ライフサイエンスコーパス: kinase

1 phorylation of p38 mitogen-activated protein kinase.

2 component of which is regulated by Aurora B kinase.

3 by glucose-6-phosphate dehydrogenase and AMP kinase.

4 myosin light chain kinase and Rho-associated kinase.

5 quired and serves as both a PINK1 and Parkin kinase.

6 en by activation of the metabolic sensor AMP kinase.

7 hly sensitive biosensors for various protein kinases.

8 ion site(s) of plant symbiotic receptor-like kinases.

9 idues in all three caspase-9 domains by nine kinases.

10 Activation of apoptosis signal-regulating kinase 1 (ASK1) in hepatocytes is a key process in the p

11 vation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylation and its autoph

12 tosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment

13 eceptor-interacting serine/threonine-protein kinase 1 (RIPK1), receptor-interacting serine/threonine-

14 mber A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (D

15 and clinically used inhibitor of sphingosine kinase 1 (SK1) FTY720 (fingolimod).

16 leading edge analyses identified Sphingosine kinase 1 (Sphk1) in the highest number of pathways affec

17 rming growth factor beta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7), which is associated with poor s

18 172 and of unc-51 like autophagy activating kinase 1 (Ulk1) at serine 555.

19 n stability of FOXO3A is regulated by Casein Kinase 1 alpha (CK1alpha) in an oncogenic RAS-specific m

20 tein kinase and phospho-AKT serine/threonine kinase 1 signaling pathways, as well as increased total

21 lts in mitogen- and stress-activated protein kinase 1/2 (MSK1/2)-catalyzed phosphorylation of histone

22 inhibition of extracellular signal-regulated kinase 1/2 activation.

23 ents, such as extracellular signal-regulated kinase 1/2 and label free, in a parallel manner without

24 rted in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote

25 mitogen-activated protein kinase interacting kinase-1 has a pivotal role in cocaine-induced connectiv

26 3 activation, independent of Janus-activated kinase-1)/Janus-activated kinase-2.

27 The tumor suppressor serine/threonine kinase 11 (LKB1/STK11) is one of the most frequently mut

28 le also enhancing Sid4's affinity for casein kinase 1delta (CK1delta).

29 We show that Abelson tyrosine-protein kinase 2 (Abl2) has a key role in regulating myofiber le

30 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitu

31 Although protein kinase casein kinase 2 (CK2) is readily detected in MKs and platelets,

32 Mutations in leucine-rich repeat kinase 2 (LRRK2) and alpha-synuclein lead to Parkinson's

33 Here we report that serine-arginine protein kinase 2 (SRPK2) phosphorylates delta-secretase and enha

34 of Janus-activated kinase-1)/Janus-activated kinase-2.

35 eceptor-interacting serine/threonine-protein kinase 3 (RIPK3), TIR-domain-containing adapter-inducing

36 l bovine serum (FBS) and a glycogen synthase kinase-3 (GSK3) inhibitor, and in serum-free media.

37 sm initiated by receptor-interacting protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase

38 ults in hyperactivation of glycogen synthase kinase 3beta (GSK3beta), followed by phosphorylation of

39 pathway and inhibition of glycogen synthase kinase 3beta (GSK3beta).

40 logical and functional role of p21-activated kinase 4 (PAK4) and its potential as a new target in MM

41 With-no-lysine kinase 4 (WNK4) regulates electrolyte homeostasis and bl

42 Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the

43 a new pathway that acts through NIMA-related kinase 6 (Nek6) and Hsp72 to promote centrosome clusteri

44 Z1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7).

45 cally, BRD4 is required for cyclin-dependent kinase 9 (CDK9) recruitment and phospho-Ser 2 carboxy-te

46 4 (BRD4) with NF-kappaB and cyclin-dependent kinase 9 (CDK9).

47 Protein kinase A (PKA) activation, which mediates CD dispersion

48 A protein kinase A (PKA) biosensor allowed us to resolve minute PK

49 nhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphodiesterase 3B (PDE3B), and a memb

50 NGF binds the tropomysin receptor kinase A (TrkA) and p75, resulting in the activation of

51 nizes TGFbeta-mediated activation of protein kinase A and inhibition of Protein kinase B (AKT).

52 yclase inhibitor MDL 12330A, and the protein kinase A antagonist cAMPS-Rp.

