ライフサイエンスコーパス: kill

1 atent HIV to an active HIV to eventually be "killed".

2 oblasts (20 years old; approximately 10%-30% killing).

3 ls or also dormant spores that are harder to kill.

4 d from prey, but not with the number of prey killed.

5 h germinated B. subtilis spores were rapidly killed.

6 netically identical to those that are easily killed.

7 ll death because anaerobic bacteria are also killed.

8 d TNF-alpha production and improved bacteria killing.

9 2 production were required for cardiomyocyte killing.

10 butes to host defense by mediating microbial killing.

11 microvessels, all without extensive vascular killing.

12 d in increased resistance of E. coli to PGRP killing.

13 keeping with reduced intracellular bacterial killing.

14 roduction and results in increased bacterial killing.

15 ely due to bacterial permissiveness to phage killing.

16 n species, which are necessary for microbial killing.

17 ic species are susceptible to male pheromone killing.

18 ype, dedicated to pathogen encapsulation and killing.

19 reduction of delayed intracellular bacterial killing.

20 ediated resistance to Pseudomonas aeruginosa killing.

21 ng for phagosome acidification and bacterial killing.

22 MTX to tumor cells and induce effective cell killing.

23 ted, result in increased resistance to serum killing.

24 n to become sensitive to complement-mediated killing.

25 HDPDL1) as a strategy to enhance CAR T-cell killing.

26 r-infiltrating CD8(+) T cells and tumor cell killing.

27 ticipated in their laser-light induced photo killing.

28 e antibiotic efficacy and enhance phagocytic killing.

29 s the causative agent of tuberculosis, which kills 1.8 million annually.

30 modified glass plate is sufficient enough to kill 10(5)CFUmL(-1) in the small time span of 5 minutes.

31 of death in children in developing regions, killing 114,900 globally in 2014.

32 These inhibitors killed 98% of ex vivo primary chronic B-lymphocytic leuk

33 ause it takes typically more than one CTL to kill a target.

34 Diet-induced obesity impaired AT1-ILC killing ability.

35 lement-mediated attack, improving phagocytic killing activity of neutrophils, and preventing bacteria

36 Opsonophagocytic killing activity showed antibody functionality.

37 brane damage and exhibited more complex cell-killing activity, probably because of two different mode

38 24 h or injected with 1.7 kBq of (211)At and killed after 1, 6, or 168 h.

39 ly injected with 0.064-42 kBq of (211)At and killed after 24 h or injected with 1.7 kBq of (211)At an

40 Integrated modelling of intracellular Mtb killing alongside conventional extracellular Mtb killing

41 There were also differences in IT-mediated killing among transfected and infected cell lines that w

42 in (PT) and adenylate cyclase toxin (ACT) to kill and modulate host cells to allow the pathogen to su

43 Here we show that Bacillus subtilis can kill and prey on Bacillus megaterium.

44 The demographic profile of those killed and kidnapped was examined, distinguishing betwee

45 To study how multistage killing and a lack of steady state influence the functio

46 GM-CSF) signaling, which stimulates pathogen killing and clearance by alveolar macrophages through ex

47 aesthetics for both scientific study, humane killing and euthanasia at end of life.

48 isting strategies known to combat fractional killing and facilitate the design of novel strategies.

49 velop a population-dynamic model quantifying killing and HGT on solid surfaces.

50 Synergistic effects of contact-killing and protein-repellent properties were shown to y

51 e mechanisms that limit effective tumor cell killing and the identification of apoptotic vulnerabilit

52 replicative stress and increased tumor cell killing and tumor control by DNA damage therapies in ani

53 ne dinucleotide phosphate) oxidase-dependent killing and, in turn, host susceptibility to invasive as

54 (5 months and 1 year; approximately 10%-20% killing) and adult fibroblasts (20 years old; approximat

55 phil extracellular trap formation, bacterial killing, and induction of apoptosis.

