ライフサイエンスコーパス: keyhole

1 Postcontrast keyhole and half-Fourier images were formed from the sam

2 The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding si

3 The nESI source incorporates a keyhole geometry ion funnel design which facilitates axi

4 ctylus punctatus), trematode parasites for a keyhole limpet (Fissurella latimarginata), and pinnother

5 Here, the unmineralized teeth of the giant keyhole limpet (Megathura crenulata) are shown to attain

6 for 19 species of the genus Haliotis plus a keyhole limpet and a more distantly related gastropod, t

7 xed with 150 mug GM-CSF) or control (100 mug keyhole limpet haemocyanin) via monthly intradermal inje

8 f an EGFRvIII-specific peptide conjugated to keyhole limpet haemocyanin.

9 -dependent antigen, 2,4-dinitrophenyl hapten-keyhole limpet hemocyanin (DNP(23)-KLH).

10 then conjugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV IC

11 ing of Id to the immunogenic carrier protein keyhole limpet hemocyanin (Id-KLH).

12 TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injecte

13 B7RP-1-Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH

14 ) followed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuva

15 unoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with gr

16 This GM2 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid

17 The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT),

18 e to immunization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid

19 al, anti-idiotypic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given w

20 ell as influenza matrix peptide (Flu-MP) and keyhole limpet hemocyanin (KLH) as control antigens.

21 Subjects were fed keyhole limpet hemocyanin (KLH) before subcutaneous immu

22 ts immunogenicity, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-

23 hat antibodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reac

24 ssful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein complete

25 nthesis and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through

26 constant regions plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were inc

27 To solve this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series o

28 soluble Delta71-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced

29 Volunteers were immunized with keyhole limpet hemocyanin (KLH) first orally and then pa

30 mor cell lysates and the immunogenic protein keyhole limpet hemocyanin (KLH) for 24 h and then combin

31 d, chemically synthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immuno

32 e C6 position (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of

33 ective antitumor immunity induced by s.c. Id-keyhole limpet hemocyanin (KLH) immunization.

34 n with 2,4,6-trinitrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-f

35 immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine se

36 ulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects.

37 Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated

38 econd-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine

39 (MyVax), comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macroph

40 rotein conjugated to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor

41 on of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunoge

42 igenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease i

43 in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-ind

44 re, the compounds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the

45 was manufactured and covalently linked with keyhole limpet hemocyanin (KLH) to generate Id/KLH.

46 d to the immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has

47 Keyhole limpet hemocyanin (KLH) was beneficial in earlie

48 o the peptides and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by th

49 different linker methods, to protein carrier keyhole limpet hemocyanin (KLH) were studied in mice.

50 d with peptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde deve

51 T-independent (TNP-LPS) or T-dependent (TNP-keyhole limpet hemocyanin (KLH)) Ag.

52 Following challenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these

53 u-His-Gly) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KL

54 Rats were immunized with keyhole limpet hemocyanin (KLH), and blood samples were

55 ponse against an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in th

56 er the addition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficac

57 were gavaged with a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immuni

58 he globo H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical ev

59 followed 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive res

60 in the primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitut

61 nti-idiotypic mAb immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus

62 However, keyhole limpet hemocyanin (KLH)-priming of IFN-gko mice

63 c mice were cocultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone)

64 MoPn), a nonprotective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific cell line (KLH-

65 usly with ovalbumin and a secondary antigen, keyhole limpet hemocyanin (KLH).

66 ere immunized with ovalbumin peptide or with keyhole limpet hemocyanin (KLH).

67 rotein conjugate, 2,4,6-trinitrophenyl (TNP)-keyhole limpet hemocyanin (KLH).

68 in mice 24 to 48 h before immunization with keyhole limpet hemocyanin (KLH).

69 c IgY production following immunization with keyhole limpet hemocyanin (KLH).

70 b, 2C10, or vehicle before immunization with keyhole limpet hemocyanin (KLH).

