ライフサイエンスコーパス: kidney

1 or the deposits of IgG and complement in the kidney.

2 dentified with pepcan-12 in brain, liver and kidney.

3 n the developing eye, neural tube, brain and kidney.

4 enal cell carcinoma in patient with solitary kidney.

5 s in cerebellum, skeletal muscle, thymus and kidney.

6 ered in adult WT and KO mouse brain, SC, and kidneys.

7 nd rapidly excretes smaller ones through the kidneys.

8 y by 12 weeks and 39% retained parts of both kidneys.

9 th and without in vivo knockdown of TRPC6 in kidneys.

10 utcomes in recipients of single and dual ECD kidneys.

11 of Henle nephron segments in mutant DeltaSRM kidneys.

12 minutes had survival similar to that of NBD kidneys.

13 ssue lipids in control and cisplatin-treated kidneys.

14 imited because of the scarce availability of kidneys.

15 d to the observed accumulation of ECM in the kidneys.

16 (TNF-alpha)/interleukin-6 (IL-6) in infected kidneys.

17 ith ITP resulted in 49 organ transplants (31 kidney, 14 liver, four heart), with only one case of TMA

18 There were 11 219 kidneys (1869 [17%] with AKI) included.

19 tical tissue (185 muSv/MBq), followed by the kidneys (23 muSv/MBq).

20 Transient transfection of human embryonic kidney 293 cells with this reporter vector increased luc

21 We excluded donors with anatomical kidney abnormalities.

22 to determine AKI status or severe congenital kidney abnormalities.

23 LSKO mice also displayed decreased liver and kidney activity of the Mn-dependent enzyme arginase.

24 uture studies will explore methods to reduce kidney activity retention and further increase tumor upt

25 Kidney AE1 (kAE1), PDLIM5 and integrin-linked kinase (IL

26 d genes NLRP3 and IL-1beta in Nrf2-deficient kidneys after UUO.

27 itization for allocation of points in the US Kidney Allocation System and Eurotransplant.

28 iated rejection (ABMR) is a leading cause of kidney allograft failure.

29 The adjusted 10-year mean kidney allograft lifespan was higher in Ki/SPK compared

30 lower risk for posttransplant malignancy in kidney allograft recipients with negative pretransplant

31 n gene expression atlas of the newborn mouse kidney, an interesting time in development when mature n

32 40-60 min and rapid clearance from blood to kidney and bladder.

33 ells significantly reduced whole body, lung, kidney and liver metastases in an experimental metastase

34 ation of the renin-angiotensin system in the kidney and mitogen-activated protein kinase signaling in

35 yzed recipients of simultaneous pancreas and kidney and pancreas after kidney transplants between Jan

36 he obesity-induced lipid accumulation in the kidney and renal dysfunction, injury, inflammation, and

37 lved in gluconeogenesis in the liver and the kidney and significantly improved the survival of mice w

38 diverge from those of RAS stimulation in the kidney and vasculature.

39 leen, with rapid blood clearance through the kidneys and bladder.

40 rapidly cleared from all other organs except kidneys and liver.

41 e counted all individual glomeruli in murine kidneys and sized the capillary tufts by combining in vi

42 anomalies affecting either the upper tract (kidneys and ureters) or lower tract (reproductive organs

43 FILNC1 is specifically expressed in kidney, and is downregulated in renal cell carcinoma; al

44 tissues, female reproductive tract tissues, kidney, and liver, potentially emulating key features of

45 ng innate lymphoid cells (ILC2) in blood and kidneys, and adoptive transfer of ILC2 also protected mi

46 icrometastases in the liver, lung, pancreas, kidneys, and bone, that have disseminated from the prima

47 ion and activity are decreased versus normal kidney; and poor patient outcome associates with lower e

48 Most DCD kidneys are from controlled DCD (cDCD; Maastricht catego

49 ice both responded with reduced body weight, kidney atrophy, hyperphosphatemia, and increased bone tu

50 an-ketoglutarate solution (SCS), followed by kidney autotransplantation.

