ライフサイエンスコーパス: killing

1 oblasts (20 years old; approximately 10%-30% killing).

2 ic species are susceptible to male pheromone killing.

3 ype, dedicated to pathogen encapsulation and killing.

4 reduction of delayed intracellular bacterial killing.

5 ediated resistance to Pseudomonas aeruginosa killing.

6 ng for phagosome acidification and bacterial killing.

7 MTX to tumor cells and induce effective cell killing.

8 lecular mimic to engage Siglec-11 and escape killing.

9 nt negative ligand to subvert TRAIL-mediated killing.

10 cting IR or chemotherapy-induced cancer cell killing.

11 ted, result in increased resistance to serum killing.

12 ce survival by interfering with MPO-mediated killing.

13 n to become sensitive to complement-mediated killing.

14 romone and are susceptible to male pheromone killing.

15 linker-warheads designed for efficient tumor killing.

16 eria and phagolysosomes to enhance bacterial killing.

17 ed for Ag-driven proliferation and cytotoxic killing.

18 HDPDL1) as a strategy to enhance CAR T-cell killing.

19 mediate protection from complement-mediated killing.

20 hich corresponding drugs exhibit synergistic killing.

21 s sufficient to sensitize cells to quinolone killing.

22 r-infiltrating CD8(+) T cells and tumor cell killing.

23 tory response coordinated with resistance to killing.

24 his response did not contribute to bacterial killing.

25 s were more sensitive to complement-mediated killing.

26 or no GM-CSF produced equivalent amounts of killing.

27 strains of A. baumannii are resistant to NHS killing.

28 PSs) to protect itself from opsonophagocytic killing.

29 Staphylococcus aureus or their intracellular killing.

30 ticipated in their laser-light induced photo killing.

31 e antibiotic efficacy and enhance phagocytic killing.

32 d TNF-alpha production and improved bacteria killing.

33 2 production were required for cardiomyocyte killing.

34 butes to host defense by mediating microbial killing.

35 microvessels, all without extensive vascular killing.

36 d in increased resistance of E. coli to PGRP killing.

37 keeping with reduced intracellular bacterial killing.

38 roduction and results in increased bacterial killing.

39 ely due to bacterial permissiveness to phage killing.

40 n species, which are necessary for microbial killing.

41 of death in children in developing regions, killing 114,900 globally in 2014.

42 Mass coral bleaching quickly ensued, killing 40% of the resident coral community in an event

43 le of p53 activation timing makes fractional killing a complex dynamical challenge, which is hard to

44 hether G. bethesdensis evades phagolysosomal killing, a host defense pathway intact in both normal an

45 its CD8 T cells with an increased number and killing ability to the tumors.

46 Diet-induced obesity impaired AT1-ILC killing ability.

47 la4, Tigit, and Btla, thereby limiting their killing ability.

48 lement-mediated attack, improving phagocytic killing activity of neutrophils, and preventing bacteria

49 Opsonophagocytic killing activity showed antibody functionality.

50 We analyzed the killing activity, oxidative burst, cytokine production,

51 brane damage and exhibited more complex cell-killing activity, probably because of two different mode

52 el, col-aaPEG displayed acceptable bacterial killing against P. aeruginosa ATCC 27853 and no nephroto

53 Integrated modelling of intracellular Mtb killing alongside conventional extracellular Mtb killing

54 There were also differences in IT-mediated killing among transfected and infected cell lines that w

55 To study how multistage killing and a lack of steady state influence the functio

56 GM-CSF) signaling, which stimulates pathogen killing and clearance by alveolar macrophages through ex

57 y target HDP induction, facilitate bacterial killing and disrupt the UPEC infection cycle.

58 oxidative burst but decreased P. aeruginosa killing and earlier cell necrosis.

59 aesthetics for both scientific study, humane killing and euthanasia at end of life.

60 isting strategies known to combat fractional killing and facilitate the design of novel strategies.

61 ibed based on observations of interbacterial killing and has been assumed to function primarily as a

62 velop a population-dynamic model quantifying killing and HGT on solid surfaces.

63 payload release by 2 days, and in vitro cell killing and in vivo tumor shrinkage 2 to 3 days later.

64 Synergistic effects of contact-killing and protein-repellent properties were shown to y

65 e mechanisms that limit effective tumor cell killing and the identification of apoptotic vulnerabilit

66 e disrupted using peptides leading to direct killing and the sensitization of PEL cells to proapoptot

67 replicative stress and increased tumor cell killing and tumor control by DNA damage therapies in ani

68 ne dinucleotide phosphate) oxidase-dependent killing and, in turn, host susceptibility to invasive as

69 ving residents at the time of the survey; 43 killings and 83 kidnappings of household members were re

70 ty analysis suggests that the actual toll of killings and kidnappings may be underestimated in our da

71 ut the current household composition and any killings and kidnappings of household members by ISIS.

72 To obtain the overall toll of killings and kidnappings, those probabilities were multi

73 (5 months and 1 year; approximately 10%-20% killing) and adult fibroblasts (20 years old; approximat

74 icantly reduced phagocyte-mediated bacterial killing, and exposure to high temperatures increased rel

75 phil extracellular trap formation, bacterial killing, and induction of apoptosis.

76 ding can restore host immunity towards tumor killing, and many new drugs have been developed to targe

77 nasopharyngeal carriage, reducing phagocytic killing, and resulting in increased inflammation and tis

78 etabolism, resistance to neutrophil-mediated killing, and survival in vivo Our investigation indicate

79 cultures, autoimmunity or self-targeted cell killing, and the engineering or control of metabolic pat

80 are important in humans, although proactive killing appears to be typically more frequent in war.

81 Both peptides were bactericidal, killing approximately 90% of Escherichia coli and Pseudo

82 Both types of killing are important in humans, although proactive kill

83 of RpoN* protected C. elegans in a paralytic killing assay, whereas worms succumbed to paralysis and

84 In a slow killing assay, which mimics establishment and proliferat

85 01) and of primary MM cells (72.9% +/- 12.2% killing at 3 days, E:T ratio 1:1; P < .05, n = 5).

86 Widespread tumor cell killing at 5 days was prevented by depletion of CD8(+) T

87 r activity, show significant selectivity for killing bacteria over mammalian cells, and finally, why

88 perimental studies suggest contact-dependent killing between different strains as a mechanism of kin

89 and Proteus mirabilis, we found the rates of killing between the strains to be highly asymmetric, i.e

90 me colicin N molecule and later, during cell killing, binding to two different receptors, OmpF and To

91 ibit comparable nonspecific opsonophagocytic killing, biofilm production, and adhesion to nasopharyng

92 paclitaxel-resistant prostate cancer cells, killing both cancer stem-like cells (CSC) and bulk tumor

93 eal that these peptides not only induce cell killing but also potently sensitize PEL to the proapopto

94 poptotic signaling responses that limit cell killing, but also primes cells for inhibitors of anti-ap

95 er in E. coli and trigger P. aeruginosa T6SS killing, but not pilus production.

96 The lack of meningococci killing by blood containing eculizumab resulted from inh

97 eptide at 0.1 nM are completely resistant to killing by C. albicans The peptide also protects macroph

98 at likely permitted CD22(+) cell escape from killing by CD22-CAR T cells.

99 Here, we show that suppression of CTL killing by CD4(+)CD25(+)Foxp3(+) regulatory T cell (Treg

100 t affect WLBU2 killing compared to decreased killing by cefazolin.

101 e pathways to predict cellular resistance to killing by DNA-damaging agents.

102 udged from flow cytometric assays, bacterial killing by GA occurred within minutes.

103 Efficient killing by GA was also demonstrated in Acinetobacter bau

104 odalis glossinidius, requires PhoP to resist killing by host derived antimicrobial peptides.

105 ex vivo, which was associated with increased killing by human neutrophils.

106 is severely attenuated in ability to resist killing by human polymorphonuclear leukocytes.

107 st vertebrates are most threatened by direct killing by humans.

108 hyloxanthin production and susceptibility to killing by hydrogen peroxide, respectively.

109 ans, its absence sensitizes the bacterium to killing by ionizing radiation (IR).

110 N-gamma sensitizes these leukemias to T cell killing by mechanisms other than MHC upregulation.

111 Bacterial killing by MSC was found to be mediated in part by secre

112 n and biofilm formation, decreases bacterial killing by neutrophil extracellular traps, and modulates

113 veloped strategies to evade phagocytosis and killing by neutrophils.

114 fied by Tn-seq in A. baumannii resistance to killing by NHS but not by normal mouse serum, highlighti

115 Killing by NK cells is mediated by a small family of act

116 levant A. baumannii strains are resistant to killing by normal human serum (NHS), an observation supp

117 is usually resists complement-mediated serum killing by recruiting to its surface a complement inhibi

118 n endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereb

119 ureus biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared

120 , forming drug-tolerant biofilms that resist killing by the immune system.

121 es lacking pAKT (P = .024) and exceeded cell killing by the PI3K-delta-specific inhibitor idelalisib.

122 with decreased metabolic rate, refractory to killing by these drugs, and able to generate drug-resist

123 th rMIF is associated with reduced bacterial killing by tobramycin.

124 ing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAI

125 development of a targeted toxin selectively killing cancer cells.

126 collected, and serum was tested for bacteria-killing capacity against Escherichia coli, as a function

127 ressive effect that results in reduced tumor-killing capacity by NK cells.

128 f up to 81 wt % and demonstrated efficacy at killing cells beyond the burst release effect.

129 Instead of killing cells, caspases now promote the generation of in

130 idative phosphorylation did not affect WLBU2 killing compared to decreased killing by cefazolin.

131 ce to antibody-dependent complement-mediated killing compared with enterocolitis-causing strains of S

132 more limited effector functions and reduced killing compared with memory-derived populations.

133 This fractional killing contributes to drug resistance in cancer.

134 P. stomatis susceptibility to extracellular killing could be attributed to the exocytosis of antimic

135 However, killing could be blocked by antibodies against FasL, whi

136 ing alongside conventional extracellular Mtb killing data, generates the biphasic responses typical o

137 Although CR-PIT can induce tumor killing deep within body, it is less effective than NIR-

138 PGRP-induced killing depended on the production of hydrogen peroxide,

139 ity and difficulties in distinguishing their killing domains from those of other competition systems.

140 s designed to release ivermectin, a mosquito-killing drug for 10 days after a single oral dose.

141 mic (PK-PD) approach we demonstrate that the killing dynamics of the intracellular Mtb sub-population

142 The cell killing effects of two representative voxels (isocenter

143 e therapy is developed for significant tumor-killing effects, more effective than conventional starvi

144 ts in 10-fold improvement of its cancer cell-killing efficacy.

145 This opens therapeutic avenues combing the killing efficiency of NK cells with the diversified targ

146 bacterium B. subtilis and good photothermal killing efficiency toward both B. subtilis and Gram nega

147 lity, increased nonspecific opsonophagocytic killing, enhanced biofilm formation, and increased adhes

148 signaling also enables sequential tumor cell killing, enhances the formation of effective immune syna

149 xygen species and protect against neutrophil killing, enhancing fitness within the heart.

150 sport inhibitors killed trypanosomes without killing erythrocytes, neurons or liver cells.

151 r biomass flocculation is a key mechanism of killing for cationic, amphipathic AMPs, which may explai

152 L-4R-signaling in vitro, uncoupling parasite killing from expulsion mechanisms.

153 Features, such as fast parasite killing, good safety margin, a potentially novel mode of

154 oxacin combinations were highly synergistic, killing >6 log CFUs/g of vegetations in 6 hours and succ

155 fast ice after 2006 ramped iceberg scouring, killing half the encrusting benthos each year in followi

156 from castor beans were the most effective in killing HIV-infected cells.

157 d severe single- or multi-organ pathologies, killing hundreds of thousands of people annually.

158 0 CFU mL(-1), rapid antibacterial rate (100% killing in 30min) and high detection sensitivity (as low

159 SS-BEN/miR-34a not only enhanced cancer cell killing in cultured human colon cancer cells, but also i

160 GAS isolates to express capsule and to evade killing in human blood, phenotypes that are not observed

161 cal models of human cancers and induced cell killing in leukemia cells.

162 flammatory cytokine expression and bacterial killing in macrophages and boosted protection against in

163 activating macrophages to induce tumor cell killing in mice.

164 mechanisms underlying incomplete tumor cell killing in oncogene-addicted cancer cells, we investigat

165 idespread CD8(+) T-cell-dependent tumor cell killing in primary tumors and metastases, and that these

166 data highlight striking differences in cell killing in vivo, depending on the cell subset and organs

167 assay and suppressed antibody-mediated cell killing in vivo.

168 lly righteous, including capital punishment, killing in war, and drone strikes that kill terrorists.

169 P7 inhibition induces significant tumor-cell killing independently of ATM and p53 through the accumul

170 to inhibit innate immune-mediated bacterial killing independently of other S. aureus proteins, since

171 The kinetics of killing individual cells that lack lamA are more uniform

172 Cytotoxic T lymphocyte (CTL)-mediated killing involves the formation of a synapse with a targe

173 a sigmoid dependence on the CTL density when killing is a multistage process, because it takes typica

174 Macrophage intracellular pathogen killing is defective in cystic fibrosis (CF), despite ab

175 Importantly, when the killing is measured before the steady state is approache

176 rimination, but it is not clear whether this killing is sufficient to explain the observed patterns.

177 Male pheromone-mediated killing is unique to androdioecious Caenorhabditis, and

178 oney-traps" attracting M. incognita and then killing it by contact or fumigation.

179 apture the observed properties of fractional killing, it was analyzed with nonlinear dynamical tools.

180 losses and the energetic gains derived from killing larger prey.

181 Consequently, for transplant recipients, killing latently infected cells could have far-reaching

182 ting of a modest increase in fusion and cell killing, lower neuraminidase activity, and reduced viral

183 ng rate on the CTLs during initial phases of killing may be indicative of a multistage killing proces

184 However, the killing mechanism of Cu-Cy nanoparticles on cancer cells

185 ncreased resistance, confirming the parasite-killing mechanism.

186 s directing robust and rapid early T. gondii-killing mechanisms in the LEW rat.

187 e significantly more sensitive to clonogenic killing mediated by platinum-based chemotherapy and IR (

188 d both volume and surface plasmas capable of killing microbes.

189 re, produce immune activation and tumor cell killing more widespread than the infection, and suppress

190 M concentrations, IB was highly effective at killing mutant FLT3-driven AML cells through a similar m

191 lectively but acted differently, extensively killing MV endothelium.

192 AR23 greatly augments myeloid cell-dependent killing of a collection of hematopoietic and nonhematopo

193 itor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abr

194 antigens and found these cells could mediate killing of autologous lymphoma cells.

195 iciently internalized via hCD22 resulting in killing of B-cell lymphoma cells.

196 observed in healthy individuals and improved killing of B. pseudomallei in vitro.

197 echanism of reactive oxygen species-mediated killing of bacteria by neutrophils.

198 f bacteria throughout the colony exceeds the killing of bacteria on the surface and pinpoints how the

199 Moreover, neutrophil-mediated killing of biofilm bacteria correlated with the evident

200 Impaired killing of biofilm parallels the decrease in NET product

201 CD8(+) T cell-dependent killing of cancer cells requires efficient presentation

202 ossibly transcription), leading to selective killing of cancer cells with BRCA1/2 mutations.

203 circuits triggered selective T cell-mediated killing of cancer cells, but not of normal cells, in vit

204 ntratumoral vessels as a result of increased killing of cancer cells, setting up a positive feedback

205 f AB307.30 but failed to increase phagocytic killing of capsule-positive strains.