71 ed with recombinant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer

72 ith 4-hydroxy-3-nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with

73 e response to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops w

74 hydroxy-3-nitrophenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337)

75 se in mice primed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH).

76 Intratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generate

77 ubjected to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibit

78 Inhibition of anti-keyhole limpet hemocyanin Ab response was dose-dependent

79 immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hy

80 rvivors mounted a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L

81 Moreover, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase

82 es to alloantigen and secondary responses to keyhole limpet hemocyanin Ag.

83 ar versus vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (G

84 latimarginata hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin,

85 CD4+ T cell sensitization to keyhole limpet hemocyanin and CD8+ T cell sensitization

86 gainst 3-hydroxykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OH

87 he immune responses to two soluble proteins, keyhole limpet hemocyanin and chicken egg albumin.

88 ne consisting of tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunolog

89 Th2 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal

90 ations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-re

91 ation to two different immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-b

92 sed humoral responses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag

93 so inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicat

94 In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine

95 impet hemocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent A

96 domain of VlsE was conjugated to the carrier keyhole limpet hemocyanin and used to immunize mice.

97 sorbent assay and immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhib

98 al responses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wil

99 Abs were induced after immunization with PC-keyhole limpet hemocyanin but at significantly lower lev

100 8+ alloreactive CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of all

101 cious vaccine, MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequ

102 to mice immunized with the native 38C13 IgM-keyhole limpet hemocyanin conjugate vaccine.

103 vaccines (MH2[R], MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine.

104 Mice vaccinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease

105 nd immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologi

106 Mice immunized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1

107 LS (SagA) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits t

108 ation of naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humo

109 h 8 injections using the standard therapy of keyhole limpet hemocyanin Id + GM-CSF.

110 40L mRNA, antigen-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+)

111 ncreased numbers of Th1 cells in response to keyhole limpet hemocyanin immunization.

112 Ficoll and in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall resp

113 timulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with

114 After immunization with OVA or keyhole limpet hemocyanin in CFA, NK cell-deficient (NK-

115 , 1,000-, or 100,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant i

116 Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated tha

117 Antibodies were raised by using keyhole limpet hemocyanin modified in vitro by 4-hydroxy

118 concurrent with a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by

119 nd that loading immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency viru

120 concurrent, secondary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippos

121 -dependent (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) ke

122 lls from normal and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminis

123 ed toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA.

124 nd we have prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS

125 ed from the original tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain v

126 g rabbits with an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide

127 Furthermore, CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced prolifera

128 ccinated with peptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary e

129 yl) form of ghrelin as compared with Ghr2 or keyhole limpet hemocyanin vaccinated controls.

130 y, delayed-type hypersensitivity response to keyhole limpet hemocyanin was diminished.

131 munogenicity of coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both Ig

132 specific Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased fo

133 of FDC networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day pe

134 roduction of high-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even a

135 hesion to CR3 counterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect ad

136 (bacteriophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction

137 nd proliferative response to recall antigen (keyhole limpet hemocyanin) were normal.

138 on of humoral immunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-depend

139 ella latimarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal ma

140 Ag (keyhole limpet hemocyanin)-specific Th1/Th2 responses of

141 ed pulp by day 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clu

142 ccharide has been synthesized, conjugated to keyhole limpet hemocyanin, and administered with the imm

143 immunized with caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody tech

144 These peptides were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit an

145 o the model Ag 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produc

146 es isolated from plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-imm

147 result, when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce signif

148 When immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1

149 Immunization with DNP-keyhole limpet hemocyanin, heat-killed Brucella abortus,

150 the Ab response to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was fo

151 Imaging of DNA, keyhole limpet hemocyanin, mouse monoclonal IgG, and glu

152 , IgM response to Pneumovax, IgG response to keyhole limpet hemocyanin, or cytokine response to LPS).

