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1 points (typically, to within approximately 1 kilobase).
2 dividual and a density of 1.1 variations per kilobase.
3 rage 3.2 single-nucleotide polymorphisms per kilobase.
4 ypically within several kilobases to tens of kilobases.
5 h the smallest genome currently known at 112 kilobases.
6 with mate-pair libraries extending up to 20 kilobases.
7 ng nearly all genes that are longer than 200 kilobases.
8 raction patterns at length scales of several kilobases.
9 s, wild-type Yan-bound regions span multiple kilobases.
10 tational hot and cold spots spanning several kilobases.
11 tivation from as far away as several hundred kilobases.
12 ically relevant level of tens to hundreds of kilobases.
13 gions of recombination extended over several kilobases.
14 recovered by another binding event within 10 kilobases.
15 equence variants (PSVs) separated by several kilobases.
16 clusters, which range from 1 to hundreds of kilobases.
17 ce accuracy of about 1 false variant per 100 kilobases.
18 de polymorphisms in genomic regions up to 50 kilobases.
19 t units, arranged in tandem over hundreds of kilobases.
20 ns and promote their assembly across several kilobases.
21 igns has been limited to tens or hundreds of kilobases.
22 ging from several hundred base pairs to many kilobases.
23 served RNA structural domains that span many kilobases.
24 nvasive variant detection across hundreds of kilobases.
25 elic gene conversion events spanning tens of kilobases.
26 etween direct and tethered GBSs over tens of kilobases.
27 ve multivalent interactions over hundreds of kilobases.
28 so identified a highly conserved sequence 21 kilobase 5' of BP4 that we called BE5.2, which contains
29 ife forms harbored approximately 3.4 introns/kilobase, a greater intron density than in most of the e
30 ss Igh domains that span tens to hundreds of kilobases, a phenomenon not observed in simple eukaryote
31 gh frequency of CNCs of tens to thousands of kilobases across the human genome that closely resemble
32 rial artificial chromosome libraries with 21-kilobase and 83-kilobase inserts in the P[acman] system.
33 urther measure a ribosome density of 1.3 per kilobase and an elongation rate of 13-18 amino acids per
34 he delayed regions can encompass hundreds of kilobases and generally correspond to regions that repli
35 les per parS site (~20) can spread over many kilobases and suggests a mechanism by which ParB protein
36 ethylated DMRs spanned up to several hundred kilobases and were frequently found at gene family clust
37 mpirical p = .04 for duplications of 100-200 kilobase) and a particular deletion region spanning gene
38 cestor of eukaryotes contained >2.15 introns/kilobase, and the last common ancestor of multicellular
39 ons at a resolution as fine as a few hundred kilobases, and the genes with the most similar synonymou
41 uently associated with cis variants within 5 kilobases, as were intron retention alternative splicing
42 e heterozygous for deletions of at least 593 kilobases at 16p11.2 and whose ascertainment included co
43 tion of discrete target fragments of several kilobases at 37 degrees C from both double- and single-s
44 lexes traveling an average distance of >/=10 kilobases at a velocity of 60 base pairs per second.
45 henomenon-duplication of tens or hundreds of kilobases at the breakpoint junction, so that the same s
46 is bound across domains spanning 10 or more kilobases at the DAFC rather than at a specific site.
48 Enhancers are often located many tens of kilobases away from the promoter they regulate, sometime
51 variants in the same gene up to hundreds of kilobases away that cannot be obtained from DNA sequenci
52 al upstream CpG island (CGI) located several kilobases away that functions as an alternative promoter
53 good indicator of eQTL targets for genes 150 kilobases away, but insulators, TF co-occurrence, open c
54 ange interactions, up to tens of hundreds of kilobases away, of a number of cis-acting regulatory DNA
55 ter gene located at distances of hundreds of kilobases away, suggesting that both proximal and distal
60 or schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions
61 of the gene, contacting a region of several kilobases, concomitant with a loss of histone H3 and H4
62 dy data set, we identified a significant 202-kilobase consensus region on Chr15q24.1 (empirical P val
63 3 Mb (P = .02), as well as a significant 114-kilobase consensus region on chr4q31.3 (empirical P valu
64 PCR products in the range of 700 bases to 2 kilobases could be amplified without addition of cosolve
65 ed proteins encoded in the approximately 100 kilobase crAssphage genome showed no significant similar
66 presses wild-type mtDNA and mtDNA with a 3.1-kilobase deletion (mtDNA) lacking four essential genes.
68 sequencing revealed a novel, heterozygous 3-kilobase deletion removing exons 7-9 of TP53 in the pati
69 tions of nucleosome density over hundreds of kilobases, delineating chromosomal domains within IgH, i
71 genomic variants (from 100 nucleotides to 10 kilobases), distinguishing these strains from the C57BL/
72 s, we observe the redistribution of XPD onto kilobase DNA strands containing a single base mismatch,
73 s of constant region exons (CHs) lie 100-200 kilobases downstream in the same transcriptional orienta
74 l elongation, even at operators located many kilobases downstream of the transcription start site and
76 in size (approximately 4 and approximately 6 kilobases) due to alternative 3' untranslated regions (U
82 tagenic synthesis is limited to within a few kilobases from the break by Mus81 endonuclease and a con
83 th modification footprints extending several kilobases from the site of dsRNA homology and with locus
85 scriptional enhancers can be located tens of kilobases from their target genes, but display character
87 e locus arose as a result of an unusual 24.7-kilobase gene duplication event mediated by the long ter
89 ent 'knock-in' targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (
97 omes to a low of 0.57 heterozygous sites per kilobase in segments inferred to have diploid Native Ame
98 Structural variations of DNA greater than 1 kilobase in size account for most bases that vary among
100 rom minicircles, which are approximately one kilobase in size, and encode between three and four gRNA
101 ged from a high of one heterozygous site per kilobase in west African genomes to a low of 0.57 hetero
103 covery and 23 for fine-mapping) spanning 300 kilobases in and around COL5A1 were genotyped and tested
104 zed noncoding RNAs that are 10's to 100's of kilobases in length and low in abundance due to efficien
105 generate short tandem repeats, often several kilobases in length, embedded within (G+C)-rich genomic
106 pe-resolved, sequence motif maps hundreds of kilobases in length, resulting in a median coverage of 1
109 ess double-stranded DNA genomes of 65 to 100 kilobases in size that encode a structural module charac
110 In contrast to hotspots, which are a few kilobases in size, and widely scattered throughout the g
111 ng domains (TADs), typically several hundred kilobases in size, form an intermediate level of organiz
114 own diabetes risk factors, odds ratios per 1-kilobase increment were 1.00 (95% CI 0.90-1.11) in white
116 stant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminate
118 at continued processive unwinding of several kilobases involves multiple monomers at the DNA unwindin
119 assembly of silenced chromatin over several kilobases is likely an important mechanism for maintaini
120 family-based analysis, an approximately 200 kilobase (kb) deletion in the first intron of the MAGI1
121 e rs1619661 variant is on chromosome 10, 132 kilobase (kb) downstream from <em>CXCL12</em>, which enc
124 uclear injection of a construct carrying a 3-kilobase (kb) region of the Rlbp1 gene and 5'-flanking s
125 method, we utilized sequence data from a 200-kilobase (kb) region on chromosome 9p21 of the human gen
126 , and specific segments at megabase (Mb) and kilobase (kb) resolutions of single average and ensemble
127 transiently transfected PC12 cells with a 9-kilobase (kb) TH promoter-luciferase (Luc) construct.