206 cific receptors, such as Ly49A, that inhibit killing of cells expressing self-MHC-I.

207 They also effectively mediated killing of chronically and acutely HIV-1 infected T cell

208 dent bacterial weapon that allows for direct killing of competitors through the translocation of prot

209 was reduced, consistent with their impaired killing of EBV-infected cells.

210 fic opsonic antibodies in mice, resulting in killing of encapsulated bacteria by phagocytic activity.

211 tudies have shown that NOX2 is essential for killing of G. bethesdensis by neutrophils and monocytes

212 genes, which are essential for the enhanced killing of ganetespib treated melanoma cells by T cells.

213 ll maturation and improved effector-mediated killing of HIV-infected CD4 T cells by the HIV envelope-

214 ary CD4 T cells, venetoclax causes selective killing of HIV-infected cells, resulting in decreased nu

215 ulation is associated with cytokine-mediated killing of human beta-cells, a process partially prevent

216 ical for Staphylococcus aureus targeting and killing of human neutrophils ex vivo and is produced in

217 cytotoxic T lymphocyte (CTL) recognition and killing of infected cells.

218 The enhanced killing of M. tuberculosis in macrophages in vivo by CD4

219 ruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.

220 rimary MM, at low E:T ratios (56.2% +/- 3.9% killing of MM.1s at 48 h, E:T ratio 1:32; P < .01) and o

221 urn lead to increased susceptibility to host killing of MRSA.

222 teine to isoniazid treatment potentiated the killing of Mtb Furthermore, we demonstrate that the addi

223 ns of anisomycin induced selective apoptotic killing of Mtb-infected human macrophages, which was com

224 Finally, selective killing of Mtb-infected macrophages and subsequent bacte

225 in-induced autophagy increased intracellular killing of Mtb.

226 ulated process to allow for effective serial killing of NK cells.

227 Phagocytosis and killing of NTHi by macrophages were evaluated by an in v

228 These aggregates can drive contact-dependent killing of other organisms, or Caulobacter cells not pro

229 1 function, we further demonstrate selective killing of p53-deficient cells with camptothecin while s

230 o the peritoneum, or improve phagocytic cell killing of pathogens.

231 P90 with ganetespib enhances T-cell-mediated killing of patient-derived human melanoma cells by their

232 efense against S. aureus both through direct killing of S. aureus and enhancing the antimicrobial fun

233 ce macrophage phagocytosis and intracellular killing of S. aureus In this study we report evidence in

234 for inflammatory cytokine production and the killing of target cells; however, much less is known abo

235 use of venetoclax, which causes preferential killing of the HIV-expressing cells.

236 antiserum mediated in vitro opsonophagocytic killing of the strain harboring the pIP501 plasmid and a

237 -1) disruption augmented CAR T cell mediated killing of tumor cells in vitro and enhanced clearance o

238 ly studied with regard to NK recognition and killing of tumors.

239 ells have been defined by nonspecific innate killing of virus-infected and tumor cells.

240 y been shown to enhance complement-dependent killing of, and facilitate bacterial clearance in, anima

241 i wafers with or without nanopillars gave no killing or rupture of dormant spores of B. subtilis, Bac

242 lls to platinum therapy and was effective in killing ovarian cancer stem cells that contribute to bot

243 oceria particles were much more effective at killing P. aeruginosa and S. epidermidis at basic pH val

244 ing the functional amount of AMPs capable of killing pathogens.

245 nsing (QS) apparatus have a rapid and potent killing phenotype following microinjection into an insec

246 oducing Th1-polarized effector cytokines and killing PIV3-expressing targets.

247 rlapping transcripts to encode both a gamete-killing poison and an antidote to the poison.

248 L-asparaginases maintain their in vitro ALL killing potential.

249 well studied, but the mechanism of helminth killing prior to expulsion remains unclear.

250 of killing may be indicative of a multistage killing process.