51 ium:phosphate ratio than barley bran and red kidney beans.

52 thin the gene expression profiles from whole kidney biopsies of patients with SLE.

53 s performed to assess the presence of RNS in kidney biopsies.

54 ntensified immunosuppression (IIS), 1155 had kidney biopsy results, and 212 had an established geneti

55 Finally, immunostaining in kidney biopsy specimens demonstrated overexpression of S

56 li and proximal tubules from 98 human needle kidney biopsy specimens for microRNA expression analysis

57 Patients with functional kidney but failed pancreas allografts after 90 days were

58 derstandings of the nano-bio interactions in kidneys but also offer a new pathway to noninvasively im

59 definitive surgical treatment in at least 1 kidney by 12 weeks and 39% retained parts of both kidney

60 ubstrate) as a potential target molecule for kidney cancer.

61 ages at diagnosis of oral cavity/pharynx and kidney cancers, possibly reflecting accelerated cancer p

62 ratory disease, and lung, skin, bladder, and kidney cancers.

63 markers following transplantation under the kidney capsule of immunocompromised mice.

64 nephrologists for the growing challenges of kidney care.

65 However, by utilizing the human embryonic kidney cell line HEK293T, it was possible to demonstrate

66 f DNA replication in HEK293T human embryonic kidney cells.

67 a synthetic gene circuit integrated in human kidney cells.

68 Kidney collecting system development requires integrin-d

69 ,424 single cells from postnatal day 1 mouse kidneys, comparing the results of the psychrophilic prot

70 ation in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the

71 cs and phosphoproteomics of freshly isolated kidney cortex identified either reduced expression or lo

72 KRD11, and TNRC18 map to active enhancers in kidney cortex.

73 d show concordant DNA methylation changes in kidney cortex.

74 ht kidney was slightly enlarged and the left kidney could not be localized.

75 nal centers and mitigated the development of kidney damage and rapid mortality in SLE mice.

76 proves kidney energy metabolism and prevents kidney damage.

77 Using paired DCD kidney data from the Australia and New Zealand Dialysis

78 ain injury, ischemia-reperfusion injury, and kidney degeneration in mammals and is also implicated in

79 BX1), a gene known to have a crucial role in kidney development.

80 veral important predictors of deceased donor kidney discard.

81 patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested.

82 The patient with chronic kidney disease (CKD) represents an extreme model for art

83 ffecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause.

84 lent in dialysis-naive patients with chronic kidney disease (CKD).

85 nsion (control) or with hypertensive chronic kidney disease (CKD).

86 oint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eG

87 ominantly with the second Ig-like polycystic kidney disease (PKD) repeat domain (PKD2) present in the

88 Uromodulin-associated kidney disease (UAKD) is caused by mutations in the urom

89 F23) increase early during acute and chronic kidney disease and are associated with adverse outcomes.

90 ctive study of 899 African American Study of Kidney Disease and Hypertension (AASK) and 761 Modificat

91 ts enrolled in the African American Study of Kidney Disease and Hypertension (AASK) Cohort Study who

92 lymphoproliferation, and significant chronic kidney disease and requiring long-term immunosuppressive

93 ase (AD) associated with their long-standing kidney disease and/or neurotoxic immunosuppressant agent

94 Most forms of chronic, progressive kidney disease are characterized by fibrosis whereby the

95 atients treated, 2250 patients had prevalent kidney disease at baseline, of whom 67% had a diagnosis

96 NTERPRETATION: Even mild-to-moderate chronic kidney disease conferred increased risk of incident peri

97 In conclusion, patients with kidney disease have olfactory deficits that may influenc

98 5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycem

99 Treatment for end-stage kidney disease is a major economic challenge and a publi

100 Some evidence suggests that chronic kidney disease is a risk factor for lower-extremity peri

101 e to reduce the dose in patients with severe kidney disease may increase bleeding risk, whereas dose

102 ay a pivotal role in inflammation in a mouse kidney disease model.

103 Patients with underlying kidney disease or abnormal serum creatinine levels on ho

104 ar K(+) loss and cytotoxicity does not drive kidney disease progression.