56 nasopharyngeal carriage, reducing phagocytic killing, and resulting in increased inflammation and tis

57 etabolism, resistance to neutrophil-mediated killing, and survival in vivo Our investigation indicate

58 cultures, autoimmunity or self-targeted cell killing, and the engineering or control of metabolic pat

59 Recent estimates report ca. 200,000 seabirds killed annually by bycatch in European waters.

60 ns to be highly asymmetric, i.e., one strain kills another at a much higher rate.

61 Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,00

62 Both peptides were bactericidal, killing approximately 90% of Escherichia coli and Pseudo

63 Based on these time-kill assays, exemplary formulations were further tested

64 01) and of primary MM cells (72.9% +/- 12.2% killing at 3 days, E:T ratio 1:1; P < .05, n = 5).

65 ctor, and granzyme B), and they were able to kill autologous antigen-loaded targets.

66 d controlled drug delivery to simultaneously kill bacteria and dismantle the biofilm matrix.

67 trophils rapidly and continuously engulf and kill bacteria during at least 4 hours of infection in vi

68 CN polycation were also able to repetitively kill bacteria in solution at high rates and with cleanin

69 h targets bacterial topoisomerases, fails to kill bacteria that have grown to high density; however,

70 taining histones are extruded to ensnare and kill bacteria.

71 ges and whole blood from Cmah(-/-) mice also killed bacteria more effectively.

72 None accumulated in mammalian cells or heat-killed bacteria, suggesting metabolism-derived specifici

73 r activity, show significant selectivity for killing bacteria over mammalian cells, and finally, why

74 Dictyostelium discoideum This social amoeba kills bacteria via phagocytosis for nutrient acquisition

75 and Proteus mirabilis, we found the rates of killing between the strains to be highly asymmetric, i.e

76 ibit comparable nonspecific opsonophagocytic killing, biofilm production, and adhesion to nasopharyng

77 dings collectively indicate platelets do not kill bloodstage Plasmodium at physiologically relevant e

78 ug TP053, a thienopyrimidine derivative that kills both replicating and nonreplicating bacilli.

79 eal that these peptides not only induce cell killing but also potently sensitize PEL to the proapopto

80 and proliferate when sustentacular cells are killed, but not when only OSNs die, indicating that HBCs

81 er in E. coli and trigger P. aeruginosa T6SS killing, but not pilus production.

82 s of Escherichia coli and P. aeruginosa were killed by a process of condensing intracellular contents

83 not express aldehyde dehydrogenase and were killed by Cy in vitro.

84 wer versus higher income counties, decedents killed by non-firearm (e.g., Taser) versus firearm mecha

85 More cells were killed by PTX dose-dense-equi than with PTX conventional

86 eptide at 0.1 nM are completely resistant to killing by C. albicans The peptide also protects macroph

87 Here, we show that suppression of CTL killing by CD4(+)CD25(+)Foxp3(+) regulatory T cell (Treg

88 e pathways to predict cellular resistance to killing by DNA-damaging agents.

89 odalis glossinidius, requires PhoP to resist killing by host derived antimicrobial peptides.

90 ex vivo, which was associated with increased killing by human neutrophils.

91 is severely attenuated in ability to resist killing by human polymorphonuclear leukocytes.

92 st vertebrates are most threatened by direct killing by humans.

93 hyloxanthin production and susceptibility to killing by hydrogen peroxide, respectively.

94 N-gamma sensitizes these leukemias to T cell killing by mechanisms other than MHC upregulation.

95 Bacterial killing by MSC was found to be mediated in part by secre

96 n and biofilm formation, decreases bacterial killing by neutrophil extracellular traps, and modulates

97 veloped strategies to evade phagocytosis and killing by neutrophils.

98 fied by Tn-seq in A. baumannii resistance to killing by NHS but not by normal mouse serum, highlighti

99 , forming drug-tolerant biofilms that resist killing by the immune system.

100 with decreased metabolic rate, refractory to killing by these drugs, and able to generate drug-resist

101 of producing strong hyperthermia efforts to kill cancer cells and hela cells under 800 nm laser irra

102 Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell su

103 nd can activate immune effector functions to kill cancer cells in vitroIn vivo, the antibody targets

104 We now show these si/shRNAs kill cancer cells through canonical RNAi by targeting th

105 magnetoelectrically assisted drug release to kill cancer cells.

106 hat uses viruses that selectively infect and kill cancer cells.

107 i-active sequences present in the genome can kill cancer cells.

108 ing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAI

109 development of a targeted toxin selectively killing cancer cells.

110 collected, and serum was tested for bacteria-killing capacity against Escherichia coli, as a function

111 ressive effect that results in reduced tumor-killing capacity by NK cells.

112 failed to inhibit downstream signaling or to kill cells harboring a high K-allele frequency.

113 , unlike cisplatin and carboplatin, does not kill cells through the DNA-damage response.

114 oncentration below the threshold required to kill cells.

115 Instead of killing cells, caspases now promote the generation of in

116 lic vulnerability that might be exploited to kill chemotherapy-resistant acute myeloid leukemia cells

117 ulated primary peritoneal neutrophils (PPNs) killed chlamydiae in vitro in an antibody-dependent mann

118 more limited effector functions and reduced killing compared with memory-derived populations.

119 This fractional killing contributes to drug resistance in cancer.

120 ing alongside conventional extracellular Mtb killing data, generates the biphasic responses typical o

121 primary viral infection as a result of heat-killed DK128 pretreatment developed subsequent heterosub

122 Protection via heat-killed DK128 was correlated with an increase in alveolar

123 respiration completely, became bactericidal, killed drug-tolerant mycobacterial persisters, and rapid

124 viduals born in 1914-1916 whose fathers were killed during World War 1.

125 Our results show that chicken cathelicidin-2 kills E. coli by permeabilizing the bacterial inner memb

126 ding a theory based on distant cytotoxic log-kill effects were unable to fit the data.

127 The cell killing effects of two representative voxels (isocenter

128 e therapy is developed for significant tumor-killing effects, more effective than conventional starvi

129 ts in 10-fold improvement of its cancer cell-killing efficacy.

130 This opens therapeutic avenues combing the killing efficiency of NK cells with the diversified targ

131 They kill endocytosed pathogens by releasing reactive oxygen

132 lity, increased nonspecific opsonophagocytic killing, enhanced biofilm formation, and increased adhes

133 signaling also enables sequential tumor cell killing, enhances the formation of effective immune syna

134 xygen species and protect against neutrophil killing, enhancing fitness within the heart.

135 oding a bacteriocin ("gallocin") is shown to kill enterococci in vitro.

136 ed NK cells, induced cytokine production and killed Env-expressing cells.

137 sport inhibitors killed trypanosomes without killing erythrocytes, neurons or liver cells.

138 esponses, human monocyte-derived macrophages killed Escherichia coli and ingested E. coli BioParticle

139 article, we show that chicken cathelicidin-2 kills Escherichia coli in an immunogenically silent fash

140 C-regulated transcription to synergistically kill even highly resistant B-ALL with diverse genetic ba

141 r biomass flocculation is a key mechanism of killing for cationic, amphipathic AMPs, which may explai

142 L-4R-signaling in vitro, uncoupling parasite killing from expulsion mechanisms.

143 ucha wtf4 as one of these genes that acts to kill gametes (known as spores in yeast) that do not inhe

144 We found that both live and antibiotic-killed GBS induce activation of PKD1 through a pathway t

145 Mouse and human RELMbeta selectively killed Gram-negative bacteria by forming size-selective

146 bactericidal drugs isoniazid and rifampicin kill greater than 99% of exponentially growing Mycobacte

147 Within 24 h captopril had killed >90% of the early instars of both species with 3(

148 oxacin combinations were highly synergistic, killing >6 log CFUs/g of vegetations in 6 hours and succ

149 istic effects, requiring 45% fewer spores to kill half of the mosquitoes in 5 days as single toxin st

150 fast ice after 2006 ramped iceberg scouring, killing half the encrusting benthos each year in followi

151 immune system, and are able to identify and kill hazardous cells.

152 pe b lipopolysaccharide (LPS) (Aa-LPS), heat-killed (HK) bacteria (Aa-HK), or live bacteria.

