, which is a key step for spermatogenesis.

55 he target nucleic acid sequence represents a key step for the development of sensitive detection prot

56 Results from this study provide a key step for the further investigation of the role of Ca

57 The key step for their efficient construction was the photo-

58 Revascularisation is a key step for tissue regeneration and complete organ engi

59 other microorganisms in the rhizosphere as a key step for understanding nutrient flow processes in mo

60 The time between angiographic key steps for patients who underwent GA and CS was evalu

61 ive and biocompatible material is one of the key steps for the advancement of electrochemical biosens

62 The key steps for the synthesis of corresponding precursors

63 cedures due to loss of optical purity in the key step, i.e., the Barton-Kellogg olefination reaction.

64 hemical engineering point of view with three key steps: i) pretreatment, ii) exfoliation, and iii) se

65 molecular reaction kinetics and represents a key step in a proposed, bimetallic mechanism for copper-

66 A key step in activation is binding of Mediator to Pol II

67 with Pol at defective replication forks is a key step in activation of the S-phase checkpoint.

68 limatic drivers of an ecological system is a key step in assessing its vulnerability to climate chang

69 Therefore, a key step in audiovisual speech perception is deciding wh

70 of Atg9-containing vesicles is considered a key step in autophagosome biogenesis, aided by Atg1 comp

71 dies have emphasized immune suppression as a key step in bacterial pathogenesis.

72 A key step in bioprocess development for monoclonal antibo

73 on of cancer cells to endothelial cells is a key step in cancer metastasis; therefore, identifying th

74 We show that the key step in controlling the velocity of a single kinesin

75 Activation of molecular oxygen is a key step in converting fuels into energy, but there is p

76 d collectively these findings suggest that a key step in deuterostome evolution was the development o

77 A key step in dissemination is bacterial interaction with

78 3' polyadenylation is a key step in eukaryotic mRNA biogenesis.

79 Site-selective protein modification is a key step in facilitating protein functionalization and m

80 ed the effects of ATZ exposure on meiosis, a key step in gametogenesis in mammals.

81 dentify reversal of polycomb repression as a key step in gene activation after injury.

82 J(c) optimization process appears to be the key step in generating this highly desirable microstruct

83 late cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by tr

84 Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients.

85 A key step in initiating BMP signaling is ligand induced p

86 Dispersal is a key step in land plant life cycles, usually via formatio

87 omain with PIP lipids is therefore seen as a key step in localization of Dok7 to the membrane and for

88 A key step in merozoite invasion is the essential binding

89 A key step in metabolomics is to perform accurate relative

90 metabolites in complex mixtures represents a key step in metabolomics.

91 on involving transendothelial migration is a key step in metastatic spread.

92 he inference of species divergence time is a key step in most phylogenetic studies.

93 terminal nitride from coordinated ammonia, a key step in NH3 oxidation.

94 itide-3-kinase-like kinase (PIKK) SMG-1 is a key step in NMD and occurs when SMG-1, its two regulator

95 The key step in our process is the conversion of solution-ph

96 s and their pairwise sequence alignment is a key step in protein comparative modeling.

97 The side-chain prediction is a key step in protein design, protein docking and structur

98 17 and reveals the molecular mechanism for a key step in SAC establishment.

99 orylates G3BP1 was not identified, leaving a key step in stress granule regulation uncharacterized.

100 is reaction, which has been proposed to be a key step in TEMPO-catalyzed synthetic transformations, o

101 Genotype imputation is a key step in the analysis of genome-wide association stud

102 Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the

103 azaguanine (CDG) synthase (QueE) catalyzes a key step in the biosynthesis of 7-deazapurine containing

104 ne and gamma-glutamyl cysteine, which is the key step in the biosynthesis of ergothioneine, an import

105 cosyl residues to xyloglucan side chains - a key step in the biosynthesis of fucosylated sidechains o

106 y structures and functions would have been a key step in the chemical evolution which led to life.

107 This is a key step in the complex exchange of signals between neur

108 ansform with dedicated mother wavelet, was a key step in the correct recognition of the objects.

109 unsymmetrical diaryl-lambda(3)-iodanes is a key step in the developed one-pot two-step method for in

110 n preferences through the two eyes, likely a key step in the development of binocular vision.

111 -like growth factor I (IGF-I) signaling is a key step in the development of cancer or neurodegenerati

112 with greater specificity against hRRM1 is a key step in the development of more effective treatments

113 ic bronchial hyperresponsiveness (NSBH) is a key step in the diagnosis of occupational asthma (OA).

114 cell receptor (TCR) to cognate ligands is a key step in the emergence of adaptive immune responses.

115 Zeb2 activation appears to be a key step in the EMT process.

116 mong cnidarians; the emergence of rods was a key step in the evolution of the vertebrate eye.

117 of the Hh signaling pathway may have been a key step in the evolution of trait thresholds, such as t

118 A key step in the fabrication process is a print-pause-pri

119 nse to intrinsic and extrinsic cues and is a key step in the formation of mature neuronal circuits.

120 Biological carbon fixation is a key step in the global carbon cycle that regulates the a

121 and phytoplankton in the surface ocean is a key step in the global carbon cycle, with almost half of

122 duction of nitrogen (N2) to ammonia (NH3), a key step in the global nitrogen cycle; and the reduction

123 A key step in the HIV-infection process is the fusion of t

124 of an N-vinylindole-2-carboxaldehyde as the key step in the installation of the stereochemical triad

125 B2H5(+) (L=Lewis base) is proposed to be the key step in the intramolecular C-H borylation of tertiar

126 gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 in

127 ng of high-affinity peptides onto MHC I is a key step in the MHC I antigen presentation pathway.

128 e, PLA2 and ENPP6 activities may represent a key step in the mineralization process.

129 environmental regularities might represent a key step in the pathway to psychotic illness.

130 n of the role of this intermediate reveals a key step in the photoswitching mechanism that is essenti

131 ameters to estimate from a given system is a key step in the process of phylogeographic inference and

132 Support is included for the key step in the process, reduction of U(VI) to U(V) .

133 A key step in the proposed mechanisms is a thermodynamical

134 Translation initiation is a key step in the regulation of gene expression.

135 ential role in controlling mRNA stability, a key step in the regulation of gene expression.

136 TET enzymes catalyse a key step in the removal of DNA methylation.

137 holesterol efflux capacity (CEC), which is a key step in the reverse cholesterol transport pathway, i

138 A key step in the synthesis is the asymmetric hydroboratio

139 The key step in the synthesis of 1 and 2 is the reaction of

140 The key step in the synthesis was a Dieckmann-analogous cycl

141 dal total synthesis was developed, where the key step in the synthesis was the selective deposition o

142 The key step in the synthetic sequence is a transition metal

143 ved monocytes into long-lived macrophages, a key step in the viral dissemination strategy.

144 tudy enzymatic hydrolysis of polyesters, the key step in their overall biodegradation process.

145 A key step in these experiments is the cleavage of cross-l

146 The key step in this chromatography-free synthesis is the co

147 A key step in this process is the recognition of the histo

148 version of configuration at phosphorus, is a key step in this process.

149 The modulation of chromatin structure is a key step in transcription regulation in mammalian cells

150 Antibody epitope mapping is a key step in understanding antibody-antigen recognition a

151 acterization of the air/water interface is a key step in understanding fundamental multiphase phenome

152 ses elicited by these stressors represents a key step in understanding potential synergies.

153 Our findings represent a key step in understanding surface spin-orbit band electr

154 icated to the O-O bond formation step as the key step in water oxidation catalysis.

155 Because a key step in Y. pseudotuberculosis internalization is int

156 Our results uncover key steps in C. elegans germline formation and define a

157 ple preparation platform that integrates the key steps in cells to sequence library sample preparatio

158 The key steps in cellular signaling and regulatory pathways

159 The fundamental characterization of the key steps in cross-coupling reactions, including C-C bon

160 x 3D neuroepithelial cysts that recapitulate key steps in early neurogenesis.

161 gs suggest that Plg and Pla regulate several key steps in inflammation resolution, namely, neutrophil

162 Three key steps in meiosis allow diploid organisms to produce

163 o-cell phenotypic heterogeneity may initiate key steps in microbial evolution of drug resistance and

164 f the MutS and MutL protein families perform key steps in mismatch correction.

165 in yeast facilitated the characterization of key steps in Muta1 transposition.

166 onal coactivator with PDZ-binding motif), as key steps in oncogenesis.

167 sformed basal progenitor cells is one of the key steps in prostate tumorigenesis, the mechanisms medi

168 However, key steps in TB pathogenesis remain poorly understood.

169 This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A.

170 Overall, these data identify key steps in the biosynthesis of pyrethrins and demonstr

171 ent, and T cell activation, all of which are key steps in the continuum from allograft insult to chro

172 The purposes of this statement are to review key steps in the development of a meta-analysis and to p

173 at the two distinct structures may represent key steps in the enzymatic activity of ADIPORs.

174 Isomerization and cycloaddition are the key steps in the GB cyclization.

175 Two key steps in the initiation of DNA replication are the a

176 Computational analysis of key steps in the pathway rationalizes the observed react

177 udies providing more accurate information on key steps in the public sector TB cascade and extension

178 ded in an activity-dependent manner and that key steps in this degradative pathway are the activation

179 Key steps in this sequence include a bioinspired oxidati

180 Key steps in this synthesis are the use of a Lewis acid

181 Key steps in vesicle-mediated trafficking include recrui

182 We found that mGluR5 is required for several key steps in wiring up the thalamocortical connections t

183 Key steps include a diastereoselective Pictet-Spengler r

184 Key steps include a Mn(III)-mediated oxidative radical c

185 Key steps include a sterically demanding Buchwald-Hartwi

186 The key steps include carbon-carbon bond formation using an

187 Other key steps include Mislow-Evans rearrangement, cross-meta

188 Novel key steps include the highly regio- and stereoselective

189 The synthesis starts from l-xylose and key steps include the stereospecific introduction of the

190 Key steps include Wittig-Horner olefination of a d-xylof

191 Key steps included (a) a Liebeskind-Srogl cross-coupling

192 functionality was synthesized, in which the key steps included (i) a [2,3]-Wittig rearrangement to p

193 The key steps involve the Diels-Alder cycloaddition of cyclo

194 Key steps involve the use of a new reagent for guanidine

195 The adapted LDS-UA-LLME protocol was the key step involved in the sample preparation, which preco

196 The key step involved the union of boryl aniline 31 with bro

197 Some of the key steps involved in these important cellular processes

198 The key step involves intramolecular 1,4-conjugate addition

199 Mechanistic investigations indicate that the key step involves single-electron-transfer reduction of

200 The key step involves the BF3-mediated electrophilic substit

201 The key step involves the effective removal of two electrons

202 The key step is a bioinspired aldol addition to set the ster

203 quinone structure is described, in which the key step is a regioselective Diels-Alder reaction betwee

204 The key step is allyl cyanate-to-isocyanate rearrangement.

205 The key step is an intramolecular [3 + 2]-cycloaddition reac

206 The key step is postulated to be the first reported examples

207 g a kinetic resolution (KR) procedure as the key step is presented.

208 t fluoxetine using remote hydroxylation as a key step is presented.

209 n the further development of such systems, a key step is the addition of communication between molecu

210 The key step is the generation of allylrhodium(I) species by

211 pose that this proprioception mechanism is a key step leading to growth arrest in the whole sepal in

212 ramolecular direct arylation reaction as the key step, making the overall process potentially scalabl

213 ibe the first cell culture system for VA1, a key step necessary for the study of its ability to cause

214 on of 1,2,3-triazine 4 with enamine 3 as the key step of a concise total synthesis of methoxatin is d

215 fate up-regulated the expression of NCED3, a key step of ABA synthesis, in guard cells.

216 vity between Ti and W and indicates that the key step of alkane metathesis (C-H bond activation follo

217 The key step of all syntheses is a perfluoroalkyl lithium-me

218 mediated C-N coupling reaction, which is the key step of catalytic C-H amidation, was investigated in

219 of zinc oxide (ZnO) nanoparticles (NPs) is a key step of controlling their environmental fate, bioava

220 ds of fructokinases (FRKs) that catalyze the key step of fructose phosphorylation, cytosolic and plas

221 (II)(Xant)Si(II)] ligand are involved in the key step of H2 cleavage and hydrogen transfer to the ole

222 The key step of manufacturing a bioelectrode is the effectiv

223 ated by oxo-iron (IV) species represents the key step of many heme and nonheme O2-activating enzymes.

224 A key step of meiosis is homologous recombination, which p

225 Here, we provide first insight into the key step of MSP-mediated phosphotransfer in a eukaryotic

226 ous NaHCO3, essentially CO2 desorption - the key step of Na2CO3/NaHCO3 based CO2 capture technologies

227 h complete uniformity, especially during the key step of sample incubation.

228 The key step of synthetic sequence was the cyclization of th

229 and -2 elucidates the factors mediating the key step of the dolichol cycle in plant cells which make

230 nt in promoting FANCD2 monoubiquitination, a key step of the Fanconi anemia pathway.

231 cies (alpha-cyano carbanion analogues), is a key step of the mechanism.

232 Furthermore, the key step of the proposed chain reaction, the oxidation o

233 The key step of this approach is an epimerization of C5 by a

234 The key step of this process involves a base-mediated ring o

235 The key step of this short sequence is a [4 + 2]/retro-[4 +

236 A key step of Wnt signaling activation is the recruitment

237 li cultures to gain further insight into the key steps of 2-acetyl-1-pyrroline (2AP) biosynthesis in

238 e [Ru(IV) -OH](-) intermediate is one of the key steps of a single-site mechanism in which all specie

239 The key steps of amidation, alcohol activation, and cyclizat

240 nnate immune checkpoints that participate in key steps of anti-tumoral immunity.