53 aused by cocaine-exacerbated D1-cAMP/protein kinase A dopamine signaling in pyramidal neurons that in

54 rived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcrip

55 the cAMP binding domain A (CBD-A) of Protein kinase A.

56 p mechanism in which 1) the cyclin-dependent kinase activating kinase Cak1 phosphorylaytes T207 durin

57 tes, including proteasome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR

58 e for membrane interaction, toward which the kinase active sites are oriented.

59 ine learning based classification of protein kinase active/inactive conformations, taking into accoun

60 h regulate autophagy induction through their kinase activities.

61 increased central nuclei, elevated creatine kinase activity and endomysial fibrosis.

62 Sin1 translation, and thus suppressed mTORC2 kinase activity and invasion in colon tumor cells.

63 wnregulation of transcription depends on ATM kinase activity and on the distance from the DSB.

64 Src tyrosine kinase activity and tyrosine phosphorylation of VE-cadhe

65 When levels of PI3-kinase activity and/or DE-Cadherin are reduced in NBs, N

66 tedly, autophosphorylated CPK28 had enhanced kinase activity at physiological concentrations of Ca(2+

67 latable S561A mutation or inhibition of Par1 kinase activity decreases SH3-GK interaction, causing PS

68 on and transport by cortical flow to control kinase activity gradients and polarity in the C. elegans

69 or pharmacologic inhibition of EGFR tyrosine kinase activity or downstream MEK activity attenuated th

70 of FRET-based kinase sensors for monitoring kinase activity under two-photon fluorescence lifetime i

71 addition, pTRS1 binding to PKR inhibited PKR kinase activity.

72 t both sites, as does the stimulation of ATM kinase activity.

73 PKR eIF2alpha binding site and blocking PKR kinase activity.IMPORTANCE The antiviral kinase PKR play

74 EMENT The Src family of nonreceptor tyrosine kinases acts in signaling pathways that regulate cell mi

75 Signaling proteins such as protein kinases adopt a diverse array of conformations to respon

76 ep of AD with a focus on the role of acetate kinase (AK), which is a key enzyme in methane production

77 y the metabolic sensor AMP-activated protein kinase (AMPK) as a beta1-integrin inhibitor in fibroblas

78 sed phosphorylation of AMP activated protein kinase (Ampk) at tyrosine 172 and of unc-51 like autopha

79 , inhibiting VEGFR2 or AMP-activated protein kinase (AMPK), a major decorin-activated energy sensor k

80 activity by promoting AMP-activated protein kinase (AMPK)-dependent trafficking of KATP and Kv2.1 ch

81 AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150.

82 Finally, we showed that A-kinase anchoring proteins play an essential role in ICAM

83 an be enzymatically phosphorylated by NAD(+) kinase and ATP or (tz) ATP to the corresponding N(tz) AD

84 eral control nonrepressed 2 serine/threonine kinase and increased expression of mammalian target of r

85 eral control nonrepressed 2 serine/threonine kinase and mammalian target of rapamycin (both molecules

86 ion for KIND1, and identify c-Jun N-terminal kinase and NF-kappaB as potential therapeutic targets fo

87 , and their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate o

88 5' adenosine monophosphate-activated protein kinase and phospho-AKT serine/threonine kinase 1 signali

89 ting PD-L1 protein stability by a cell cycle kinase and reveals the potential for using combination t

90 yosin-signaling pathways, myosin light chain kinase and Rho-associated kinase.

91 t is required for activation of SRC tyrosine kinase and simultaneously coordinates the attenuation of

92 phosphorylation of mitogen-activated protein kinases and Akt, and upregulation of p53, p21, and p16.

93 l mechanisms, that is, activation of Src/Abl kinases and degradation of beta-catenin/E-cadherin.

94 se inhibitory activity (toward both isolated kinases and EPCs) remained almost untouched and comparab

95 Calcium orchestrates the activity of several kinases and phosphatases, which interact in a coordinate

96 ses SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress responsive kinase), w

97 kinase kinase-extracellular signal-regulated kinase) and S6K-RPS6 (ribosomal protein S6 kinase-riboso

98 that the concerted action of DDK, Polo-like kinase, and CDK1 promotes efficient SC destruction at th

99 work, the starvation-induced Ser/Thr protein kinase ArnS (Saci_1181) which is located proximally to t

100 80x10(-8)), whereas SNPs associated with Src kinase-associated phosphoprotein 1 (SKAP1), matrix metal

101 H2A (gammaH2A) formed by Rad3/ATR checkpoint kinase at DNA lesions; however, the putative scaffold in

102 -induced dimerization of a receptor tyrosine kinase at the cell surface and directly measure binding

103 chloroplast import machinery, the regulatory kinase at the outer chloroplast membrane 1 (KOC1).

104 ple factors downstream of the core responder kinase ATM/ATR.

105 for example, that inhibiting the set of four kinases AURKB, NEK1, TTK, and WEE1 causes simulated HeLa

106 ortantly, we discover that receptor tyrosine kinase AXL is a transcriptional target of BCL6 in GBM an

107 f protein kinase A and inhibition of Protein kinase B (AKT).

108 nal-regulated kinase, phosphorylated protein kinase B, phosphorylated mammalian target of rapamycin,

109 Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets BCR signaling and is par

110 inib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BT

111 UC > 0.7) was achieved for approximately 200 kinases by (1) combining open with proprietary data, (2)

112 ulated CLR endocytosis and activated protein kinase C (PKC) in the cytosol and extracellular signal r

113 or -independent for co-dependency on protein kinase C delta (PKCdelta).

114 of focal adhesion kinase (FAK) in a protein kinase C dependent manner.

115 pha network, we identified the major protein kinase C substrate MARCKS (myristoylated alanine-rich C

116 rt by spatially restricting atypical protein kinase C, a negative regulator of non-muscle myosin IIB.

117 ent on C5aR1, intracellular calcium, protein kinase C, and calmodulin, and downstream signaling regul

118 ithelial cells transduced Gbetagamma-protein kinase C- and Gbetagamma-metalloproteinase/EGFR-dependen

119 ch 1) the cyclin-dependent kinase activating kinase Cak1 phosphorylaytes T207 during MI, and 2) Smk1

120 t the combination of activity of several key kinases can predict the occurrence of long-lasting forms

121 Although protein kinase casein kinase 2 (CK2) is readily detected in MKs

122 PI3KC3-C1 consists of the lipid kinase catalytic subunit VPS34, the VPS15 scaffold, and

123 etermine the functions of cell cycle-related kinase (CDK20) in radiochemoresistance.

124 mTOR and inhibitors of the cyclin-dependent kinases CDK4 and CDK6 substantially improve progression-

125 y controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression

126 oup of "plant-like" Ca(2+)-dependent protein kinases (CDPKs) transduces cytosolic Ca(2+) flux into en

127 yeast Schizosaccharomyces pombe, the protein kinase Cdr1 is a mitotic inducer that promotes mitotic e

128 m sensors (CBLs) and CBL-interacting protein kinases (CIPKs) are involved in Al resistance.

129 several RAS pathway proteins, including the kinases CK2 and p-ERK1/2 and the signaling scaffold KSR1

130 Optogenetic control of Rho-kinase combined with computational modeling reveals that

131 F-regulated scaffold that modulates receptor kinase complex assembly.

132 The Ctk1 kinase complex binds RNA in vitro, consistent with direc

133 a-arrestin, which is activated via the TORC1 kinase complex upon arginine uptake.

134 otein is implicated in the regulation of MAP kinase-controlled processes involved in mating, filament

135 g the Chaetomium thermophilum RIOK-2 protein kinase (Ct-RIOK-2) crystal structure 4GYG as a template.

136 tion of the receiver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (CKI1RD) from Arabidopsis

137 Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the eff

138 the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohe

139 , kcs1Delta (IP6 5-kinase), vip1Delta (IP6 1-kinase), ddp1Delta (inositol pyrophosphatase), or kcs1De

140 Here, we report an ATM-kinase dependent, unforeseen function of the nuclear iso

141 AS amplification increases receptor tyrosine kinase-dependent activation of RAS more potently in colo

142 the phosphorylation of Dam1 protein by Ipl1 kinase destabilizes this interaction.

143 mputational modeling reveals that active Rho-kinase diffuses to growing other immature neurites and i

144 Dual leucine zipper kinase (DLK) has been implicated in cell death signaling

145 that mutations in the N-terminal end of the kinase domain are more disruptive of protein function.