105 ge in patient-reported overall health on the Kidney Disease Quality of Life Survey (median score, 0 i

106 Kidney disease severity varies considerably and accurate

107 the development and progression of diabetic kidney disease than placebo.

108 Advanced chronic kidney disease was defined by a sustained reduction in e

109 All-cause death and incident chronic kidney disease were secondary outcomes.

110 ned risk of developing chronic and end-stage kidney disease, an association that is largely attribute

111 -cardiac variables (body-mass index, chronic kidney disease, and chronic obstructive pulmonary diseas

112 hypertension, leg ulcers, priapism, chronic kidney disease, and large-artery ischemic stroke.

113 I was associated with development of chronic kidney disease, conversion to chronic dialysis, hospital

114 r requirement, thrombocytopenia, preexisting kidney disease, failed ventilator liberation, and acute

115 In end-stage chronic kidney disease, the option of organ transplantation is l

116 ablished cardiovascular disease, and chronic kidney disease.

117 get for the treatment of fibrosis in chronic kidney disease.

118 r frequency influencing the risk of diabetic kidney disease.

119 bnormalities including patients with chronic kidney disease.

120 iovascular risk factors, stroke, and chronic kidney disease.

121 BTBR Lep(ob) mice exhibited diabetic kidney disease.

122 ncreatic neoplasia, and 1 case of polycystic kidney disease.

123 rotein causing autosomal dominant polycystic kidney disease.

124 hich intravital FLIM can be applied to study kidney diseases and metabolism.

125 ression of ShcA in several human proteinuric kidney diseases compared with normal conditions.

126 riants in the APOL1 gene are associated with kidney diseases in African ancestral populations; yet, t

127 ent knowledge of medical outcomes after live kidney donation necessary to support donor candidates in

128 We surveyed 51 living kidney donors (LKDs) who donated from 01/2015 to 3/2016

129 ed risk of ESRD has been reported for living kidney donors, and appears to be higher for those donati

130 a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD)

131 o offer a new pathway to noninvasively image kidney dysfunction and local injuries at the anatomical

132 vascular hemodynamics recovery, and limiting kidney dysfunction in a vasopressinergic-dependent manne

133 ity), incidence of osteonecrosis of the jaw, kidney dysfunction, skeletal morbidity rate (mean number

134 the induction of a myokine, irisin, improves kidney energy metabolism and prevents kidney damage.

135 Treatment of rat kidney epithelial cells (NRK-52E) with the mitochondrial

136 mbryonic kidney), Vero (African-green monkey kidney epithelial), 3T12 (mouse fibroblast), and RAW 264

137 obligation that the organization has to the kidney exchange paired recipient, the naming of alternat

138 ve transplant center participation in paired kidney exchanges may increase sex equity in LDKT.

139 dantly in the liver and secreted through the kidneys, exhibit male-biased expression.

140 stages of FSGS, fawn-hooded hypertensive rat kidneys exhibited distinctly increased APA staining in a

141 antation plays an important role in treating kidney failure in patients with end-stage liver disease.

142 r to be mediated by paracrine FGF control of kidney FGFR1 and subsequent regulation of soluble Klotho

143 enhances Smad7 protein expression in primary kidney fibroblasts.

144 a novel therapeutic approach for attenuating kidney fibrosis.

145 linked to their function in maintaining the kidney filtration barrier.

146 TCs) must provide informed consent to accept kidneys from increased risk donors (IRD), but poorly und

147 on and improved energy metabolism in injured kidneys from mPGC-1alpha mice.

148 glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, beta2-microglob

149 nced stages of kidney disease independent of kidney function and glycemia.

150 primary outcome was the time to recovery of kidney function defined as return of postintervention cr

151 ctomy versus radical nephrectomy to preserve kidney function has not been well established.

152 plication of MR-MEGA to trans-ethnic GWAS of kidney function in 71,461 individuals indicates stronger

153 To determine whether the acute declines in kidney function in the intensive BP lowering arm of two

154 Normal kidney function involves numerous different cell types,

155 multaneous assessment of excretory liver and kidney function is still an unmet need in experimental s

156 p between pro-ENK level and deterioration of kidney function over time.