241 standing of the forces that dictate the four key steps of chaperone-client interaction: initial bindi

242 oming HIV-1 replication complexes and affect key steps of infection.

243 epetitive tasks and guides users through the key steps of kinetic analysis: determination of constrai

244 trolled genes, many of which are involved in key steps of metabolism.

245 s, constituting new bright sensors for these key steps of synaptic transmission.

246 nd experimental evidence is provided for the key steps of the catalytic cycle.

247 by the lack of experimental data concerning key steps of the cycle, because these steps can only be

248 Methods to quantitatively characterize these key steps of the metastatic cascade in mammalian models

249 The key steps of the method are 1) initial design of a combi

250 This work reveals that Akt controls several key steps of the PNS myelination.

251 ting section and video material illustrating key steps of the procedure.

252 of a dienolate and a Heck reaction, are the key steps of the reaction sequence.

253 involved in cyst dormancy and hatching, two key steps of their development.

254 Key steps of this process are (i) phosphoinositide-depen

255 istribution along the neuronal membrane is a key step on the way to understanding neural computations

256 Two synthetic strategies to produce the key-step precursor, the investigation and optimization o

257 t the cellular programs responsible for this key step remain unclear.

258 ing to gain a molecular understanding of the key steps required for autophagy.

259 Its key step, Sertoli cell differentiation in the embryonic

260 One key step studying interactions of microplastics with our

261 Alveolar epithelial cell (AEC) injury is a key step that contributes to a profibrotic microenvironm

262 HSV nuclear egress is a key step that determines the outcome of viral infection.

263 As a consequence, the key steps that control the scope of viable substrates an

264 I highlight the key steps that have been taken towards delivering a full

265 ar abundant in lignocellulosic biomass, is a key step to achieve a viable production of second-genera

266 This key step to generate a suitably protected chiral myo-ino

267 The key step to identify the sialylated N-glycans was to qua

268 e the improved temperature responses to be a key step to improve modelling of crops under rising temp

269 One key step to mediate this metabolic adaptation is the sta

270 the Amadori products (APs) formation is the key step to mitigate the Maillard reaction (MR) in milk.

271 A key step to reconstructing signaling networks involves i

272 pecific recognition of signal molecules is a key step to select the symbiotic partner.

273 vestigated in animal models, which will be a key step to translating these findings into clinical pra

274 ach behind the two methods consists of three key steps to check and remove suspected anomalies that d

275 ive ART scale-up and is actively promoting 3 key steps to mitigate the impact of HIVDR: (1) routine a

276 e cyclizations of gamma-amino ketones as the key steps to set the stereochemistry.

277 nce in closely related lineages, providing a key step toward a more mechanistic understanding of the

278 pling to slow IKs deactivation and provide a key step toward developing mechanism-based therapies.

279 In addition, our findings represent a key step toward engineering a pyrenoid into crops to enh

280 en in "proto-Kranz" species, and, as such, a key step toward engineering C4 rice has been achieved.

281 Alcohol tolerance is a key step toward escalating alcohol consumption and subse

282 prevalence of drug-resistant mutations is a key step toward generating more effective therapeutics.

283 in any given immunological interaction is a key step toward integrating immunology with organ physio

284 t of economic water oxidation catalysts is a key step toward large-scale water splitting.

285 particular interest; as such an ability is a key step toward the development of artificial sensors, r

286 th mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposu

287 related to hydroformylation and represents a key step toward the rational design of new heterogeneous

288 d characterizing RBP binding preferences are key steps toward understanding the basic mechanisms of t

289 sensitivity to specific threats is likely a key step towards a better understanding of species respo

290 Universal health coverage is a key step towards achieving the right care.

291 This represents a key step towards developing a robust hybridization platf

292 that maintaining structural stability is the key step towards high-voltage operation of layered-catho

293 Our method represents a key step towards reliable modeling of complex, real-worl

294 This work may represent a key step towards scalable production of high-performance

295 These results represent a key step towards the integration of low-dimensional mate

296 n response to environmental variability is a key step towards understanding if and how microbial euka

297 he design of acoustic devices and provides a key-step towards realizing spatial sound modulators.

298 The key step utilizes a novel intermolecular [4+2] cycloaddi

299 The key step was an unprecedented NaBH4-promoted one-pot red

300 Key steps were a palladium-catalyzed C(sp3)X-C(sp3)ZnX N