153 TCR-transduced HLA-A2(+) T cells efficiently killed HLA-A2(+)H3.3K27M(+) glioma cells in an antigen-

154 and other oxidation-prone folate derivatives kills human, mouse and chicken cells that cannot detoxif

155 tivations of the Tsavo and Mfuwe man-eaters (killed in 1898 in Kenya and 1991 in Zambia, respectively

156 ally, with two-thirds of all monitored fauna killed in a single year (2009).

157 e contributed to findings that children were killed in increasing proportions over time, ultimately c

158 SS-BEN/miR-34a not only enhanced cancer cell killing in cultured human colon cancer cells, but also i

159 cal models of human cancers and induced cell killing in leukemia cells.

160 flammatory cytokine expression and bacterial killing in macrophages and boosted protection against in

161 activating macrophages to induce tumor cell killing in mice.

162 mechanisms underlying incomplete tumor cell killing in oncogene-addicted cancer cells, we investigat

163 idespread CD8(+) T-cell-dependent tumor cell killing in primary tumors and metastases, and that these

164 data highlight striking differences in cell killing in vivo, depending on the cell subset and organs

165 assay and suppressed antibody-mediated cell killing in vivo.

166 lly righteous, including capital punishment, killing in war, and drone strikes that kill terrorists.

167 P7 inhibition induces significant tumor-cell killing independently of ATM and p53 through the accumul

168 The ability to kill individual or groups of cells in vivo is important

169 ) T cells require <24 h to find, locate, and kill infected hepatocytes, active migration of Ag-specif

170 Human cytotoxic lymphocytes kill intracellular microbes.

171 active against MRSA, it does not effectively kill intracellular MRSA due to the molecular size and po

172 s) into their surroundings to immobilize and kill invading micro-organisms.

173 th depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissue

174 a sigmoid dependence on the CTL density when killing is a multistage process, because it takes typica

175 Macrophage intracellular pathogen killing is defective in cystic fibrosis (CF), despite ab

176 Importantly, when the killing is measured before the steady state is approache

177 Male pheromone-mediated killing is unique to androdioecious Caenorhabditis, and

178 oney-traps" attracting M. incognita and then killing it by contact or fumigation.

179 apture the observed properties of fractional killing, it was analyzed with nonlinear dynamical tools.

180 losses and the energetic gains derived from killing larger prey.

181 enchyme cells surrounding postnatal GPs were killed, left bone growth was nevertheless reduced.

182 The experimental regimens kill M. tuberculosis much more rapidly than the standard

183 to infection with live and gamma-irradiated (killed) M. tuberculosis.

184 ociated stimuli could be used to attract and kill malaria vectors more successfully than individual s

185 bbles the EDR could exceed values that would kill many cells used in bioreactors, including Chinese H

186 Here we show that ME3 depletion selectively kills ME2-null PDAC cells in a manner consistent with an

187 However, the killing mechanism of Cu-Cy nanoparticles on cancer cells

188 s directing robust and rapid early T. gondii-killing mechanisms in the LEW rat.

189 e significantly more sensitive to clonogenic killing mediated by platinum-based chemotherapy and IR (

190 d both volume and surface plasmas capable of killing microbes.

191 Viral infections kill millions yearly.

192 s (TB) is a deadly infectious disease, which kills millions of people every year.

193 hemotherapy effect was based on the log-cell kill model.

194 autophagy will increase drug sensitivity and kill more cancer cells.

195 a and the neglected tropical diseases (NTDs) kill more than 800,000 people annually, while creating l

196 more sensitive to antimicrobial peptides was killed more efficiently by IFN-beta than was the wild-ty

197 Pneumonia kills more children each year worldwide than any other d

198 pids to bind to its intracellular target and kill mosquitoes.

199 al release enabled rifampicin to effectively kill Mtb at concentrations that were insufficient to act

200 Because a single CTL can kill multiple targets, degranulation must be tightly reg

201 lectively but acted differently, extensively killing MV endothelium.