153 T-dependent Ag, phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a

154 pulsing DCs with the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral deliver

155 Following vaccination with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral res

156 After immunization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolate

157 d primary response to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severel

158 mary allergic sensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human

159 ndent neoantigens, bacteriophage phiX174 and keyhole limpet hemocyanin, was also evaluated.

160 ing two recombinant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from un

161 decarboxylase (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(n

162 ystemically administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were

163 man apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-

164 of B7-H1Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation

165 ient in Mac-1 were defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated ph

166 sotypes distinct from those generated by the keyhole limpet hemocyanin-epitope conjugates.

167 nced proliferation and cytokine secretion by keyhole limpet hemocyanin-experienced CD4(+) T cells.

168 onor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy co

169 MR-1 in various preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloanti

170 Guinea pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding

171 VA-immunized mice, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersen

172 f concanavalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of sple

173 tion with LPS or upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in th

174 3 to 24 h of incubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S

175 mice that were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitr

176 The sera raised against keyhole limpet hemocyanin-SV1 hapten, showed binding val

177 n with a thymus-dependent Ag, phosphocholine-keyhole limpet hemocyanin.

178 single ascending dose groups challenged with keyhole limpet hemocyanin.

179 following immunization of male SJL mice with keyhole limpet hemocyanin.

180 eptides was increased by conjugating them to keyhole limpet hemocyanin.

181 uptake using FITC-labeled tetanus, OVA, and keyhole limpet hemocyanin.

182 tion, including host-restricted responses to keyhole limpet hemocyanin.

183 monas exotoxin A, as well as to the model Ag keyhole limpet hemocyanin.

184 cell response against 2,4,6 trinitro-phenyl-keyhole limpet hemocyanin.

185 an isotype-matched control Ig, conjugated to keyhole limpet hemocyanin.

186 otetraose, or to oligosaccharides present on keyhole limpet hemocyanin.

187 zation with the T cell-dependent (TD) Ag DNP-keyhole limpet hemocyanin.

188 ice were similar after immunization with DNP-keyhole limpet hemocyanin.

189 coll and to the T cell-dependent antigen TNP-keyhole limpet hemocyanin.

190 s immunized with UO(2)(2+)-DCP conjugated to keyhole limpet hemocyanin.

191 ing of lymphoma immunoglobulin conjugated to keyhole limpet hemocyanin.

192 n a mammalian cell and chemically coupled to keyhole limpet hemocyanin.

193 Cys-27-NH2 as a hapten, conjugated to BSA or keyhole limpet hemocyanin.

194 that had been immunized with trinitrophenyl-keyhole limpet hemocyanin.

195 bits (27- to 81-fold) after conjugation with keyhole limpet hemocyanin.

196 strong suppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasi

197 er, pulsing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags

198 nd linked GH to a carrier protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reac

199 ith the phase III clinical trial vaccine, GH-keyhole limpet hemocyanion/QS21, the GH-DT/C34 vaccine e

200 GNE-KLH (keyhole limpet hemocyannin) was found to elicit persiste

201 st as much as the more obvious outgroup, the keyhole limpet, an observation common to other DNA seque

202 Focusing on keyhole limpets, genera Fissurella and Diodora from Cape

203 Within the three cell type cluster complex, keyhole limpit hemocyanin or tetanus toxoid-reactive Th

204 Both keyhole lymphet hemocyanin conjugates induced IgM and Ig

205 these constructs as free glycopeptides or as keyhole lymphet hemocyanin conjugates.

206 ses to NP-KLH (4-hydroxy-3-nitrophenylacetyl/keyhole lymphocyte hemocyanin) immunization.

207 y of the full-Fourier image, whereas the 50% keyhole method degraded the spatial resolution by a fact

208 In particular, the keyhole pore formation is experimentally revealed with h

209 aker technique had less recurrences than the keyhole technique (OR 2.3, 95% CI 1.2-4.6; P = 0.016).

210 iled gradient-recalled-echo imaging with the keyhole technique during the administration of 0.1 mmol/

211 he Sugarbaker technique is superior over the keyhole technique showing fewer recurrences.

212 leoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening.