ライフサイエンスコーパス: killer

1 is is the world's leading infectious disease killer.

2 e eradication of one of the world's greatest killers.

3 A novel cell surface epitope, human natural killer 1 (HNK-1), was the target of the antibodies in 3

4 se 2 (B3GAT2), a member of the human natural killer 1 carbohydrate pathway.

5 he carbohydrate epitope HNK-1 (human natural killer-1).

6 rom a fast transition to a high level of p53 killer (a p53 phosphoform which promotes commitment to a

7 in antiviral immunity by regulating natural killer and CD8(+) T cells, epigenetic downregulation of

8 IR (CD3/CD4/CD8 T, natural killer, and B cells) was measured biweekly until 12 week

9 optosis regulator (Bax) and Bcl-2 antagonist/killer (Bak) proteins to inhibit premature apoptosis of

10 onic mucous hypersecretion.Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via

11 t-infection correlated with stronger natural killer, CD4+ T and CD8+ T cell responses.

12 ivating or inhibitory effects during natural killer cell (NK cell) activation.

13 on, IFNgamma response, CD16-mediated natural killer cell activation, and monocyte/macrophage activati

14 cal defense, including inhibition of natural killer cell activity with ongoing lowering of Ig levels

15 lving phagosome formation as well as natural killer cell and IL-3 signaling.

16 bacteria may not easily become resistant to killer cell attack.

17 e checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered,

18 Specific natural killer cell depletion 24 hours pre-acute myocardial infa

19 Natural killer cell development and maturation were arrested.

20 ment induced TSLP, HLA class II, and natural killer cell group 2D (NKG2D) ligand expression in the le

21 The functions of activating members of the killer cell Ig-like receptor (KIR) family are not fully

22 with C1-specific and C2-specific lineage III killer cell Ig-like receptors (KIR).

23 lotypes having the Bw4 epitope recognized by killer cell Ig-like receptors of NK cells, allotypes hav

24 pes having the C1 epitope also recognized by killer cell Ig-like receptors, and allotypes having neit

25 ize, that NK cell alloreactivity mediated by killer cell immunoglobulin-like receptor (KIR)-HLA inter

26 in immunity, but how HLA class I (HLA-I) and killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)

27 upregulated NKp44 expression, and remarkable killer cell immunoglobulin-like receptor acquisition.

28 ype, and more frequently expressed educating killer cell immunoglobulin-like receptors compared with

29 nosine signaling is found to promote natural killer cell maturation and antitumor immunity and reduce

30 absent T cells and normal B-cell and natural killer cell numbers.

31 Natural killer cell receptors and other genes related to the imm

32 complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the

33 y pathology, stronger and persistent natural killer cell responses, and the extended induction of pro

34 he death of CD56(bright) NK cells, a natural killer cell subset whose expansion is correlated with au

35 composition of gammadelta T-cell and natural killer cell subsets.

36 or) and lineage (B cell, T cell, and natural killer cell).

37 ed expression of IFNgamma-inducible, natural killer cell, and T cell transcripts, but less expression

38 ymphocyte attenuator (BTLA); and the natural killer cell-activating receptor CD160.

39 still revealed diversity in a set of natural killer cell-associated receptors.

40 ting Kupffer cells, mature activated natural killer cells (CD69+), and PD-1+ effector memory T cells

41 A tissue-resident population of natural killer cells (NK cells) in the liver has recently been d

42 ratio and increased CD16(+)CD56(hi) natural killer cells (NK), CD4(+) effector memory T cells (Tem),

43 mory CD8(+) T cells (TRMs), resident natural killer cells (NKRs), and tumor-associated macrophages (T

44 requencies of intrathecal CD56bright natural killer cells (r = 0.28; P = .007).

45 on profiles of a receptor protein in natural killer cells among donors infected with human cytomegalo

46 Type I and II IFNs, as well as natural killer cells and CD8(+) T cells, were indispensible to t

47 iency characterized by lack of T and natural killer cells and infant death from infection.

48 rs of IL-22 post-PH are conventional natural killer cells and innate lymphoid cells type 1.

49 ement deposition and accumulation of natural killer cells and monocytes/macrophages in capillaries an

50 ral immune cell populations, such as natural killer cells and virus-specific T cells.

51 Natural killer cells are able to directly lyse tumor cells, ther

52 Natural killer cells constitute potent innate lymphoid cells tha

53 Natural killer cells controlled early infection but were not ess

54 Bispecific killer cells engagers (BiKEs) which can bind to natural

55 Immunologically, natural killer cells had an immature phenotype and impaired cyto

56 MSCs significantly decreased natural killer cells in the heart and spleen and neutrophils in

57 Although the role of T cells and natural killer cells in tumor immunology has been established, l

58 timulated both cytotoxic T cells and natural killer cells of cell-mediated immunity to provide tumor

59 ite replication, possibly as innate parasite killer cells or function in eliciting pathogenesis.

60 Natural killer cells showed reduced T-bet expression at day 1 wi

61 -producing dendritic cells (DCs) and natural killer cells than Cd36(-/-) mice.

62 at anti-CD27 stimulated CD8(+) T and natural killer cells to release myeloid chemo-attractants and in

63 Because killer cells use a multipronged strategy to target vital

64 uid (including B cells, T cells, and natural killer cells) (cohort 1).

65 aRIIIa (expressed on macrophages and natural killer cells) and FcgammaRIIIb (expressed on neutrophils

66 immune cells (antitumor macrophages, natural killer cells) associated with clearance of senescent tum

67 Teffs, natural killer cells, and eosinophils also responded, with their

68 e, including monocytes, neutrophils, natural killer cells, and eosinophils.

69 th correlated expression in T cells, natural killer cells, and erythroblasts.

70 T cells, reduced T-bet expression by natural killer cells, and expansion of blood monocytes with less

71 cking CD8 and CD4 T-cell activation, natural killer cells, and IFN activation associated significantl

72 e the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated prote

73 une cells including the conventional natural killer cells, lymphoid tissue inducers, type 1, 2, and 3

74 ng cytotoxic effector cells, such as natural killer cells, monocytes, and polymorphonuclear cells.

75 ns, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated

76 patic macrophage infiltration, while natural killer cells, natural killer T cells, neutrophils and de

77 matory cytokine responses by DCs and natural killer cells, Th1 development, phagocytic receptor expre

78 virus, and develop susceptibility to natural killer cells.

79 s of lymphomas arising from B, T, or natural killer cells.

80 tory signaling initiated by CD160 in natural killer cells.

81 lymphomas that arise from B, T, and natural killer cells.

82 was not able to stimulate T cells or natural killer cells.

83 nce of T cells, dendritic cells, and natural killer cells.

84 ctive cytotoxic T lymphocytes and/or natural killer cells.

85 is produced by cytotoxic T cells and natural killer cells.

86 ding, fibroblasts to cytotoxicity by natural killer cells.

87 receptors (microORs), are the strongest pain killers clinically available.

88 ulted from expansion of a transduced natural killer clone in response to chronic Epstein-Barr virus v

89 SR-1 increased conventional natural killer (cNK) cell differentiation, whereas TCDD treatmen

90 l to carry out the dual roles of a probe and killer for bacteria.

91 ased system acts as both a sensing probe and killer for bacteria.

92 Natural killer gene complex-encoded immunomodulatory C-type lect

93 The natural killer group 2D (NKG2D) receptor is a potent immune-acti

94 ry receptors, including NKG2A and inhibitory killer Ig-like receptors (KIRs), was negatively correlat

95 ignals for NK cell inhibition via inhibitory killer immunoglobulin-like (KIR) receptors and interrupt

96 Cancer is rapidly becoming the top killer in the world.

97 ealed a highly similar expression pattern of killer inhibitory receptors and other candidate molecule

98 and T cells (CD4(+), gammadelta and natural killer) into the brain of wild-type mice.

99 As a "silent killer", kidney disease is often hardly detected at an e

100 ession of IL-12-dependent differentiation of killer-like receptor G1(+) effector CD8 T cells and IFN-

101 ions within the three genes impaired natural killer lymphocyte cytotoxicity in vivo.

102 he adaptive immune system, including natural killer (NK) and CD8(+) T cells.

103 nic hepatitis B virus (HBV)-infected natural killer (NK) and CD8(+) T cells.

104 ionally distinct from adipose mature natural killer (NK) and immature NK cells.

105 tosis marked by massive expansion of natural killer (NK) and T cell compartments.

106 ing receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD15

107 jor determinant of antibody-mediated natural killer (NK) cell activation in HT biopsies; however, lit

108 ement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infecti

109 ng T regulatory cells, and decreased natural killer (NK) cell activation.

110 Only the KW cocktail modulated natural killer (NK) cell activity and neutrophil and monocyte ph

111 Combining natural killer (NK) cell adoptive transfer with hypomethylating

112 Donor natural killer (NK) cell alloreactivity in HCT can control leuke

113 Natural killer (NK) cell alloreactivity is favored after double

114 vent relapse depends partly on donor natural killer (NK) cell alloreactivity.

115 , leading to cellular activation and natural killer (NK) cell degranulation.

116 n-induced pulmonary inflammation and natural killer (NK) cell effector function.

117 We now identify novel natural killer (NK) cell evasion functions for four members: US1

118 b molecule Qa-1 impairs CD8 Treg and natural killer (NK) cell function and promotes a lupus-like auto

119 We studied the contribution of natural killer (NK) cell functional features in HIV patients con

120 ifications amongst mature T-cell and natural killer (NK) cell neoplasms.

121 , CD4+ (CMV-Th) T cell activity, and natural killer (NK) cell number were measured by flow cytometry.

122 r interleukin-6 (IL-6)-signaling and natural killer (NK) cell pathways.

123 Mouse liver contains two natural killer (NK) cell populations, one of which recirculates

124 ress-induced cellular ligand for the natural killer (NK) cell receptor NKp30.

125 Natural killer (NK) cell receptors (NKRs) play a crucial role in

126 eir capacity to regulate antiporcine natural killer (NK) cell responses.

127 For both vaccine regimens, natural killer (NK) cell signatures negatively correlated with a

128 The human natural killer (NK) cell surface is naturally coated with IgG bo

129 anti-PD-L1/PD-1 agents in enhancing natural killer (NK) cell's function remains largely unknown.

130 Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 levels were p

131 ue-derived Rorc(fm+) ILCs acquire an natural killer (NK) cell/ILC1-like phenotype.

132 unctional defects of innate effector natural killer (NK) cells and cytotoxic T-lymphocyte responses t

133 44, encoded by NCR2 and expressed on natural killer (NK) cells and innate lymphoid cells, recognizes

134 is study, we evaluated the impact of natural killer (NK) cells and myeloid (mDCs) and plasmacytoid (p

135 The former treatment activates nature killer (NK) cells and NK T cells, which partially enhanc

136 profile that overlaps with those of natural killer (NK) cells and other ILCs.

137 nt development and function of human natural killer (NK) cells and T cell subsets limit the applicabi

138 ells, but whether and how it affects natural killer (NK) cells and their alloreactivity is largely un

139 Natural killer (NK) cells are critical innate effector cells who

140 Human natural killer (NK) cells are generated from CD34(+) precursors

141 Natural killer (NK) cells are important in host defense against

142 Natural killer (NK) cells are innate lymphoid cells which mediat

143 Natural killer (NK) cells are key mediators in the control of cy

144 Natural killer (NK) cells are located at the periphery of the ly

145 Maturation of human natural killer (NK) cells as defined by accumulation of cell-sur

146 To test the hypothesis that natural killer (NK) cells can decrease the risk of leukemia rela

147 Natural killer (NK) cells can induce liver fibrosis remission by

148 Natural Killer (NK) cells confer protection from tumors and infe

149 to middle cerebral artery occlusion, natural killer (NK) cells display remarkably distinct temporal a

150 Natural killer (NK) cells express MHC class I (MHC-I)-specific r

151 Adult natural killer (NK) cells express only IL2Rbeta and IL2Rgamma su

152 Here, we demonstrate that natural killer (NK) cells from mice lacking the type I IFN-alpha

153 BACKGROUND & AIMS: Low activity of natural killer (NK) cells has been associated with increased ris

154 Classically, natural killer (NK) cells have been defined by nonspecific innat

155 r many years, human peripheral blood natural killer (NK) cells have been divided into functionally di

156 Natural killer (NK) cells have long been considered short-lived

157 dies have evaluated the functions of natural killer (NK) cells in experimental animal models of ather

158 the extensive knowledge about human natural killer (NK) cells in peripheral blood, relatively little

159 metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemina

160 he percentage of active CD8(+) T and natural killer (NK) cells in the tumor microenvironment, while r

161 Furthermore, the frequency of natural killer (NK) cells increased, the proportion of NK cells

162 hed, its role on the infiltration of natural killer (NK) cells into tumors remains unknown.

163 1 innate lymphoid cells (ILC1s) from natural killer (NK) cells is a gene signature indicative of 'imp

164 Natural killer (NK) cells localize in the microcirculation in an

165 Natural killer (NK) cells mediate important innate immunity that

166 Multi-cellular cluster formation of natural killer (NK) cells occurs during in vivo priming and pote

167 Natural killer (NK) cells play a key role in immunity, but how H

168 Natural killer (NK) cells play a key role in innate immunity by

169 Natural killer (NK) cells play a major role in anti-viral immuni

170 ntrol the spread of virus, for which natural killer (NK) cells play a pivotal role.

171 Natural killer (NK) cells play an essential role in antiviral im

172 Natural killer (NK) cells play an important role in surveillance

173 r percentage of effector T cells and natural killer (NK) cells present in the lung.

174 Natural killer (NK) cells provide protection against infectious

175 Natural killer (NK) cells recognize and kill cancer cells and in

176 s engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A

177 ntibody-mediated protection in vivo, natural killer (NK) cells were dispensable for protective immuni

178 tivation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages resulting in hypercyt

179 ssion on peripheral blood monocytes, natural killer (NK) cells, and NK T cells was measured, as well

180 recognition receptors in myeloid and natural killer (NK) cells, has been shown to play both activatin

181 ts and retain potential for EOMES(+) natural killer (NK) cells, interferon gamma-positive (IFN-gamma(

182 r they also inhibit the functions of natural killer (NK) cells, key effectors of the Graft versus Leu

183 pro-allergic immune cells including natural killer (NK) cells, NKT cells, and memory CD8(+) T cells.

184 7 is largely confined to T cells and natural killer (NK) cells, reducing the risk of off-target-organ

185 al lymphocytes, including subsets of natural killer (NK) cells, T cells, and B cells.

186 to define a STAT5 gene signature in natural killer (NK) cells, the prototypical ILC subset, and prov

187 mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic coloni

188 ADCC is mediated largely by natural killer (NK) cells, which control their activation status

189 less is known about their effects on natural killer (NK) cells, which help control metastasis.

190 d a central role for neutrophils and Natural Killer (NK) cells, with underexpression of T- and B cell

191 y immune cells including T cells and natural killer (NK) cells.

192 eceptor expressed on activated T and natural killer (NK) cells.

193 expression/function of PD-1 on human natural killer (NK) cells.

194 n interferon-(IFN)-gamma produced by natural killer (NK) cells.

195 mmation by monocytes/macrophages and natural killer (NK) cells.

196 r the development and maintenance of natural killer (NK) cells.

197 ves the cells vulnerable to lysis by natural killer (NK) cells.

198 se involving both CD8(+) T cells and natural killer (NK) cells.

199 GOF mutations on the functioning of natural killer (NK) cells.

200 receptor expressed on the surface of natural killer (NK) cells.

201 of cytotoxic lymphocytes, including natural killer (NK) cells.

202 pansion of CD56(dim) NKG2A(+) KIR(-) natural killer (NK) cells.

203 ngerin(+) dendritic cells (LDC), and natural killer (NK) cells.

204 y cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.

205 ritic cells, monocytes, B cells, and natural killer (NK) cells.

206 kpoint that limits the maturation of natural killer (NK) cells.

207 iltrating interferon gamma-producing natural killer (NK) cells.

208 ion of LILRB1-expressing B cells and natural killer (NK) cells.

209 e cells acting against the virus are Natural Killer (NK) cells.

210 terized plasmacytoid dendritic cell, natural killer (NK), and T-cell activation using flow cytometry

211 that genes known to be expressed by natural killer (NK), lymphoid tissue inducer (LTi), and innate l

212 Natural killer (NK)-cell cytotoxicity assays can quickly screen

213 ons associated with myeloid, B-, and natural killer (NK)-cell deficiency.

214 duced both autologous and allogeneic natural killer (NK)-cell degranulation and NK-cell-mediated anti

215 the T-lymphocyte, B-lymphocyte, and natural killer (NK)-cell differentiation defect in interleukin-2

216 (IELs) lacking classical B-, T-, and natural killer (NK)-cell lineage markers (Lin(-)IELs) in the duo

217 ng receptors that are engaged during natural killer (NK)-target cell contact remains undefined.

218 genes, particularly those related to natural killer (NK)/CD8+ T-cell cytotoxicity, separated the 2 gr

219 We show that LukPQ is a potent and specific killer of equine neutrophils and identify equine-CXCRA a

220 lar atrophy (SMA), the most common inherited killer of infants, is caused by insufficient expression

221 muscular atrophy is the most common genetic killer of infants.

222 though cardiovascular disease is the primary killer of women in the United States, women and female a

223 Cardiovascular disease (CVD) is the number 1 killer of women in the United States, yet few younger wo

224 women were unaware that CVD is the number 1 killer of women; only 11% knew a woman who died from CVD

225 is response was independent of CTLs, natural killer or natural killer T cells.

226 is dependent on location (distance from the killer) or the evolution of resistance.

227 y encoded photosensitizing proteins, such as KillerRed, permit spatiotemporal optogenetic ablation wi

228 es on the evolution of a microecology from a killer-prey relationship to coexistence using two differ

229 h are then released as functionally modified killer protocells capable of rekilling.

230 The coacervate microdroplets act as killer protocells for the obliteration of the target pro

231 Invariant natural killer T (iNKT) cells are innate-like T cells that play

232 Invariant natural killer T (iNKT) cells are innate-like T cells that recog

233 CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T lymphocytes stro

234 reveal a critical role for invariant natural killer T (iNKT) cells in switching inflammation to tissu

235 Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of

236 Invariant natural killer T (iNKT) cells recognize lipid antigens presented

237 s) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T

238 Whether innate-like invariant natural killer T (iNKT) cells, with remarkable immunomodulatory

239 ns (alphaGalCer or OCH) to invariant natural killer T (iNKT) cells.

240 actionated conventional T, invariant natural killer T (iNKT) or gammadelta T cells, and is characteri

241 tential association between absolute natural killer T (NKT) cell numbers and the subsequent developme

242 Semi-invariant natural killer T (NKT) cells are innate-like lymphocytes with im

243 Our mouse model required host natural killer T (NKT) cells to induce tolerance.

244 an be enhanced by engaging help from natural killer T (NKT) cells.

245 trongly reduced numbers of invariant natural killer T and regulatory T (Treg) cells and altered compo

246 ed with reduced numbers of invariant natural killer T and Treg cells that likely contribute to the pa

247 uced expression of genes critical to natural killer T cell (NKT) and gammadelta T-cell differentiatio

248 nnate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, mucosal-associated

249 clude the gamma-delta T cell and the Natural Killer T cell.

250 Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes

251 pment and proliferation of invariant natural killer T cells (iNKT cells).