157 Kidney function was significantly better in group 2, if

158 creased risk of death rises exponentially as kidney function worsens and is largely attributable to d

159 lomerular filtration rate (eGFR, a marker of kidney function) and serum PFOA concentration were measu

160 on produced significant changes in VO2 peak, kidney function, or urine albumin-to-creatinine ratio.

161 lating GDF-15 are associated with decline in kidney function.

162 ect kidney's filtration barrier and preserve kidney function.

163 lead to progressive fibrosis and decline in kidney function.

164 nephropathy, whereas CB1R blockade improves kidney function.

165 non-coding genomic regions, associated with kidney function.

166 Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule

167 origin of multiple GU tissues, including the kidneys, gonads, and reproductive ductal systems: the in

168 Removal of the scaffolds or kidney grafts resulted in immediate return to hyperglyce

169 with placebo, bosutinib at 200 mg/d reduced kidney growth in patients with ADPKD.

170 Although KFTS kidneys have less favorable donor, graft, and recipient

171 These include kidney, heart, and lung candidates who are highly-allose

172 ryonic stem cells (ESCs) and human embryonic kidney (HEK) cells.

173 epithelia (HAE) in vitro In human embryonic kidney HEK293 cells, the transfection of a duplex HBoV1

174 lation at the HOXA5 locus in human embryonic kidney (HEK293T) cells.

175 y, transwell assays using Madin-Darby canine kidney II cell line cells stably expressing specific upt

176 stained expansion of IL-33 receptor-positive kidney ILC2s and ameliorated adriamycin-induced glomerul

177 gistry data were collected on deceased donor kidneys implanted between November 1, 2012, and April 30

178 rescued HDG and PLK2 overexpression-induced kidney injuries.

179 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years

180 Acute kidney injury (AKI) in children is associated with poor

181 he 4140 patients (2.5%) without severe acute kidney injury (P<0.001).

182 ase, failed ventilator liberation, and acute kidney injury +/- hemodialysis requirement.

183 tylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angi

184 One death in the everolimus group (acute kidney injury associated with diarrhoea), and two deaths

185 Severe acute kidney injury conferred an increased risk of death by da

186 showed the strongest association with acute kidney injury in a replication patient population contai

187 Acute kidney injury is a risk factor for delirium and coma dur

188 To examine whether acute kidney injury is associated with delirium and coma in cr

189 Acute kidney injury is associated with high mortality, especia

190 Acute kidney injury is common and is associated with poor outc

191 ide for preventing contrast-associated acute kidney injury is marginal, if any.

192 idkine, adiponectin, apolipoprotein C-I, and kidney injury molecule-1).

193 f the 543 patients (11.0%) with severe acute kidney injury versus 105 of the 4140 patients (2.5%) wit

194 Contrast-associated acute kidney injury was a secondary end point.

195 Severe acute kidney injury was associated with increased use of mecha

196 ICU length of stay, lower incidence of acute kidney injury, acute respiratory distress syndrome, and

197 iciency in JG cells of adult mice results in kidney injury, and suggest that JG cells are critically

198 evelopment of hyperchloremic acidosis, acute kidney injury, and survival among those with higher and

199 ephritis, contributing to the development of kidney injury.

200 ty-three percent of patients developed acute kidney injury.

201 as glomerular damage due to glycerol-induced kidney-injury had strongest impact on DY-654 elimination

202 s Cl(-)/HCO3(-) exchange in erythrocytes and kidney intercalated cells where it functions to maintain

203 Dosimetry estimates indicate that the kidney is the dose-limiting organ, with an estimated hum

204 anical and electrical dysfunction and in the kidney, it predicts the onset of renal failure.