251 Furthermore, low-dose DAC preserved HSPC-NK killing, proliferation, and interferon gamma production

252 We find that at steady state the total killing rate (i.e., the number of target cells killed by

253 Compared to single-stage killing, the total killing rate during multistage killing saturates at high

254 Second, the total killing rate exhibits a sigmoid dependence on the CTL de

255 In conclusion, a sigmoid dependence of the killing rate on the CTLs during initial phases of killin

256 ult in a peak in the dependence of the total killing rate on the target cell density.

257 lymphoid tissue and correlates of bacterial killing, reduced checkpoint signaling, and the relocatio

258 lexes and reduces antibody binding and serum killing relative to the parental strain, suggesting that

259 chemotherapy and IR ( approximately 70%-80% killing) relative to young fibroblasts (5 months and 1 y

260 ng, the total killing rate during multistage killing saturates at higher CTL and target cell densitie

261 ce to antibody-dependent complement-mediated killing secondary to genetic deletion is not necessarily

262 athematically demonstrate that T6SS-mediated killing should favour the evolution of public goods coop

263 response emerges for two reasons: First, the killing signal of each CTL gets diluted over several tar

264 rence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and

265 ost cell oxidative stress as a mechanism for killing T. gondii.

266 panied by a decrease in spore resistance and killing take place.

267 ion of specific CTLs producing cytokines and killing target cells in vivo at levels seen when using V

268 hroughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause

269 roups was a sequence motif critical for cell-killing that is generally not found in bacteriocins targ

270 ases perform physiological functions without killing the cell remains unclear.

271 ate in other physiological functions without killing the cells.

272 were indeed very effective in rupturing and killing the growing bacterial cells, while wafers withou

273 hages infected with mycobacteria efficiently killing the infected cells and decreasing survival of my

274 of pro-apoptotic granzymes, thereby rapidly killing the target cell.

275 Compared to single-stage killing, the total killing rate during multistage killin

276 Top predators can suppress mesopredators by killing them, competing for resources and instilling fea

277 ted in resistant mice and is responsible for killing tissue-embedded larvae.

278 antibodies for their ability to deliver cell-killing toxins to HIV-infected cells and to perform othe

279 multiple cell death pathways preferentially killing transformed and cancer stem cells.

280 EAB feeds and develops beneath the bark, killing trees rapidly.

281 Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor

282 dothelium, LUV-TRAIL being more efficient in killing tumour cells, showing no effect on the integrity

283 CD4 + CTL killing was also detected in FV-infected granzyme B knoc

284 as visualized microscopically, and bacterial killing was assessed by bacterial culture.

285 The defect in COPD AM intracellular killing was associated with a reduced ratio of mROS/supe

286 tion spread to tumor cells, where tumor cell killing was much more widespread than the infection.

287 urophilic granules and is used for microbial killing, was found to be mobilized to the PMN surface an

288 tus is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sep

289 riable, numerous instances of cross-reactive killing were observed.

290 cient to protect cells against TRAIL-induced killing, whereas immunodepletion of TRAILshort with a sp

291 a simple dynamical framework for fractional killing, which predicts that cell fate can be altered in

292 decreased resistance to neutrophil-mediated killing, which resulted in selection for the modA2 OFF s

293 y neutrophils, S. aureus shows resistance to killing, which suggests the presence of phagosomal immun

294 erived a general functional response for CTL killing while considering that CTLs form stable synapses

295 MCs), sensitize tumours to TNF-alpha-induced killing while simultaneously blocking TNF-alpha growth-p

296 l, as ookinetes lacking P47 are targeted for killing while traversing the mosquito midgut cells and e

297 ncides with increased susceptibility to CD40 killing, while in normal cells CD40 signalling is cytopr

298 r, the VC(R) isomer, mediated effective cell killing with a cysteine-VC(R)-MMAE catabolite generated

299 impairs optimal ROS production for bacterial killing with important implications for host survival in

300 D4 T cells and a novel mechanism of parasite killing within infected erythrocytes.