252 have previously found that invariant natural killer T cells (iNKTs) are involved in CM allergy sensit

253 Invariant natural killer T cells (iNKTs), a small population characterized

254 antigen receptor (TCR) expressed by natural killer T cells (NKT cells) and the antigen-presenting mo

255 Valpha24-invariant natural killer T cells (NKTs) localize to tumors and have inhere

256 As natural killer T cells and liver injury are central in liver reg

257 CD4 and natural killer T cells and neutrophils were markedly reduced in

258 rent study is to explore the role of natural killer T cells in impaired liver regeneration.

259 as been shown that the proportion of natural killer T cells is markedly elevated during liver regener

260 Natural killer T cells play an important role in liver regenerat

261 ymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T cells, an

262 tration, while natural killer cells, natural killer T cells, neutrophils and dendritic cells hepatic

263 4 days before partial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-treated

264 Natural killer T cells- deficient or mice injected with anti CD1

265 ecialized subset of T cells known as natural killer T cells.

266 dependent of CTLs, natural killer or natural killer T cells.

267 kemic cells by human CD5(+) cytokine-induced killer T cells.

268 re regulated via recipient invariant natural killer T-cell (iNKT) interleukin-4-driven expansion of d

269 ectly in the expansion of protective natural killer T-cell populations.

270 Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for

271 In the current study, using natural killer/T-cell lymphoma (NKTL) as a disease model, we fou

272 dence of AITL, extranodal nasal-type natural killer/T-cell lymphoma and NK-cell leukemia (ENKCL), and

273 luding acute lymphoblastic leukemia, natural killer/T-cell lymphoma, and acute myeloid leukemia, as w

274 ll as non-Hodgkin, Hodgkin and nasal natural killer/T-cell lymphomas, although all three TET family g

275 transition from early inflammatory cytotoxic killers to myeloid-like APC in response to infectious st

276 Salish Sea, the endangered Southern Resident Killer Whale (SRKW) is a high trophic indicator of ecosy

277 Analysing population genomic data from killer whale ecotypes, which we estimate have globally r

278 The critically endangered, Southern Resident killer whale population of the northeastern Pacific Ocea

279 eductions in sea ice and increases in Arctic killer whale sightings, killer whales have the potential

280 ted responses of long-finned pilot whales to killer whale sound playbacks and two anthropogenic sourc

281 Killer whale sounds elicited increased calling rates and

282 ber of polar bears (PB; Ursus maritimus) and killer whales (KW; Orcinus orca) were used for in vitro

283 predation by three species of pinnipeds and killer whales (Orcinus orca) on Chinook salmon (Oncorhyn

284 ndividual-based demographic data in resident killer whales and show that when mothers and daughters c

285 on across the regions in our model, overall, killer whales consume the largest biomass of Chinook sal

286 by post-reproductive females can explain why killer whales have evolved the longest post-reproductive

287 increases in Arctic killer whale sightings, killer whales have the potential to reshape Arctic marin

288 of Chinook salmon consumed by pinnipeds and killer whales increased from 6,100 to 15,200 metric tons

289 Culture seems to have driven killer whales into distinct ecotypes, which may be incip

290 rsisted steadily for 10 d, the duration that killer whales remained in Admiralty Inlet.

291 effects models, we show that the presence of killer whales strongly alters the behavior and distribut

292 In killer whales the ecotype divisions, together with found

293 When killer whales were present (within about 100 km), narwha

294 dataset by synchronously tracking predator (killer whales, [Formula: see text] = 1; representing a f

295 a unique long-term dataset on wild resident killer whales, where females can live decades after thei

296 ption by recovering pinnipeds and endangered killer whales.

297 data demonstrating that ampetoids are "fast killers", which rapidly aggregate bacterial ribosomes in

298 Tuberculosis remains a major killer worldwide, not the least because of our incomplet

299 at and low-pH environment of toxin-secreting killer yeasts, K28 is structurally stable and biological

300 re refined targeting, we introduce here the "Killer Zipper" (KZip(+)), a suppressor that makes Split