205 ivary, and lacrimal glands as well as to the kidney, leading to dose-limiting toxicities and adverse

206 sociated nephropathy, the classic HIV-driven kidney lesion among individuals of African descent, has

207 SOCS1 peptidomimetic also exhibited reduced kidney leukocyte recruitment (T lymphocytes and classic

208 residue 22,23-dihydroavermectin B1a in fat, kidney, liver and muscle bovine tissues using UHPLC-MS/M

209 t, transgenic mice that expressed KCP in the kidney, liver, and adipose tissues were resistant to dev

210 Solitary kidney, liver, heart, and lung transplants performed bet

211 Bim-deleted kidney macrophages exhibit a novel transcriptional lupus

212 In contrast, the kidneys of IL-36 receptor (IL-36R) knockout mice exhibit

213 b(+)F4/80(-)I-A(-) glomerular macrophages in kidneys of mice with GN and the inhibition of proteinuri

214 rolimus and 2 generics in individuals with a kidney or liver transplant.

215 ween 2 generic products in individuals after kidney or liver transplantation following current FDA bi

216 Kidney paired donation (KPD) is an important tool to fac

217 ansplant patients including 182 simultaneous kidney-pancreas and 84 pancreas alone transplants were r

218 , including IPF; scleroderma; myelofibrosis; kidney-, pancreas-, and heart-fibrosis; and nonalcoholic

219 significantly increase bacterial burdens and kidney pathology in mice infected with MRSA.

220 abnormalities, mitochondrial dysfunction and kidney pathology.

221 inary biomarkers during ex vivo normothermic kidney perfusion (EVKP) may aid in the assessment of a k

222 fusion (EVKP) may aid in the assessment of a kidney prior to transplantation.

223 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxin

224 n and mRNA expression analyses revealed that kidney proximal tubules express transmembrane fatty acid

225 OA increased cystogenesis in polycystic kidney rats by 35%; in contrast, hepatic cystic areas we

226 uded in the posttransplant evaluation for 70 kidney recipients.

227 ternal KPD LDKTs facilitated by the National Kidney Registry in the United States from 2008 to 2015,

228 mediated via a specific cell type within the kidney remains unknown.

229 Kidney replacement therapy is used when complications ca

230 efficiency in all tissues (aorta, brain and kidney), resulted in rapid lethality marked by weight lo

231 Intravital imaging of post-ischemic kidneys revealed reduced vascular leak with alphavbeta5

232 In explant cultures of embryonic kidney rudiments, retinoic acid stimulated Nrip1 express

233 t strengthening this interaction may protect kidney's filtration barrier and preserve kidney function

234 graft, and recipient risk factors than NKAS kidneys, short-term graft and patient outcomes are accep

235 Simultaneous liver-kidney (SLK) transplantation plays an important role in

236 pelvis injection enables transposon mediated-kidney specific gene transfer in adult mice.

237 122 QTNs were associated with allometries of kidney, spleen and liver weights to body weight, 36 of w

238 oluble oxalate in foods is major concern for kidney stone formers due to its tendency to increase uri

239 average radiation dose for CT evaluation for kidney stones by querying a national dose registry.

240 reduced-radiation dose CT for evaluation of kidney stones has increased since 2011-2012, but remains

241 e computed tomography (CT) for evaluation of kidney stones increased in 2015-2016 compared with that

242 ed regularly, can lead to the development of kidney stones.

243 urce Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expr

244 progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis,

245 ide in cancers from prostate, breast, colon, kidney, thyroid, and lymphoid tissues as well as NETs as

246 eattle Kidney Study (SKS), we tested whether kidney tissue expression of GDF15 mRNA correlates with c

247 Older patients with ESRD who receive a kidney transplant (KT) may develop post-KT dementia and

248 al studies have described ED use rates among kidney transplant (KTx) recipients, and the factors asso

249 Kidney transplant candidates (KTCs) must provide informe

250 A significant proportion of kidney transplant centers are identified as low performi

251 (PSR), January 2013 to July 2015 among adult kidney transplant centers.

252 1993 and 2012 were extracted from the French kidney transplant database.