202 Killed mycobacteria maintained differential hydrophobici

203 e coming century - can stress and ultimately kill native coldwater fish in lakes where thermal strati

204 receptor (CAR) T cells, which recognized and killed normal and malignant TRBC1(+), but not TRBC2(+),

205 AR23 greatly augments myeloid cell-dependent killing of a collection of hematopoietic and nonhematopo

206 antigens and found these cells could mediate killing of autologous lymphoma cells.

207 echanism of reactive oxygen species-mediated killing of bacteria by neutrophils.

208 f bacteria throughout the colony exceeds the killing of bacteria on the surface and pinpoints how the

209 CD8(+) T cell-dependent killing of cancer cells requires efficient presentation

210 ossibly transcription), leading to selective killing of cancer cells with BRCA1/2 mutations.

211 ntratumoral vessels as a result of increased killing of cancer cells, setting up a positive feedback

212 cific receptors, such as Ly49A, that inhibit killing of cells expressing self-MHC-I.

213 dent bacterial weapon that allows for direct killing of competitors through the translocation of prot

214 ll maturation and improved effector-mediated killing of HIV-infected CD4 T cells by the HIV envelope-

215 ulation is associated with cytokine-mediated killing of human beta-cells, a process partially prevent

216 ruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.

217 rimary MM, at low E:T ratios (56.2% +/- 3.9% killing of MM.1s at 48 h, E:T ratio 1:32; P < .01) and o

218 teine to isoniazid treatment potentiated the killing of Mtb Furthermore, we demonstrate that the addi

219 Finally, selective killing of Mtb-infected macrophages and subsequent bacte

220 in-induced autophagy increased intracellular killing of Mtb.

221 ulated process to allow for effective serial killing of NK cells.

222 P90 with ganetespib enhances T-cell-mediated killing of patient-derived human melanoma cells by their

223 efense against S. aureus both through direct killing of S. aureus and enhancing the antimicrobial fun

224 ce macrophage phagocytosis and intracellular killing of S. aureus In this study we report evidence in

225 for inflammatory cytokine production and the killing of target cells; however, much less is known abo

226 use of venetoclax, which causes preferential killing of the HIV-expressing cells.

227 -1) disruption augmented CAR T cell mediated killing of tumor cells in vitro and enhanced clearance o

228 ly studied with regard to NK recognition and killing of tumors.

229 ells have been defined by nonspecific innate killing of virus-infected and tumor cells.

230 unclear whether bSi with the nanopillars can kill only growing bacterial cells or also dormant spores

231 i wafers with or without nanopillars gave no killing or rupture of dormant spores of B. subtilis, Bac

232 eir chances of spreading by using poisons to kill other alleles, and antidotes to save themselves.

233 s and drugs for tuberculosis, a disease that kills over 1.8 million people each year.

234 is, is an opportunistic fungal pathogen that kills over 200,000 individuals annually.

235 ginosa (pyocin Sn) was produced and shown to kill P. aeruginosa thereby validating our pipeline.

236 results show that the shell also evolved to kill parasitic nematodes and this is the only example of

237 ing the functional amount of AMPs capable of killing pathogens.

238 (Mvarphi) and the ability of these cells to kill/phagocytose Candida albicans or Escherichia coli ce

239 nsing (QS) apparatus have a rapid and potent killing phenotype following microinjection into an insec

240 L-asparaginases maintain their in vitro ALL killing potential.

241 tions producing colicins, an antibiotic that kills producer cells' close relatives.

242 Furthermore, low-dose DAC preserved HSPC-NK killing, proliferation, and interferon gamma production

243 nergy between the two domains and is able to kill Pseudomonas aeruginosa at sub-micromolar concentrat

244 Compared to single-stage killing, the total killing rate during multistage killing saturates at high

245 Second, the total killing rate exhibits a sigmoid dependence on the CTL de

246 ult in a peak in the dependence of the total killing rate on the target cell density.