129 ation was characterized as a deletion of 112 kilobase (kb), encompassing over 90% of PRPF31 and five
136 ll rare exonic CNV in the size range of 1-30 kilobases (kb), making use of the eXome Hidden Markov Mo
143 s inflated with short repeats and is tens of kilobases larger than the ptDNAs of its closest known ph
147 d base-pair level models (BPLMs) to simulate kilobase-length dsDNAs and dsRNAs under external forces
149 g chromosomal regions of tens to hundreds of kilobases long that are derived from two closely related
152 Schwann cells and harbored a homozygous 10.7-kilobase-long deletion encompassing a myelin-specific en
153 pre-mRNA) that is initiated within a several-kilobase-long region, called the transcription start sit
157 population-specific selective signals to 55 kilobases (median), identifying known and novel causal v
160 d robustness, we synthesized the entire 16.3-kilobase mouse mitochondrial genome from 600 overlapping
165 ectral abundance factor (NSAF) and reads per kilobase of exon model per million mapped reads (RPKM) a
166 ssion quantification matrices (Fragments Per Kilobase Of Exon Per Million Fragments Mapped, Transcrip
167 model per million mapped reads and reads per kilobase of gene model per million mapped reads, for qua
168 dated a 2-fold cutoff and 10 RPKM (reads per kilobase of mappable length per million mapped reads) (~
169 variants in the tumors: 0.66 variations per kilobase of sequence, compared with the corresponding no
170 cts and introduced new strategies, reads per kilobase of splice junction model per million mapped rea
171 ly 28,900 transcripts was >/=2 fragments per kilobase of transcript per million mapped fragments, and
173 ch to measure the effects of a total of >450 kilobases of 3' UTR sequences from >2,000 human genes on
174 otable in that rs910652 is located within 78 kilobases of ADAM33, which is one of the most well studi
175 , Bayesian and parsimony analyses of over 41 kilobases of aligned DNA sequence from 62 single-copy nu
177 Factor) genes showed that 97% were within 50 kilobases of an inducible CBP peak, and 70% of these req
178 We found that Slx4 is recruited within a few kilobases of an irreparable DSB, through the interaction
179 y bind AhR on the CYP1A locus, we scanned 75 kilobases of chromosome 15 sequence for high-affinity Ah
180 verted repeats that are separated by several kilobases of DNA and share >20 base pairs of homology.
181 he sloppy paired (slp) locus, we analyzed 30 kilobases of DNA encompassing the tandem, coordinately r
182 wed by replication that can copy hundreds of kilobases of DNA from a donor molecule all the way throu
183 ineages of insects, based on approximately 8 kilobases of DNA sequence data from a worldwide sample i
184 lymerase II (Pol II) transcribes hundreds of kilobases of DNA, limiting the production of mRNAs and l
187 art sites, potentially bypassing hundreds of kilobases of interspersed sequence on the linear genome.
188 omosomes (BACs) containing approximately 200 kilobases of mammalian genomic DNA tagged with lac opera
189 also constructed phylogenetic trees from 14 kilobases of nuclear genes for representatives from most
194 he following biomarkers were associated with kilobase pair differences in LTL: BMI -0.00478 (95% CI -
198 lete chemical synthesis to minimize the 1079-kilobase pair synthetic genome of Mycoplasma mycoides JC
199 that displayed ESBL activity possessed a 140-kilobase-pair plasmid that produced the TEM-63 beta-lact
200 ion of Sir proteins over a region of several kilobase pairs compared to the telomeric repeat, even th
201 shared a rare haplotype of approximately 644 kilobase pairs containing the c.828+3A>T mutation, which
202 es with knots for DNA molecules of up to 166 kilobase pairs in length and find that the knotting occu
207 i-essential genes, produced JCVI-syn3.0 (531 kilobase pairs, 473 genes), which has a genome smaller t
211 ding reporting the read counts and reads per kilobase per million mapped reads (RPKM) for genes selec
212 Defining a gene with more than one read per kilobase per million mapped reads as expressed, we ident
213 734 were transcriptionally active (reads per kilobase per million reads >/= 3), representing approxim
216 cates on single-stranded DNA (ssDNA), it has kilobase processivity; yet, it is unable to processively
217 encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (
218 In addition, we discovered extensive (>1 kilobase) protein occupancy domains (EPODs), some of whi
219 ids, composed of up to five DNA parts in the kilobase range with efficiencies of between 75 and 100%.
221 mediated by nonhomologous end-joining using kilobase, rather than megabase, fragments of DNA, which
222 l-time sequencing, which generates long (>16 kilobases) reads with random errors, we assembled 99% (2
224 h variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 (0.35%)
225 odds ratio = 1.27) was identified with a 170-kilobase region on chromosome 1q32 that contains 3 genes
226 tically mapped the carbonaria morph to a 200-kilobase region orthologous to a segment of silkworm chr
227 vo 16p11.2 deletion, extending through a 593-kilobase region previously associated with autism and me
228 ochores or CpG enriched segments across a 22 kilobase region surrounding the IGF2 gene in the South A
230 a locus has been coarsely localized to a 200-kilobase region, but the specific identity and nature of
233 ven with analysis window sizes as small as 1 kilobase, reliable profiles can be generated with as lit
234 g development, primarily in units of 400-800 kilobases ('replication domains'), whose positions are p
236 ly inferred copy number at equivalent to 100-kilobase resolution genome-wide from a platform targetin
237 actions, and applied it to generate a map at kilobase resolution of the haploid genome of Saccharomyc
238 dentify >25,000 discrete origin sites at sub-kilobase resolution on the human genome, with high conco
239 r identifying and mapping large deletions at kilobase resolution, suggesting that data generated from
243 cherichia coli chromosome ( approximately 10 kilobases) reveal large-scale conformational transitions
245 been demonstrated previously with a multiple-kilobase 'scaffold strand' that is folded into a flat ar
246 f guide RNAs (gRNAs) to program thousands of kilobase-scale deletions that deeply scan across a targe
248 Gene silencing showed that genes in a 31-kilobase segment at rhg1-b, encoding an amino acid trans
249 ion of a cytogenetically cryptic event: a 77-kilobase segment from chromosome 15 was inserted en bloc
251 ntiguous chromosomal segments of hundreds of kilobases separated by smaller segments where the replic
252 h some vendors are beginning to supply multi-kilobase sequence-verified constructs, synthesis workflo
254 hundred nucleotides apart are clustered over kilobase-sized regions, often associated with sites of D
256 a mouse lacking the entire approximately 400-kilobase Slam locus, which encodes all six SFRs and CD48
259 ediated H3K9me3 methylation over hundreds of kilobases surrounding HBB and on G9a-mediated H3K9me2 me
260 ing ~18,000 single guide RNAs targeting >700 kilobases surrounding the genes NF1, NF2, and CUL3, whic
261 across large genomic regions (more than 100 kilobases) surrounding two key autoimmunity risk loci, C
264 e MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tiss
267 oscopic, intralocus deletions of hundreds of kilobases that often result in inactivation of associate
269 tural variants including medium size (from 1 kilobase to 1 megabase) deletions and duplications, and
272 hromosomal DSBs separated by several hundred kilobases to be frequently joined together and discuss t
273 olor imaging of regions ranging from tens of kilobases to megabases with the same basic protocol.
276 revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions
277 aging for different epigenetic states at the kilobase-to-megabase scale, a length scale that is direc
278 s, whereas regional centromeres span several kilobases up to megabases and do not seem to have DNA se
286 ucleotide polymorphism (SNP) rs11674786 (2.7 kilobases upstream of the family with sequence similarit
288 ingle nucleotide polymorphism (rs12979860) 3 kilobases upstream of the IL28B gene, which encodes the
289 maternal transcripts originate from several kilobases upstream of the imprinting control region (ICR
291 cations overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide
292 ponses (P = 0.0007), and SNP rs16983422 (2.8 kilobases upstream of the visinin-like 1 gene (VSNL1)) w
293 e integrated HPV-18 genome approximately 500 kilobases upstream, and enabled global analyses of the r
294 LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10
296 richodesmium, when normalized per intergenic kilobase, was comparable and twofold higher than that fo
298 on extends beyond the promoter, over tens of kilobases; we term such patterns of histone modification
299 Microdeletions and microduplications >100 kilobases were identified by microarray comparative geno
300 versions/deletions) spanning several hundred kilobases were identified that contributed significantly
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