253 e recently established that HIV-1 can infect kidney transplant epithelial cells in the absence of det

254 Lower eGFR 1 year after kidney transplant is associated with shorter allograft a

255 ording to quartiles of risk of mortality and kidney transplant on the basis of multivariable Cox mode

256 , and screening for urologic malignancies in kidney transplant patients is warranted, and as such, th

257 here were 13 trials (n = 9850) that included kidney transplant recipients (6 trials), patients who ha

258 escribe the results in a cohort of 10 stable kidney transplant recipients (median of 4.3 years posttr

259 s in pediatric and adolescent deceased donor kidney transplant recipients aged 21 years or younger us

260 al and transplant history from 977 prevalent kidney transplant recipients enrolled in the Malnutritio

261 The risk of graft failure in young kidney transplant recipients has been found to increase

262 enal Data System records of Medicare-insured kidney transplant recipients in 2000 to 2011 to determin

263 human immunodeficiency virus/HCV coinfected kidney transplant recipients with ledipasvir-sofosbuvir

264 Kidney transplant recipients with urinary angiogenin amo

265 e, and treatment of urologic malignancies in kidney transplant recipients.

266 is the second leading cause of graft loss in kidney transplant recipients.

267 ween BKV and urothelial carcinogenesis among kidney transplant recipients.

268 e associated with adverse outcomes in stable kidney transplant recipients.

269 own about their association with outcomes in kidney transplant recipients.

270 ry at all US centers including our own (open kidney transplant).

271 ith quadrimembral amputations and a previous kidney transplant.

272 donor-derived KS in the recipient of a liver-kidney transplant.

273 he presence of sex disparity in living donor kidney transplantation (LDKT) remains controversial.

274 an important tool to facilitate living donor kidney transplantation (LDKT).

275 tified all patients who underwent LSG before kidney transplantation from 2011-2016 (n = 20).

276 uppression, graft and patient outcomes after kidney transplantation have improved considerably.

277 Data of all first kidney transplantation performed before 30 years of age

278 After kidney transplantation, early readmission is independent

279 atients were excluded from consideration for kidney transplantation.

280 Among the 12,831 DCD kidneys transplanted, kidneys with WIT</=48 minutes had

281 hundred sixty-five adults with PCKD received kidney transplants (303 tx alone, 161 simultaneous, 27 p

282 neous pancreas and kidney and pancreas after kidney transplants between January 1994 and July 2013.

283 Based on an analysis of 542 pediatric kidney transplants recorded by the UK Transplant Registr

284 plement-dependent endothelial cell injury in kidney transplants, as assessed by expression of endothe

285 ld potentially improve graft survival in DCD kidney transplants.

286 on of major Na(+) transporters all along the kidney tubule.

287 in patients with bilateral multifocal (BMF) kidney tumours and clinical manifestations of Birt-Hogg-

288 f Birt-Hogg-Dube (BHD) syndrome, or with BMF kidney tumours as the only manifestation; however, their

289 ention and a greater than 5-fold decrease in kidney uptake relative to MIP-1095.

290 transcriptionally active in 293T (embryonic kidney), Vero (African-green monkey kidney epithelial),

291 was located in the inguinal canal, the right kidney was slightly enlarged and the left kidney could n

292 ly better in group 2, if the implantation of kidneys was delayed >48 hours (P < 0.01).

293 al effects of FXR and TGR5 activation in the kidney, we reasoned that FXR and TGR5 could be excellent

294 After 30 minutes of warm ischemia, right kidneys were removed from 30-kg Yorkshire pigs and prese

295 rotissues derived from normal organs (heart, kidney) were relatively consistent when comparing microt

296 and dendritic cell increase in the affected kidneys, whereas renal neutrophil numbers were not affec

297 Use of expanded criteria donor (ECD) kidneys, which are associated with a reduced graft survi

298 e need better methods to assess viability of kidneys with high KDPI.

299 nhibition enhanced tubular cell apoptosis in kidneys with IRI, which was associated with excessive ca

300 describe the characteristics and outcomes of kidneys with KDPI of 80 or greater that were procured fr

301 Among the 12,831 DCD kidneys transplanted, kidneys with WIT</=48 minutes had survival similar to th