146 1 mono-methylates lysine 721 in the tyrosine kinase domain of EGFR, and that this methylation leads t

147 to sequences outside of-but adjacent to-the kinase domain of TrkA.

148 f necrosis, is executed by the mixed lineage kinase domain-like (MLKL) protein, which is triggered by

149 e-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein (MLKL), which results in disr

150 conventional Src inhibitors that target the kinase domain.

151 eraction and reveals novel potential protein kinase drug targets.

152 ndomized noninferiority clinical trials: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 an

153 nstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links

154 e cytosol and extracellular signal regulated kinase (ERK) in the cytosol and nucleus.

155 on of Src and extracellular signal-regulated kinase (ERK).

156 timulatory effect on extracellular regulated kinase (ERK1/2) was blocked by the Src family kinase inh

157 We have found that focal adhesion kinase expression is downregulated under a high glucose

158 resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C dependent manner.

159 Inhibition of focal adhesion kinase (FAK) rescued SERT function in synapses of KI mic

160 tion of occludin Ser(490) and focal adhesion kinase (FAK) Ser(722) and Tyr(576).

161 Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AKT and MAPK pathway signaling unde

162 locks PKD2's interaction with Focal Adhesion Kinase (FAK).

163 atopoietic cells, and is a member of the Tec kinase family that also includes Btk.

164 a, and A3) as well as a potent activity at a kinase, FLT3.

165 showed a clear substrate preference of both kinases for d-ribulose over a range of other sugars and

166 loped quantitative motifs for a selection of kinases from each branch of the kinome, with and without

167 A family of different eIF2alpha kinases function in the integrative stress response to i

168 Experiments with inhibitors of protein kinase G (PKG), protein kinase A (PKA), phosphodiesteras

169 The TTK protein kinase gene (TTK) on chromosome 6q14.1 was the most sign

170 ed signaling is primarily regulated via GPCR kinase (GRK)-mediated phosphorylation of activated recep

171 ing and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2-S2814 residue

172 ctivated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly interacts with a novel bindi

173 m/calmodulin (Ca(2+)/CaMK)-dependent protein kinase II (CaMKII) to the hippocampal PSD.

174 hen the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitor

175 tion of calcium/calmodulin-dependent protein kinase II, which promoted both hepatic insulin resistanc

176 The lipid kinase phosphatidylinositol 4-kinase IIIbeta (PI4KB) is an essential host factor for m

177 hat is an upstream regulator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an i

178 showed up-regulation of inhibitor of kappaB kinase (IKK) and increased phosphorylation of the NF-kap

179 ockdown of Akt1 and the NF-kappaB-activating kinase IKKbeta cooperatively downregulated histone H4 ex

180 The exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in gen

181 he regulatory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocortico

182 9 cells, suggesting a conserved role of this kinase in the epigenic activation of MOR in neurons.

183 d to determine the involvement of individual kinases in agonist-induced P-UAEC proliferation.

184 The central role of protein kinases in controlling disease processes has spurred eff

185 re we show that drugs that inhibit important kinases in the BCR signaling pathway inhibit activation

186 (dual serine-threonine and tyrosine protein kinase) in all four affected family members.

187 the expression of an endogenous Braf(D631A) kinase-inactive isoform in mice (corresponding to the hu

188 f not only GPCRs, but also receptor tyrosine kinases, including the highly cancer relevant insulin-li

189 Our findings show how GSK3 kinase inhibition can greatly enhance the mature charact

190 discovered a highly selective and potent BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibi

191 iagnosis and following conventional tyrosine kinase inhibitor (TKI) treatment.

192 netarsudil 0.02% ophthalmic solution, a rho-kinase inhibitor and norepinephrine transporter inhibito

193 ory of food-induced anaphylaxis with the ABL kinase inhibitor imatinib protected the mice from severe

194 inase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicating that the action of pilo

195 Bumped kinase inhibitors (BKIs) of Cryptosporidium parvum calci

196 Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent a

197 n toxicity in patients treated with tyrosine kinase inhibitors at levels not detectable via dermatolo

198 tivity observed between RAS activity and RAF kinase inhibitors in driving RAF activation.

199 Insofar as kinase inhibitors interfere with signaling dynamics, and

200 Epidermal growth factor receptor tyrosine kinase inhibitors, including gefitinib, erlotinib, and a

201 identified as potent ATP-competitive protein kinase inhibitors.

202 lts justify further investigation of AT with kinase inhibitors.

203 ng, persistent state in response to targeted kinase inhibitors.

204 ing endothelial progenitor EP cells) and the kinase inhibitory activity (toward both isolated kinases

205 Kinases (previously referred to as MUT9-like kinases) interact with and phosphorylate photoexcited CR

206 y, it reveals that mitogen-activated protein kinase interacting kinase-1 has a pivotal role in cocain

207 The absence of the Tec family kinase Interleukin-2 inducible T cell kinase (Itk) resul

208 rget of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activat

209 The Tec tyrosine kinase is expressed in many cell types, including hemato

210 ease the expression of the most abundant PDH kinase isoforms (e.g., PDK3), ameliorating PDH activity

211 family kinase Interleukin-2 inducible T cell kinase (Itk) results in T cell immunodeficiency in mice

212 More recently, clinical trials with Janus kinase (JAK) inhibitors have shown that cytokine recepto

213 icits neuroinflammation and c-Jun-N-terminal kinase (JNK) activation, which is associated with memory

214 t ATZ induces activation of c-Jun N-terminal kinase (JNK) and c-Jun and that genetic ablation of JNK1

215 c-Jun N-terminal kinase (JNK) plays a vital role in malignant transformat

216 th IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an important mediator of autoimmune an

217 ing Arg82p could propagate in ipk1Delta (IP5 kinase), kcs1Delta (IP6 5-kinase), vip1Delta (IP6 1-kina

218 vated protein/extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase) and

219 ation disrupts its interaction with upstream kinase LATS1, prevents its phosphorylation, and activate

220 and Physcion activates AMP-activated protein kinase, leading to synergistic inhibition of human leuke

221 regulated by kinases, such as the LIM domain kinase (LIMK), which regulates actin activity through ph

222 n receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway.

223 ially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate downstr

224 es into a refractory state: IL-1R-associated kinase-M, NFkB2/p100, and hypoxia-inducible factor-1alph

225 vates a prototypic mitogen-activated protein kinase (MAPK) cascade and triggers a dose-dependent diff

226 a meiosis-specific mitogen-activated protein kinase (MAPK) in Saccharomyces cerevisiae that couples s

227 Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man a

228 first glimpse of what an active TAM receptor kinase may look like and suggesting a potential role for

229 Our data suggest that Src kinase may represent a potential target that could inter

230 ctivation, we proposed that proline-directed kinases might specifically initiate the activation of CD

231 rine 14 of TRPC6 is embedded in a basophilic kinase motif that is highly conserved across species.

232 ong them, invertebrate tropomyosin, arginine kinase, myosin light chain, sarcoplasmic calcium-binding

233 rial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) catalyzes phosphorylat

234 In cancer cells, kinases of the Clk family control the supply of full-len

235 The p38 MAPK family is composed of four kinases of which p38alpha/MAPK14 is the major proinflamm

236 defects, while inhibiting myosin light chain kinase or phosphorylation of focal adhesion kinase was i

237 r, these data identify activation of the MAP kinase pathway in microglia as a cause of neurodegenerat

238 measurements across a comprehensive panel of kinases/phosphatases knockouts and time-resolved perturb

239 The lipid kinase phosphatidylinositol 4-kinase IIIbeta (PI4KB) is

240 In these stresses, different kinases phosphorylate eukaryotic initiation factor eIF2a

241 hosphorylated extracellular signal-regulated kinase, phosphorylated protein kinase B, phosphorylated

242 indicating that Gi/o and phosphoinositide 3-kinase (PI3K) mediate the increase independently of epid

243 PKR kinase activity.IMPORTANCE The antiviral kinase PKR plays a critical role in controlling HCMV rep

244 te key processes in human cells, and protein kinases play a pivotal role in health and disease.

245 We demonstrate that the polo-like kinase PLK-1 mediates the repulsive coupling between MEX

246 The mitotic kinase Plk1 contributes to the DNA damage response (DDR)

247 PK), a major decorin-activated energy sensor kinase, prevented decorin-evoked TFEB induction and nucl

248 four closely related Photoregulatory Protein Kinases (previously referred to as MUT9-like kinases) in

249 Here, we show that p38alpha kinase promotes EZH2 degradation in differentiating musc

250 irus (HCMV) infection activate the antiviral kinase protein kinase R (PKR), which potently inhibits v

251 both Src and extracellular signal regulated kinase proteins and with an increased expression of epit

252 e activation state of phosphatidylinositol 3-kinase (PtdIns3K) correlated with the macropinocytic act

253 ection activate the antiviral kinase protein kinase R (PKR), which potently inhibits virus replicatio

254 lation of the innate immune effector protein kinase R, which phosphorylates the eukaryotic initiation

255 with the calcium pump PMCA2 and the tyrosine kinase receptor ErbB2/HER2 in normal mammary epithelial

256 euregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schiz

257 th factors that are ligands for the tyrosine kinase receptor, Tie2.

258 Only a few hundreds of protein kinases regulate key processes in human cells, and prote

259 We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and A

260 n of sda, and Sda inhibits histidine protein kinases required for activation of the transcription fac

261 d kinase) and S6K-RPS6 (ribosomal protein S6 kinase-ribosomal protein S6) axes.

262 is triggered by receptor-interactive protein kinases (RIPK) 1 and 3.

263 Inhibition of Rho-associated kinase (ROCK) prevented cytoskeletal defects, while inhi

264 o-associated, coiled-coil containing protein kinase (ROCK).

265 Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinflammatory T cell

266 organic molecules against receptor tyrosine kinases (RTKs) has been shown to be a valuable strategy.

267 ther S. aureus strains, the sensor histidine kinase SaeS has an L18P (T53C in saeS) substitution, whi

268 re we improved the sensitivity of FRET-based kinase sensors for monitoring kinase activity under two-

269 demonstrated that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC with exacerb

270 sphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-catenin.

271 Here we report that Src family kinases (SFK) and focal adhesion kinase (FAK) sustain AK

272 Protein levels of the kinase SGK1 did not change.

273 The Abl tyrosine kinase signaling network controls cell migration, epithe

274 of IFNalpha, IFNbeta, IFNL1, IFNL2, or Janus kinase signaling via signal transducer and activator of

275 erations that activate cytokine receptor and kinase signaling.

276 cant homology with the force-activated titin kinase, smMLCK is suspected to be also regulatable by me

277 t hydrotropism depends on the ABA signalling kinase SnRK2.2 and the hydrotropism-specific MIZ1, both

278 WNK4 phosphorylates the kinases SPAK (Ste20-related proline alanine-rich kinase)

279 Here, we used a multiplexed assay for kinase specificity (MAKS) to identify the substrates dir

280 nt XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

281 bstrate MARCKS (myristoylated alanine-rich C kinase substrate) as a potential target molecule for kid

282 estigated the conformational dynamics of the kinase-substrate interface.

283 In cells, actin dynamics are regulated by kinases, such as the LIM domain kinase (LIMK), which reg

284 ptor (BCR)-proximal effector spleen tyrosine kinase (SYK), which we identified as an HSP90 client pro

285 We further identified SYK as a critical kinase that phosphorylates MyD88, promoted MyD88-depende

286 ng MOB1's differential binding to Hippo core kinases, thereby establishing MOB1 variants with selecti

287 complex and is responsible for bringing the kinase to sites of DNA damage.

288 of which may trigger phasiRNAs from numerous kinase transcripts.

289 that PKG, a malarial cGMP-dependent protein kinase, triggers egress, activating malarial proteases a

290 aggregation of the metabolic enzyme pyruvate kinase under environmental stress and propose a method t

291 ting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha, and consequently pro

292 l enrichment strategy targets intact protein kinases via capture on immobilized multiplexed inhibitor

293 in ipk1Delta (IP5 kinase), kcs1Delta (IP6 5-kinase), vip1Delta (IP6 1-kinase), ddp1Delta (inositol p

294 kinase or phosphorylation of focal adhesion kinase was ineffective.

295 inase) and OSR1 (oxidative stress responsive kinase), which then phosphorylate and activate the renal

296 Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to p

297 nd application of single-chain cofactor-free kinases with photoswitchable activity.

298 nverge on p38alpha mitogen-activated protein kinase within the fibroblast to program the fibrotic res

299 sphorylation that are often clustered, where kinases work together in a hierarchical manner to create

300 ls deficient in the regulator diacylglycerol kinase zeta (DGKzeta) with or without PD-1/PD-L1 blockad