247 lymphoid tissue and correlates of bacterial killing, reduced checkpoint signaling, and the relocatio

248 chemotherapy and IR ( approximately 70%-80% killing) relative to young fibroblasts (5 months and 1 y

249 t, we determined the ability of platelets to kill S. aureus directly; and, second, we tested the poss

250 aeruginosa to produce virulence factors that kill S. aureus These data could provide important clues

251 ray diffraction and that it is sufficient to kill S. aureus These results suggest that, in addition t

252 PBMCs of IP children stimulated with heat-killed S. pneumoniae had significantly reduced percentag

253 While P. aeruginosa readily kills S. aureusin vitro, the two species can coexist for

254 osomal compartments and a reduced ability to kill Salmonella enterica serovar Typhimurium compared to

255 ng, the total killing rate during multistage killing saturates at higher CTL and target cell densitie

256 ce to antibody-dependent complement-mediated killing secondary to genetic deletion is not necessarily

257 ets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals.

258 response emerges for two reasons: First, the killing signal of each CTL gets diluted over several tar

259 ion of a senolytic molecule that selectively killed SnCs validated these results in transgenic, non-t

260 , and we observed that IFN-beta can directly kill Staphylococcus aureus Further, a mutant S. aureus t

261 ns to bridge the gap between the "kick" and "kill" steps of this eradication strategy.

262 approaches is considered incompatible as MAT kills sterile and 'wild' males indiscriminately.

263 A "kick and kill" strategy proposes "kick" of the latent HIV to an a

264 principle for the efficacy of a "release and kill" strategy.

265 kylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine er

266 itro disk diffusion, broth dilution and time-kill studies.

267 ity, including a single small-molecule-based kill switch, low escape frequency, and unaffected protei

268 Both kill switches were shown to maintain functionality in vi

269 ost cell oxidative stress as a mechanism for killing T. gondii.

270 ion, survival and polarization signals or to kill target cells, for example in the form of antibody-d

271 ts model, in both cases describing CTLs that kill target cells.

272 ment, killing in war, and drone strikes that kill terrorists.

273 hroughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause

274 roups was a sequence motif critical for cell-killing that is generally not found in bacteriocins targ

275 promising hyperthermia effects to completely kill the tumors.

276 were indeed very effective in rupturing and killing the growing bacterial cells, while wafers withou

277 hages infected with mycobacteria efficiently killing the infected cells and decreasing survival of my

278 ion from an R-loop-initiating plasmid origin kills the double rnhAB mutant, revealing generation of R

279 zymes, causing metabolic catastrophe, and it kills the parasite.

280 Compared to single-stage killing, the total killing rate during multistage killin

281 d to increase the diversity by the virtue of Kill-the-Winner infection bias preventing the fastest gr

282 Top predators can suppress mesopredators by killing them, competing for resources and instilling fea

283 can be targeted to Siglec-8-bearing cells to kill these cells.

284 ted in resistant mice and is responsible for killing tissue-embedded larvae.

285 multiple cell death pathways preferentially killing transformed and cancer stem cells.

286 We report a way to selectively kill Trypanosoma by blocking glycosomal/peroxisomal impo

287 Glucose-transport inhibitors killed trypanosomes without killing erythrocytes, neuron

288 poptosis-inducing ligand (TRAIL) selectively kills tumor cells, without damaging normal cells.

289 dothelium, LUV-TRAIL being more efficient in killing tumour cells, showing no effect on the integrity

290 Platelets effectively killed two different strains of S. aureus.

291 selected for broad capability to bind and/or kill viruses and bacteria.

292 as visualized microscopically, and bacterial killing was assessed by bacterial culture.

293 The defect in COPD AM intracellular killing was associated with a reduced ratio of mROS/supe

294 tus is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sep

295 riable, numerous instances of cross-reactive killing were observed.

296 decreased resistance to neutrophil-mediated killing, which resulted in selection for the modA2 OFF s

297 y neutrophils, S. aureus shows resistance to killing, which suggests the presence of phagosomal immun

298 MCs), sensitize tumours to TNF-alpha-induced killing while simultaneously blocking TNF-alpha growth-p

299 Killed whole-cell oral cholera vaccines (kOCVs) are beco

300 D4 T cells and a novel mechanism of parasite killing within infected erythrocytes.